Lai H-C, Shirakawa H, Agista AZ, Hao Y-P, Yang S-C, Lin M-T, Yeh S-L, Yeh C-L. Dietary tryptophan supplementation attenuates lipopolysaccharide-induced acute lung injury in a murine model of colitis. Nutrients, 2026, 18, 2042. [MDPI]
Loe PY, Ohsaki Y, Yang S-C, Shirakawa H, Chiu W-C. Full-Fat Rice Bran Ameliorates Insulin Resistance and Modulates Muscle-Related Parameters in High-Fat Diet–Fed Ovariectomized Mice with Potential Involvement of the Gut–Muscle Axis. Nutrients, 2026, 18, 1774. [MDPI]
Hsiao T-C, Hsu C-D, Xiao Q, Chen Y-H, Piriou Y, Shirakawa H, Yang S-C. Combined fish oil and pine bark extract supplementation improves short-term memory and the antioxidant status in middle-aged and older adults with mild cognitive impairment: a randomized double-blind, parallel-group trial. Antioxidants, 2026, 15, 588. [MDPI]
Salamah MP, Mayangsari Y, Shirakawa H, Agista AZ, Saputra WD. Germinated Cempo Ireng Black Rice (Oryza sativa L.) Demonstrates Functional Anti-Obesity Effects in High-Fat Diet-Induced Rats. Trends Sci, 2026, 23, 12735. [TiS]
Harada H, Ohsaki Y, Agista AZ, Ho H-J, Hirose T, Yamada K, Furukawa M, Nochi T, Chiu W-C, Chen Y-L, Yeh C-L, Yang S-C, Mori T, Shirakawa H. Extracellular Vesicle from Chlorella vulgaris Alleviates Hepatic Fibrosis in a Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease through Modulation of Inflammatory Signaling. Int J Mol Sci, 2026, 27, 3735. [MDPI]
Murakami R, Ohsaki Y, Ito H, Ho H-J, Agista AZ, Chiang Y-F, Chen Y-L, Maekawa M, Hirose T, Hara K, Chiu W-C, Yeh C-L, Hsia S-M, Yang S-C, Mano N, Mori T, Shirakawa H. Effect of Vitamin K Supplementation on Testosterone Production in a Rat Model of Late-Onset Hypogonadism. Foods, 2026, 15, 1070. [MDPI]
Toyoshi E, Watanabe M, Namai F, Yamane K, Kashima T, Ikeda-Ohtsubo W, Agista AZ, Yoshida A, Sakuma T, Fukuda I, Suzuki K, Yoshioka G, Imai Y, Tsuchida S, Nishiyama E, Shinkai H, Muneta Y, Uenishi H, Tobe R, Shirakawa H, Maekawa M, Mano N, Kitazawa H, Nishiyama K. Dynamics of tryptophan metabolites and microbial adaptations during corn by-product fermentation in the pig gut microbiome. J. Anim. Sci. Biotechnol., 2026, 17, 32. [Springer]
白川仁 健康寿命延伸に資する食品成分の新たな機能性に関する基礎研究 日本栄養・食糧学会誌（2026）79, 21-28. [J-Stage]
Xiao Q, Chen Y-H, Fu L-C, Nurrahma HA, Lai J-H, Shirakawa H, Yang S-C. Protective effects of fish oil against brain impairment in rats with chronic ethanol-induced liver damage involving the NRF2 pathway and oxidative stress. Antioxidants, 2025, 14, 704. [MDPI]
Su L-H, Tsai W-C, Shirakawa H, Tsai Y-L, Yeh S-L, Yeh C-L. Glutamine administration attenuates poly(I:C)-induced lung injury by reducing neutrophil infiltration and activating the TLR-3 antiviral pathway. Nutrients, 2025, 17, 1700. [MDPI]
Satake Y, Katsura T, Zhuang T, Urakawa M, Mineshima Y, Baba T, Yoshida G, Kitazawa H, Shirakawa H, Nakamura T, Nochi T, Sakai Y, Satoh M, Haga S, Aso H, Uemoto Y. Development of prediction equations for immunoglobulin A, G, and M concentrations in mature milk from Holstein cows using milk infrared spectral data. J. Dairy Sci., 2025, 108, 7354-7369. [ScienceDirect]
白川仁 ビタミンKおよび関連イソプレノイドのもつ新たな健康機能性に関する研究 ビタミン（2025）99, 1-9. [J-Stage]
Fu L-C, Liu W-T, Shirakawa H, Chen Y-H, Xiao Q, Yang S-C. Effects of sesamin on sleep quality and the antioxidative status in patients with low arousal threshold obstructive sleep apnea syndrome and those at risk of obstructive sleep apnea syndrome. J. Func. Food, 2024, 123, 106564. [ScienceDirect]
Agista AZ, Kato A, Goto T, Koseki T, Oikawa A, Ohsaki Y, Yamaki M, Yeh C-L, Yang S-C, Ardiansyah, Budijanto S, Komai M, Shirakawa H. Fermented rice bran mitigated the syndromes of type 2 diabetes in KK-Ay mice model. Metabolites, 2024, 14, 614. [MDPI]
Ito J, Nakamura T, Toyama T, Chen D, Berndt C, Poschmann G, Mourão ASD, Doll S, Suzuki M, Zhang W, Zheng J, Trümbach D, Yamada N, Ono K, Yazaki M, Kawai Y, Arisawa M, Ohsaki Y, Shirakawa H, Wahida A, Proneth B, Saito Y, Nakagawa K, Mishima E, Conrad M. PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization. Mol. Cell, 2024, 84, 4629-4644.e9. [ScienceDirect]
Dini UK, Mayangsari Y, Ardiansyah, Shirakawa H, Saputra WD. Germinated IR-64 Brown Rice Improves Hyperglycemia in Diabetic Rats. Nutrire, 2024, 49, 49. [Springer]
Chao Y-W, Yu-Tung Y-T, Yang S-C, Shirakawa H, Su L-H, Loe PY, Chiu W-C. The Effects of Rice Bran on Neuroinflammation and Gut Microbiota in Ovariectomized Mice Fed a Drink with Fructose. Nutrients, 2024, 16, 2980. [MDPI]
Mantiri SA, Mayangsari Y, Ardiansyah, Shirakawa H, Saputra WD. In vivo evaluation of germinated IR-64 brown rice dietary administration on the lipid blood profiles of rats with hypercholesterolemia. Nutrire, 2024, 49, 44. [Springer]
Liu Z-Y, Xiao Q, Chena Y-H, Lai J-H, Shirakawa H, Yang S-C. Effects of fish oil on insulin resistance in the brain of rats with alcoholic liver damage. J. Func. Food, 2024, 120, 106369. [ScienceDirect]
Budijanto S, Kurniati Y, Nuraida L, Dewi FNA, Priosoeryanto BP, Yuliana ND, Ardiansyah, Saepuloh U, Safrida, Shirakawa H. The inhibition of colon cancer development by black rice bran on BALB/C Mice. AIMS Agri. Food, 2024, 9, 789–800. [AIMS Press]
Agista AZ, Chien Y-S, Koseki T, Nagaoka H, Ohnuma T, Ohsaki Y, Yeh C-L, Yang S-C, Ardiansyah, Budijanto S, Komai M, Shirakawa H. Investigation of Rhizopus oligosporus metabolites in fermented wheat bran and its bio function in alleviating colitis in mice model. Metabolites, 2024, 14, 359. [MDPI]
Alauddin M, Amin MR, Siddique MA, Hiwatashi K, Shimakage A, Takahashi S, Shinbo M, Komai M, Shirakawa H. In silico and in vivo experiment of soymilk peptide (tetrapeptide - FFYY) for the treatment of hypertension. Peptides, 2024, 175, 171170. [ScienceDirect]
Hsu F-Y, Suh-Ching Yang S-C, Fat-Moon Suk F-M, Shirakawa H, Chiu W-C, Yi-Jen Liao Y-J. Dietary rice bran attenuates hepatic stellate cell activation and liver fibrosis in mice through enhancing antioxidant ability. J. Nutri. Biochem., 2024, 125, 109565. [ScienceDirect]
Wee VTK, Shirakawa H, Yeh S-L, Yeh C-L. Fermented rice bran supplementation attenuates colonic injury through modulating intestinal aryl hydrocarbon receptor and innate lymphoid cells in mice with dextran sodium sulfate-induced acute colitis. J. Nutri. Biochem., 2024, 123, 109493. [ScienceDirect]
大崎雄介、白川仁 ビタミンKとビタミンK関連物質による抗炎症作用とその機序 日本栄養・食糧学会誌 (2024) 77, 103-108. [J-Stage]
岡田和花、大崎雄介、白川仁 認知機能障害モデル動物に対するガラクトース投与の相反する効果 ビタミン (2024) 98, 358-362. [J-Stage]
塩沢浩太、大崎雄介、白川仁 新規形態のビオチン塩の開発とその効果 ビタミン (2024) 98, 21-24. [J-Stage]
Imoto T, Hoshino Y, Sato Y, Ohsaki Y, Shirakawa H. Eating Habits and Mental Health of College Students in Japan during the COVID-19 Pandemic. COVID, 2023, 3, 1721–1732. [MDPI]
Uemoto Y, Katsura T, Endo Y, Tanaka K, Zhuang T, Urakawa M, Baba T, Yoshida G, Wang H, Kitazawa H, Shirakawa H, Nakamura T, Nochi T, Aso H. Genetic aspects of immunoglobulins and cyclophilin A in milk as potential indicators of mastitis resistance in Holstein cows. J. Dairy Sci., 2024, 107, 1577-1591. [ScienceDirect]
Kabir T, Yoshiba H, Agista AZ, Sultana H, Ohsaki Y, Chiu-Li Yeh C-L, Hirakawa R, Tani H, Ikuta T, Nochi T, Yang S-C, Shirakawa H. Protective Effects of Gnetin C from Melinjo Seed Extract against High Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model. Nutrients, 2023, 15, 3888. [MDPI]
Huang P-X, Yeh C-L, Yang S-C, Shirakawa H, Chang C-L, Chen L-H, Chiu Y-S, Chiu W-C. Rice Bran Supplementation Improves Gut Dysbiosis and Mitigate Muscle Atrophy in Ovariectomized Mice Fed with a High-Fat Diet. Nutrients, 2023, 15, 3514. [MDPI]
Budijanto S, Nurtiana W, Muniroh A, Kurniati Y, Nuraida L, Priosoeryanto BP, Dewi FNA, Ardiansyah, Yuliana ND, Safrida S, Shirakawa H. Dietary Supplementation of Black Rice Bran to Colon Carcinogen-Induced Mice: Examining the Development of Colorectal Cancer by Improving Environmental Colon Conditions. Heliyon, 2023, 9, e18528. [ScienceDirect]
Noguchi T, Kitaura H, Marahleh A, Agista AZ, Ohsaki Y, Shirakawa H, Mizoguchi I. Fermented rice bran supplementation inhibits LPS-induced osteoclast formation and bone resorption in mice, and fermented rice bran extract directly inhibits osteoclast formation and TNF-α expression in macrophages. Nutrients, 2023, 15, 3044. [MDPI]
Yamaki M, Saito H, Mimori T. Suzuki Y, Nagasaki M, Suzuki K, Satoh-Kuriwada S, Shoji N, Isono K, Goto T, Shirakawa H, Komai M. Analysis of Genetic Polymorphism of Bitter Taste Receptor TAS2R38 and TAS2R46, and Its Relationship with Eating and Drinking Habits in Japanese ToMMo Subjects. J. Nutr. Sci. Vitaminol., 2023, 69, 347–356. [Jstage]
Xiao Q, Chen Y-H, Chen Y-L, Chien Y-S, Hsieh L-H, Shirakawa H, Yang S-C. Potential Benefits of Epidermal Growth Factor for Inhibiting Muscle Degrative Markers in Rats with Alcoholic Liver Damage. Int. J. Mol. Sci., 2023, 24, 8845. [MDPI]
Handoko DD, Kaseh AM, Cempaka L, David W, Kusbiantoro B, Agista AZ, Ohsaki Y, Shirakawa H, Ardiansyah. Effects of household-scale cooking on volatile compounds, sensory profile, and hypotensive effect of Kenikir (Cosmos caudatus). AIMS Agri. Food, 2023, 8, 198-213. [AIMS Press]
Shiozawa K, Maeda M, Ho H-J, Katsurai T, Howlader MZH, Horiuchi K, Sugita Y, Ohsaki Y, Agista AZ, Goto T, Komai M, Shirakawa H. Biotin enhances testosterone production in mice and in mouse testis-derived cells. Nutrients, 2022, 14, 4761. [MDPI]
Nakano T, Hayashi S, Ochiai Y, Shirakawa H, Wu H, Endo H, Yu H. Modification of the oxygen radical absorbance capacity assay and its application in evaluating the total antioxidative state in fish. Adv. Redox Res., 2022, 6, 100049. [ScienceDirect]
Agista AZ, Tanuseputero SA, Koseki T, Ardiansyah, Budijanto S, Sultana H, Ohsaki Y, Yeh C-L, Yang S-C, Komai M, Shirakawa H. Tryptamine, a microbial metabolite in fermented rice bran suppressed lipopolysaccharide-induced inflammation in a murine macrophage model. Int. J. Mol. Sci., 2022, 23, 11209. [MDPI]
Urakawa M, Zhuang, T, Sato H, Takanashi S, Yoshimura K, Endo Y, Katsura T, Umino T, Tanaka K, Kobayashi H, Takada N, Kozutsumi T, Kumagai H, Asano T, Sazawa K, Ashida N, Rose M, Kitazawa H, Shirakawa H, Watanabe K, Nochi T, Nakamura T, Aso H. Prevention of mastitis in multiparous dairy cows with a previous history of mastitis by oral feeding with probiotic Bacillus subtilis. Anim. Sci. J., 2022, 93, e13764. [Wiley]
Safrida S, Budijanto S, Nuraida L, Priosoeryanto BP, Saepuloh U, Marya SS, Ardiansyah, Shirakawa H. Fermented Black Rice Bran Extract Inhibit Colon Cancer Proliferation in WiDr Cell Lines. Food Sci. Technol., 2022, 42, e14422. [SciELO]
Astuti RD, Fibri DLN, Handoko DD, David W, Budijanto S, Shirakawa H, Ardiansyah. The volatile compounds and aroma description in various fermented and non-fermented rice bran. Fermentation, 2022, 8, 120. [MDPI]
Kuroiwa T, Ohtani Y, Obara Y, Terada F, Watanabe K, Shirakawa H, Komai M, Satoh H, Sato S, Ichijo T. Effect of vitamin K3 supplementation on Immunoglobulin G concentration in colostrum of periparturient Holstein dairy cows. Anim. Sci. J., 2022, 93, e13706. [Wiley]
Chen T-Y, Chen Y-L, Chiu W-C, Yeh C-L, Tung Y-T, Shirakawa H, Liao W-T, Yang S-C. Effects of the water extract of fermented rice bran on liver damage and intestinal injury in aged rats with high-fat diet feeding. Plants, 2022, 11, 607. [MDPI]
Nadhifah AM, Fibri DLN, Handoko DD, David W, Budijanto S, Shirakawa H, Ardiansyah. The volatile compounds and aroma profile of pigmented rice bran after fermentation. Curr. Res. Nutr. Food Sci., 2022, 10, 145-170. [CRNFSJ]
Bai H, Arai H, Ikuta K, Ishikawa S, Ohtani Y, Iwashita K, Okada N, Shirakawa H, Komai M, Terada F, Obara Y. Effects of dietary vitamin K3 supplementation on vitamin K1 and K2 (menaquinone) dynamics in dairy cows. Anim. Sci. J., 2022, 93, e13680. [Wiley]
Ho H-J, Shirakawa H. Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease. Cells, 2022, 12, 88. [MDPI]
Mizuno K, Watanabe K, Yamano E, Ebisu K, Tajima K, Nojima J, Ohsaki Y, Kabayama S, Watanabe Y. Antioxidant effects of continuous intake of electrolyzed hydrogen water in healthy adults. Heliyon, 2022, 8, e11853. [ScienceDirect]
Matsuki T, Hirose T, Ohsaki Y, Shimada S, Endo A, Ito H, Takahashi C, Yamakoshi S, Oba-Yabana I, Anan G, Kato T, Tajima R, Nakayama S, Kimura T, Nakamura H, Tani J, Takahashi K, Kure S, Mori T. Inhibition of platelet-derived growth factor pathway suppresses tubulointerstitial injury in renal congestion. J. Hypertens., 2022, 40, 1935-1949. [Lippincott]
Islam J, Agista AZ, Watanabe K, Nochi T, Aso H, Ohsaki Y, Koseki T, Komai M, Shirakawa H. Fermented rice bran supplementation attenuates chronic colitis-associated extraintestinal manifestations in female C57BL/6N mice. J. Nutr. Biochem., 2022, 99, 108855. [ScienceDirect]
Ogawa S, Ohsaki Y, Shimizu M, Nako K, Okamura M, Kabayama S, Tabata K, Tanaka Y, Ito S. Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial. Diabetol. Int., 2022, 13, 209-219. [SpringerLink]
Shiozawa K, Agista AZ, Ohsaki Y, Shirakawa H. Emergence of Novel Functions of Vitamins for the Prevention of Life-Style Related Diseases. J. Nutr. Sci. Vitaminol., 2022, 68, S8-S10. [Jstage]
大崎雄介、Afifah Zahra Agista、白川仁 ピリドキサミンによる神経保護を介した統合性失調症改善の可能性 ビタミン (2022) 96, 474-476. [日本ビタミン学会]
大崎雄介、塩沢浩太、白川仁 糖尿病と高血圧に対して期待されるビオチンの効果 食と医療 （2022）22, 65-70.
Chen Y-H, Chiu W-C, Xiao Q, Chen Y-L, Shirakawa H, Yang S-C. Synbiotics alleviate hepatic dame, intestinal injury and muscular beclin-1 elevation in rats after chronic ethanol administration. Int. J. Mol. Sci., 2021, 22, 12547. [MDPI]
Saputra WD, Shono H, Ohsaki Y, Sultana H, Komai M, Shirakawa H. Geranylgeraniol Inhibits Inflammation induced by Lipopolysaccharide in MG6 mouse microglial-derived cells via NF-κB signaling modulation. Int. J. Mol. Sci., 2021, 11, 10543. [MDPI]
Sultana H, Komai M, Shirakawa H. Role of Vitamin K in Cholestatic Liver Disease. Nutrients 2021, 13, 2515. [MDPI]
Xiao Q, Chen Y-H, Pratama SA, Y Chen Y-L, Shirakawa H, Peng H-C, Yang S-C. The Prophylactic Effects of Glutamine on Muscle Protein Synthesis and Degradation in Rats with Ethanol-Induced Liver Damage. Nutrients, 2021, 13, 2788. [MDPI]
Agista AZ, Rusbana TB, Islam J, Ohsaki Y, Sultana H, Hirakawa R, Watanabe K, Nochi T, Ardiansyah, Slamet Budijanto S, Yang SC, Koseki T, Aso H, Komai M, Shirakawa H. Fermented rice bran supplementation prevented the development of intestinal fibrosis due to DSS-induced inflammation in mice. Nutrients, 2021, 13, 1869. [MDPI]
Ardiansyah, Nada A, Rahmawati NTI, Oktriani A, David W, Astuti RM, Handoko DD, Kusbiantoro B, Budijanto S, Shirakawa H. Volatile Compounds and Sensory Profile of Fermented Rice Bran. Plants, 2021, 10, 1073. [MDPI]
Sultana H, Kato A, Ohashi A, Takashima R, Katsurai T, Sato S, Monma M, Ohsaki Y, Goto T, Komai M, Shirakawa H. Effect of vitamin K-mediated PXR activation on drug-metabolizing gene expression in human intestinal carcinoma LS180 cell line. Nutrients, 2021, 13, 1709. [MDPI]
Rana MM, Shiozawa K, Mukai K, Takayanagi K, Eguchi K, Sultana H, Ohsaki Y, Komai M, Shirakawa H. S-allyl Cysteine Enhances Testosterone Production in Mice, and Mouse Testis Derived I-10 Cells. Molecules, 2021, 26, 1697. [MDPI]
Sotome R, Hirasawa A, Kikusato M, Kuriyagawa A, Watanabe K, Furukawa K, Collin A, Amo T, Shirakawa H, Takahashi H, Wu G, Nochi T, Shimmura T, Walden CH, Toyomizu M. In vivo emergence of beige-like fat in chickens as physiological adaptation to cold environments. Amino Acid, 2021, 53, 381-393. [PMC]
Ardiansyah, Ariffa F, Astuti RM, David W, Handoko DD, Budijanto S, Shirakawa H. Non-volatile compounds and blood pressure lowering activity of Inpari 30 and Cempo Ireng fermented and non-fermented rice bran. AIMS Agri. Food, 2021, 6, 337-359. [AIMS Press]
Hsu C-D, Hsieh L-H, Chen Y-L, Lin I-C, Chen Y-R, Chen C-C, Shirakawa H, Yang S-C. Complementary effects of pine bark extract supplementation on inattention, impulsivity and antioxidative status in children with attention-deficit hyperactivity disorder: a double-blinded randomized placebo-controlled crossover study. Phytother. Res., 2021, 35, 3226-3235. [Pubmed]
Yamakoshi S, Ito O, Rong R, Ohsaki Y, Nakamura T, Hirose T, Takahashi K, Mori T, Totsune K, Kohzuki M. High Salt Intake-Increased (Pro)renin Receptor Expression Is Exaggerated in the Kidney of Dahl Salt-Sensitive Rats. Hypertension, 2021, 75, 1447-1454. [Pubmed, AHA/ASA]