Lee JH, Rabl L, Gamerdinger M, Goyal V, Khakzar KM, Barbosa NM, Abramovich J, Morales-Polanco F, Köhler A, Samatova E, Rodnina MV, Deuerling E, Frydman J. “NAC controls nascent chain fate through tunnel sensing and chaperone action” bioRxiv 2025.07.27.667080 (2025)
*Di Fraia D, *Marino A, *Lee JH, Sacramento EK, Baumgart M, Bagnoli S, Balla T, Schalk F, Kamrad S, Guan R, Caterino C, Giannuzzi C, Silva P, Sahu AK, Gut H, Siano G, Tiessen M, Terzibasi-Tozzini E, Fornasiero EF, Gagneur J, Englert C, Patil KR, Correia-Melo C, Nedialkova DD, Frydman J, Cellerino A, Ori A. “Altered translation elongation contributes to key hallmarks of aging in the killifish brain” Science 389, eadk3079 (2025) *contributed equally
Lentzsch A, Lee JH, Shan SO. "Mechanistic insights into protein biogenesis and maturation on the ribosome" J Mol Biol. In Press (2025)
Morales-Polanco F, *Lee JH, *Barbosa NM, Frydman J. “Cotranslational mechanisms of protein biogenesis and complex assembly in eukaryotes” Annu. Rev. Biomed. Data Sci. 5:67-94 (2022) *contributed equally
*Lee JH, *Jomaa A, Chung S, Hwang Fu YH, Qian R, Sun X, Hsieh HH, Chandrasekar S, Bi X, Mattei S, Boehringer D, Weiss S, Ban N, Shan SO. “Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER” Sci. Adv. 7(21):eabg0942 (2021) *contributed equally
Hsieh H, Lee JH, Chandrasekar S, Shan SO. “A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex” Nat Commun 11(1):5840 (2020)
Hwang Fu YH, Chandrasekar S, Lee JH, Shan SO. “A molecular recognition feature mediates ribosome-induced SRP-receptor assembly during protein targeting” J Cell Biol. 218(10):3307-3319 (2019)
Lee JH, Chandrasekar S, Chung S, Hwang Fu YH, Liu D, Weiss S, Shan SO. “Sequential activation of human signal recognition particle by the ribosome and signal sequence drives efficient protein targeting” Proc. Natl. Acad. Sci. 115(24) (2018)
Kobayashi K, Jomaa A, Lee JH, Chandrasekar S, Boehringer D, Shan SO, Ban N. “Structure of a prehandover mammalian ribosomal SRP-SRP receptor targeting complex” Science 360(6386):323-7 (2018)
Ariosa A, Lee JH, Wang S, Saraogi I, Shan SO. “Regulation of a chaperone improves substrate specificity during cotranslational protein targeting” Proc. Natl. Acad. Sci. 112(25):E3169-78 (2015)