CRINA Research Day 2024 Schedule

Dr. Pamela Hoodless is Director and Distinguished Scientist of the Terry Fox Laboratory, BC Cancer Research Institute

Abstract: Cancers progress often involves the reactivation of embryonic programs through expression of transcription and epigenetic factors. In aggressive hepatocellular carcinoma (HCC), embryonic factors, such as Alpha-fetoprotein (AFP), are used diagnostically to monitor tumour burden. However, whether this represents an entire embryonic program and how it is activated is unclear. We have examined how transcriptional and epigenetic networks are regulated in hepatocyte differentiation using human pluripotent stem cells. Recently, we used single cell Multiomics to compare normal liver and matched adjacent non-tumour and HCC samples. We compared networks involved in hepatic differentiation with changes associated with HCC to determine the similarities and differences between cancer and embryonic development.

Chairs: Amy MacKinnon, Adam Brown, Dr. Alan Underhill

10:30 - 10:40: "Investigating the Role of FABP7 on Glioblastoma Bioenergetics" - Cécilia Bernier 

10:40 - 10:50: "Nanotubes mediated mitochondria transfer from normal to cancer cells promotes Mesenchymal-to-Epithelial Transition (MET) required for metastasis in cancer" - Kleouforo-Paul Dembele 

10:50 - 11:00: "Demonstration of Human Betaretrovirus Infection in Breast Cancer Patients through Proviral Integration Identification and Cellular Immune Responses" - Seyed Sajjad Zadian

11:00 - 11:10: "p53 associated de novo activation of VWF expression in tumor cells" - Noorossadat Seyyedi 

11:10 - 11:20: "MAEA loss impairs homologous recombination and replication fork protection" - Eli Zeinali 

11:20 - 11:30: "Infection of primary mammary fibroblasts with cytomegalovirus coordinately increases autotaxin-lysophosphatidate-inflammatory signaling, which could increase breast cancer metastasis" - Humayara Khan 

11:30 - 11:40: "Genomic instability and DNA damage regulate STING activation through characteristic cytosolic DNA structures in colorectal cancer" - Shayla Mosley

11:40 - 11:50: "Effect of mtDNA and gDNA on Immune Cell Activation in Colorectal Cancer Subtypes" - Angie Chen

11:50 - 12:00: "Oh my NOD! Investigating the role of NOD2 in intestinal homeostasis" - Mckenna Eklund 

Chairs: Nazret Russon, Bruce Cameron, Dr. Elaine Leslie

10:30 - 10:40: "Molecular Crosstalk: Arsenic Trioxide Orchestrates AHR and NRF2 to Upregulate NQO1 Expression in Hepatic and Extrahepatic Tissues of C57Bl/6 Mice" - Sara Elmahrouk 

10:40 - 10:50: "Effects of Bortezomib Treatment on Protein Dynamics in Multiple Myeloma: Degradation and Synthesis" - Lina Alhourani 

10:50 - 11:00: "The effects of docosahexaenoic acid (DHA) supplementation during neoadjuvant breast cancer therapy on oxylipin production by lipopolysaccharides (LPS)-stimulated peripheral blood mononuclear cells" - Jaqueline de Lima Munhoz 

11:00 - 11:10: "Novel Therapeutic Strategies to Delay Relapse and Overcome Resistance in Chronic Lymphocytic Leukemia: Targeting Lysosomal Function and Autophagy" - Madhumita Manivannan 

11:10 - 11:20: "Preclinical 3D Model Drug Repurposing Screen Identifies Doxorubicin as an Effective Anti-cancer Therapy for Dedifferentiated Endometrial and Ovarian Cancers" - Pooja Praveen Kumar 

11:20 - 11:30: "Exploring the role of glutathione metabolism on chemotherapy-related hearing loss in pediatric cancer patients through the use of small-molecule inhibitors" - Asna Latif 

11:30 - 11:40: "Inhibition of ZNF281 Hinders the Tumor Growth  and Metastatic Spread of Advanced Prostate Cancer" - Guocheng Huang 

11:40 - 11:50: "N-Myristoylation Inhibition Reduces Mitochondrial Complex I Protein Levels, Activity and Cancer Stem Cell Growth" - Rony Pain

11:50 - 12:00: "Arsenic and Selenium Efflux from Human Red Blood Cells" - Serena Li

Panelists: Dr. Linda Watson, Adam Brown, Amy MacKinnon, Bruce Cameron, Nazret Russon

Chair: Dr. Ing Swie Goping

Panelists: Drs. Kristi Baker, Dan Schiller, Paul LaPointe, John Walker, Roseline Godbout, Adam Kinnaird

Chair: Dr. Hanne Ostergaard