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RHSA Gr12 Biology 2021-2022
  • Home
  • Biochem
  • Homeo
  • Genetics
  • Biotech labs
  • Metabolism
  • Culminating 2024-5
  • Multiple Choice Extra practice Review (RTOR)
  • More
    • Home
    • Biochem
    • Homeo
    • Genetics
    • Biotech labs
    • Metabolism
    • Culminating 2024-5
    • Multiple Choice Extra practice Review (RTOR)

Molecular Genetics

UPDATED Unit Outline 

McGraw Hill Online textbook 2002

Interesting connection to our work    Aging skin of wrinkles without same side-effects

01- Intro to Molecular Genetics p 218-228

Intro to Molecular Genetics.pptx

Intro to Molecular Genetics.docs

01 Nucleic Acid Comparison V4, Answers

Video Nucleotides and DNA 3 min

01 nucleic acids and nitrogen bases.pdf

Bozeman Science - Nucleic Acids 8 min

Har Gobind Khorana - Nobel winner: Deciphered Central Dogma wikipedia

02- DNA structure and composition, DNA coiling, p 229-234 

02 DNA Structure and Coiling V2.pptx

02 DNA Structure and Coiling note v2.doc, worksheet

Watson, Crick and the Discovery of DNA Structure 8:56 min  

How DNA is packaged 1:42 min

 Coiling and Replication 3 min Watch from 0-1:40 min only

Ted Talk - James Watson in 2005 20 min

Ameoba sisters video~8 mins- DNA vs RNA

03- DNA Replication, p 234-240  DNA --> more DNA

03 Replication V3.pptx

03 Replication note and diagram.docx

Bozeman Science - DNA Replication 10 min

Simple Replication video 4 min - careful - we say new nucleotides added at the open 3' end only.

Replication Review WS

Replication Review WS Answers 

 Coiling and Replication 3 min Watch from 1:40-3:05 min 

Ameoba sisters- DNA replication

DNA replication ws

04-The Central Dogma, the triplet hypothesis, p 252-256 

DNA --> transcription --> RNA --> translation --> protein

04 The Central Dogma Note V4.docx

04 The Central Dogma Assignment V5.docx  

04 The Central Dogma Big Pic Reviewed.docx, answers

Bozeman Science - The Central Dogma 10 min

Khan Academy Central Dogma

05-Protein Synthesis: Step 1 – Transcription Textbooks click here pg 257, 258, 259, 260, 261 , 268

05 Transcription 4 steps note V3.docx - do questions. note taking activity

05 Transcription- answers- updated

05 Protein Synthesis Diagram activity pg 1.doc

05_protein_synthesis_diagram_activity_pg2.jpg

Bozeman Science - Transcription and Translation 12 min, watch only until 8:50 as there is a major error after that point.

Gene Expression Simulation (PHET) - Awesome, try it!

 06-Protein Synthesis Step 2 – Translation, p 263-271

Good video explaining the role of animo acids

06 Translation Note V2.docx, splicing worksheet

06 Protein Synthesis transcription and translation activity.docx, 

06 Protein Synthesis Activity  Answers, Part 1,  Part 2,

Video - Transcription and Translation 3 min, 

Overview of lessons 2-8, Video 7 min

Video - complete lessons for genes, Central Dogma, transcription and translation 45 min

TED Talk Dr Ken Dill The protein folding problem (2013)

Summary chart Homework-Replication, Transcription, Translation, partial answers- you need to do the chart on your own

Concord Consortium Animation

Protein Synthesis Activity  Answers, Part 1,  Part 2,

07- Transcriptional Control in Eukaryotes, Bozeman Science Gene Regulation

06A Genes and Genome V5.pptx, note

Transcriptional control PowerPoint, note, worksheet

08:Operons and Transcriptional control in Prokaryotes, note

 Ameoba sisters video- Operons

Enrichment videos- The Genome and Epigenome, Epigenome changes in mice Dr. Dana Dolinoy of Duke University video

PBS epigenetics video

A Tale of Two Mice PBS Nova Interactive 

X Inactivation and Epigenetics 11 min

Epigenetics and You - NOVA documentary 52 min

ADHD, A Healthy Diet for Mom and Epigenetics

ADHD and folic acid levels in pregnancy

Cool link and videos on epigenetics

Ameoba sisters epigenetics

Formaldehyde altering epigenetic expression

Cannabis use alters DNA methylation, with implications beyond smoking effects 

09 Assignment:   

  •  Mutations- requires only textbook- questions from assignment WILL appear on your unit test

  • Mutations solutions

Mutation video

Mutations video -Bozeman Science

10- Restriction Endonucleases, PCR, Gel Electrophoresis, p 293-296

Amoeba sisters PCR video

10 Biological Tools and Techniques part 1.docx

Biotech activity-in class

10 DNA to the races.pdf

Making an agarose gel - 2:30

Ameoba sisters- Biotech

Running a gel electrophoresis - 4 min

DNA Fingerprinting - Bozeman - 6 min

Molecular Biology - Genetic Engineering - Bozeman - 14 min

PCR video- Public Health Ontario Covid PCR test

11 Biotechnology Part 2 - Recombinant DNA, plasmids, p 303-306

11 Biological_Tools_and_Techniques part 2.docx      

11 RECOMBINANT DNA EXERCISE.doc      Human Insulin DNA       Plasmid DNA.jpg

Genetic engineering - 10 min

CRISPR Revolutionary Gene Editing - clay motion video

Naturally occurring off switches in CRISPR-Cas9

GFP fish     Big Bang Theory - Sheldon and Fish

Crispr video-Ted Ed video

Glass Microbiology-Artist Luke Jerram 

12 Genetics Review: TM unit test rvw 2020.doc, Answers

Molecular Genetics Veritech Review


Biotech Labs

Micro pipetting basics, micro pipetting practice sheets, Pipetting PowerPoint

Loading gels for electrophoresis

PGlo Lab: 

Resources: Introduction presentation  another PowerPoint presentation of pGlo, pGlo annimation video

 and video, Bozeman Science Transformation Lab, and  another video for reference

Student lab manual (extended version)- for reference, Student lab to complete and submit

PCR labs:

Khan Academy video

Possible PCR extension to pGLO lab- coming soon

PCR and Electrophoresis Lab - High School Prank Gone Wrong v1-

Demystifying PCR Presentation


Assessments:

  • Quiz

  • Central Dogma Assignment

  • 06 Protein Synthesis Activity -Transcription 

  • 11 RECOMBINANT DNA EXERCISE.doc , inquiry activity- submit chart only

  • PGLO lab

  • PCR lab

  • Gel electrophoresis lab

  • Unit test

Formative Assessment: For your learning

  • Micro pipetting basics mini lab

  • Prelab for electrophoresis

Some very cool links

Epstein Barr virus aka the herpes virus that causes 'Mono" appears to have a causal role in acquiring MS

Drew Barry Ted Talk - Molecular Animations

Drew Barry Blog, http://richerramblings.wordpress.com/2012/01/12/drew-berry-animations-of-unseeable-biology/

Reversal of biological clock restores vision in old mice- a study published in Nature Magazine

PBS epigenetics video

A Tale of Two Mice PBS Nova Interactive 

X Inactivation and Epigenetics 11 min

Epigenetics and You - NOVA documentary 52 min

ADHD, A Healthy Diet for Mom and Epigenetics

ADHD and folic acid levels in pregnancy

Cool link and videos on epigenetics

Ameoba sisters epigenetics

Formaldehyde altering epigenetic expression

Cannabis use alters DNA methylation, with implications beyond smoking effects  

Watch: How do vaccines work?

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