Publications

[2025]

90. P. Yadav, T. A. Asa, M. Cebeci, M. Choi, Y. J. Seo*, "Primer Extension-Mediated Aptamer-Gated DNA-Encoded Library Screening for Physiologically Relevant Ligand Discovery", J. Med. Chem. 2025, 68, 16227−16236.

89. T.A. Asa, C. D. Singh, T. S. Singh,  S. Salahi, K. M. Alom , Y. J. Seo*,  "Nonenzymatically modified mRNA for regulating translation and apoptosis by modulating Cancer epigenetics", Bioorganic  Chemistry  157  (2025)  108328.

[2024]

88. K. M. Alom, T. A. Asa, Y. J. Seo*,  "Simple enzymatic incorporation of 2′OMeU nucleotide at the end of the Poly‑A Tail for Enhancement of the mRNA Stability and Protein Expression ",  ACS Chem. Biol. 2024, 19, 2206−2213.

87. T. A. Asa,  Y. J. Seo*,  " I-motif  sensor  for  the  fluorometric  detection  of Monkeypox", Analyst,  2024,  149,  4514.

86. T. A. Asa, P. Kumar, Y. J. Seo*, "Dual amplification–based ultrasensitive and highly selective colorimetric detection of miRNA" Talanta, 2024, 268, 125269.

[2023]

85. C. Dhurbachandra Singh 1, K. M. Alom 1, D. K. Kannan, T. Simander Singh, S. Samantaray, G. S. Ravi Kumara, Y. J. Seo*, "mRNA incorporation of C(5)-halogenated pyrimidine ribonucleotides and induced high expression of corresponding protein for the development of mRNA vaccine" Bioorganic Chemistry, 2023, 141, 106897.

84. K. M. Alom, Y. J. Seo*, "Triple Ligation-based Formation of G-quadruplex for Simultaneous Detection of Multiple miRNAs "Analyst, 2023, 148, 4283 - 4290. 

83. T. A. Asa, Y. J. Seo*, "Multiple gene detection using a selective fluorophore probe–RNA hybridization/graphene oxide quenching system", Analyst, 2023, 148, 3622-3631.

82. K. M. Alom, Y. J. Seo*, "Blocker‑dUThiophene poly tailing‑based method for assessing methyl transferase activity", Analytical and Bioanalytical Chemistry, 2023, 415, 4631-4638.

81. K. I.Oh, H. S. Jin, T. Balasubramaniyam, J. Y. Shin, S. R. Choi, Y. J.Seo, B. S. Kim,Y. J. Seo, S.  R.Kwon, N. K. Kim, J. H. Lee* Entropy-driven conformational transition of flexible Z-DNA to a novel non-B helix by double-methylated guanosine, Journal of Molecular Liquids,2023, 383,122071.

80. K. M. Alom,  and Y. J. Seo* " Rolling circle transcription/G-quadruplex/QnMorpholine probe for highly selective and sensitive detection of alkaline phosphatase activity" Analytical Biochemistry, 2023, 665, 115050.

79.T A. Asa,  P. Kumar, J. Lee, and Y. J. Seo* "Multiple ligation–Assisted recombinase polymerase amplification for highly sensitive and selective colorimetric detection of SARS-CoV-2", Talanta, 2023, 252, 123835- 123843.

[2022]

78. K. M. Alom, G. S. Ravi Kumara, and Y. J. Seo* "22AG G-Quadruplex RNA/QnMorpholine–Mediated Fluorimetric Detection of miR-21",  Analytical Biochemistry, 2022, 656, 114879.

77.G. S. Ravi Kumara, V. Babagond, and Y. J. Seo* "Cu2+–diethylaminosalicylaldehyde self-dimer for regulation of DNA amplification with changes in fluorescence" Sensors & Actuators: B. Chemical, 2022,369 , 132270-132280.

76. M. H. Choi, J. Lee, and Y. J. Seo* "Dual-Site Ligation-Assisted Loop-Mediated Isothermal Amplification (dLig-LAMP) for Colorimetric, and Point-of-Care Determination of Real SARS-CoV-2"  Microchimica Acta, 2022, 189, 176-186.

75. K. M. Alom, G. S. Ravi Kumara, and Y. J. Seo* "Unnatural nucleotide-based rkDNA probe combined with graphene oxide for detection of alkaline phosphatase activity"  Bioorg Med Chem Lett, 2022,64, 128694-128699.

74. M. H. Choi, G. S. Ravi Kumara, J. Lee, and Y. J. Seo*, "Point-of-care COVID-19 testing: colorimetric diagnosis using rapid and ultra-sensitive ramified rolling circle amplification", Analytical and Bioanalytical Chemistry, 2022, 414, 5907–5915 

73. G. S. Ravi Kumara, and Y. J. Seo* "Directly arylated oligonucleotides as fluorescent molecular rotors for probing DNA single-nucleotide

 polymorphisms" Bioorganic Medicinal Chemistry, 2022, 56, 116617-116621.

72. P. Kumar, G. S. Ravi Kumara, and Y. J. Seo*, "Copper complex of a thienyl-hydrazone rhodamine derivative is a highly selective colorimetric

 sensor for pyrophosphate", Tetrahedron Letters, 2022, 89, 153606.

71.T A. Asa, G. S. Ravi Kumara, and Y. J. Seo* "Highly Sensitive, Selective, and Rapid Detection of miRNA-21 using an RCA/G-Quadruplex/QnDESA Probing System " Analytical Method, 2022, 14, 97-100.

70. G. S. Ravi Kumara, A. Pandith,  and Y. J.  Seo* "A Fluorescent Molecular Rotor for the Selective Detection of the Hybrid-Conformation 22AG G-Quadruplex" Bioorganic Medicinal Chemistry Letter. 2022, 55, 128462-128465.

69. V. T. Nguyen, G. S. Ravi Kumara, K. R. Bhattarai, H–J. Chae, and Y. J. Seo* "Stepwise and site-selective enzymatic introduction of multiple functional groups to turn-on multiple fluorescence in long DNA strands" Sensors & Actuators: B. Chemical. 2022, 352, 131043- 131052.

[2021]

68. M. H. Choi, V. T. Nguyen,  G. S. Ravi Kumara, Y. J. Seo* "RNA polymerase–mediated stepwise RNA-primed RNA polymerization for site-specific multiple labeling into RNA: A FRET probe detects the structural change of an RNA G-quadruplex"  ACS Synthetic Biology, 2021, 10, 3139-3147

67. M. H. Choi, Y. J. Seo*  "Rapid and Highly Sensitive Hairpin Structure-Mediated Colorimetric Detection of miRNA" Analytica Chimica Acta, 2021, 1176, 338765.

66. G. S. Ravi Kumara, Y. J. Seo* "Polymerase-mediated synthesis of p-vinylaniline–coupled fluorescent DNA for the sensing of nucleolin protein–c-myc G-quadruplex interactions" Organic & Biomolecular Chemistry, 2021, 19, 5788-5793.

65. G. S. Ravi Kumara, A. Pandith, Y. J. Seo* "Direct and Selective Metal-Free N6-Arylation of Adenosine Residues for Simple Fluorescence" Chem. Commun, 2021, 57, 5450-5453.

64. M. H. Choi, J. Lee, Y. J. Seo*  "Combined recombinase polymerase amplification/rkDNA–graphene oxide probing system for detection of SARS-CoV-2", Analytica Chimica Acta, 2021, 1158, 338390.

63. A. Pandith, U. Nagarajachari, G. S. Ravi Kumara, S. Lee, C. J. Park, K. Sannathammegowda, and Y. J. Seo*  "Loop-Mediated Fluorescent Probe for Selective Discrimination of Parallel and Antiparallel G-Quadruplexes"  Bioorganic Medicinal Chemistry, 2021, 35, 116077.

[2020]

62. M. H. Choi, G. S. Ravi Kumara, Y. J. Seo* "rkDNA–graphene oxide as a simple probe for the rapid detection of miRNA21",Bioorg Med Chem Lett, 2020, 30, 127398.

61. G. S. Ravi Kumara, A. Pandith, Y. J. Seo* "Highly Fluorescent Morpholine Naphthalimide Deoxyuridine Nucleotide for the Detection of miRNA 24-3P through Rolling Circle Amplification", Analyst, 2020, 145, 4777

60. V. T. Nguyen, A. Pandith, Y. J. Seo* "Propargyl amine-selective dual fluorescence turn-on method for post-synthetic labeling of DNA", Chem. Commun, 2020, 56, 3199.

[2019]

59. A. Pandith, Y. J. Seo*  "Label-Free Sensing Platform for miRNA-146a Based on Chromo-Fluorogenic Pyrophosphate Recognition", Journal of Inorganic Biochemistry, 2020, 203,110867.

58. A. Pandith, G. S. Ravi Kumara,   Y. J. Seo* "Recent Developments in Novel Blue/Green/Red/NIR Small Fluorescent Probes for In Cellulo Tracking of RNA/DNA G-Quadruplexes" Journal of Photochemistry & Photobiology,C: Photochemistry Reviews, 2019, 40, 81.

57. A. Pandith, H.-Y.Kim, T. Shin,  Y. J. Seo*  "Unprecedented Green-Emissive Boranyl-Hydrazone Supramolecular Assemblies and Their In Vitro Diagnostic Applications " Journal of Photochemistry & Photobiology, B: Biology, 2019, 297, 111553.

56. V. T. Nguyen, B. H. Le, Y. J. Seo*  " T7 exo-mediated FRET-breaking combined with DSN-RNAse-TdT for the detection of microRNA with ultrahigh signal-amplification " , Analyst, 2019, 144, 3216 .

55. B. H. Le, V. T. Nguyen, Y. J. Seo* "Site-specific incorporation of multiple units of functional nucleotides into DNA using a step-wise approach with polymerase and its application to monitoring structural changes" , Chem. Commun, 2019, 55, 2158.

54. A. Pandith, K. R. Bhattarai, G. S. Ravi Kumara, H-J. Chae, and Y. J. Seo* "Novel Fluorescent C2-Symmetric Sequential On-Off-On Switch for Cu2+ and Pyrophosphate and Its Application in Monitoring of Endogenous Alkaline Phosphatase Activity", Sensors & Actuators: B. Chemical. 2019. 282, 730.

[2018]

53. B. H. Le, T. V. T. Nguyen, H. N. Joo, and  Y. J. Seo* " Large-Stokes-Shift-Based Folded DNA Probing Systems Targeting DNA and miRNA 21 with Signal Amplification", Bioorg Med Chem, 26, 4881.

52. B. H. Le , and Y. J. Seo* "Transcription of Unnatural Fluorescent Nucleotides and their Application with Graphene Oxide for the Simple and Direct Detection", Bull. Korean Chem. Soc., 39, 1054-1057. Highlited as a Front Cover.

51. A. Pandith, J. C Koo, and  Y. J. Seo* "Daphnetin: A novel blue-green photonic switch for disodium phosphates that allows monitoring of polymerase chain reactions", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 204,  620.

50. B. H. Le , and  Y. J. Seo* "Direct incorporation and extension of fluorescent nucleotide through the rolling circle DNA amplification for detection of miRNA 24-3P", Bioorg Med Chem Lett, 2018, 28, 2035.

49. B. H. Le , and  Y. J. Seo* "Highly sensitive microRNA 146a detection using Gold Nanoparticle-based CTG repeat Probing system and Isothermal Amplification" Analytica Chimica Acta, 2018, 999, 155.

[2017]

48. T. V. T. Nguyen,  B. H. Le , and  Y. J. Seo*  "Highly Fluorescence Quenching Graphene Oxide-Based Oligodeoxynucleotide Hairpin Systems for Probing CNG DNA Repeat Sequences" Tetrahedron Letters,2017, 58, 3301.

47. B. H. Le, H. N. Joo, D. W. Hwang, K. W. Kim, and Y. J. Seo* "AuNP- CTG based probing system targeting CAG repeat DNA and RNA sequences" Bioorg Med Chem Lett , 2017,27, 3772.

46. H. N. Joo, T. V. T. Nguyen, H. K. Chae and Y.J. Seo* " pH-Dependant Fluorescence Switching of an i-Motif Structure Incorporating an Isomeric Azobenzene/Pyrene Fluorophore" Bioorg Med Chem Lett 2017,27, 2415.

45. B. H. Le, J. C. Koo, H. N. Joo and Y. J. Seo*  " Diverse Size Approach to Incorporate and Extend Highly Fluorescent Unnatural Nucleotide into DNA"  Bioorg Med Chem, 2017, 25, 3591.

44. T. V. T. Nguyen and Y. J. Seo*  " Highly sensitive fluorescent sensor targeting CuCl2 based on thiophene attached anthracene compound (TA)"Tetrahedron Letters, 2017,58,941.

43. H. N. Joo, B. h. Le and Y. J. Seo*  "Azo-pyrene–based fluorescent sensor of reductive cleavage of isomeric azo functional group" Tetrahedron Letters, 2017, 58, 679.

[2015]

42.  H. N. Joo and Y. J. Seo* "Single Excitation Three Color Folded DNA Probe for SNP Typing" Bioorg Med Chem Lett, 2015, 25, 5286.

41.  H. N. Joo and Y. J. Seo* "Using Gold Aggregation to Probe the Inhibition and Destruction of the G-quadruplex structure by TT-Dimerization" Bioorg Med Chem Lett, 2015, 25, 2434.

40.  I. S. Kim and Y. J. Seo*  "Light Induced TT Dimerization and Its Effect on Human Telomere G-quadruplex Formation"Bull. Korean Chem. Soc. 2015, 36, 1729.

39. H. N. Joo and Y. J. Seo*  "Multiplex Fluorophore Molecular Beacon; Detection of Target sequence Using Large Stokes Shift and Multiple Emission Signal Properties",  Chem. Commun, 2015,  51, 2939.

38.   H. N. Joo and  Y. J. Seo* "A novel gold based molecular beacon for probing CNG DNA repeat sequences" Tetrahedron Letters, 2015, 56, 542

37. I. S. Shin, D. G. Lee, J. H. Lee , H-J Jeong, and Y. J. Seo* "Chacterization and Histone Deacetylase Inhibitory Activity of Three Novel Fluorescent Benzamide Derivatives" Bull. Korean Chem. Soc. 2015, 36, 1-8.

[2014]

* Our unnatural genetic alphabet(d5SICS -dNaM) related reserarch ( Floyd et.al. Nature 2014, 509, 385-388) was chosen as "People's Choice for Breakthrough of the Year!" from Science.  본 연구실의 리더가 Floyd 연구그룹에서 개발한 d5SICS -dNaM 인공유전자(JACS, 2011,133, 19878; JACS, 2009, 131, 5046; JACS, 2009, 131, 3246)가 후속 연구(Floyd 연구팀에서 진행)를 통해 박테리아에서 작용한다는것이 증명되었고(Floyd et.al. Nature, 2014, 509, 385-388), 이러한 연구 결과가  사이언스지가 선정한 올해의 10대 과학업적에 선정 되었으며, 그 중에서도 다수의 과학자들이 뽑은 올해의  가장 획기적인 연구결과로 선정됨(자세한 내용은 아래 웹사이트 참조).

http://breakthroughs.sciencemag.org/

http://news.sciencemag.org/scientific-community/2014/12/breakthrough-year-top-10-scientific-achievements-2014

http://news.sciencemag.org/biology/2014/05/designer-microbes-expand-lifes-genetic-alphabet

36. G.Ingale and Y.J.Seo*, "Synthesis of Azo Compounds With Different Sized Fluorophores and Characterization of Their Photophysical Properties Based on Trans to Cis Conformational Change", Tetrahedron Letters, 2014, 55, 5247-5250.

35.    D. G. Lee, I. S. Kim, J. W. Park,   Y. J. Seo*,  "Multiplexed fluorophore systems on DNA      (MFD) with New Diverse Fluorescence Properties and Ability to Sense Hybridization Dynamics",   Chem.Commun, 2014, 50, 7273.

34.   Y. J. Seo, L. Muench, Y. Kang, A. Reid, S. Caesar, J. Logan, F. Wagner, E. Holson, S. J. Haggarty,  N. D. Volkow, J. S. Fowler, J. M. Hooker, S. W. Kim, " Image-guided parallel synthesis of potent blood-brain barrier permeable histone deacetylase inhibitors", ACS Chem. Neurosci, 2014, 5, 588. 

C&E News highlighted as a 'Science Concentrate' our work recently published in ACS Chemical Neuroscience

33.   I. S. Kim and Y. J. Seo*, "Probe Development for Detection of TERRA 1 intramolecular G-quadruplex Formation Using  a Fluorescent Adenosine Derivative ", Bioorg Med Chem Lett, 2014,  24, 1589. 

32.   I. S. Kim and  Y. J. Seo*, "Synthesis and Characterization of Fluorescent Adenosine Derivative for Detection of Intermolecular RNA G-quadruplex", Tetrahedron Letters, 2014, 55, 1461. 

31.   K. T. Kim, R. N. Veedu, Y. J. Seo and B. H. Kim*, "Quencher-Free Molecular Beacons as Probes for Oligonucleotides Containing CAG Repeat Sequences", Chem. Commun, 2014, 50, 1561.

30. J. W. Park, B. H. Kim* and Y. J. Seo*  "Fluorescence modification of the AAAA (4A) loop: Toward a probe of the structural dynamics of the i-motif of the retinoblastoma gene' Chem. Commun., 2014, 50, 52. 

[2013]

29.    Y. J. Seo L. Muench, A. Reid, J. Chen, Y. Kang, J. M. Hooker, N.D. Volkow, J.S. Fowler, S.W. Kim "Radionuclide Labeling and Evaluation of Candidate Radioligands for PET Imaging of Histon Deacetylase in the Brain"  Bioorg Med Chem Lett. 2013,  23, 6700.

28. Y. J. Seo*, "Thiphen-derivatized Fluorescent Benzamides as Possible Probes for Histon Deacetylases" Bull. Korean Chem. Soc. 2013, 34, 2249.

27.   Y. J. Seo* and B. H. Kim*, “Ethynylpyrene induces pH-dependent, fluorescencedetectable, reversible DNA condensation and decondensation” RSC Advances, 2013, 3, 9150.

Papers Before Chonbuk National University

26.     Y. J. Seo, D. A. Malyshev,  T. Lavergne, P. Ordoukhanian and F. E. Romesberg, “Site Specific Labeling of DNA and RNA Using an Efficiently Replicated and Transcribed Class of Unnatural Base Pairs” J. Am. Chem. Soc. Article , 2011,133, 19878.

25.    J. Zimmermann, M.Thielges, Y. J. Seo, P. Dawson, F.E. Romesberg, “Cyano Groups as Probes of Protein Microenvironments and Dynamics” Angew. Chem. Int. Ed. 2011, 50, 8333.

24.     D. A. Malyshev, Y. J. Seo, P. Ordoukhanian, and F. E. Romesberg, “PCR With an ExpandedGenetic Alphabet,” J. Am. Chem. Soc. 2009, 131, 14620.

23.     Y. J. Seo and F. E. Romesberg, “Major Groove Derivatization of an Unnatural Base Pair,” ChemBioChem. 2009, 10, 2394.

22.     Y. J. Seo, M. Shigeo, and Floyd E. Romesberg, “Transcription of an Expanded Genetic Alphabet,” J. Am. Chem. Soc. 2009, 131, 5046.

21.     Y. J. Seo, G. T. Hwang, P. Ordoukhanian, and F. E. Romesberg, “Optimization of an Unnatural Base Pair,” J. Am. Chem. Soc. 2009, 131, 3246.

20.     Y. J. Seo, I. J. Lee and B. H. Kim, “Homoadenine Signaling System for Homosequence SNP Typing,” Mol. BioSystems. 2009, 5, 235.

19.     H. S. Jeong, Y. J. Seo, E. K. Bang, G. T. Hwang, J. H. Jung, S. K. Jang, and B. H. Kim, “Cholesterol-Linked Pyrene Excimer Molecular Beacon with Enhanced Cell Permeability,” Nucleic Acids Symposium Series 2008, 52, 351.

18.     Y. J. Seo, I. J. Lee, and B. H. Kim, “Detection of Structure Switching in G-Quadruplexes Using an End Stacking Probe,” Bioorg. Med. Chem. Lett. 2008, 18, 3910.

17.     Y. J. Seo, S. Bhuniya, J. W. Yi, and B. H. Kim, “A Co-Assembled Probing System Using the Homoadenine Self Duplex Signal,” Tetrahedron Lett. 2008, 49, 2701.

16.     N. Venkatesan, Y. J. Seo, and B. H. Kim, “Quencher free Molecular Beacons: A New Strategy in Fluorescence based Nucleic Acids Analysis,” Chem. Soc. Rev. 2008, 37, 648.

15.     Y. J. Seo, S. Bhuniya, S. Tapadar, J. W. Yi, and B. H. Kim, “Expanded Fluorescent Nucleoside Analog as Hybridization Probe,” Bull. Kor. Chem. Soc. 2007, 28, 1923.

14.     Y. J. Seo, I. J. Lee, J. W. Yi, and B. H. Kim, “Probing the Stable G-Quadruplex Transition Using Quencher-Free End-Stacking Ethynyl Pyrene-Adenosine,” Chem. Commun. 2007, 2817.

13.     Y. J. Seo, H. Rhee, T. Joo, and B. H. Kim, “Self-Duplex Formation of an APy-Substituted Oligodeoxyadenylate and Its Unique Fluorescence,” J. Am. Chem. Soc. 2007, 129, 5244.

12.     Y. J. Seo, S. Bhuniya, and B. H. Kim, “Reversible Sol–Gel Signaling System with epMB for the Study of Enzyme and pH-Triggered Oligonucleotide Release from a Biotin Hydrogel,” Chem. Commun.2007, 1804.

11.     J. H. Ryu, Y. J. Seo, G. T. Hwang, J. Y. Lee, and B. H. Kim, “Triad Base Pairs Containing a Fluorene Unit for Quencher-Free SNP Typing,” Tetrahedron 2007, 63, 3538.

10.     Y. J. Seo, H. S. Jeong, E. K. Bang, G. T. Hwang, J. H. Jung, S. K. Jang, and B. H. Kim, “Cholesterol-Linked Fluorescent Molecular Beacons With Enhanced Cell Permeability,” Bioconjugate Chem. 2006, 17, 1151.

9.     S. Bhuniya, Y. J. Seo, and B. H. Kim, “(S)-(+)-Ibuprofen-Based Hydrogelators: An Approach Toward Anti-Inflammatory Drug Delivery,” Tetrahedron Lett. 2006, 47, 7153.

8.     N. Venkatesan, Y. J. Seo, E. K. Bang, S. M. Park, Y. S. Lee, and B. H. Kim, “Chemical Modification of Nucleic Acids Toward Functional Nucleic Acid Systems,” Bull. Kor. Chem. Soc. 2006, 27, 613.

7.     Y. J. Seo, G. T. Hwang, and B. H. Kim, “Quencher Free Molecular Beacon Systems With Two Pyrene Units in the Stem Region,” Tetrahedron Lett. 2006, 47, 4037.

6.     Y. J. Seo and B. H. Kim, “Probing the B-to-Z-DNA Duplex Transition Using Terminally Stacking Ethynyl Pyrene-Modified Adenosine and Uridine Bases,” Chem. Commun. 2006, 150.

5.     Y. J. Seo, J. H. Ryu, and B. H. Kim, “Quencher Free, End Stacking Oligonucleotides for Probing Single-Base Mismatches in DNA,” Org. Lett. 2005, 7, 4931.

4.     Y. J. Seo, G. T. Hwang, and B. H. Kim, “Pyrene-Labeled Deoxyuridine and Deoxyadenosine: Fluorescent Discriminating Phenomena in Their Duplex and Hairpin Oligonucleotides,” Nucleic Acids Symposium Series 2005, 49, 135.

3.     G. T. Hwang, Y. J. Seo, and B. H. Kim, “Pyrene-Labeled Deoxyuridine and Deoxyadenosine: Fluorescent Discriminating Phenomena in Their Oligonucleotides,” Tetrahedron Lett. 2005, 46, 1475.

2.     G. T. Hwang, Y. J. Seo, and B. H. Kim, “A Highly Discriminating Quencher-Free Molecular Beacon for Probing DNA,” J. Am. Chem. Soc. 2004, 126, 6528.

1.     G. T. Hwang, Y. J. Seo, S. J. Kim, and B. H. Kim, “Fluorescent Oligonucleotide Incorporating 5-(1-Ethynylpyrenyl)-2´-deoxyuridine: Sequence-Specific Fluorescence Changes Upon Duplex Formation,” Tetrahedron Lett. 2004, 45, 3543.