Publications
2024
54. Rais, Y.; Drabovich, A.P. Identification and quantification of human relaxin proteins by immunoaffinity-mass spectrometry. bioRxiv, 2024, 10.1101/2024.01.12.575440 [PDF]
2023
53. Tang, W.; Drabovich, A.P. The proteomic toolbox for identification, quantification, and characterization of polyclonal antibodies. bioRxiv, 2023, 10.1101/2023.10.27.564451 [PDF]
52. Zhang, J.; Kanoatov, M.; Jarvi, K; Gauthier-Fisher, A.; Moskovtsev, S.I.; Librach, C.; Drabovich, A.P. Germ cell-specific proteins AKAP4 and ASPX facilitate identification of rare spermatozoa in non-obstructive azoospermia. Molecular & Cellular Proteomics, 2023, 22, 100556 [PDF]
51. Walter, J.; Eludin, Z.; Drabovich, A.P. Redefining Serological Diagnostics with Immunoaffinity Proteomics. Clinical Proteomics, 2023, 20, 42 [PDF]
50. Dara, D.; Drabovich, A.P. Assessment of risks, implications, and opportunities of waterborne neurotoxic pesticides. Journal of Environmental Sciences, 2023, 125, 735-741 [PDF]
2022
49. Fu, Z.; Rais, Y.; Dara, D.; Jackson, D.; Drabovich, A.P. Rational Design and Development of SARS-CoV-2 Serological Diagnostics by Immunoprecipitation-Targeted Proteomics . Analytical Chemistry, 2022, 94, 12990−12999 [PDF]
48. Zhang, J.; Kanoatov, M.; Jarvi, K; Gauthier-Fisher, A.; Moskovtsev, S.I.; Librach, C.; Drabovich, A.P. Germ cell-specific proteins ACRV1 and AKAP4 facilitate identification of rare spermatozoa in semen of non-obstructive azoospermia patients. medRxiv, 2022, https://doi.org/10.1101/2022.09.15.22280011 [PDF]
2021
47. Fu, Z.*; Rais, Y.*; Drabovich, A.P. Immunoprecipitation-targeted proteomics assays facilitate rational development of SARS-CoV-2 serological diagnostics. medRxiv, 2021, https://doi.org/10.1101/2021.10.25.21265408 [PDF]
46. Rais, Y.; Fu, Z.; Drabovich, A.P. Mass spectrometry-based proteomics in basic and translational research of SARS-CoV-2 coronavirus and Its emerging mutants. Clinical Proteomics, 2021,18, 1-16 [PDF]
45. Fu, Z.; Rais, Y.; Bismar, T.A.; Hyndman, M.E.; Le, X. C.; Drabovich, A.P. Mapping isoform abundance and interactome of the endogenous TMPRSS2-ERG fusion protein by orthogonal immunoprecipitation-mass spectrometry assays. Molecular & Cellular Proteomics 2021, 20, 100075 [PDF]
44. Jarvi K., Schlegel P., Schiza C., Drabovich A.; Susan Lau, S.; Soosaipillai, A.; Korbakis, D.; Brinc, D.; Mullen, B.; Diamandis, E. Semen biomarker TEX101 predicts sperm retrieval success for men with testicular failure. F1000Research 2021, 10, 569 [PDF]
2020
43. Rais, Y. and Drabovich A.P. Gasoline-derived methyl tert-butyl ether as a potential obesogen linked to metabolic syndrome. Journal of Environmental Sciences, 2020, 91, 209-211 [PDF]
2019
42. Drabovich, A.P.*; Saraon, P.; Drabovich, M.; Karakosta, T.D.; Dimitromanolakis, A.; Hyndman, E.; Jarvi, K.; Diamandis, E.P. Multi-omics biomarker pipeline reveals elevated levels of protein-glutamine gamma-glutamyltransferase 4 in seminal plasma of prostate cancer patients. Molecular & Cellular Proteomics, 2019, 18, 1807-1823 [PDF]
41. Schiza, C.; Korbakis, D.; Jarvi, K.; Diamandis, E.P.; Drabovich, A.P. Identification of TEX101-associated proteins through proteomic measurement of human spermatozoa homozygous for the missense variant rs35033974. Molecular & Cellular Proteomics, 2019, 18, 338-351 [PDF]
40. Drabovich, A.P.; Martínez-Morillo, E.; Diamandis, E.P. “Chapter 3 - Protein Biomarker Discovery: An Integrated Concept” in “Proteomics for Biological Discovery, 2nd Edition”, edited by T.D. Veenstra and J.R. Yates, Wiley, 2019, 63-88 [PDF]
2018
39. Schiza, C.; Korbakis, D.; Panteleli, E.; Jarvi, K.; Drabovich, A.P.; Diamandis, E.P. Discovery of a human testis-specific protein complex TEX101-DPEP3 and selection of its disrupting antibodies. Molecular & Cellular Proteomics, 2018, 17, 2480-2495 [PDF]
38. Begcevic, I.; Brinc, D.; Dukic, L.; Simundic, A-M.; Zavoreo, I.; Kes, V. B.; Martinez-Morillo, E.; Batruch, I.; Drabovich, A.P.; Diamandis, E.P. Targeted mass spectrometry-based assays for relative quantification of thirty brain-related proteins and their clinical applications. Journal of Proteome Research, 2018, 17, 2282-2292
2017
37. Korbakis, D.; Schiza, C.; Brinc, D.; Soosaipillai, A; Karakosta, T.D.; Legare, C.; Sullivan, R.; Mullen, B.; Jarvi, K; Diamandis, E.P.; Drabovich, A.P.* Preclinical evaluation of a TEX101 protein ELISA test for the differential diagnosis of male infertility. BMC Medicine, 2017, 15, 60 [PDF]
2016
36. Karakosta, T.D.; Soosaipillai, A.; Diamandis, E.P.; Batruch, I.; Drabovich, A.P.* Quantification of Human Kallikrein-Related Peptidases in Biological Fluids by Multi-Platform Targeted Mass Spectrometry Assays. Molecular & Cellular Proteomics, 2016, 15, 2863-2876 [PDF]
35. Drabovich, A.P.*; Pavlou, M.P.; Schiza, C.; Diamandis, E.P. Dynamics of protein expression reveals primary targets and secondary messengers of estrogen receptor alpha signaling in MCF-7 breast cancer cells. Molecular & Cellular Proteomics, 2016, 15, 2093-2107 [PDF]
34. Dimitrakopoulos, L.; Prassas, I.; Diamandis, E.P.; Nesvizhskii, A.I.; Kislinger, T.; Jaffe, J.D. and Drabovich, A. Proteogenomics: opportunities and caveats. Clinical Chemistry, 2016, 62, 551-557
33. Konvalinka, A.; Batruch, I.; Tokar , T.; Dimitromanolakis, A.; Reid, S.; Song, X; Pei, Y.; Drabovich, A.P.; Diamandis, E.P.; Jurisica, I.; Scholey, J.W. Quantification of Angiotensin II-Regulated Proteins in Urine of Patients with Polycystic and Other Chronic Kidney Diseases by Selected Reaction Monitoring, 2016, Clinical Proteomics 13, 16
32. Begcevic, I.; Brinc, D.; Drabovich, A.P.; Batruch, I.; Diamandis, E.P. Identification of brain-enriched proteins in the cerebrospinal fluid proteome by LC-MS/MS profiling and mining of the Human Protein Atlas. Clinical Proteomics, 2016, 11, 13
31. Bieniek, J.M.; Drabovich, A.P.; Lo, K.C. Seminal biomarkers in the evaluation of male fertility. Asian Journal of Andrology, 2016, 18, 1-8
2015
30. Drabovich, A.P*., Martínez-Morillo, E. and Diamandis, E.P. Toward an integrated pipeline for protein biomarker development. Biochimica et Biophysica Acta, 2015, 1854, 677-686
29. Korbakis, D.; Brinc, D.; Schiza, C.; Soosaipillai, A; Jarvi, K; Drabovich, A.P.*; Diamandis, E.P. Immunocapture-selected reaction monitoring screening facilitates the development of ELISA for the measurement of native TEX101 in biological fluids. Molecular & Cellular Proteomics, 2015, 14, 1517-26
2014
28. Drabovich, A.P.; Saraon, P.; Jarvi, K.; Diamandis, E.P. Seminal Plasma as a Diagnostic Fluid for Disorders of Male Reproductive System. Nature Reviews Urology, 2014, 11, 278-88
27. Martínez Morillo, E., Nielsen, H., Batruch, I., Drabovich, A.P., Begcevic, Lopez, M., Minthon, L., Bu, G. Mattsson, N., Portelius, E., Hansson, O., Diamandis, E. Assessment of peptide chemical modifications during the development of an accurate and precise multiplex selected reaction monitoring assay for apolipoprotein E isoforms. Journal of Proteome Research, 2014, 13, 1077-87
26. Schiza, C.G.; Jarvi, K.; Diamandis, E.P.; Drabovich, A.P. An emerging role of TEX101 protein as a male infertility biomarker. Electr. J. Int. Fed. Clin. Chem. Lab. Med., 2014, 25, 9-26
25. Saraon, P.; Drabovich, A.P.; Jarvi, K.; Diamandis, E.P. Mechanisms of androgen-independent prostate cancer. Electr. J. Int. Fed. Clin. Chem. Lab. Med., 2014, 25, 42-54
2013
24. Drabovich, A.P.; Dimitromanolakis, A.; Saraon, P.; Soosaipillai, A.; Batruch, I.; Mullen, B.J.; Jarvi, K.A.; Diamandis, E.P. Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma. Science Translational Medicine 2013, 5, 212ra160
23. Drabovich, A.P.; Pavlou, M.P.; Batruch, I.; Diamandis, E.P. “Chapter 2 - Proteomic and Mass Spectrometry Technologies for Protein Biomarker Discovery” in “Proteomic and Metabolomic Approaches to Biomarker Discovery”, edited by H.J. Issaq and T.D. Veenstra, Elsevier, 2013, 17-37
22. Konvalinka, A.; Zhou, J.; Dimitromanolakis, A.; Drabovich, A.P.; Fang, F.; Gurley, S.; Coffman, T.; Diamandis, E.P.; Scholey J.W. Determination of an Angiotensin II-Regulated Proteome in Primary Human Kidney Cells by Stable Isotope Labeling of Amino Acids in Cell Culture (SILAC). Journal of Biological Chemistry, 2013, 288, 24834-47
21. Saraon, P.; Cretu, D.; Musrap, N.; Karagiannis, G.S.; Batruch, I.; Drabovich, A.P.; van der Kwast, T.; Mizokami, A.; Morrissey, C.; Jarvi, K.; Diamandis, E.P. Quantitative Proteomics Reveals that Enzymes of the Ketogenic Pathway are Associated with Prostate Cancer Progression. Molecular & Cellular Proteomics, 2013, 12, 1589-601
20. Cho, C.K.; Drabovich, A.P.; Karaggianis, G.S.; Dason, S.; Diamandis, E.P. Quantitative proteomics analysis of amniocytes reveals potentially dysregulated molecular networks in trisomy 21. Clinical Proteomics, 2013, 10, 2
2012
19. Drabovich, A.P.; Pavlou, M.P.; Dimitromanolakis, A.; Diamandis, E.P. Quantitative Analysis of Energy Metabolic Pathways in MCF-7 Breast Cancer Cells by Selected Reaction Monitoring Assay. Molecular & Cellular Proteomics, 2012, 11, 422-34
18. Saraon, P.; Musrap, N.; Cretu, D.; Karagiannis, G.S.; Batruch, I.; Smith, C.; Drabovich, A.P.; Trudel, D.; van der Kwast, T.; Colm, M.; Morrissey, C.; Jarvi, K.; Diamandis, E.P. Proteomic profiling of androgen-independent prostate cancer cell lines reveals a role for protein S during the development of high grade and castrate-resistant prostate cancer. Journal of Biological Chemistry, 2012, 287, 34019-31
17. Martínez-Morillo, E.; Cho, C.-K. J., Drabovich, A.P.; Shaw, J.L.V.; Soosaipillai, A.; Diamandis, E.P. Development of a multiplex selected reaction monitoring assay for quantification of biochemical markers of Down syndrome in amniotic fluid samples. Journal of Proteome Research, 2012, 11, 3880-7
16. Prakash, A.; Rezai, T.; Krastins, B.; Sarracino, D.; Athanas, M.; Russo, P.; Zhang, H.; Tian, Y.; Li, Y.; Kulasingam, V.; Drabovich, A.; Smith, C.R.; Batruch, I.; Oran, P.E.; Fredolini, C.; Luchini, A.; Liotta, L.; Petricoin, E.; Diamandis, E.P.; Chan, D.W.; Nelson, R.; Lopez, M.F. Inter-laboratory reproducibility of SRM assays using multiple upfront analyte enrichment strategies. Journal of Proteome Research, 2012, 11, 3986-95
2011
15. Drabovich, A.P.; Jarvi, K.; Diamandis, E.P. Verification of Male Infertility Biomarkers in Seminal Plasma by Multiplex Selected Reaction Monitoring Assay. Molecular & Cellular Proteomics, 2011, 10, M110.004127
14. Cho, C.K.; Drabovich, A.P.; Batruch, I.; Diamandis, E.P. Verification of biomarker discovery approach for detection of Down syndrome in amniotic fluid via multiplex selected reaction monitoring (SRM) assay. Journal of Proteomics, 2011, 74, 2052-2059
2010
13. Drabovich, A.P. and Diamandis, E.P. Сombinatorial peptide libraries facilitate development of multiple reaction monitoring assays for low-abundance proteins. Journal of Proteome Research, 2010, 9, 1236–1245
12. Prakash, A.; Rezai, T.; Krastins, B.; Sarracino, D.; Athanas, M.; Russo, P.; Ross, M.M.; Zhang, H.; Tian, Y.; Kulasingam, V.; Drabovich, A.P.; Smith, C.; Batruch, I.; Liotta, L.; Petricoin, E.; Diamandis, E.P.; Chan, D.W.; Lopez, M.F. A platform for establishing inter-laboratory reproducibility of selected reaction monitoring-based mass spectrometry peptide assays. Journal of Proteome Research, 2010, 9, 6678-88
2009
11. Drabovich, A.P., Berezovski, M.V., Musheev M., Krylov, S.N. Selection of Smart Small-Molecule Ligands: the Proof of Principle. Analytical Chemistry 2009, 81, 490-494 [PDF]
2007
10. Drabovich, A.P.; Okhonin, V.; Berezovski, M.; Krylov, S.N. Smart aptamers facilitate multi-probe affinity analysis of proteins with ultra-wide dynamic range of measured concentrations. Journal of the American Chemical Society 2007, 129, 7260-7261 [PDF]
9. Liu, Z.; Drabovich, A.P.; Krylov, S.N.; Pawliszyn, J. Dynamic Kinetic Capillary Isoelectric Focusing: A Powerful Tool for Studying Protein-DNA Interactions. Analytical Chemistry 2007, 79, 1097-1100 [PDF]
2006
8. Drabovich, A.P.; Berezovski, M.; Okhonin, V.; Krylov, S.N. Selection of smart aptamers by methods of kinetic capillary electrophoresis. Analytical Chemistry 2006, 78, 3171-3178 [PDF]
7. Drabovich, A.P.; Krylov, S.N. Identification of Base Pairs in Single-Nucleotide Polymorphisms by MutS Protein-Mediated Capillary Electrophoresis. Analytical Chemistry 2006, 78, 2035-2038 [PDF]
6. Berezovski, M.; Musheev, M.U.; Drabovich, A.P.; Jitkova, J.; Krylov, S.N. Non-SELEX: selection of aptamers without intermediate amplification of candidate oligonucleotides. Nature Protocols 2006, 1, 1359-1369 [PDF]
5. Berezovski, M.; Musheev, M.; Drabovich, A.; Krylov S.N. Non-SELEX Selection of Aptamers. Journal of the American Chemical Society 2006, 128, 1410 -1411 [PDF]
4. Drabovich, A.P.; Berezovski, M.; Krylova, S.M.; Musheev, M.U.; Krylov, S.N. Non-Equilibrium Capillary Electrophoresis of Equilibrium Mixtures (NECEEM) as Swiss Army Knife for Selection of Aptamers. P/ACE Setter 2006, 10 (1), 1- 5 [PDF]
2005
3. Drabovich, A.; Berezovski, M.; Krylov, S.N. Selection of smart aptamers by equilibrium capillary electrophoresis of equilibrium mixtures (ECEEM). Journal of the American Chemical Society 2005, 127, 11224-11225 [PDF]
2. Berezovski, M.; Drabovich, A.; Krylova, S.M.; Musheev, M.; Okhonin, V.; Petrov, A.; Krylov, S.N. Nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM) – a universal tool for selection of aptamers. Journal of the American Chemical Society 2005, 127, 3165-3171 [PDF]
2004
1. Drabovich, A.; Krylov, S.N. Single-stranded DNA-binding protein facilitates gel-free analysis of polymerase chain reaction products in capillary electrophoresis. Journal of Chromatography A 2004, 1051, 171-175 [PDF]