We are developing unique random peptide gene libraries expressed in mammalian cells for the phenotype-based screenings. We use CRISPR-Cas system for the gene library construction.
We are developing reporter gene cell lines regarding non-canonical translations for drug discovery and searching of new target proteins.
CAG-repeat non-canonical translation
Stress-induced 5'-UTR translation
We are developing peptidomimetics by incorporating non-natural amino acid residues. Peptides are prepared by solid-phase peptide synthesis.
Chem. Commun, 2022, 58, 945.
We are synthesizing resins for the purification of precursors for biodegradable polymers and additives. Those precursors are generated from the sea plants and agricultural wastes.