At the early stage, these projects will heavily involve bio-instrumentation, optical design, system calibration, and Monte Carlo modeling of light propagation in biological tissues.
Time-of-flight diffuse optical spectroscopy for monitoring of oxygenation and blood flow
The aims of this project is to build and implement a portable time-domain diffuse optical spectroscopy for better extracting oxygenation and blood flow in the skin and the brain.
Current gold standard is impractical for early detection of melanoma and has low accuracy. The main reason for the low inaccuracy is because histologic representations of melanoma vary greatly and they often mimic the appearance of BCC (non-malignant skin cancers), making visual assessment of melanoma a great challenge for physicians. The low true positive rate cases are also accompanied with overdiagnosis, requiring more biopsy samples to be collected for pathological analysis.
More advanced optical methods are still imperfect.
This project aim to develop a simple, low cost wide-field polarized and spectral microscopy system that is powered by AI for better screening of melanoma and common types of skin cancers.