Publications

S Jang#, S Shin#, Y Jeong, D Lim.
Genome editing for engineering stem cell-derived pancreatic β cells: recent trends and future perspectives.
Organoid 2023, 3, e17. (#equal contribution)

N Wieder, JC Fried, C Kim, E-H Sidhom, MR  Brown, JL Marshall, C Arevalo, M Dvela-Levitt, M Kost-Alimova, J Sieber, KR Gabriel, J Pacheco, C Clish, HS Abbasi, S Singh, JC Rutter, M Therrien, H Yoon, ZW Lai, A Baublis, R Subramanian, R Devkota, J Small, V Sreekanth, M Han, D Lim, AE Carpenter, J Flannick, H Finucane, MC Haigis, M Claussnitzer, E Sheu, B Stevens, BK Wagner, A Choudhary, JL Shaw, JL Pablo, A Greka.
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Cell Metabolism 2023, 35, 887–905.

D Lim#, Q Zhou#, KJ Cox#, BK Law#, M Lee#, P Kokkonda#, V Sreekanth#, R Pergu, SK Chaudhary, SA Gangopadhyay, B Maji, S Lai, Y Amako, DB Thompson, HKK Subramanian, MF Mesleh, V Dančík, PA Clemons, BK Wagner, CM Woo, GM Church, A Choudhary.
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules.
Nature Cell Biology 2022, 24, 1766–1775. (#equal contribution)

K Yamada, A Deb, VM Shoba, D Lim, B Maji, AE Modell, A Choudhary.
Rational design of silicon-based zinc ionophores with antibacterial activity.
Angewandte Chemie International Edition 2022, 61, e202201698.

S Shin#, S Jang#, D Lim.
Small molecules for enhancing the precision and safety of genome editing.
Molecules 2022, 27, 6266. (#equal contribution)

WG Byun#, D Lim#, SB Park.
Small-molecule modulators of protein–RNA interactions.
Current Opinion in Chemical Biology 2022, 68, 102149. (#equal contribution)

AE Modell#, D Lim#, TM Nguyen#, V Sreekanth#, A Choudhary.
CRISPR-based therapeutics: current challenges and future applications.
Trends in Pharmacological Sciences 2022, 43,  151−161. (#equal contribution)

V Sreekanth, Q Zhou, P Kokkonda, HC Bermudez-Cabrera, D Lim, BK Law, BR Holmes, SK Chaudhary, R Pergu, BS Leger, JA Walker, DK Gifford, RI Sherwood, A Choudhary.
Chemogenetic system demonstrates that Cas9 longevity impacts genome editing outcomes.
ACS Central Science 2020, 6, 2228−2237.

D Lim, V Sreekanth, KJ Cox, BK Law, BK Wagner, JM Karp, A Choudhary.  
Engineering designer beta cells with a CRISPR-Cas9 conjugation platform.
Nature Communications 2020, 11, 4043.
† Highlighted in Faculty Opinions.

WG Byun#, D Lim#, SB Park.  
Discovery of small‐molecule modulators of protein–RNA interactions by fluorescence intensity‐based binding assay.
ChemBioChem 2020, 21, 818−824. (#equal contribution)
† Featured as a cover article.

B Maji, SA Gangopadhyay, M Lee, M Shi, P Wu, R Heler, B Mok, D Lim, SU Siriwardena, B Paul, V Dančík, A Vetere, MF Mesleh, LA Marraffini, DR Liu, PA Clemons, BK Wagner, A Choudhary.  
A high-throughput platform to identify small-molecule inhibitors of CRISPR-Cas9.
Cell 2019, 177, 1067−1079.

SA Gangopadhyay, KJ Cox, D Manna, D Lim, B Maji, Q Zhou, B Maji, Q Zhou, A Choudhary. 
Precision control of CRISPR-Cas9 using small molecules and light.
Biochemistry 2019, 58, 234−244.

D Lim#, WG Byun#, SB Park.
Restoring let-7 microRNA biogenesis using a small-molecule inhibitor of the protein–RNA interaction.
ACS Medicinal Chemistry Letters 2018, 9, 1181−1185.  (#equal contribution)

W Cho, JY Koo, Y Park, K Oh, S Lee, JS Song, MA Bae, D Lim, DS Lee, SB Park.
Treatment of sepsis pathogenesis with high mobility group box protein 1-regulating anti-inflammatory agents.
Journal of Medicinal Chemistry 2017, 60, 170−179.

 D Lim, WG Byun, JY Koo, H Park, SB Park.
Discovery of a small-molecule inhibitor of protein–microRNA interaction using binding assay with a site-specifically labeled Lin28.
Journal of the American Chemical Society 2016, 138, 13630−13638.

S Lee, Y Nam, JY Koo, D Lim, J Park, J Ock, J Kim, K Suk, SB Park.
A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation.
Nature Chemical Biology 2014, 10, 1055−1060.

SS Choi, ES Kim, M Koh, SJ Lee, D Lim, YR Yang, HJ Jang, K Seo, SH Min, IH Lee, SB Park, PG Suh, JH Choi.
A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity.
Journal of Biological Chemistry 2014, 289, 26618−26629.

S Lee#, D Lim#, E Lee, N Lee, H Lee, J Cechetto, M Liuzzi, LH Freitas-Junior, JS Song, MA Bae, S Oh, L Ayong, SB Park.  (#equal contribution)
Discovery of carbohybrid-based 2-aminopyrimidine analogues as a new class of rapid-acting antimalarial agents using image-based cytological profiling assay.
Journal of Medicinal Chemistry 2014, 57, 7425−7434.

M Koh, J Park, JY Koo, D Lim, MY Cha, A Jo, JH Choi, SB Park.
Phenotypic screening to identify small‐molecule enhancers for glucose uptake: target identification and rational optimization of their efficacy.
Angewandte Chemie International Edition  2014, 53, 5102−5106.

D Lim, SB Park.
Synthesis of molecular frameworks containing two distinct heterocycles connected in a single molecule with enhanced three-dimensional shape diversity.
Chemistry−A European Journal 2013, 19, 7100−7108.

DK Kim, D Ryu, M Koh, MW Lee, D Lim, MJ Kim, YH Kim, WJ Cho, CH Lee, SB Park, SH Koo, HS Choi.
Orphan nuclear receptor estrogen-relatd receptor γ (ERRγ) is key regulator of hepatic gluconeogenesis.
Journal of Biological Chemistry 2012, 287, 21628−21639.

B Kim, D Lim, HJ Jin, HY Lee, S Namgung, Y Ko, SB Park, S Hong.
Family-selective detection of antibiotics using antibody-functionalized carbon nanotube sensors.
Sensors and Actuators B: Chemical 2012, 66, 193−199.

D Lim, YH Kim, JC Joo, YJ Yoo. 
Electroenzymatic synthesis of (S)-styrene oxide employing zinc oxide/carbon black composite electrode.
Enzyme and Microbial Technology 2010, 47, 313−321.