Publications

2026

Chen JJ, Gong X, Mak M, Li FQ, Takemaru KI. 

Basal body docking failure triggers centriole clustering and elimination in mammalian spermatogenesis

EMBO Rep, 14, 5039-5061, 2026. PMID: 42471456. View Article

Selected for the Journal Cover. 

Zhang X, Luo C, Coughlin K Jr., Li FQ, Takemaru KI, Wan L. 

Transcriptomic regulation of pancreatic acinar cell homeostasis and plasticity 

Biochem Soc Trans, 54, 681-697, 2026. PMID: 42237897. View Article

Byun K, Lin Y, Li FQ, Takemaru KI, Cheung L. 

Loss of primary cilia in late pituitary organogenesis does not cause endocrine dysfunction

J Anat, 2026. PMID: 42387855. View Article

2025

Kim EN, Li FQ, Takemaru KI. 

ciBAR1 loss in mice causes laterality defects, pancreatic degeneration, and altered glucose tolerance

Life Sci Alliance, 8, e202402916, 2024. PMID: 39622622. View Article

Selected for the Journal Cover. 

2024

Yamaguchi H, Kitami M, Li M, Swaminathan S, Darabi R, Takemaru KI, Komatsu Y. 

Disruption of distal appendage protein CEP164 causes skeletal malformation in mice

Biochem Biophys Res Commun, 741, 151063, 2024. PMID: 39612644. View Article

Hoque M, Li FQ, Weber WD, Chen JJ, Kim, EN, Kuo PL, Visconti PE, Takemaru KI. 

The Cby3/ciBAR1 complex positions the annulus along the sperm flagellum during spermiogenesis

J Cell Biol, 223, e202307147, 2024. PMID: 38197861. View Article

Selected for the Journal Cover. Featured in "Spotlights".

2022

Reed M, Takemaru KI, Ying G, Frederick JM, Baehr W. 

Deletion of CEP164 in mouse photoreceptors post-ciliogenesis interrupts ciliary intraflagellar transport (IFT)

PLoS Genet, 19, e1010154, 2022. PMID: 36074756. View Article 

Xue Y, Gursky Z, Monte B, Koundal S, Liu X, Lee H, Michurina TV, Mellanson KA, Zhao L, Nemajerova A, Kahle KT, Takemaru KI, Enikolopov G, Peunova NI, Benveniste H. 

Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus

Fluids Barriers CNS, 19, 20, 2022. PMID: 35248089.  View Article

Hoque M, Kim EN, Chen D, Li FQ, Takemaru KI. Review

Essential roles of efferent duct multicilia in male fertility

Cells, 11, 341, 2022. PMID: 35159149. View Article

2021

Cyge B, Voronina V, Hoque M, Kim EN, Hall J, Bailey-Lundberg JM, Pazour GJ, Crawford HC, Moon RT, Li FQ, Takemaru KI. 

Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis 

Sci Rep, 11, 17220, 2021. PMID: 34446743. View Article

Hoque M, Chen D, Hess RA, Li FQ, Takemaru KI.

CEP164 is essential for efferent duct multiciliogenesis and male fertility

Reproduction, 162, 129-139, 2021. PMID: 34085951. View Article

Selected for the Journal Cover. 

Mikhailik A, Michurina TV, Dikranian K, Hearn S, Maxakov VI, Siller SS, Takemaru KI, Enikolopov G, Peunova N. 

nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea 

Life Sci Alliance, 4, e202000981, 2021. PMID: 33653689. View Article

2020

Takemaru L*, Pandya P*, Lake MW, Carter CA, Li FQ. *Contributed equally.

Investigating the role of the novel ESCRT-III recruitment factor CCDC11 in HIV budding: A potential target for antiviral therapy 

J Emerging Investigators. 2020. View Article

Barton BE, Herrera GG, Anamthathmakula P, Rock JK, Willie A, Harris EA, Takemaru KI, Winuthayanon W. 

Roles of steroid hormones in oviductal function

Reproduction, 159, R125-R137, 2020. PMID: 32040278. View Article

Li FQ, Chiriboga L, Black MA, Takemaru KI, Raffaniello RD. 

Chibby is a weak regulator of beta-catenin activity in gastric epithelium

J Cell Physiol, 234, 1871-1879, 2019. PMID: 30063079. View Article

2019

Choi YJ, Laclef C, Yang N, Andreu-Cervera A, Lewis J, Mao X, Li L, Snedecor ER, Takemaru KI, Qin C, Schneider-Maunoury S, Shroyer KR, Hannun YA, Koch PJ, Clark RA, Payne AS, Kowalczyk AP, Chen J. 

RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis

PLoS Genet, e1007914, 2019. PMID: 30689641. View Article

Li H, Guo C, Kim-Holzapfel D, Li W, Altshuller Y, Schroeder B, Liu W, Meng Y, French JB, Takemaru KI, Frohman MA, Jia S. 

Fast, volumetric live-cell imaging using high-resolution light-field microscopy

Biomed Opt Express, 10, 29-49, 2019. PMID: 30775081. View Article

2018

Ahmed A*, Lee J*, Parker JE*, Rizvon A, Nyayapathi V, Li FQ, Lake MW, Takemaru KI. *Contributed equally.

The cilium- and centrosome-associated protein CCDC11 is required for cytokinesis via midbody recruitment of the ESCRT-III membrane scission complex subunit CHMP2A

J Emerging Investigators. 2018. View Article

Wang C, Li J, Takemaru KI, Jiang X, Xu G, Wang B. 

Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse

Development. 145, 2018; PMID: 29487109. View Article

2017

Siller SS, Sharma H, Li S, Yang J, Zhang Y, Holtzman MJ, Winuthayanon W, Colognato H, Holdener BC, Li FQ, Takemaru KI. 

Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation

PLoS Genet, 13, e1007128, 2017. PMID: 29244804. View Article

Featured in "BPoD-Biomedical Picture of the Day".

Mirsaidi N, Burns MP, McClain SA, Forsyth E, Li J, Dukes B, Lin D, Nahvi R, Giraldo J, Patton M, Wang P, Lin K, Miller E, Ratliff T, Hamidi S, Crist S, Takemaru KI, Szema A. 

Enhanced mortality to metastatic bladder cancer cell line MB49 in vasoactive intestinal peptide gene knockout mice

Front Endocrinol, 8, 162, 2017. PMID: 28824540. View Article

Li S, O'Neill SR, Zhang Y, Holtzman MJ, Takemaru KI, Korach KS, Winuthayanon W. 

Estrogen receptor alpha is required for oviductal transport of embryos

FASEB J, 31, 1595-607, 2017. PMID: 28082352. View Article

Fischer V, Wong M, Li FQ, Takemaru KI. 

Chibby1 knockdown promotes mesenchymal-to-epithelial transition-like changes

Cell Cycle, 16, 448-56, 2017. PMID: 28107095. View Article

2016

Nemajerova A, Kramer D*, Siller SS*, Herr C*, Shomroni O, Pena T, Gallinas Suazo C, Glaser K, Wildung M, Steffen H, Sriraman A, Oberle F, Wienken M, Hennion M, Vidal R, Royen B, Alevra M, Schild D, Bals R, Donitz J, Riedel D, Bonn S, Takemaru KI, Moll UM, Lize M. *Contributed equally.

TAp73 is a central transcriptional regulator of airway multiciliogenesis

Genes Dev, 30, 1300-1312, 2016. PMID: 27257214. View Article

Highlighted in “Outlook”.

Li FQ*, Chen X*, Fisher C, Siller SS, Zelikman K, Kuriyama R, Takemaru KI. *Contributed equally.

BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis

Mol Cell Biol, 36, 2668-2680, 2016. PMID: 27528616. View Article

Selected for the Journal Cover. 

2015

Siller SS*, Burke MC*, Li FQ, Takemaru KI. *Contributed equally.

Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells

Cell Cycle, 15, 3163-3172, 2015. PMID: 26266958. View Article

Mancini M, Leo E, Takemaru KI, Campi V, Castagnetti F, Soverini S, De Benedittis C, Rosti G, Cavo M, Santucci MA, Martinelli G. 

14-3-3 binding and sumoylation concur to the down-modulation of beta-catenin antagonist chibby 1 in chronic myeloid leukemia

PLoS One, 10, e0131074, 2015. PMID: 26147002. View Article

Chen J, Laclef C, Moncayo A, Snedecor ER, Yang N, Li L, Takemaru KI, Paus R, Schneider-Maunoury S, Clark RA. 

The ciliopathy gene Rpgrip1l is essential for hair follicle development

J Invest Dermatol, 135, 701-709. PMID: 25398052. View Article

Li FQ, Siller SS, Takemaru KI. Review

Basal body docking in airway ciliated cells

Oncotarget, 6, 19944-19945, 2015. PMID: 26343519. View Article

2014

Rodriguez JP, Coulter M, Miotke J, Meyer RL, Takemaru KI, Levine JM. 

Abrogation of beta-catenin signaling in oligodendrocyte precursor cells reduces glial scarring and promotes axon regeneration after CNS injury

J Neurosci, 34, 10285-10297, 2014. PMID: 25080590. View Article

Lee YL, Sante J, Comerci CJ, Cyge B, Menezes LF, Li FQ, Germino GG, Moerner WE, Takemaru KI, Stearns T. 

Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function

Mol Biol Cell, 25, 2919-2933, 2014. PMID: 25103236. View Article

Burke MC, Li FQ, Cyge B, Arashiro T, Brechbuhl HM, Chen X, Siller SS, Weiss MA, O'Connell CB, Love D, Westlake CJ, Reynolds SD, Kuriyama R, Takemaru KI. 

Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation

J Cell Biol, 207, 123-137 2014. PMID: 25313408. View Article

Selected for the Journal Cover. Highlighted in “In This Issue”.

2013

Mancini M, Leo E, Takemaru KI, Campi V, Borsi E, Castagnetti F, Gugliotta G, Santucci MA, Martinelli G. 

Chibby drives beta-catenin cytoplasmic accumulation leading to activation of the unfolded protein response in BCR-ABL1+ cells

Cell Signal, 1820-1827, 2013. PMID: 23707389. View Article

2012

Steere N, Chae V, Burke M, Li FQ, Takemaru KI, Kuriyama R. 

A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation

PLoS One, 7, e41077, 2012. PMID: 22911743. View Article

Kumamoto N, Gu Y, Wang J, Janoschka S, Takemaru KI, Levine J, Ge S. 

A role for primary cilia in glutamatergic synaptic integration of adult-born neurons

Nat Neurosci, 15, 399-405, S1. PMID: 22306608. View Article

Takemaru KI, Chen X, Li FQ. Book Chapter

Beta-Catenin

Encyclopedia of Signaling Molecules 

Springer, 192-196, 2012. View Article

2011

Cyge B, Fischer V, Takemaru KI, Li FQ. 

Generation and characterization of monoclonal antibodies against human Chibby protein

Hybridoma, 30, 163-168, 2011. PMID: 21529289. View Article

2010

Love D, Li FQ, Burke MC, Cyge B, Ohmitsu M, Cabello J, Larson JE, Brody SL, Cohen JC, Takemaru KI. 

Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/beta-catenin antagonist Chibby

PLoS One, 5, e13600, 2010. PMID: 21049041. View Article

Li FQ*, Mofunanya A, Fischer V, Hall J, Takemaru KI*. Co-correspondence.

Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling

Mol Biol Cell, 21, 311-322, 2010. PMID: 19940019. View Article

Nominated for MBoC InCytes.

2009

Voronina VA, Takemaru KI*, Treuting P, Love D, Grubb BR, Hajjar AM, Adams A, Li FQ, Moon RT*. Co-correspondence.

Inactivation of Chibby affects function of motile airway cilia

J Cell Biol, 185, 225-233, 2009. PMID: 19364920. View Article

Mofunanya A, Li FQ, Hsieh JC, Takemaru KI. 

Chibby forms a homodimer through a heptad repeat of leucine residues in its C-terminal coiled-coil motif

BMC Mol Biol, 10, 41, 2009. PMID: 19435523. View Article

Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rheaume C, Bilanchone V, Veltmaat JM, Takemaru KI, Millar S, Lee EY, Lewis MT, Li B, Dai X. 

Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation

J Cell Biol, 185, 811-826. PMID: 19487454. View Article

Cohen JC, Killeen E, Chander A, Takemaru KI, Larson JE, Treharne KJ, Mehta A. 

Small interfering peptide (siP) for in vivo examination of the developing lung interactonome

Dev Dyn, 238, 386-393, 2009. PMID: 19161244. View Article

Takemaru KI, Fischer V, Li FQ. Review

Fine-tuning of nuclear beta-catenin by Chibby and 14-3-3

Cell Cycle, 8, 210-213, 2009. PMID: 19158508. View Article

2008

Xing Y, Takemaru KI, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W. 

Crystal structure of a full-length beta-catenin

Structure, 16, 478-487, 2008. PMID: 18334222. View Article

Highlighted in "Preview".

Li FQ*, Mofunanya A, Harris K, Takemaru KI*. *Co-correspondence.

Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity

J Cell Biol, 181, 1141-1154, 2008. PMID: 18573912. View Article

Research Highlight by Kritikou, E. AKTing in Wnt pathway. Nat Rev Mol Cell Biol, 9, 584, 2008. Selected for Faculty of 1000 Biology.

Cohen JC, Larson JE, Killeen E, Love D, Takemaru KI. 

CFTR and Wnt/beta-catenin signaling in lung development

BMC Dev Biol, 8, 70, 2008. PMID: 18601749. View Article

Qualified as “Highly accessed”.

Takemaru KI, Ohmitsu M, Li FQ. Book Chapter

An oncogenic hub: beta-catenin as a molecular target for cancer therapeutics

Handb Exp Pharmacol, 186, 261-284, 2008. PMID: 18491056. View Article

2007

Singh AM, Li FQ, Hamazaki T, Kasahara H, Takemaru KI, Terada N. 

Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells

Circulation, 115, 617-626, 2007. PMID: 17261658. View Article

Li FQ, Singh AM, Mofunanya A, Love D, Terada N, Moon RT, Takemaru KI. 

Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling

Mol Cell Biol, 27, 4347-4354, 2007. PMID: 17403895. View Article

2006

Schuierer MM, Graf E, Takemaru KI, Dietmaier W, Bosserhoff AK. 

Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines

World J Gastroenterol, 12, 1529-1535, 2006. PMID: 16570344. View Article