This research aims to reduce the use of chemical fertilizers and peticides by utilizing household organic waste, namely onion skins. This processing also aims to fertilize and overcome plants that was attacked by mealybugs, caterpillars, grasshoppers, and other disturbing insects. The content of Acetogenin, Calcium, Potassium, and Phosphorus compounds in onion skins can cause disruption of the digestive organs of insect pests that attack plants. The processing of this biopesticide fertilizer is done by collecting kitchen waste and then soaking it in water for 2 nights. While the dregs of the soaking results can be used as solid fertilizer because it contains high nutrients. The results of this processing shows that lettuce using biopesticides has a bright color, the leaves look blooming, and do not wither quickly.