Research
We will engineer mammalian cells with advanced genome-editing tools to create 'designer cells'. These cells could be used as cell-based therapeutics and tools for biological research. Additionally, we aim for developing gene-therapy platforms to treat refractory diseases.
1. Genome editing
New methods for highly efficient knockin-based genome editing.
Prime editing for the generation of various cell lines.
2. Synthetic biology
Construction of stimuli-responsive genetic circuits for precise control of gene expression.
Application of the genetic circuits to design biopharmaceuticals.
3. Cell and gene therapy
Designer stem cell-derived β cells and islet organoids for treating diabetes.
Safety switches for cell-based therapeutics.
A gene therapy platform based on engineered intracellular binders such as nanobodies and DARPins.