Publications

Peer-reviewed articles (Complete list @ Google Scholar)

2025

• Chen Y, Xi J,  V. N. Du Le, Ramella-Roman J, Li X. Gold Nanocages with a Long Surface Plasmon Resonance Peak Wavelength as Contrast Agents for Optical Coherence Tomography Imaging at 1060 nm. Nanomaterials. 5(10), 755 (2025). https://doi.org/10.3390/nano15100755

• V. N. Du Le*, S. Fronckowiak, E. Badolato "A Cost-Effective Method for the Spectral Calibration of Photoplethysmography Pulses: The Optimal Wavelengths for Heart Rate Monitoring" Sensors 25(7), 2311 (2025). https://doi.org/10.3390/s25072311

• V. N. Du Le* "Monte Carlo Guidance for Better Imaging of Boreal Lakes in the Wavelength Region of 400–800 nm", Sensors 2025, 25(4), (2025); https://doi.org/10.3390/s25041020

2024

• E. Badolato, A. Little, and V. N. Du Le* "Improving Heart Rate Monitoring in the Obese with Time-of-Flight Photoplethysmography (TOF-PPG): A Quantitative Analysis of Source-Detector-Distance Effect", Optics Express  32(3), (2024).  https://doi.org/10.1364/OE.510977 

• T. Boonya-ananta, M. Gonzalez, A. Ajmal, V. N. Du Le, E. DeHoog, M. J. Paidas, A. Jayakumar, J. C. Ramella-Roman, "Speculum-free portable preterm imaging system", J. Biomed. Opt. 29(5), 052918 (2024).https://doi.org/10.1117/1.JBO.29.5.052918

2022

• M. Gonzalez,  V. N. Du Le, J.C. Ramella-Roman. Confocal Laser Scanning Polarimetry. In: Ramella-Roman, J.C., Novikova, T. (eds) Polarized Light in Biomedical Imaging and Sensing. Springer (2022). https://doi.org/10.1007/978-3-031-04741-1_12

• A. J. Rodrigueza, T. Anantaa, M. Gonzaleza, V. N.  Du Le, J. Fined, C. Palaciosc, M. J. McShaned, G. L. Cotéd, J.C. Ramella-Roman, “Skin optical properties in the obese and their relation to body mass index”. J. Biomed. Opt (2022). https://doi.org/10.1117/1.JBO.27.3.030902 

2021

• Ajmal, T. Boonya-Ananta, A. J. Rodriguez, V. N. Du Le, and J. C. Ramella-Roman “A Monte Carlo Analysis of Optical Heart Rate sensors in Commercial Wearables: The Effect of Skin Tone and Obesity on Photoplethysmography (PPG) Signal” Biomedical Optics Express 12(12), (2021). https://doi.org/10.1364/BOE.439893

• H. R Lee, I. Saytashev, V. N. Du Le, M. Mahendroo, J.  Ramella-Roman, and T. Novikova, " Mueller matrix imaging for collagen scoring in mice model of pregnancy ". Scientific Reports 11(1), (2021). https://doi.org/10.1038/s41598-021-95020-8

• C. Roa, V. N. Du Le*, M. Mahendroo, J. C. Ramella-Roman, "Auto-detection of cervical collagen and elastin in Mueller matrix polarimetry microscopic images using K-NN and Semantic Segmentation classification " Biomedical Optics Express 12(4), (2021). https://doi.org/10.1364/BOE.420079

2020

• T. Boonya-Ananta, A. J Rodriguez, A. Ajmal, V. N. Du Le, Anders K Hansen, Joshua D Hutcheson, Jessica C Ramella-Roman "Synthetic Photoplethysmography (PPG) of the radial artery through parallelized Monte Carlo and its correlation to Body Mass Index (BMI) " Scientific Reports 11, 2570 (2021). https://doi.org/10.1038/s41598-021-82124-4 

• V. N. Du Le*, I. Saytashev, S. Saha, P. F. Lopez, M. Laughrey, and J. C. Ramella-Roman, "Depth-resolved Mueller matrix polarimetry microscopy of the rat cornea," Biomedical Optics Express 11, 5982-5994 (2020). https://doi.org/10.1364/BOE.402201

• V. N. Du Le, and V.J. Srinivasan. "Beyond diffuse correlations: deciphering random flow in time-of-flight resolved light dynamics," Optics Express 28, 11191-11214 (2020). https://doi.org/10.1364/OE.385202

• O. Kholiqov, W. Zhou, T. Zhang, V. N. Du Le and V.J. Srinivasan, " Time-of-flight resolved light field fluctuations reveal deep human tissue physiology," Nature Communications, 11(1), 1-15 (2020). https://doi.org/10.1038/s41467-019-14228-5 

2012-2019

• V. N. Du Le*, M. Manser, S. Gurm, B. Wagner, J. Hayward and Q. Fang, “Calibration of Spectral Imaging Devices with Oxygenation-Controlled Phantoms: Introducing a Simple Gel-based Hemoglobin Model”, Frontiers in Physics 7 (2019). https://doi.org/10.3389/fphy.2019.00192 

• N. Shalaby, A. Al‐Ebraheem, V. N. Du Le, S. Cornacchi, Q. Fang, T. Farrell, P. Lovrics, G. Gohla, S. Reid, N. Hodgson, M. Farquharson "Time-resolved fluorescence (TRF) and diffuse reflectance spectroscopy (DRS) for margin analysis in breast cancer," Lasers in Surgery and Medicine 50(3), 236-245 (2018). doi: 10.1002/lsm.22795 

• V. N. Du Le, J. Provias, N. Murty, M. S. Patterson, Z. Nie, J. E. Hayward, T. J. Farrell, W. McMillan, W. Zhang, and Q. Fang “Dual Modality Optical Biopsy of Glioblastomas Multiforme with Diffuse Reflectance and Fluorescence: Ex Vivo Retrieval of Optical Properties,” J. Biomedical Optics 22(2), 027002 (2017). https://doi.org/10.1117/1.JBO.22.2.027002 

•  Z. Nie, V. N. Du Le, D. Cappon, J. Provias, N. Murty, J. E. Hayward, T. J. Farrell, M. S. Patterson, W. McMillan, and Q. Fang. “Integrated Time-resolved Fluorescence and Diffuse Reflectance Spectroscopy Instrument for Intraoperative Detection of Brain Tumor Margin,” J. Selected Topic in Quantum Electronics, IEEE 22(3): 6802109 (2016). doi: 10.1109/JSTQE.2015.2510964 

• V. N. Du Le, M. S. Patterson, T. J. Farrell, J. E. Hayward, and Q. Fang “Experimental recovery of intrinsic fluorescence and fluorophore concentration in the presence of hemoglobin: spectral effect of scattering and absorption on fluorescence,” J. Biomedical Optics 20 (12), 127003 (2015). https://doi.org/10.1117/1.JBO.20.12.127003 

• V. N. Du Le, Z. Nie, J. E. Hayward, T. J. Farrell, and Q. Fang “Measurements of extrinsic fluorescence in Intralipid and polystyrene microspheres”, Biomedical Optics Express 5 (8):2726-2735 (2014). https://doi.org/10.1364/BOE.5.002726

• V. N. Du Le, Q. Wang, T. Gould J. Ramella-Roman, J. Pfefer, “Vascular contrast in Narrow Band and white light imaging”, Applied Optics 53 (18), 4061-4071 (2014).https://doi.org/10.1364/AO.53.004061

• V. N. Du Le*, Q. Wang, J. Ramella-Roman, and J. Pfefer “Monte Carlo modeling of light-tissue interactions in Narrow Band Imaging”, J. Biomedical Optics 18 (1), 010504 (2013).https://doi.org/10.1117/1.JBO.18.1.010504

• Q. Wang, V. N. Du Le, J. Ramella-Roman, and J. Pfefer “Broadband UV-Vis optical property measurement in layered turbid media”, Biomedical Optics Express 3 (6), 1226-1240 (2012).https://doi.org/10.1364/BOE.3.001226

Conference Proceedings

1. E. Badolato, S. Fronckowiak, and V. N. Du Le* "Steady state versus time-resolved photoplethysmography (PPG): the effect of epidermal thickness (Conference Presentation)", Proc. SPIE PC13308, Design and Quality for Biomedical Technologies XVIII, PC1330807 (2025); https://doi.org/10.1117/12.3050156

2. V. N. Du Le* "A portable Mueller matrix microscope for melanoma detection", Proc. SPIE PC13149, Unconventional Imaging, Sensing, and Adaptive Optics 2024, PC1314904 (4 October 2024); https://doi.org/10.1117/12.3029998

3. V. N. Du Le, E. Badolato,"Isolating True Photoplethysmography in Wearable Optical Sensors from Skin Thickness and Skin Tone: A Time-of-Flight Solution". Optica Sensing Congress 2023, STu5C.5 (download)

4. N. Gary, V. N. D. Le, J. Wojak, M. Adel, J. Ramella-Roman, and A. D. Silva, "An efficient deep learning segmentation scheme for cervical collagen and elastin quantification in Mueller matrix polarimetry microscopic images," in Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN), Technical Digest Series (Optica Publishing Group, 2022), paper TM4B.2.

5. H. R. Lee, I. Saytashev, V. N. D. Le, M. Mahendroo, J. Ramella-Roman, and T. Novikova, "Assessment of Preterm Birth Risk by Collagen Scoring with Polarized Light in Mice Model of Pregnancy," in Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN), Technical Digest Series (Optica Publishing Group, 2022), paper TM4B.4.

6. T. Boonya-Ananta, M. Gonzalez, V. N. Du Le, E. DeHoog, M.J. Paidas, A. Jayakumar, and J. C. Ramella-Roman "A speculum free portable preterm imaging system", Proc. SPIE 11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022, 119630A (4 March 2022); https://doi.org/10.1117/12.2609915 

7. J. Wang, J. Coburn, C. Liang, N. Woolsey, Du Le, J. Ramella-Roman, Y. Chen, and J. Pfefer "Characterization and application of 3D-printed phantoms for biophotonic imaging", Proc. SPIE 8719, Smart Biomedical and Physiological Sensor Technology X, 87190Y (31 May 2013); https://doi.org/10.1117/12.2018285 

8. J. C. Ramella-Roman, T. Ho, Du Le, P. Ghassemi, T. Nguyen, A. Lichy, and S. Groah "Monitoring the impact of pressure on the assessment of skin perfusion and oxygenation using a novel pressure device", Proc. SPIE 8576, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIII, 85760N (20 March 2013); https://doi.org/10.1117/12.2006256 

9. Q. Wang, Du Le, J.C. Ramella-Roman, and J. Pfefer "Spectral variations in narrow band imaging depth-selectivity: mucosal scattering vs. hemoglobin absorption", Proc. SPIE 8573, Design and Quality for Biomedical Technologies VI, 85730N (13 March 2013); https://doi.org/10.1117/12.2008768 

10. J. C. Ramella-Roman, Du V. N. Le, P. Ghassemi, T.A. Nguyen, A. Lichy, and S. Groah "Skin microvascular and metabolic response to pressure relief maneuvers in people with spinal cord injury", Proc. SPIE 8579, Optical Interactions with Tissue and Cells XXIV, 85790R (15 February 2013); https://doi.org/10.1117/12.2006260 

11. Du Le, Q. Wang, J. Ramella-Roman, and J. Pfefer "Quantitative evaluation of mucosal vascular contrast in narrow band imaging using Monte Carlo modeling", Proc. SPIE 8367, Smart Biomedical and Physiological Sensor Technology IX, 836709 (16 May 2012); https://doi.org/10.1117/12.918375 

12. Q. Wang, Du Le, J. Ramella-Roman, and J. Pfefer "Visualization of mucosal vasculature with narrow band imaging: a theoretical study", Proc. SPIE 8215, Design and Quality for Biomedical Technologies V, 821505 (28 February 2012); https://doi.org/10.1117/12.906817 

Patents

Systems and methods for visualizing elastin and collagen in tissue Patent number: 11170199