Embedded Files
Research articles (2020~present)
The new Bruton’s tyrosine kinase inhibitors SPA8007 and SPA8009 reduce stemness and invasiveness of patient-derived glioblastoma tumorspheres
The new Bruton’s tyrosine kinase inhibitors SPA8007 and SPA8009 reduce stemness and invasiveness of patient-derived glioblastoma tumorspheres
Euna Jo, Eun Lee, Yoojung Oh, Dongkyu Lee, Byungho Lee, Kibyeong Kim, Ran Joo Choi, Jiyun Hong, Yuesong Jeon, Hyewon Cho, Yong-Sung Choi, Sangwoo Kim, So Young Won, Seonah Choi, Tae Hoon Roh, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Raok Jeon, Seok-Gu Kang
Transl. Oncol. 2026, 63, 102585
Design and Synthesis of Potent and Selective Urea-linked Benzenesulfonamide Analogs as Carbonic Anhydrase II Inhibitors
Design and Synthesis of Potent and Selective Urea-linked Benzenesulfonamide Analogs as Carbonic Anhydrase II Inhibitors
Jisoo Kim, Eun Lee, Daniela Vullo, Chandra Bhushan Mishra, Claudiu T. Supuran, Raok Jeon
Eur. J. Pharm. Sci. 2025, 213, 107233
Exploring structural and biological insights of TEAD through rational design and synthesis of niflumic acid derivatives
Exploring structural and biological insights of TEAD through rational design and synthesis of niflumic acid derivatives
Yong-Sung Choi, Yoon-Jung Kim, Yeram Jeon, Jong Soon Kang, Juhee Lee, Eunmi Hong,
Young-Hoon Park, Wantae Kim, Boksik Cha and Raok Jeon
J. Enzyme Inhib. Med. Chem. 2024, 39, 241995
Discovery of organosulfur-based selective HDAC8 inhibitors with anti-neuroblastoma activity
Discovery of organosulfur-based selective HDAC8 inhibitors with anti-neuroblastoma activity
Hyewon Cho, Eun Lee, Jisoo Kim, Soojeong Shin, Yoon-Jung Kim, Heejin Lee, Ji Hoon Yu, Yong Hyun Jeon, Sang Wu Lee, So Young Lee, Ki Whan Park, Jong Soon Kang, So Hee Kwon, Yonjung Kim, Raok Jeon
Eur. J. Pharm. Sci. 2024, 203,106921
Multitarget action of Benzothiazole-piperazine small hybrid molecule against Alzheimer’s disease: In silico, In vitro, and In vivo investigation
Multitarget action of Benzothiazole-piperazine small hybrid molecule against Alzheimer’s disease: In silico, In vitro, and In vivo investigation
Chandra Bhushan Mishra, Shruti Shalini, Siddharth Gusain, Pawan Kumar, Shikha Kumari, Yong-Sung Choi, Jyoti Kumari, Bala Krishna Moku, Anita Kumari Yadav, Amresh Prakash, Raok Jeon, Manisha Tiwari
Biomed. Pharmacother. 2024, 174, 116484
Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice
Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice
Yuancheng Mao, Eun Lee, Xiaohui Yang, Eun Ju Bae, Raok Jeon & Byung-Hyun Park
J. Enzyme Inhib. Med. Chem. 2022, 37, 2133–2146
Therapeutic Efficacy of Novel HDAC Inhibitors SPA3052 and SPA3074 against Intestinal Inflammation in a Murine Model of Colitis
Therapeutic Efficacy of Novel HDAC Inhibitors SPA3052 and SPA3074 against Intestinal Inflammation in a Murine Model of Colitis
Ji-In Yoon , Hyewon Cho, Raok Jeon and Mi-Kyung Sung
Pharmaceuticals 2022, 15, 1515
The potential anti-amyloidogenic candidate, SPA1413, forAlzheimer's disease
The potential anti-amyloidogenic candidate, SPA1413, forAlzheimer's disease
Seong Soo A. An, Kyu Hwan Shim, Shinwoo Kang, Young Kyo Kim, Lalita Subedi, Hyewon Cho, Seong-Min Hong, Mario A. Tan, Raok Jeon, Keun-A Chang, Sun Yeou Kim
Br J Pharmacol. 2022;179:1033–1048
Anti-breast cancer action of carbonic anhydrase IX inhibitor 4-[4-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-benzylidene-hydrazinocarbonyl]-benzenesulfonamide (BSM-0004): in vitro and in vivo studies
Anti-breast cancer action of carbonic anhydrase IX inhibitor 4-[4-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-benzylidene-hydrazinocarbonyl]-benzenesulfonamide (BSM-0004): in vitro and in vivo studies
Chandra Bhushan Mishra, Raj Kumar Mongre, Amresh Prakash, Raok Jeon, Claudiu T. Supuran & Myeong-Sok Lee
J. Enzyme Inhib. Med. Chem. 2021, 36:1, 954-963
Anti-inflammatory Effects of S. cumini Seed Extract on Gelatinase-B (MMP-9) Regulation against Hyperglycemic Cardiomyocyte Stress
Anti-inflammatory Effects of S. cumini Seed Extract on Gelatinase-B (MMP-9) Regulation against Hyperglycemic Cardiomyocyte Stress
Neha Atale,Chandra Bhushan Mishra, Shrey Kohli, Raj Kumar Mongre, Amresh Prakash, Sweta Kumari, Umesh C. S. Yadav, Raok Jeon, and Vibha Rani
Oxid. Med. Cell. Longev. 2021, 14 pages, 2021
Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach
Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach
Chandra Bhushan Mishra, Preeti Pandey, Ravi Datta Sharma, Md. Zubbair Malik, Raj Kumar Mongre, Andrew M. Lynn, Rajendra Prasad, Raok Jeon and Amresh Prakash
Brief. Bioinform. 2021, 03. 22. 22(2):1346-1360
Histone deacetylase 8 inhibition alleviates cholestatic liver injury and fibrosis
Histone deacetylase 8 inhibition alleviates cholestatic liver injury and fibrosis
Chang Hun Lee a, Yunjung Choi, Hyewon Cho, In Hyuk Bang, Lihua Hao, Seung-Ok Lee, Raok Jeon, Eun Ju Bae, Byung-Hyun Park
Biochem. Pharmacol. 2021, Volume 183, 114312
Structure–Activity Relationship of Phytoestrogen Analogs as ERα/β Agonists with Neuroprotective Activities
Structure–Activity Relationship of Phytoestrogen Analogs as ERα/β Agonists with Neuroprotective Activities
Hye Won Cho, Hyo Jin Gim, Hua Li, Lalita Subedi, Sun Yeou Kim, Jae-Ha Ryu, Raok Jeon
Chem. Pharm. Bull. 2021, 69, 99–105
Discovery of 5-Phenoxy-2-aminopyridine Derivatives as Potent and Selective Irreversible Inhibitors of Bruton’s Tyrosine Kinase
Discovery of 5-Phenoxy-2-aminopyridine Derivatives as Potent and Selective Irreversible Inhibitors of Bruton’s Tyrosine Kinase
Eun Lee, Hyewon Cho, Da Kyung Lee, JuHyun Ha, Byeong Jo Choi, Ji Hye Jeong, Jae-Ha Ryu, Jong Soon Kang and Raok Jeon
Int. J. Mol. Sci. 2020, 21, 8006
Discovery of Tricyclic Pyranochromenone as Novel Bruton’s Tyrosine Kinase Inhibitors with In Vivo Antirheumatic Activity
Discovery of Tricyclic Pyranochromenone as Novel Bruton’s Tyrosine Kinase Inhibitors with In Vivo Antirheumatic Activity
Hyewon Cho, Eun Lee, Hye Ah Kwon, Lee Seul, Hui-Jeon Jeon, Ji Hoon Yu, Jae-Ha Ryu and Raok Jeon
Int. J. Mol. Sci. 2020, 21, 7919
Patents (2020~present)
퀴놀린 계열 히스톤디아세틸화 효소 저해활성물질, 이의 제조방법 및 이를 유효성분으로 포함하는 약학적 조성물
출원번호: 10-2023-0060769 (2023. 05. 10)
신규 2-(페닐아미노)피리딘 계열의 TEAD 저해제 및 이를 포함하는 약학조성물
.출원번호: 10-2023-0026303 (2023. 02. 27.)
피라졸로[3,4-d]피리미딘 계열 p21-activated kinase 4 (PAK4) 저해제 및 이를 포함하는 약학 조성물
출원번호: 10-2022-0036547 (2022. 03. 24)
신규 이원환의 히스톤 탈아세틸화 효소 저해제 및 이를 포함하는 약학조성물
출원번호: 10-2023-0034328 (2023. 03. 16), PCT/KR2023/003560 (2023. 03. 17)
신규 헤테로고리 히스톤 탈아세틸화 효소 저해제 및 이를 포함하는 약학조성물
출원번호: 10-2023-0034303 (2023. 03. 16), PCT/KR2023/003562 (2023. 03. 17)
아미노피리딘 계열의 브루톤티로신인산화효소 저해활성을 갖는 약학적 조성물
등록번호: 10-2476027 (2022. 12. 06)
항암, 항염증 효능을 가진 삼원환의 약학적 조성물
등록번호: 10-2465988 (2022. 11. 07)
뇌암의 예방 또는 치료용 조성물
출원번호: 10-2021-0070823 (2021. 06. 01), PCT/KR2022/007807 (2022. 06. 02)
항섬유화 활성을 갖는 신규 헤테로고리 화합물
출원번호: 10-2022-0033174 (2022. 03. 17)
3-페닐-2H-크로멘 유도체 및 이를 함유하는 알츠하이머의 예방 또는 치료용 약학적 조성물
출원번호: 10-2021-0116327 (2021. 09. 01)
치환된 인돌 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 PPARα, PPARγ 및 PPARδ 관련 질환의 예방 또는 치료용 약학적 조성물
등록번호: 10-2242658 (2021. 04. 15)
교모세포종의 예방 또는 치료용 신규 약학적 조성물
등록번호: 10-2132960 (2020. 07. 06)
신경모세포종 또는 류마티스 관절염의 예방 또는 치료용 약학적 조성물
PCT/KR2019/000687 (2019. 01. 17)
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