WORK EXPERIENCES

2023-  Professor, Kanagawa University

2017-2023  Associate Professor, Kanagawa University

2013-2017 Assistant Professor, The University of Tokyo

2012-2013 JSPS Research Fellow (PD) The University of Tokyo - McMaster University

2009-2012 JSPS Research Fellow (DC1) University of Tsukuba

EDUCATION

2012 PhD (Sports Science) University of Tsukuba, Graduate School of Comprehensive Human Sciences

2009 MSc (Sports Science) The University of Tokyo, Graduate School of Arts and Sciences

2007 BSc (Biology) Osaka University, School of Science

PUBLICATIONS

67. Shirai T, Shinkai H, Tanimura R, Uemichi K, Sugiyama S, Takeda K, Kitaoka Y, Takemasa T. Exercise modality-dependent mitochondrial respiratory capacity in satellite cells and conditioned serum-induced responses in cultured myotubes. Exp Physiol. In press.

66. Takahashi K, Shirai T, Mukai K, Ebisuda Y, Sugiyama F, Yoshida T, Kitaoka Y. Transcriptomic responses of equine skeletal muscle to acute exercise in a hot environment. Physiol Genomics. 57:450-455, 2025

65. Shirai T, Uemichi K, Takemasa T, Kitaoka Y. Unilateral electrical stimulation of mice induces transcriptional response in stimulated leg with limited effect on non-stimulated contralateral leg. Exp Physiol. In press.

64. Takahashi K, Mukai K, Takahashi Y, Ebisuda Y, Hatta H, Kitaoka Y. Comparison of long- and short- rest periods during high-intensity interval exercise on transcriptomic responses in equine skeletal muscle. Physiol Genomics. 57:28-39, 2025

63. Miyaji T, Kasuya R, Sawada A, Sawamura D, Kitaoka Y, Miyazaki M. Akt1 deficiency does not affect fiber type composition or mitochondrial protein expression in skeletal muscle of male mice. Physiol Rep. 12:e70048, 2024

62. Kubo S, Yaeshima K, Suzuki T, Daigo E, Kitaoka Y, Kinugasa R. Influence of foot strike pattern on co-contraction around the ankle and oxygen uptake during running at 19 km/h. Physiol Rep. 12:e70023, 2024

61. Takahashi K, Mukai K, Ebisuda Y, Sugiyama F, Yoshida T, Hatta H, Kitaoka Y. Effects of pacing strategy on metabolic responses to 2-min intense exercise in Thoroughbred horses. Sci Rep. 14:18352, 2024

60. Takei N, Inaba T, Morita Y, Kakinoki K, Hatta H, Kitaoka Y. Differential patterns of sweat and blood lactate concentration response during incremental exercise in varied ambient temperatures: A pilot study. Temperature, 11:247-253, 2024

59. Takahashi K, Kitaoka Y, Hatta H. Better maintenance of enzymatic capacity and higher levels of substrate transporter proteins in skeletal muscle of aging female mice. Appl Physiol Nutr Metab. 49:1100-1114, 2024

58. Takahashi K, Kitaoka Y, Hatta H. Effects of endurance training under calorie restriction on energy substrate metabolism in mouse skeletal muscle and liver. J Physiol Sci. 74:32, 2024

57. Takahashi K, Mukai K, Takahashi Y, Ebisuda Y, Hatta H, Kitaoka Y. Metabolomic responses to high-intensity interval exercise in equine skeletal muscle: effects of rest interval duration. J Exp Biol. 227:jeb246896, 2024

56. Takahashi K, Kitaoka Y, Hatta H. Sex-specific differences in the metabolic enzyme activity and transporter levels in mouse skeletal muscle during postnatal development. Appl Physiol Nutr Metab. 48:361-378, 2023

55. Takahashi K, Kitaoka Y, Matsunaga Y, Hatta H. Effects of Endurance Training on Metabolic Enzyme Activity and Transporter Proteins in Skeletal Muscle of Ovariectomized Mice. Med Sci Sports Exerc. 55:186-198, 2023 

54. Miyazaki M, Shimozuru M, Kitaoka Y, Takahashi K, Tsubota T. Regulation of protein and oxidative energy metabolism are down-regulated in the skeletal muscles of Asiatic black bears during hibernation. Sci Rep. 12:19723, 2022

53. Matsunaga Y, Tamura Y, Takahashi K, Kitaoka Y, Takahashi Y, Hoshino D, Kadoguchi T, Hatta H. Branched-chain amino acid supplementation suppresses the detraining-induced reduction of mitochondrial content in mouse skeletal muscle. FASEB J. 36:e22628, 2022

52. Kitaoka Y*, Takahashi K*, Hatta H. Inhibition of monocarboxylate transporters (MCT) 1 and 4 reduces exercise capacity in mice. Physiol Rep. 10:e15457, 2022 (*equal contribution)

51. Shirai T, Kitaoka Y, Uemichi K, Tokinoya K, Takeda K, Takemasa T. Effects of lactate administration on hypertrophy and mTOR signaling activation in mouse skeletal muscle. Physiol Rep. 10:e15436, 2022

50. Takahashi K, Kitaoka Y, Hatta H. Effects of endurance training on metabolic enzyme activity and transporter protein levels in the skeletal muscles of orchiectomized mice. J Physiol Sci. 72:14, 2022

49. Takahashi K, Tamura Y, Kitaoka Y, Matsunaga Y, Hatta H. Effects of Lactate Administration on Mitochondrial Respiratory Function in Mouse Skeletal Muscle. Front Physiol. 13:920034, 2022

48. Shirai T, Kitaoka Y, Fruuchi K, Takeda K, Uemichi K, Takemasa T. The effects of calorie restriction on functional overload-induced muscle hypertrophy in mice. Adv. Exerc. Sports Physiol. 1-6, 2022

47. Kitaoka Y, Mukai K, Tonai S, Ohmura H, Takahashi T. Effect of post-exercise muscle cooling on PGC-1α and VEGF mRNA expression in Thoroughbreds. Comp Exer Physiol. 18:21-25, 2022

46. Mukai K, Kitaoka Y, Takahashi Y, Takahashi T, Takahashi K, Ohmura H. Moderate-intensity training in hypoxia improves exercise performance and glycolytic capacity of skeletal muscle in horsess. Physiol Rep. 9:e15145, 2021

45. Kitaoka Y. The Role of Nrf2 in Skeletal Muscle on Exercise Capacity. Antioxidants 10:1712, 2021 (Review Article)  

44. Takahashi K, Kitaoka Y, Matsunaga Y, Hatta H. Lactate administration does not affect denervation-induced loss of mitochondrial content and muscle mass in mice. FEBS Open Bio. 11:2836-2844, 2021

43. Shirai T, Uemichi K, Hidaka Y, Kitaoka Y, Takemasa T. Effect of lactate administration on mouse skeletal muscle under calorie restriction. Current Research in Physiology. 4: 202-208, 2021

42. Kitaoka Y*, Miyazaki M*, Kikuchi S. Voluntary exercise prevents abnormal muscle mitochondrial morphology in cancer cachexia mice. Physiol Rep. 9:e15016, 2021 (*equal contribution)

41. Kitaoka Y, Asaka M, Takahashi Y, Hatta H, Yanagihara D. Effects of coffee intake on expression of monocarboxylate transporters in mouse cerebellar and cerebral cortex. Adv. Exerc. Sports Physiol. 26:49-53, 2021

40. Mukai K, Ohmura H, Takahashi Y, Kitaoka Y, Takahashi T. Four weeks of high-intensity training in moderate, but not mild hypoxia improves performance and running economy more than normoxic training in horses. Physiol Rep. 9:e14760, 2021

39. Takahashi K, Kitaoka Y, Matsunaga Y, Hatta H. Effect of post-exercise lactate administration on glycogen repletion and signaling activation in different types of mouse skeletal muscle. Current Research in Physiology, 3, 34-43, 2020

38. Wang W, Mukai K, Takahashi K, Ohmura H, Takahashi T, Hatta H, Kitaoka Y. Short‐term hypoxic training increases monocarboxylate transporter 4 and phosphofructokinase activity in Thoroughbreds. Physiol Rep. 8:e14473, 2020

37. Kitaoka Y, Mukai K, Takahashi K, Ohmura H, Hatta H. Effect of lactate administration on exercise-induced PGC-1α mRNA expression in Thoroughbreds. Comp Exer Physiol. 16: 253-258, 2020

36. Takahashi K, Kitaoka Y, Yamamoto K, Matsunaga Y, Hatta H. Oral Lactate Administration Additively Enhances Endurance Training-Induced Increase in Cytochrome C Oxidase Activity in Mouse Soleus Muscle. Nutrients, 12, 770, 2020

35. Kitaoka Y, Watanabe D, Nonaka Y, Yagishita K, Kano Y, Hoshino D. Effects of clenbuterol administration on mitochondrial morphology and its regulatory proteins in rat skeletal muscle. Physiol Rep. 7:e14266, 2019

34. Takahashi K, Kitaoka Y, Matsunaga Y, Hatta H. Effects of lactate administration on mitochondrial enzyme activity and monocarboxylate transporters in mouse skeletal muscle. Physiol Rep. 7:e14224, 2019

33. Kitaoka Y, Tamura Y, Takahashi K, Takeda K, Takemasa T, Hatta H. Effects of Nrf2 deficiency on mitochondrial oxidative stress in aged skeletal muscle. Physiol Rep. 7:e13998, 2019

32. Kitaoka Y, Fujimaki S, Machida M, Takemasa T. Effect of voluntary wheel running exercise on mitochondrial fusion and fission proteins in aged mouse skeletal muscle. Adv. Exerc. Sports Physiol. 24:39-43, 2018 

31. Takeda K, Kitaoka Y, Watanabe K, Miyakawa S, Lindley MR, Takemasa T. Effects of eicosapentaenoic acid intake on denervation-induced mitochondrial adaptation in mouse skeletal muscle. J Phys Fitness Sports Med. 7:261-267, 2018

30. Takeda K, Kitaoka Y, Takemasa T. High-intensity intermittent swimming training increases mitochondrial dynamics proteins in mouse skeletal muscle. Adv. Exerc. Sports Physiol. 24:13-16, 2018

29. Tamura Y, Matsunaga Y, Kitaoka Y, Hatta H. Effects of heat stress treatment on age-dependent unfolded protein response in different types of skeletal muscle. J Gerontol A Biol Sci Med Sci. 72:299-308, 2017

28. Kitaoka Y, Takeda K, Tamura Y, Fujimaki S, Takemasa T, Hatta H. Nrf2 deficiency does not affect denervation-induced alterations in mitochondrial fission and fusion proteins in skeletal muscle. Physiol Rep. 4:e13064, 2016 

27. Kitaoka Y, Nakazato K, Ogasawara R. Combined effects of resistance training and calorie restriction on mitochondrial fusion and fission proteins in rat skeletal muscle. J Appl Physiol. 121:806-810, 2016  

26. Hoshino D, Setogawa S, Kitaoka Y, Masuda H, Tamura Y, Hatta H, Yanagihara D. Exercise-induced expression of monocarboxylate transporter 2 in the cerebellum and its contribution to motor performance. Neurosci Lett. 633:1-6, 2016  

25. Takahashi Y, Tamura Y, Matsunaga Y, Kitaoka Y, Terada S, Hatta H. Effects of taurine administration on carbohydrate metabolism in skeletal muscle during the post-exercise Phase. J Nutr Sci Vitaminol. 62:257-264, 2016

24. Ogasawara R, Fujita S, Hornberger TA, Kitaoka Y, Makanae Y, Nakazato K, Ishii N. The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise. Sci Rep. 6:31142. 2016 

23. Hoshino D, Kitaoka Y, Hatta H. High-intensity interval training enhances oxidative capacity and substrate availability in skeletal muscle. J Phys Fitness Sports Med. 5:13-23, 2016 (Review Article)  

22. Kitaoka Y, Takeda K, Tamura Y, Hatta H. Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle. Appl Physiol Nutr Metab. 41:695-698, 2016 

21. Matsunaga Y, Tamura Y, Takahashi Y, Masuda H, Hoshino D, Kitaoka Y, Saito N, Nakamura H, Takeda Y, Hatta H. Pre-exercise casein peptide supplementation enhances endurance training-induced mitochondrial enzyme activity in slow twitch muscle, but not fast twitch muscle of high fat diet-fed mice. J Phys Fitness Sports Med. 5:377-384, 2015 

20. Kitaoka Y, Ogasawara R, Tamura Y, Fujita S, Hatta H. Effect of electrical stimulation-induced resistance exercise on mitochondrial fission and fusion proteins in rat skeletal muscle. Appl Physiol Nutr Metab. 40:1137-1142, 2015 

19. Abe T, Kitaoka Y, Kikuchi DM, Takeda K, Numata O, Takemasa T. High-intensity interval training-induced metabolic adaptation coupled with an increase in Hif-1α and glycolytic protein expression. J Appl Physiol. 119:1297-1302, 2015 

18. Nilsson MI, MacNeil LG, Kitaoka Y, Suri R, Young SP, Kaczor JJ, Nates NJ, Ansari MU, Wong T, Ahktar M, Brandt L, Hettinga BP, Tarnopolsky MA. Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease. Free Radic Biol Med. 87:98-112, 2015 

17. Tamura Y, Kitaoka Y, Matsunaga Y, Hoshino D, Hatta H. Daily heat stress treatment rescues denervation-activated mitochondrial clearance and atrophy in skeletal muscle. J Physiol. 593:2707-2720, 2015 

16. Saleem A, Safdar A, Kitaoka Y, Ma X, Marquez OS, Akhtar M, Nazli A, Suri R, Turnbull J, Tarnopolsky MA. Polymerase gamma mutator mice rely on increased glycolytic flux for energy production. Mitochondrion. 21:19-26, 2015 

15. Kitaoka Y, Endo Y, Mukai K, Aida H, Hiraga A, Hatta H. Muscle glycogen breakdown and lactate metabolism during intensive exercise in Thoroughbred horses. J Phys Fitness Sports Med. 3: 451-456, 2014 

14. Nilsson MI, Macneil LG, Kitaoka Y, Alqarni F, Suri R, Akhtar M, Haikalis ME, Dhaliwal P, Saeed M, Tarnopolsky MA. Redox state and mitochondrial respiratory chain function in skeletal muscle of LGMD2A patients. PLoS One. 9: e102549, 2014 

13. Kitaoka Y, Takahashi Y, Machida M, Takeda K, Takemasa T, Hatta H. Effect of AMPK activation on monocarboxylate transporter (MCT)1 and MCT4 in denervated muscle. J Physiol Sci. 64: 59-64, 2014 

12. Kitaoka Y. McArdle Disease and Exercise Physiology. Biology. 3: 157–166, 2014 (Review Article)  

11. Kitaoka Y, Ogborn DI, Nilsson MI, Mocellin NJ, MacNeil LG, Tarnopolsky MA. Oxidative stress and Nrf2 signalling in McArdle disease. Mol Genet Metab. 110: 297-302, 2013 

10. Hoshino D, Yoshida Y, Kitaoka Y, Hatta H, Bonen A. High-intensity interval training increases intrinsic rates of mitochondrial fatty acid oxidation in rat red and white skeletal muscle. Appl Physiol Nutr Metab. 38: 326–333, 2013 

9. Kitaoka Y, Endo Y, Mukai K, Aida H, Hiraga A, Takemasa T, Hatta H. Effect of acute exercise on monocarboxylate transporters 1 and 4 in untrained and trained Thoroughbreds. Am J Vet Res. 74: 642-647, 2013 

8. Kitaoka Y, Ogborn DI, Mocellin NJ, Schlattner U, Tarnopolsky MA. Monocarboxylate transporters and mitochondrial creatine kinase protein content in McArdle disease. Mol Genet Metab. 108:259-262, 2013 

7. Kitaoka Y, Mukai K, Aida H, Hiraga A, Masuda H, Takemasa T, Hatta H. Effects of high-intensity training on lipid metabolism in Thoroughbreds. Am J Vet Res. 73:1813-1818, 2012 

6. Kitaoka Y, Hoshino D, Hatta H. Monocarboxylate transporter and lactate metabolism. J Phys Fitness Sports Med. 1:247-252, 2012 (Review Article)  

5. Hoshino D, Kitaoka Y, Masuda H, Hatta H. Adaptation of monocarboxylate transporters in skeletal muscle. Adaptive Medicine, 4:1-8, 2012 (Review Article)  

4. Kitaoka Y, Machida M, Takemasa T, Hatta H. Expression of monocarboxylate transporter (MCT) 1 and MCT4 in overloaded mice plantaris muscle. J Physiol Sci. 61:467-472, 2011 

3. Kitaoka Y, Hoshino D, Mukai K, Hiraga A, Takemasa T, Hatta H. Effect of growth on monocarboxylate transporters and indicators of energy metabolism in the gluteus medius muscle of Thoroughbreds. Am J Vet Res. 72:1107-1111, 2011 

2. Kitaoka Y, Masuda H, Mukai K, Hiraga A, Takemasa T, Hatta H. Effect of training and detraining on monocarboxylate transporter (MCT)1 and MCT4 in Thoroughbred horses. Exp Physiol. 96:348-355, 2011 

1. Kitaoka Y, Wakasugi Y, Hoshino D, Mukai K, Hiraga A, Hatta H. Effects of high-intensity training on monocarboxylate transporters in Thoroughbred horses. Comp Exer Physiol. 6:171-175, 2010

INVITED PRESENTATIONS (International)

4. Kitaoka Y. Lactate transporters in skeletal muscle. European College of Sport Science, Prague, Czech Republic, 2019

3. Kitaoka Y. Oxidative stress, mitochondrial dynamics, and muscle atrophy. International Conference for Adaptations and Nutrition in Sports, Chonburi, Thailand, 2018

2. Kitaoka Y. Exercise-induced mitochondrial adaptations in skeletal muscle: beyond biogenesis. Khon Kaen University, Thailand, 2017

1. Kitaoka Y. Lactate: a signaling molecule for training adaptation. Ergogenic Aids and Nutritional Supplements for Health and Sports, Khon Kaen, Thailand, 2016

INVITED REVIEWER

Acta Physiologica, Advances in Exercise and Sports Physiology, Aging, Aging Cell, American Journal of Physiology, Annals of Clinical and Translational Neurology, Antioxidants, Archives of Physiology and Biochemistry, Biochemistry and Biophysics Reports, Biochemistry and Cell Biology, British Journal of Cancer, BMC Genomics, Canadian Journal of Physiology and Pharmacology, Cell Transplantation, Chinese Journal of Physiology, Clinical and Experimental Pharmacology and Physiology, Journal of Clinical Rheumatology, European Journal of Sports Science, Free Radical Research, Frontiers in Physiology, Geriatrics & Gerontology International, International Journal of Molecular Sciences, IUBMB Life, Medical Science Monitor, Medicine & Science in Sports & Exercise, Metabolites, Molecular and Cellular Endocrinology, Nutrients, Journal of Nutritional Biochemistry, Nutrition Research, Oxidative Medicine and Cellular Longevity, Pflügers Archiv - European Journal of Physiology, Journal of Physical Fitness and Sports Medicine, The Journal of Physiology, Physiological Reports, PLOS One, Scientific Reports, Sports Medicine, SpringerPlus

AWARDS

Elsevier Family Support Award, Cell Symposia, 2015

International Early Career Physiologist Travel Award, American Physiological Society, 2013

LINKS

Hatta Lab. (University of Tokyo)

http://park.itc.u-tokyo.ac.jp/hatta