Exploring NNMT: from metabolic pathways to therapeutic targets

Park J, Shin EJ, Kim TH, Yang JH, Ki SH, Kang KW, Kim KM 

- Archives of Pharmacal Research (2024) 47(12):893-913 (IF: 6.9, JCR 4.2%) (Review)

Blockade of forkhead box protein O1 signaling alleviates primary sclerosing cholangitis-induced sarcopenia in mice model

Kim DH, Kim J, Park J, Kim TH, Han YH 

- Life Sciences (2024) 356:123042 (IF: 5.2, JCR 11.3%) 

Epsti1 Regulates the Inflammatory Stage of Early Muscle Regeneration through STAT1-VCP Interaction.

Kim JW, Bae JH, Go GY, Lee JR, Jeong Y, Kim JY, Kim TH, Kim YK, Han JW, Oh JE, Hahn MJ, Kang JS, Bae GU 

- International Journal of Biological Sciences (2024) 20(9): 3530-3543 (IF: 8.2, JCR 9.9%) 

Dual-Emissive Detection of ATP and Hypochlorite Ions for Monitoring Inflammation-Driven Liver Injury in Vitro and in Vivo.

Fortibui MM$, Park C$, Kim NY, Kim TH*, Lee MH* 

- Analytical Chemistry (2024) 96: 9408-9415 (IF: 6.7, JCR 5.7%) ($equally contributed; *co-correspondence)

Ginsenosides for the treatment of insulin resistance and diabetes: Therapeutic perspectives and mechanistic insights.

Kim TH 

- Journal of Ginseng Research (2024) 48(3): 276-285 (IF: 6.8, JCR 2.3%) (Review)

A novel A2a adenosine receptor inhibitor effectively mitigates hepatic fibrosis in a metabolic dysfunction-associated steatohepatitis mouse model.

Park S, Hwang S, Sun J, Jeon KH, Sheen N, Shin S, Kim TH, Lee YS, Seo W, Ryu JS, Kwon Y. 

- International Journal of Biological Sciences (2024) 20(5): 1855-1870 (IF: 8.2, JCR 9.9%) 

Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives.

Ha Y*, Jeong I*, Kim TH. 

- Biomedicines (2022) 10:2530. (IF: 3.9, JCR 24.0%) (Review) (*equally contributed)

Gα12 overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation. 

Tak J, Kim YS, Kim TH, Park GC, Hwang S, Kim SG. 

- Theranostics (2022) 12(4):1570-1588. (IF: 12.4, JCR 4.2%)

NRF2-mediated SIRT3 induction protects hepatocytes from ER stress-induced liver injury.

Kim A, Koo JH, Lee JM, Joo MS, Kim TH, Kim H, Jun DW, Kim SG. 

- FASEB J (2022) 36(3):e22170. (IF: 4.4, JCR 13.8%)

Overproduction of inter-α-trypsin inhibitor heavy chain 1 after loss of Gα13 in liver exacerbates systemic insulin resistance in mice.

Kim TH, Koo JH, Heo MJ, Han CY, Kim YI, Park SY, Cho IJ, Lee CH, Choi CS, Lee JW, Kim W, Cho JY, Kim SG. 

- Science Translational Medicine (2019) 11(513):eann4735. (IF: 15.8, JCR 1.1%)

Liver X Receptor α-Induced Cannabinoid Receptor 2 Inhibits Ubiquitin-Specific Peptidase 4 Through miR-27b, Protecting Hepatocytes from TGF-β.

Wu HM, Kim TH, Kim A, Koo JH, Joo MS, Kim SG. 

- Hepatology Communications (2019) 3(10):1373-1387. (IF: 5.6, JCR 16.8%)

Role of CXCR6 in Antitumor Immune Surveillance.

Kim TH, Kim SG. 

- Gastroenterology (2019) 156(6):1565-1568. (IF: 25.7, JCR 2.8%) (Editorial)

LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis.

Joo MS, Koo JH, Kim TH, Kim YS, Kim SG.

- EbioMedicine (2019) 40:488-503. (IF: 9.7, JCR 6.4%)

Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression.

Heo MJ, Kim TH, You JS, Blaya D, Sancho-Bru P, Kim SG.

- Gut (2019) 68:704-720. (IF: 23.0, JCR 3.5%)

Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism.

Koo JH, Kim TH, Park SY, Joo MS, Han CY, Choi CS, Kim SG.   

- Journal of Clinical Investigation (2017) 127(10):3845-3860. (IF: 13.3, JCR 2.1%) 

Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function. 

Han CY*, Kim TH*, Koo JH, Kim SG. 

- Archives of Pharmacal Research (2016) 39(8):1062-1074. (IF: 6.9, JCR 4.2%) (*equal contribution)

Gα12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4α inactivation, which causes c-Met induction.

Yang YM, Lee CG, Koo JH, Kim TH, Lee JM, An J, Kim KM, Kim SG. 

- Oncotarget (2015) 6(22):19055-19069. 

SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis.

Shin SY*, Kim TH*, Wu H, Choi YH, Kim SG. 

- European Journal of Pharmacology (2014) 727:115-124. (IF: 4.2, JCR 11.3%) (*equal contribution)

An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK.

Kim TH, Eom JS, Lee CG, Yang YM, Lee YS, Kim SG. 

- British Journal of Pharmacology (2013) 168(7):1647-1161. (IF: 6.8, JCR 5.1%)

Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid.

Yang YM, Seo SY, Kim TH, Kim SG.  

- Hepatology (2012) 56(6):2209-2220. (IF: 12.9, JCR 4.9%)

Clinical outcomes of occupational exposure to n,n-dimethylformamide: perspectives from experimental toxicology.

Kim TH, Kim SG.  

- Safety and Health at Work (2011) 2(2):97-104. (IF: 3.5, JCR 20.8%) (Review)

Inhibition of liver X receptor-α-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition.

Kim YM*, Kim TH*, Kim YW, Yang YM, Ryu da H, Hwang SJ, Lee JR, Kim SC, Kim SG. 

- Free Radical Biology and Medicine (2010) 49(11):1722-1734. (IF: 7.1, JCR 8.1%) (*equal contribution)

Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary hepatocytes.

Kay HY, Won Yang J, Kim TH, Lee da Y, Kang B, Ryu JH, Jeon R, Kim SG. 

- Journal of Nutrition (2010) 140:1211-1219. (IF: 3.7, JCR 32.5%) 

Synergistic hepatotoxicity of N,N-dimethylformamide with carbon tetrachloride in association with endoplasmic reticulum stress.

Kim TH, Kim YW, Shin SM, Kim CW, Yu IJ, Kim SG.  

- Chemico-Biological Interactions (2010) 184(3):492-501. (IF: 4.7, JCR 15.1%) 

Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis.

Kim YW, Kim YM, Yang YM, Kim TH, Hwang SJ, Lee JR, Kim SC, Kim SG.   

- Free Radical Biology and Medicine (2010) 48(4):567-578. (IF: 7.1, JCR 8.1%)