Throughout her career as an academic, from her undergraduate studies until her career as a professor, Esther Lederberg faced discrimination as a result of her gender.
During her undergraduate career, Esther was discouraged from pursuing biochemistry. Instead, she was encouraged to study literature and language, where she would have greater career opportunities as a woman (Ferrell 2018). Despite being dissuaded, she pursued and achieved her undergraduate degree, graduating with academic distinction (Schaechter 2016).
In 1958, Joshua became chair of the Department of Genetics at Stanford, while Esther and two other women had to petition the dean to use funds, that were supposed to be allocated for the purpose of hiring women, to hire them as female professors (Ferrell 2018). At this time, there were no female professors at Stanford University, although there were several women who met the criteria. Esther and the other two women were highly qualified, however, the dean only offered one position. Esther received it because she was willing to accept the rank of "research professor", otherwise known as "senior scientist", without tenure. Even though Esther was two years older than Joshua, and arguably just as qualified, she obtained the lower rank position, and had to fight to obtain it in the first place.
Furthermore, she was not promoted to adjunct professor until 1974, fifteen years after being hired (Schaechter 2016). Previously she was considered a senior scientist, a position considered higher rank than her position as a professor. Despite her extensive credentials and education, Esther had to fight to maintain her position at Stanford University. Her former collaborator, Luigi Cavalli, fought for her retention and is quoted saying "Dr. Esther Lederberg has enjoyed the privilege of working with a very famous husband. This has been at times also a setback, because inevitably she has not been credited with as much of the credit as she really deserved." (Ferrell 2018). Stanford ultimately kept Esther "coterminous with research support", meaning her salary depended on grants (Ferrell 2018). Esther worked at Stanford for 27 years, yet she never received tenure, unlike her male colleagues. The gender discrimination of the time ultimately denied her of the prestigious positions she deserved.
In 1953, Joshua and Esther published their paper conducting various lysogenic crosses on the lambda bacteriophage to better understand the genetic basis of lysogenicity (Ferrell 2018). In this paper, they give credit for their inspiration to Esther's previous work on the lysogenicity of the K-12 E. coli strain (Lederberg and Lederberg 1953). However, even though the lambda phage was discovered in 1951 by Esther, neither of her papers regarding the K-12 stain were cited in her paper with Joshua (Ferrell 2018).
In 1952, Joshua and Norton Zinder published their paper about the discovery of generalized transduction in Salmonella. Genetics textbooks have mentioned that Esther participated in their discovery, yet she received no credit for her work (Ferrell 2018). Esther was considered an experimentalist, while her husband was not, thus many of their published works together relied on her skills as a researcher and experimentalist (Ferrell 2018; Schaechter 2016). Despite her efforts, she was not always included as an author on published papers, nor was her experimental help always credited, such as in this instance.
Esther did not receive credit for her work on E. coli conducted with her husband and George Beadle. Instead, articles discussing their work on E. coli and the Nobel Prize research referred to her as an assistant (Tatum 1959). During his Nobel Prize Banquet speech, Joshua did not mention Esther (Nobel Prize Organization c2021). Additionally, during the Nobel Prize lecture, he briefly mentioned her first lysogenic crosses (Nobel Prize 2021), but failed to credit her for other groundwork essential to his Nobel Prize-winning research.
To learn more about her contributions to the Nobel Prize research, please see the 'Nobel Prize' Tab: