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Publications
Vascular Destabilization and Pericyte Detachment are Mediated by hIAPP Aggregation in Transgenic Mice
Koepke J, Gonçalves LM, Barboza CA, Aplin AC, Hackney DJ, Gharib SA, Mohn O, Teng M, Castillo JJ, Almaça J, Hull-Meichle RL. bioRxiv [Preprint]. 2026 Feb 22:2026.02.21.707196. DOI 64898/2026.02.21.707196
Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis
Mummey HM, Corban S, Lucero J, Melton RL, Pittigher M, Johnston VC, Deutsch GH, D'Antonio-Chronowska A, Wang A, Hull-Meichle RL, Gaulton KJ. bioRxiv [Preprint]. 2025 Dec 16:2025.12.14.694120. DOI 64898/2025.12.14.694120
Research updates in cystic fibrosis related diabetes: Understanding pathophysiology, expanding animal and human islet models, and advancing clinical and translational research
Melissa S Putman, Rebecca L Hull-Meichle, Shafagh A Waters, Katherine Tuggle, Paula Sommer, Rebecca Conway, Lee A Borthwick, Jakob G Knudsen, E Danielle Dean, Sarah A Stanley, Xingshen Sun, John F Engelhardt, Shih-Hsing Leir, Lena Eliasson, Bibi Uhre Nielsen, Darko Stefanovski, Amanda Brennan, Charlotte K Boughton, Andrea Kelly, Amir Moheet, James AM Shaw. J Cyst Fibros 2026 May. 25(3), 393–4052026. DOI 1016/j.jcf.2026.03.021
Role of the Pancreatic Islet Microvasculature in Health and Disease.
Aplin AC, Aghazadeh Y, Mohn OG, Hull-Meichle, RL: Role of the Pancreatic Islet Microvasculature in Health and Disease. J Histochem Cytochem 72:711-72810, 2024. DOI 1369/00221554241299862
Pancreas and islet morphology in cystic fibrosis: Clues to the etiology of cystic fibrosis-related diabetes.
Malik SS, Padmanabhan D, Hull-Meichle, RL: Pancreas and islet morphology in cystic fibrosis: Clues to the etiology of cystic fibrosis-related diabetes. Front Endocrinol 14:1269139, 2023. DOI 3389/fendo.2023.1269139
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.
Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M. Diabetes. 2023 Apr 1;72(4):433-448 and 2022 Oct 1;51(9):1061-1073. DOI 10.2337/db22-0942
Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice
Castillo JJ, Aplin AC, Hackney DJ, Hogan MF, Esser N, Templin AT, Akter R, Kahn SE, Raleigh DP, Zraika S, Hull RL. Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice. Diabetologia. 2022 Oct;65(10):1687-1700. DOI 1007/s00125-022-05756-9
SGLT2-i improves markers of islet endothelial cell function in db/db diabetic mice
Hogan MF, Hackney DJ, Aplin AC, Mundinger TO, Larmore MJ, Castillo JJ, Esser N, Zraika S, Hull RL. SGLT2-i improves markers of islet endothelial cell function in db/db diabetic mice. J Endocrinol. 2021 Feb;248(2):95-106. DOI 10.1530/JOE-20-0354.
Islet Interleukin-1β immunoreactivity is an early feature of cystic fibrosis that may contribute to β-cell failure
Hull RL, Gibson RL, McNamara S, Deutsch GH, Fligner CL, Frevert CW, Ramsey BW, Sanda S. Islet Interleukin-1β immunoreactivity is an early feature of cystic fibrosis that may contribute to β-cell failure. Diabetes Care. 2018 Apr;41(4):823-830. DOI 2337/dc17-1387
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