Synthetic Biology & Medicinal Chemistry Lab

Education and training

(2010.7.-2012.7.) Research Associate, Brookhaven National Laboratory(미국 국가연구소)

(2007.2.-2010.7.) Post. Doc, The Scripps Research Institute(TSRI)(스크립스 연구소)

(2004.3.-2006.8.) Ph.D. Pohang University of Science and Technology(POSTECH) (포항공대)

(1986.3.-1995.2.) B.S. and M.S. Ajou University(아주대)

주요경력

2021.10- 전북대학교 화학과 정교수

2018.1-2018.12 한국분자세포생물학회 리보핵산 분과 재무간사

2018.1-2018.12 대한화학회 생명화학분과 홍보위원

2017.7 - 현재 전북대학교 화학과 학과장

2016.9 - 현재 전북대학교 화학과 부교수

2015.3 - 현재 한국핵산학회 이사

2014.1 - 2016.12 대한화학회 전북지부 간사장

2012.9 - 2016.9 전북대학교 화학과 조교수

Young Jun Seo, Ph.D.

Professor

Department of Chemistry

Chonbuk National University(CBNU)

Jeonju 561-756, Korea

Tel: +82-63-270-3417

E-mail: yseo@jbnu.ac.kr

Welcome to our laboratory, where chemists and biologist work together to understand how origin of life at the molecular level helps to shape the living world. These web pages describe some of our recent work and provide links to our published papers. Inspired by what origin of life in nature, we strive to put those same forces to work in the laboratory to develop compounds that have practical benefit.

Sincerely,

Young Jun. Seo

My research have focused on the synthesis and applications of functional nucleotides. This work led me to further concentrate on developing a new probing system that detects single nucleotide polymorphisms (SNPs), and DNA structural changes, including G-quadruplexes, i-motifs, and B-Z transitions. I also have developed the novel oligonucleotide delivery system using Cholesterol in a human hepatoma cell line to monitoring the RNA dynamics. At the Scripps Research Institute, my research focused on expanding the genetic alphabet and code, utilizing synthetic unnatural bases with an ultimate aim of implementing this principle in the central dogma of molecular biology. This is a challenging problem requiring a combination of synthetic chemistry, biochemistry, and molecular biology, and requires the identification of an unnatural base pair that is well replicated and transcribed into RNA by DNA and RNA polymerases, respectively. I also developed enzymatically site-selectively modified DNA/RNA that has the potential to revolutionize the ubiquitous biotechnological-, medical-, and materials-applications of oligonucleotides. I moved to Brookhaven National Laboratory to extend my researches in synthetic biology to study the human brain using Positron Emission Tomography under Dr. Joanna S. Fowler. My research focused on in vivo brain imaging of epigenetic processes targeting the HDAC enzyme.