Khaliq Lab
Representative publications:
Axonal control of striatal dopamine release:
Kramer PF, Brill-Weil SG, Cummins AC, Zhang R, Camacho-Hernandez GA, Newman AH, Eldridge MAG, Averbeck BB, Khaliq ZM. Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers. Neuron. 2022 Sep 21;110(18):2949-2960. pdf
Liu C, Cai X, Ritzau-Jost A, Kramer PF, Li Y, Khaliq ZM, Hallermann S, Kaeser PS. An action potential initiation mechanism in distal axons for the control of dopamine release. Science. 2022 Mar 25; 375 (6587) : 1378-1385. pdf
Kramer PF, Twedell EL, Shin JH, Zhang R, Khaliq ZM. Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release. Elife. 2020 Sep 1;9:e55729. doi: 10.7554/eLife.55729. pdf
Diversity of dopaminergic neuron subpopulations:
Evans RC, Twedell EL, Zhu M, Ascencio J, Zhang R, Khaliq ZM. Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons. Cell Rep. 2020 Sep 15;3211):108156. pdf
Evans RC, Zhu M, Khaliq ZM (2017) Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels. Journal of Neuroscience, 37(13):3704-3720. pdf
Tarfa RA, Evans RC, Khaliq ZM (2017) Enhanced Sensitivity to Hyperpolarizing Inhibition in Mesoaccumbal Relative to Nigrostriatal Dopamine Neuron Subpopulations. Journal of Neuroscience, 37(12):3311-3330. pdf
Other Publications:
Carmichael K, Evans RC, Lopez E, Sun L, Kumar M, Ding J, Khaliq ZM, Cai H. Function and Regulation of ALDH1A1-Positive Nigrostriatal Dopaminergic Neurons in Motor Control and Parkinson's Disease. Front Neural Circuits. 2021 May 17;15:644776. doi: 10.3389/fncir.2021.644776. PMID: 34079441; PMCID: PMC8165242.
Wu J, Kung J, Dong J, Chang L, Xie C, Habib A, Hawes S, Yang N, Chen V, Liu Z, Evans R, Liang B, Sun L, Ding J, Yu J, Saez-Atienzar S, Tang B, Khaliq Z, Lin DT, Le W, Cai H. (2019) Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning. Cell Reports, 28 (5): 1167-1181.
Philippart F, Khaliq ZM (2018) G(i/o) protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN. eLife. pii: e40984. pdf
Aflaki E, Borger DK, Moaven N, Stubblefield BK, Rogers SA, Patnaik S, Schoenen FJ, Westbroek W, Zheng W, Sullivan P, Fujiwara H, Sidhu R, Khaliq ZM, Lopez GJ, Goldstein DS, Ory DS, Marugan J, Sidransky E (2016) A new glucocerebrosidase chaperone reduces alpha synuclein and glycolipid in iPSC-derived dopaminergic neurons from patients with Gaucher Disease and Parkinsonism. Journal of Neuroscience, 36(28)7441-52. pdf
Hage TA, Sun Y, Khaliq ZM (2016) Electrical and Ca (2+) signaling in dendritic spines of substantia nigra dopaminergic neurons. eLife. pii: e13905. pdf
Kimm T, Khaliq ZM, Bean BP (2015) Differential Regulation of Action Potential Shape and Burst-Frequency Firing by BK and Kv2 Channels in Substantia Nigra Dopaminergic Neurons. Journal of Neuroscience, 35(50):16404-17. pdf
Hage TA, Khaliq ZM (2015) Tonic firing rate controls dendritic Ca2+ signaling and synaptic gain in substantia nigra dopamine neurons. Journal of Neuroscience, 35(14):5823-36. pdf
Khaliq ZM, Bean BP (2010) Pacemaking in dopaminergic ventral tegmental area neurons: depolarizing drive from background and voltage-dependent sodium conductances. Journal of Neuroscience, 30(21):7401-13. pdf
Khaliq ZM, Bean BP (2008) Dynamic, nonlinear feedback regulation of slow pacemaking by Atype potassium current in ventral tegmental area neurons. Journal of Neuroscience, 28(43):10905-17. pdf