We are developing unique random peptide gene libraries expressed in mammalian cells for the phenotype-based screenings. We use CRISPR-Cas system for the gene library construction.

We are developing reporter gene cell lines regarding non-canonical translations for drug discovery and searching of new target proteins.

1. CAG-repeat non-canonical translation

2. Stress-induced 5'-UTR translation

We are developing peptidomimetics by incorporating non-natural amino acid residues. Peptides are prepared by solid-phase peptide synthesis.