Viral proteins and genomes could be damaged under environmental stressors like temperature and sunlight. Nevertheless, due to the vesicle-mediated en bloc transmission of multiple virions, viral vesicles could potentially induce a robust host immune response even if they lose full infectivity, despite their high persistence following exposure to environmental stressors. As individuals are more likely to be exposed to viruses that have endured environmental conditions, it is essential to explore the host immune response in the context of viral vesicles exposure to environmental stressors.