Ketamine is FDA-approved as a surgical anesthetic. However, it is legally used "off-label" in sub-anesthetic doses for psychiatric conditions. Esketamine (Spravato), a form of ketamine, is FDA-approved for treatment-resistant depression (TRD) and major depressive disorder with acute suicidal ideation.
Ketamine's effects are often rapid, with many patients reporting significant relief from depressive or suicidal symptoms within hours to days of the initial treatment, which is much faster than traditional antidepressants.
In a controlled, clinical setting with professional medical supervision, the risk of addiction is considered low. The dosages and administration schedules are managed specifically for therapeutic effect, minimizing the risk associated with recreational misuse.
The antidepressant effects are often temporary, lasting from a few days to a few weeks after a single treatment. For sustained benefits, patients typically require a structured series of initial treatments followed by occasional maintenance or "booster" sessions. Participating in psychotherapy can increase the duration of benefits of ketamine.
The most common effects are temporary and short-lived, including dissociation (a trance-like feeling), elevated blood pressure, dizziness, and mild nausea. These are closely monitored and typically resolve shortly after the session ends.
It is generally contraindicated for patients with uncontrolled hypertension (high blood pressure), a history of psychosis or schizophrenia, or current active substance abuse, as these conditions can pose safety risks.
Psychotherapy, particularly in the days following the session, is believed to prolong and maximize therapeutic gains. It helps patients integrate the insights gained during the neuroplastic window, solidifying changes in thought and behavior for better long-term results.
KAP most commonly utilizes oral (lozenge/troche) or intramuscular (IM) injection routes to allow for a predictable yet manageable psychedelic-level dose that is conducive to a therapeutic experience.
In KAP, a therapist is typically present (or immediately accessible) to monitor safety, provide a grounding presence, and serve as a container for the emergent emotional material, though they may remain mostly silent during the peak effects.
Preparation involves setting a clear intention (a focus or goal for the session), wearing comfortable clothes, and fasting for a few hours prior to minimize the risk of nausea. You will not be able to to drive the day of treatment and you should not enter into any legal contracts.
At the doses used in KAP, you will experience an altered state, but you will remain conscious. You may be less verbal during the peak dissociative phase but will be able to communicate before and during the descent.
Eye masks and curated music are used to reduce external stimulation and guide the internal experience. They help create a safe, internalized setting to facilitate introspection and emotional release.
The primary dissociative effects of the medicine typically wear off within 60 to 90 minutes after administration. You will need a period of recovery and must have a ride home, as driving is not permitted.
Dissociation is a temporary, altered state where you may feel a sense of separation from your ordinary self, body, or surroundings. It is often described as a "trance-like" state that provides psychological distance from painful thoughts or memories.
Absolutely not. You must arrange for an adult to drive you home. It is strongly recommended to treat the rest of the day as a period of rest and reflection, avoiding work, major decisions, or operating machinery.
While the medicine can induce vivid imagery or altered perceptions, the experience is generally manageable and is not a classic psychedelic trip. The presence of a supportive therapist minimizes the risk of distress, and challenging moments are often viewed as valuable therapeutic material.
Each person's treatment plan will differ based on need. The recommendation is for a client to have 4-6 medication sessions over 4 weeks.
One-time comprehensive evaluation: $175
Preparation session: $150 per session (client may choose to have two)
Medication session: $475 per session (4-6 recommended but may only need a single booster treatment)
Integration session: $150 per session (typically 1 per medication session)