Publications
- Books-
3. Walsh, C. T., Tang, Y. “Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery, 2nd edition.” Royal Society of Chemistry, 2022
2. Walsh, C. T., Tang, Y. "The Chemical Biology of Human Vitamins." Royal Society of Chemistry, 2018. Link
1. Walsh, C. T., Tang, Y. “Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery.” Royal Society of Chemistry, 2017. Link
- Peer-Reviewed Publications -
(*: corresponding authors; bold: undergraduate authors)
2024
245. Liu, coming soon
244. Chiang, C. Y., submitted
243. Zhang, Y., submitted
242. Sun, Z., submitted
241. Song, Y., Wang, W., Yang, J., Gao, D., Billingsley, J. M., Wang, S., Zhu, Y., Wang, J., Ju, J., Yan, Y.*, Tang, Y. "β-Terrecyclene synthase constructs the quadrane backbone in terrecyclic acid biosynthesis." 2024, Chem. Sci. accepted. Link
240. Abad, A. Seshadri, K., Ohashi, M.*, Delgadillo, D., de Moraes, L., Nagasawa, K., Liu, M., Johnson, S., Nelson, H., Tang, Y.* "Discovery and Characterization of Pyridoxal 5’-Phosphate-Dependent Cycloleucine Synthases." 2024, J. Am. Chem. Soc. accepted. Preprint
239. Johnson, C., Ohashi, M.*, Tang, Y.* “How Fungi Biosynthesize 3-Nitropropanoic Acid: the Simplest yet Lethal Mycotoxin.” 2024, Org. Lett. 26, 3158-3163. Link
238. Dror, M., Misa, J., Yee, D. A., Chu, A. M., Yu, R. K., Chan, B. B., Aoyama, L. S., Chaparala, A. P., O’Connor, S. E., Tang, Y.* “Engineered Biosynthesis of Plant Heteroyohimbine and Corynantheine Alkaloids in Saccharomyces cerevisiae.” 2024, J. Ind. Microb. Biotechnol. vol 51, kuad047. Link
237. Delgadilo, D. A., Burch, J. E., Kim, L. J., de Moraes, L. S., Niwa, K., Williams, J., Tang, M. J., Lavallo, V. G., Chhetri, B. K., Jones, C. G., Rodriguez, I. H., Signore, J. A., Marquez, L., Bhanushali, R., Woo, S., Kubanek, J.*, Quave, C.*, Tang, Y.*, Nelson, H. M.* "High-Throughput Identification of Crystalline Natural Products from Crude Extracts Enabled by Microarray Technology and MicroED." 2024, ACS Cent. Sci. 10, 176-183. Link
2023
236. Sato, M; Sakano, S; Nakahara, M; Tamura, Y; Hara, K; Hashimoto, H; Tang, Y.*; Watanabe, K.* "Uncommon Arrangement of Self-resistance Allows Biosynthesis of de novo Purine Biosynthesis Inhibitor that Acts as an Immunosuppressor." 2023, J. Am. Chem. Soc. 145, 26883–26889. Link
235. Yan, C. Han, W., Zhou, Q., Niwa, K. Tang, M. J., Burch, J. E., Zhang, Y., Delgadillo, D. A., Sun, Z., Wu, Z., Jacobsen, S. E., Nelson, H. M., Houk, K. N., Tang, Y.* "Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure." 2023, J. Am. Chem. Soc. 145, 25080–25085. Link
234. Liu, M., Ohashi, M.*, Zhou, Q., Sander, J. N., McCauley, E. P., Crews, P., Houk, K. N.*, Tang, Y.*, "Enzymatic Benzofuranoindoline Formation in the Biosynthesis of the Strained Bridgehead Bicyclic Dipeptide (+)-Azonazine A." 2023, Angew. Chem. Intl. Ed. accepted. Link
233. Sun, Z., Tang, Y.*, "No Job too Small for a Giant Enzyme" 2023, Nat. Chem. Biol. 19, 934-946. Link
232. Han, W., Wu, Z., Zhong, Z., Williams, J., Jacobsen, S. E., Sun, Z.* Tang, Y.*, "Assessing the Biosynthetic Inventory of the Biocontrol Fungus Trichoderma afroharzianum T22." 2023, J. Agric. Food Chem. 71, 11502–11519. Link
231. Niwa, K., Ohashi, M.*, Xie, K., Chiang, C. Y., Jamieson, C. S., Sato, M., Watanabe, K., Liu, F., Houk, K. N.*, Tang, Y.* "Biosynthesis of Polycyclic Natural Products from Conjugated Polyenes via Tandem Isomerization and Pericyclic Reactions." 2023, J. Am. Chem. Soc. 145, 13520–13525. Link
230. Jenner, M.,*#,, Hai, Y.,*# Nguyen, H. H., Passmore, M., Skyrud, W., Kim, J., Garg, N. K., Zhang, W., Loo, R. R., Tang, Y. "Elucidating the molecular programming of a nonlinear nonribosomal peptide synthetase responsible for fungal siderophore biosynthesis." 2023. Nature Communications Link.
229. Zhang, Y-L., Go, E. B., Perlatti, B., Wu, L., Bills, G. F., Ohashi, M.*, Tang, Y.*, "Biosynthesis of AS2077715 and Funiculosin: Pathway Reconstitution and Identification of Enzymes that Form the All-cis Cyclopentanetetraol Moiety." J. Am. Chem. Soc. 2023, 145, 6643-6647. Link
228. Ohashi, M., Tan, D., Lu, J., Jamieson, C. S., Kanayama, D., Zhou, J.*, Houk, K. N.*, Tang, Y.*, "Enzymatic cis-Decalin Formation in Natural Product Biosynthesis." J. Am. Chem. Soc.. 2023, 145, 3301–3305. Link
227. Yee, D. A. Niwa, K., Perlatti, B., Chen, M., Li, Y., Tang, Y.* "Genome Mining of Unknown Unknown Natural Products." Nat. Chem. Biol. 2023, 19, 633-640. Link
226. Chiang, C. Y., Ohashi, M.*, Tang, Y.*, "Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining." Nat. Prod. Rep. 2023, 40, 89-127. Link
2022
225. Tararina, M. A., Yee, D. A., Tang, Y., Christianson, D. W.* "Structure of the Repurposed Fungal Terpene Cyclase FlvF Implicated in the C–N Bond-Forming Reaction of Flavunoidine Biosynthesis." Biochemistry, 2022, 61, 2014–2024. Link
224. Tang, M-C., Shen, C., Deng, Z., Ohashi, M., Tang, Y.*, “Combinatorial Biosynthesis of Terpenoids through Mixing-and-Matching Sesquiterpene Cyclase and Cytochrome P450 Pairs." Org. Lett. 2022, 24, 4783-4787. Link
223 Yee, D. A., Tang, Y.*,. "Investigating Fungal Biosynthetic Pathways Using Heterologous Gene Expression: Aspergillus nidulans as a Heterologous Host." Methods in Molecular Biology, 2022, 2489, 41-52. Link
222. Jamieson, C. S., Ohashi, M., Houk, K. N.*, Tang, Y.*,. "Computational prediction and experimental validation of a bridged cation intermediate in akanthomycin biosynthesis." J. Am. Chem. Soc. 2022, 144, 5280–5283. Link
221. Misa, J., Billingsley, J. M., Niwa, K., Yu, R., Tang, Y.*,. "Engineered Production of Strictosidine and Analogs in Yeast." ACS Syn. Biol. 2022, 11, 1639–1649. Link
220. Sun, Z., Jamieson, C. S., Ohashi, M., Houk, K. N.*, Tang, Y.*,. "Discovery and Characterization of a Terpene Biosynthetic Pathway featuring a Norbornene-forming Diels-Alderase." Nat. Communications. 2022, 13, 1-12. Link Preprint here on ChemRxiv.
219. Cheng, W., Chen, M., Ohashi, M.*, Tang, Y.*, “Biosynthesis of Terpenoid-Pyrrolobenzoxazine Hybrid Natural Product CJ-12662." Angew. Chem. Intl. Ed. 2022, e202116928 Link
2021
218. Go, E.B., Kim, L-J., Nelson, H. M.*, Ohashi, M.*, Tang, Y.*, “Biosynthesis of the Fusarium Mycotoxin (−)-Sambutoxin." Org. Lett. 2021, 23, 7819-7823. Link
217. Okorafor, I.# Chen, M.# Tang, Y.* , "High-Titer Production of Olivetolic Acid and Analogs in Engineered Fungal Host Using a Nonplant Biosynthetic Pathway." 2021, ACS Syn. Biol, 10, 2159-2166. Link
216. Kim, L. J.#, Ohashi, M.#, Zhang, Z.#, Tan, D., Asay, M., Cascio, D., Rodriguez, J., Tang, Y.* , Nelson, H.* "Prospecting for natural products by genome mining and microcrystal electron diffraction." Nat. Chem. Biol. 2021, 17, 872–877. Link UCLA Chemistry Coverage C&ENews
215. Bat-Erdene, U.#, Billingsley, J. B.# Turner, W. C., Lichman, B. R., Ippoliti, F. M., Garg, N. K., O'Connor, S. E., Tang, Y.* "Cell-Free Total Biosynthesis of Plant Terpene Natural Products Using an Orthogonal Cofactor Regeneration System." ACS Catal. 2021, 11, 9898–9903. Link
214. Xie, L., Zang, X., Cheng, W., Zhang, Z., Zhou, J.*, Chen, M.*, Tang, Y.* "Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase ." J. Am. Chem. Soc. 2021, 143, 9575–9584. Link
213. Liu, M., Ohashi, M.*, Sung, Y-S, Scherlach, K., Watanabe, K., Hertweck, C.* Tang, Y.* "AoiQ Catalyzes Geminal Dichlorination of 1,3-Diketone Natural Products." J. Am. Chem. Soc. 2021, 143, 7267–7271. Link
212. Jamieson, C.S.#, Misa, J.#, Tang, Y.* , Billingsley, J. M.* "Biosynthesis and synthetic biology of psychoactive natural products." Chem. Soc. Rev. 2021, 50, 6950-7008. Link
211. Anthony, S. M., Tona, V., Zou, Y., Morrill, L. A., Billingsley, J. M., Lim, M., Tang, Y.* , Houk, K. N.*, Garg, N. K.* "Total Synthesis of (−)-Strictosidine and Interception of Aryne Natural Product Derivatives “Strictosidyne” and “Strictosamidyne"", J. Am. Chem. Soc. 2021, 143, 7471–7479. Link
210. Liu, N., Abramyan, E. D., Chang, W., Perlatti, B., Harvey, C. J. B., Bills, G. F., Tang, Y.* "Targeted Genome Mining Reveals the Biosynthetic Gene Clusters of Natural Product CYP51 Inhibitors ." J. Am. Chem. Soc. 2021, 143, 6043–6047. Link
209. Ohashi, M.#, Kakule, T.#, Tang, M-C., Jamieson, C. S., Liu, M., Zhao, Y-L. Houk, K. N.*, Tang, Y.* , "Biosynthesis of para-Cyclophane-Containing Hirsutellone Family of Fungal Natural Products." J. Am. Chem. Soc. 2021, 143, 5605–5609. PMCID: PMC8094548. Link
208. Sato, M., Kishimoto, S., Yokoyama, M., Jamieson, C. S., Narita, K., Maeda, N., Hara, K., Hashimoto, H., Tsunemastsu, Y., Houk, K. N., Tang, Y., Wananabe, K.* "Catalytic mechanism and endo-to-exo selectivity reversion of an octalin-forming natural Diels–Alderase." Nature Catalysis, 2021, 4, 223–232. Link
207. Wang, J., Liang, J., Chen, L., Zhang, W., Kong, L., Peng, C., Su, C., Tang, Y., Deng, Z., Wang, Z.* "Structural basis for the biosynthesis of lovastatin." Nat. Commun. 2021, Article number: 867 (2021). Link
206. Zhu, Y.; Wang, J.; Mou, P.; Yan, Y.; Chen, M., Tang, Y.* "Genome mining of cryptic tetronate natural products from a PKS-NRPS encoding gene cluster in Trichoderma harzianum t-22. " Org. Biomol. Chem. 2021, 19, 1985-1990. Link
205. Zhang, Z.; Tamura, Y.; Tang, M., Qiao, T., Sato, M., Otsu, Y., Sasamura, S., Taniguchi, M., Watanabe, K.*, Tang, Y.* "Biosynthesis of the Immunosuppressant (−)-FR901483. " J. Am. Chem. Soc. 2021, 143, 132–136. PMCID: PMC8094545. Link
204. Gao, D.#, Jamieson, C. S.#, Wang, Q.#, Yan, Y., Zhou, J.*, Houk, K. N,*, Tang, Y.* "A Polyketide Cyclase That Forms Medium-Ring Lactones. " J. Am. Chem. Soc. 2021, 2021, 143, 80–84. PMCID: PMC8094545. Link
2020
203. Hai, Y., Chen, M., Huang, A. Tang, Y.* , "Biosynthesis of Mycotoxin Fusaric Acid and Application of a PLP-Dependent Enzyme for Chemoenzymatic Synthesis of Substituted L-Pipecolic Acids." J. Am. Chem. Soc. 2020, 142, 19668–19677. PMCID: PMC8093010. Link ChemRxiv. Link
202. Hai, Y. Jenner, M.*, Tang, Y.* "Fungal siderophore biosynthesis catalysed by an iterative nonribosomal peptide synthetase ." Chem. Sci. 2020, 11, 11525-11530. Link
201. Yan, Y., Zang, X., Jamieson, C. S., Lin, H-C., Houk, K. N., Zhou, J.*, Tang, Y.* "Biosynthesis of the fungal glyceraldehyde-3-phosphate dehydrogenase inhibitor heptelidic acid and mechanism of self-resistance." Chem. Sci. 2020, 11, 9554-9562 . Link
200. Ohashi, M.#, Jamieson, C. S.#, Cai, Y.#, Tan, D., Kanayama, D., Tang, M., Anthony, S. M., Chair, J. V., Barber, J. S., Picazo, E., Kakule, T. B., Cao, S., Garg, N. K., Zhou, J.*, Houk, K. N.*, Tang, Y.* "An Enzymatic Alder-ene Reaction." Nature. 2020, 586, 64-69. PMCID: PMC7534572. Link
199. Zhang, Z., Qiao, T., Watanabe, K.*, Tang, Y.* "Concise biosynthesis of phenylfuropyridones from fungi." Angew. Chem. Intl. Ed. 2020, 59, 19889-19893. Link
198. Liu, M., Ohashi, M.*, Tang, Y.* "Engineered Biosynthesis of Fungal 4-Quinolone Natural Products." Org. Lett. 2020, 22, 6637–6641. Link
197. Chen, M., Liu, C., Tang, Y.* "Discovery and Biocatalytic Application of a PLP-Dependent Amino Acid γ-Substitution Enzyme That Catalyzes C–C Bond Formation." J. Am. Chem. Soc. 2020, 142, 10506-10515. PMCID: PMC7335459 Link
196. Undramaa Bat-Erdene, Kanayama, D., Tan, D., Turner, W., Houk, K. N., Ohashi, M.*, Tang, Y.*, “Iterative Catalysis in the Biosynthesis of Mitochondrial Complex II Inhibitors Harzianopyridone and Atpenin B” J. Am. Chem. Soc. 2020, 142, 8550-8554. PMCID: PMC7335460. Link
195. Chen, K. L., Lai, C. Y., Pham, M. T. , Chein. R. J. , Tang, Y., Lin, H-C.* "Enzyme-Catalyzed Azepinoindole Formation in Clavine Alkaloid Biosynthesis." Org. Lett. 2020, 22, 3302-3306. PMCID: PMC8092377. Link
194. Hai, Y., Huang, A., Tang, Y.* "Biosynthesis of Amino Acid-Derived alpha-Pyrones by an NRPS-NRPKS Hybrid Megasynthetase in Fungi." J. Nat. Prod. 2020, 83, 593-600. PMCID: PMC7166049 (invited article for a special issue dedicated to Prof. Jon Clardy) Link
193. Yee, D. A.; Kakule, T.; Cheng, W.; Chen, M.; Chong, C.; Hai, Y.; Hang, L.; Hung, Y.; Liu, N.; Ohashi, M.; Okorafor, I.; Song, Y.; Tang, M-C.; Zhang, Z.; Tang, Y.* "Genome Mining of Alkaloidal Terpenoids from a Hybrid Terpene and Nonribosomal Peptide Biosynthetic Pathway." J. Am. Chem. Soc. 2020, 142, 710-714. PMCID: PMC7000236 Link
192. Yan, Y., Liu, N., Tang, Y.* "Recent developments in self-resistance gene directed natural product discovery." Nat. Prod. Rep, 2020, 37, 879-892. PMCID: PMC7340575. Link
191. Hung, Y-S., Zhao, Z-Y., Soohoo, A., Tang, Y.* "Genome Mining of Fungi" Comprehensive Natural Products III: Chemistry and Biology, 2020, Volume 6, 34-49. Link
190. Go, E., Tang, Y.* "Fungal Highly Reducing Polyketide Synthases and Associated Natural Products" Comprehensive Natural Products III: Chemistry and Biology, 2020, Volume 1, 333-364 . Link
2019
189. Liu, L., Tang, M-C., Tang, Y.* “Fungal Highly Reducing Polyketide Synthases Biosynthesize Salicylaldehydes that are Precursors to Epoxycyclohexenol Natural Products.” J. Am. Chem. Soc. 2019, 141, 19538-19541. PMCID: PMC6924165 Link
188. Hai, Y., Jenner, M., Tang, Y.* “Complete Stereoinversion of L-tryptophan by a Fungal Single Module Nonribosomal Peptide Synthetase.” J. Am. Chem. Soc. 2019, 141, 8198-8206. PMCID: PMC6927398 Link
187. Kishimoto, S., Tsunematsu, Y., Matsushita, T., Hara, K., Hashimoto, H., Tang, Y., Watanabe, K.* "Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide Biosynthesis." Biochemistry, 2019, 58, 3933-3937. Link
186. Cai, Y., Hai, Y., Ohashi, M., Jamieson, C. S., Garcia-Borras, M., Houk, K. N.*, Zhou, J.*, Tang, Y.* "Structural Basis for Stereoselective Dehydration and Hydrogen-Bonding Catalysis by the SAM-Dependent Pericyclase LepI." Nature Chemistry, 2019, 11, 812–820. PMCID: PMC6708486 Link BioRxiv, DOI: https://doi.org/10.1101/491761. Link
185. Yee, D. A., DeNicola, A. B., Billingsley, J. M., Creso, J. G., Subrahmanyam, V., Tang, Y.* " Engineered Mitochondrial Production of Monoterpenes in Saccharomyces cerevisiae." Metab. Eng. 2019, 55, 76-84. PMCID: PMC6717016 Link
184. Billingsley, J. M., Anguiano, J. L., Tang, Y.* "Production of semi-biosynthetic nepetalactone in yeast." J. Ind. Microb. Biotechnol. 2019, 46, 1365-1370. PMCID: PMC6927397 Link
183. Tang, M-C., Fischer, C. R., Chair, J. V., Tan, D., Suresh, S., Chu, A., Miranda, M., Smith, J., Zhang, Z., Garg, N. K., St. Onge, R. P.*, Tang, Y.* “Thioesterase-catalyzed aminoacylation and thiolation of polyketides in fungi.” J. Am. Chem. Soc. 2019, 141, 8198-8206. PMCID: PMC6589186 Link
182. Hai, Y., Huang, A., Tang, Y.* "Structure-guided function discovery of an NRPS-like glycine betaine reductase for choline biosynthesis in fungi." Proc. Natl. Acad. Sci. U.S. A. 2019, 116, 10348-10353. PMCID: PMC6535007 Link BioRxiv, 2019, DOI: https://doi.org/10.1101/559534 . Link
181. Zhang, Z., Jamieson, C. S., Zhao, Y-L., Li, D., Ohashi, M.*, Houk, K. N.*, Tang, Y.*, “Enzyme-catalyzed inverse-electron demand Diels-Alder reaction in the biosynthesis of antifungal ilicicolin H.” J. Am. Chem. Soc. 2019, 141, 5659–5663. PMCID: PMC6585442 Link
180. Zhao, Z-Y., Yin, Y., Hung, Y., Tang, Y.* "Genome Mining Reveals Neurospora crassa can Produce the Salicylaldehyde Sordarial." J. Nat. Prod., 2019, 8, 1029-1033. PMCID: PMC6933945 Link
179. Chen, M., Liu, Q., Gao, S-S., Young, A. E., Jacobsen, S. E., Tang, Y.*, "Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant."Proc. Natl. Acad. Sci. U. S. A. 2019, 116, 5499-5504 . PMCID: PMC6431147 Link
178. Tan, D., Jamieson, C. S., Ohashi, M., Tang, M-C.*, Houk, K. N.*, Tang, Y.*, “Genome-mined Diels-Alderase catalyzes formation of the cis-octahydrodecalins of varicidin A and B.” J. Am. Chem. Soc. 2019, 141, 769-773. PMCID: PMC6475471 Link
177. DeNicola, A. B., Tang, Y. "Therapeutic approaches to treat human spliceosomal diseases." Curr. Opin. Biotechnol. 2019, 60, 72-81. Link
176. Bond, C. M., Tang, Y.* "Engineering Saccharomyces cerevisiae for production of simvastatin " Metabolic Engineering, . 2019, 51, 1-8. PMCID: PMC6348118 Link
175. Jamieson, C. S., Ohashi, M., Liu, F., Tang, Y.*, Houk, K. N.* “The Expanding World of Biosynthetic Pericyclases: Cooperation of Experiment and Theory for Discovery.” Nat. Prod. Rep. 2019, 36, 698-713. PMCID: PMC6461539 Link
2018
174. Yan, Y., Liu, Q., Jacobsen, S. E.*, Tang, Y.*, " The Impact and Prospect of Natural Product Discovery in Agriculture." EMBO Reports, 2018, DOI 10.15252/embr.201846824. (Invited opinion on Science and Society). PMCID: PMC6216283 Link
173. Kishimoto, S., Hara, K. Hashimoto, H., Hirayama, Y., Champagne, P. A., Houk, K. N., Tang, Y., Watanabe, K.* "Enzymatic one-step ring contraction for quinolone biosynthesis." Nature Communications, 2018, Article number: 2826 . Link
172. Yan, Y,# Liu, Q.#, Zang, X.#, Yuan, S., Bat-Erdene, U., Nguyen, C. Gan, J., Zhou, J.*, Jacobsen, S. E.*, Tang, Y.*, " Resistance-Gene Directed Discovery of a Natural Product Herbicide with a New Mode of Action." Nature, 2018, 559, 415-418. PMCID: PMC6097235 Link
171. Ippoliti, F. M. Barber, J. S., Tang, Y. Garg, N. K*, “Synthesis of 8-Hydroxygeraniol.” J. Org. Chem., 2018, 83, 11323–11326. Link
170. Tang, M-C.#, Zou, Y.#, Yee, D. A., Tang, Y.*, "Identification of the Pyranonigrin A Biosynthetic Gene Cluster by Genome Mining in Penicillium thymicola IBT5891." AICHE J., 2018, 64, 4182-4186. (Invited article for special issue Honoring Jay Bailey) PMCID: PMC6777573 Link
169. Gao, S-S., Zhang, T., Garcia-Borras, M., Hung, Y-S., Billingsley, J. M., Houk, K. N.*, Hu, Y.*, Tang, Y.* “Biosynthesis of Heptacyclic Duclauxins Requires Extensive Redox Modifications of the Phenalenone Aromatic Polyketide” J. Am. Chem. Soc. 2018, 140, 6991–6997. MCID: PMC6309916 Link
168. Li, L.#, Tang, M-C.#, Tang, S., Gao, S., Soliman, S., Hang, L., Xu, W., Ye, T., Watanabe, K., Tang, Y.*, "Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids." J. Am. Chem. Soc. 2018, 140, 2067-2071. PMCID: PMC5817883 Link
167. Harvey, C.#, Tang, M-C.#, (Stanford/UCLA U01 Team), Tang, Y., Hillenmeyer, M. E.* “HEx: a heterologous expression platform for the discovery of fungal natural products.” bioRxiv, 2018, https://doi.org/10.1101/247940. Link Science Advances, 2018, DOI: 10.1126/sciadv.aar5459. Link
166. Hai, Y., Tang, Y.*, “Biosynthesis of long-chain N-acyl amide by a truncated PKS-NRPS hybrid megasynthase in fungi.” J. Am. Chem. Soc. 2018, 140, 1271–1274. PMCID: PMC5817892 Link
165. Bai, J., Mu, R., Dou, M., Yan, D., Liu, B., Wei, Q., Wan, J., Tang, Y., Hu, Y.* “Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids.” Acta Pharmaceutica Sinica B, 2018, 8(4):687-697 . Link
164. Walsh, C. T.*, Tang, Y.* "Recent Advances in Enzymatic Complexity Generation: Cyclization Reactions." Biochemistry 2018, 57, 3087–3104. PMCID: PMC5988943 Link
163. Walsh, C. T.*, Tu, B. P.*, Tang, Y.*, "Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism." Chem. Rev. 2018, 118, 1460-1494. PMCID: PMC5831524 Link
2017
162. Billingsley, J. M., DeNicola, A. B., Barber, J. S., Tang, M-C., Horecka, J., Chu, A., Garg, N. K., Tang, Y.*, “Engineering the Biocatalytic Selectivity of Iridoid Production in Saccharomyces cerevisiae.” Metab. Eng. 2017, 44, 117-125. PMCID: PMC5705256. Link
161. Tang, M-C., Cui, X., He, X., Ding, Z., Zhu, T., Tang, Y.*, Li, D.* “Late-Stage Terpene Cyclization by an Integral Membrane Cyclase in the Biosynthesis of Isoprenoid Epoxycyclohexenone Natural Products.” Org. Lett. 2017, 19, 5376–5379. PMCID: PMC5682560 Link
160. Ohashi, M., Liu, F., Hai, Y., Chen, M., Tang, M-C., Yang, Z., Sato, M., Watanabe, K.*, Houk, K. N.*, Tang, Y.*, “SAM-Dependent Enzyme-Catalysed Pericyclic Reactions in Natural Product Biosynthesis.” Nature. 2017, 549, 502–506. PMCID: PMC5679075 Link.
159. Zhang, Y., Zou, Y., Brock, N. L., Huang, T., Lan, Y., Wang, X., Deng, Z., Tang, Y., Lin, S.* "Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily." J. Am. Chem. Soc. 2017,139, 11887–11894 Link
158. Hang, L., Tang, M-C., Harvey, C. J. B., Page, C. G., Li, J., Hung, Y., Liu, N., Hillenmeyer, M. E., Tang, Y.*, "Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain." Angew. Chem. Intl. Ed. 2017, 56, 9556-9560. PMCID: PMC5580239 Link
157. Liu, N., Hung, Y., Gao, S-S., Hang, L., Zou, Y., Chooi, Y-H.*, Tang, Y.*, "Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway." Org. Lett. 2017, 19, 3560–3563. PMCID: PMC5673471 Link
156. Sato, M., Dander, J. E., Sato, C., Hung, Y., Gao, S-S, Tang, M-C, Hang, L., Winter, J. M., Garg, N. K.*, Watanabe, K.*, Tang, Y.*, “Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases.” J. Am. Chem. Soc. 2017, 139, 5317–5320. PMCID: PMC5673468 Link
155. Bai, J., Yan, D., Zhang, T., Guo, Y,, Liu, Y., Zou, Y., Tang, M-C., Liu, B., Wu, Q., Yu, S.* Tang, Y.*, Hu, Y.* "A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A", Angew. Chem. Intl. Ed. 2017, 56, 4782–4786. Link
154. Gao, S-S., Garcia-Borras,M., Barber, J. S., Hai, Y., Duan, A., Garg, N. K.*, Houk, K. N.*, Tang, Y.*, “Enzyme-Catalyzed Intramolecular Enantioselective Hydroalkoxylation.” J. Am. Chem. Soc. 2017, 139, 3639-3642. PMCID: PMC5474393 Link
153. Zou, Y., Garcia-Borras, M., Tang, M-C., Hirayama, Y., Li, D., Li, L., Watanabe, K., Houk, K. N.*, Tang, Y.*, “Enzyme-Catalyzed Cationic Epoxide Rearrangements in Quinolone Alkaloid Biosynthesis.” Nat. Chem. Biol. 2017, 13, 325-332. PMCID: PMC5310975 Link
152. Tang, M-C.,# Zou, Y.,# Watanabe, K., Walsh, C. T.*, Tang, Y.* "Oxidative Cyclization in Natural Product Biosynthesis." 2017, Chem. Rev. 117, 5226–5333. PMCID: PMC5406274 Link
2016
151. Li, L. Yu, P., Tang, M-C., Zou, Y., Gao, S-S., Hung, Y-S., Zhao, M., Watanabe, K.*, Houk, K. N.*, Tang, Y.* "Biochemical Characterization of a Eukaryotic Decalin-Forming Diels-Alderase." J. Am. Chem. Soc. 2016, 138, 15837–15840 . PMCID: PMC5323083 Link
150. Zhang, J., Liu, N.#, Cacho, R. A.#, Gong, Z., Liu, Z., Qin, W., Tang, C., Tang, Y.*, Zhou, J.*, “Structural Basis of Nonribosomal Peptide Macrocyclization in Fungi .” Nat. Chem. Biol. 2016, 12, 1001-1003. PMCID: PMC5110376 Link
149. Yu, X., Liu, F., Zou, Y., Tang, M-C. Hang, L., Houk, K. N.*, Tang, Y.* "Biosynthesis of Strained Piperazine Alkaloids – Uncovering the Concise Pathway of Herquline A."J. Am. Chem. Soc. 2016, 138, 13529–13532. PMCID: PMC5378693 Link
148. Hang, L.#, and Liu, N.#, Tang, Y.* "Coordinated and Iterative Enzyme Catalysis in Fungal Polyketide Biosynthesis." ACS Catalysis 2016, 6, 5935–5945 (invited perspective). PMCID: PMC5436725 Link
147. Grandner, J. M., Cacho, C. A., ., Tang, Y. * Houk, K. N.* “Mechanism of the P450-Catalyzed Oxidative Cyclization in the Biosynthesis of Griseofulvin.” ACS Catal. 2016, 6, 4506–4511. Link
146. Yamamoto, T., Tsunematsu, Y., Hara, K., Suzuki, T., Kishimoto, S., Kawagishi, H., Noguchi, H., Hashimoto, H., Tang, Y., Hotta, K., Watanabe, K.* "Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis." Angew. Chem. Intl. Ed. 2016, 55, 6207-6210. PMCID: PMC5089960 Link
145. Gao, S-S., Duan, A., Xu, W., Yu, P., Hang, L., Houk, K. N.*, Tang, Y.* "Phenalenone Polyketide Cyclization Catalyzed by Fungal Polyketide Synthase and Flavin-Dependent Monooxygenase."J. Am. Chem. Soc. 2016, 138, 4249–4259. Link
144. Lin, H-C., McMahon, T., Patel, A., Corsello, M., Simon, A., Xu, W., Zhao, M., Houk, K. N.*, Garg, N. K.*, Tang, Y.*. "P450-Mediated Coupling of Indole Fragments to Forge Communesin and Unnatural Isomers."J. Am. Chem. Soc. 2016, 138, 4002–4005. Link
143. Sato, M., Winter, J. M., Kishimoto, S., Noguchi, H., Tang, Y., Watanabe, K.* " Combinatorial Generation of Chemical Diversity by Redox Rnzymes in Chaetoviridin Biosynthesis." Org. Lett. 2016, 18, 1446-1449. Link
142. Billingsley, J. M.#, DeNicola, A. B.#, Tang, Y.* “Technology development for natural product biosynthesis in Saccharomyces cerevisiae.” Curr. Opin. Biotechnol. 2016, 42, 74-83. (Pharmaceutical Biotechnology issue) PMCID: PMC5026534 Link
141. Oikawa, H.*, Tang, Y.* "Exploring the Diversification Mechanism of Sskeletal Construction in Representative Natural Product Families." J. Antibiot. 2016, 69, 471-472. (Editorial on Special Issue honoring Prof. David Cane) Link
140. Zhao M., Lin, H.-C. Tang, Y.* “Biosynthesis of the α-Nitro-containing Cyclic Tripeptide Psychrophilin.” J. Antibiot. 2016, 69, 571-573. (Invited publication for Special Issue honoring Prof. David Cane) Link
139. Bond, C. M.#, Tang, Y.*, Li. L.#, “Saccharomyces cerevisiae as a Tool for Mining, Studying and Engineering Fungal Polyketide Synthases.” Fungal Genet. Biol. 2016, 89, 52-61. Link
138. Cacho, R. C., Tang, Y.* “Reconstitution of Fungal Nonribosomal Peptide Synthetases in Yeast and In Vitro.” Methods Mol. Biol. 2016, 1401,103-119. Link
137. Cochrane, R., Sanichar, R., Lambkin, G., Xu, W., Tang, Y., Vederas, J. C.*, “Identification and Reconstitution of the Polyketide Synthases Responsible for Biosynthesis of the Anti-Malarial Agent, Cladosporin.” Angew. Chem. Intl. Ed. 2016, 55, 664-668. Link
136. Xu, W., Raetz, L. B., Wang, P., Tang, Y.* “An ATP-Dependent Ligase Catalyzes the Fourth Ring Cyclization in Tetracycline Biosynthesis.” Tetrahedron 2016, 72, 3599-3604. (Invited submission for Special Issue on Natural Product-Inspired Approaches to Combat Bacteria) Link
135. Noey, E. L., Tibrewal, N., Jimenez-Oses, G., Osuna, S., Park, J., Bond, C., Casio, D., Liang, J., Zhang, X., Huisman, G., Tang, Y.*, Houk, K. N.*, “Origins of Stereoselectivity in Evolved Ketoreductases.” Proc. Natl. Acad. Sci., U. S. A., 2016, 112, E7065–E7072, doi: 10.1073/pnas.1507910112. Link, News
2015
134. Cacho, R. A., Thuss, J., Xu, W., Sanichar, R., Gao, Z., Nguyen, A., Vederas, J. C.*, Tang, Y.* “Understanding Programming of Fungal Iterative Polyketide Synthases: the Biochemical Basis for Regioselectivity by the Methyl-transferase Domain in the Lovastatin Megasynthase.” J. Am. Chem. Soc. 2015, 137, 15688-15691. Link
133. Guo, Y-Y., Li, H., Zhou, Z-X., Mao, X-M., Tang, Y., Chen, X., Jiang, X-H., Liu, Y, Jiang, H., Li, Y-Q.*, “ Identification and Biosynthetic Characterization of Natural Aromatic Azoxy Products from Streptomyces chattanoogensis L10.” Org. Lett. 2015, 17, 6114-6117. Link
132. Tang, M-C., Lin, H-C., Li, D., Zou, Y., Li, J., Xu, W., Cacho, R. A., Hillenmeyer, M., Garg, N. K., Tang, Y.* “Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast.” J. Am. Chem. Soc. 2015, 137, 13724–13727. Link
131. Cochrane, R., Gao, Z., Lambkin, G., R., Xu, W., Winter, J. M., Marcus, S. L., Tang, Y., Vederas, J. C.*, “Comparison of 10,11-dehydrocurvularin polyketide synthases from Alternaria cinerariae and Aspergillus terreus highlights key structural motifs.” ChemBioChem 2015, 16, 2479-2483. Link
130. Sato, M., Yagishita, F., Mino, T., Uchiyama, N., Patel, A., Chooi, Y., Goda, Y., Xu, W., Noguchi, H., Yamamoto, T., Hotta, K., Houk, K. N., Tang, Y., Watanabe, K.* “Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition.” ChemBioChem 2015, 16, 2294-2298. Link
129. Mao, X-M., Zhan, Z-J., Grayson, M. N., Tang, M-C., Xu, W., Li, Y-Q., Yin, W-B., Lin, H-C., Chooi, Y., Houk, K. N., Tang, Y.*, “Efficient Biosynthesis of Fungal Polyketides Containing the Dioxabicyclo-octane Ring System.” J. Am. Chem. Soc. 2015, 137, 11904-11907. Link
128. Medema, M. H. et al. “Minimum Information about a Biosynthetic Gene Cluster.” Nat. Chem. Biol. 2015, 11, 625-631. Link
127. Winter, J. M., Cascio, D.; Dietrich, D.; Sato, M.; Watanabe, K.; Sawaya, M.; Vederas, J. C.; Tang, Y*, “Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis.”. J. Am. Chem. Soc. 2015, 137, 9885-9893. Link
126. Mao, X-M., Xu, W., Li, D., Yin, W-B., Chooi, Y-H., Li, Y-Q., Tang, Y*, Hu, Y.* “Epigenetic Genome Mining of an Endophytic Fungus Leads to Pleiotropic Biosynthesis of Natural Products.” Angew. Chem. Intl. Ed. 2015, 54, 7592–7596. Link.
125. Zou, Y., Zhan, Z., Li, D., Tang, M-C., Cacho, R. A., Watanabe, K., Tang, Y.* “Tandem Prenyltransferases Catalyze Isoprenoid Elongation and Complexity Generation in Biosynthesis of Quinolone Alkaloids.” J. Am. Chem. Soc. 2015, 137, 4980-4983. Link
124. Mao, X-M., Luo, S., Zhou, R-C., Wang, F., Yu, P., Sun, N., Chen, X-X., Tang, Y., Li, Y-Q.* “Transcriptional Regulation of the Daptomycin Gene Cluster in Streptomyces roseosporus by an Autoregulator, AtrA.” J. Biol. Chem. 2015, 290, 7992-8001. Link
123. Lin, H-C., Chiou, G., Chooi, Y., McMahon, T. C., Xu, W., Garg, N. K.*, Tang, Y.* “Elucidation of the Concise Biosynthetic Pathway of the Communesin Indole Alkaloids.” Angew. Chem. Intl. Ed. 2015, 54, 3004-3007. (VIP paper) Link
122. Cacho, R. A., Tang, Y., Chooi, Y.*, “Next-generation Sequencing Approach for Connecting Secondary Metabolites to Biosynthetic Gene Clusters in Fungi.” Front. Microbiol. 2015, DOI: 10.3389/fmicb.2014.00774. Link
121. Soliman, S., Tang, Y.* “Natural and Engineered Production of Taxadiene with Taxadiene Synthase.” Biotechnol. Bioeng. 2015, 112, 229-235. Link
2010-2014
120. Zou, Y., Xu, W., Tsunematsu, Y., Tang, M-C., Watanabe, K., Tang, Y. * “Methylation-dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis.” Org. Lett. 2014, 16, 6390-6393. Link
119. Winter, J. M., Tang, Y. * “Natural products: Getting a handle on peptides.” Nat. Chem. 2014, 6, 1037–1038. (Invited Commentary) Link
118. Zhao, M.; Liu, Y.; Hsieh, R.; Wang, N.; Tai, W.; Joo, K.; Wang, P.; Gu, Z.; Tang, Y.* “Clickable Protein Nanocapsules for Targeted Delivery of Recombinant p53 Protein.” J. Am. Chem. Soc. 2014, 136, 15319–15325. Link
117. Xu, W., Gavia, D., Tang, Y.* “Biosynthesis of Fungal Indole Alkaloids” Nat. Prod. Rep. 2014, 31, 1474-1487. Link
116. Tsunematsu, Y.; Fukutomi, M.; Saruwatari, T.; Noguchi, H.; Hotta, K.; Tang, Y. , Watanabe, K.* “Elucidation of the Pseurotin Biosynthetic Pathway Reveals Trans-Acting C-Methyltransferase and Source of Chemical Diversity Generation.” Angew. Chemie. Intl. Ed. 2014, 53, 8475-8479. Link
115. Zabala, A. O., Chooi, Y., Choi, M., Lin, H-C., Tang, Y.* “Fungal Polyketide Synthase Product Chain-Length Control by Partnering Thiohydrolase” ACS. Chem. Biol. 2014, 9, 1576-1586. Link
114. Hu, Y., Dietrich, D., Xu, W., Thuss, J. A., Wang, J., Yin, W-B., Qiao, K., Vederas, J. C.*, Tang, Y.* “A Carbonate-Forming Baeyer-Villiger Monooxygenase.” Nat. Chem. Biol. 2014, 10, 552–554. Link
113. Jiménez-Osés, G.; Osuna, S.; Gao, X.; Sawaya, M. R.;Gilson, L.; Collier, S. J.;Huisman, G. W.*; Yeates, T. O.*; Tang, Y.*; Houk, K. N.* “The Role of Distant Mutations and Allosteric Regulation on LovD Active Site Dynamics.” Nat. Chem. Biol. 2014, 10, 431–436. Link
112. Lin, H-C; Tsunematsu, Y.; Dhingra, S.; Xu, W.; Fukutomi, M.; Chooi, Y.; Cane, D. E.; Calvo, A.; Watanabe, K.; Tang, Y.* “Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of a Multifunctional Cytochrome P450 in the Fumagillin Pathway.” J. Am. Chem. Soc. 2014, 136, 4426-4436. Link
111. Mao, X, Ren, N., Sun, N., Wang, F., Zhou, R., Tang, Y., Li, Y.* “Proteasome involvement in a complex cascade mediating SigT degradation during differentiation of Streptomyces coelicolor.” FEBS Lett, 2014, 588, 608-613. Link
110. Tibrewal, N.*, Tang, Y.* “Biocatalysts for Natural Product Biosynthesis.” Annu. Rev. Chem. Bio. Eng. 2014, 5, 347-366. Link
109. Li, L. Wang, P., Tang, Y.* “C-Glycosylation of Anhydrotetracycline Scaffold with SsfS6 from the SF2575 Biosynthetic Pathway.” J. Antibiot. 2014, 67, 65-70. (Chris Walsh Issue) Link
108. Chooi, Y., Hong, Y., Cacho, R. A., Tantillo, D. J.*, Tang, Y.* “A Cytochrome P450 Serves as an Unexpected Terpene Cyclase during Fungal Meroterpenoid Biosynthesis.” J. Am. Chem. Soc. 2013, 135, 16805–16808. Link
107. Dhingra, S., Lee, A., Lin, H-S., Tang, Y., Rokas, A., Calvo. A. M.*, “The fumagillin gene cluster, an example of thousands of genes under veA control in Aspergillus fumigatus.” PLoS ONE, 2013, 8(10): e77147. doi:10.1371/journal.pone.0077147. Link
106. Liu, Y., Ding, G., Li, Y., Qu, J., Ma, S., Lv, H., Liu, Y., Wang, W., Dai, J., Tang, Y., Yu, S.* “Structures and Absolute Configurations of Penicillactones A–C from an Endophytic Microorganism, Penicillium dangeardii Pitt.” Org. Lett. 2013, 15, 5206–5209. Link
105. Cacho, R. A. Chooi, Y., Zhou, H., Tang, Y.* “Complexity Generation in Fungal Polyketide Biosynthesis: a Spirocycle-Forming P450 in the Concise Pathway to the Antifungal Drug Griseofulvin.” ACS Chem. Biol. 2013, 8, 2322–2330. Link
104. Gao, X., Jiang, W., Jiménez-Osés, G., Choi, M. S., Houk, K. N., Tang, Y.*, Walsh, C. T.*, “An Iterative, Bimodular Nonribosomal Peptide Synthetase that Converts Anthranilate and Tryptophan into Tetracyclic Asperlicins.” Chem. Biol. 2013, 20, 870-878. Link See Former Member (both Tang and Walsh!) Wenjun Zhang’s paper in the same issue.
103. Winter, J. M, Chiou, G., Bothwell, I. Xu, W., Garg, N. K., Luo, M. K., Tang, Y.* “Expanding the Structural Diversity of Polyketides by Exploring the Cofactor Tolerance of an Inline Methyltransferase Domain.” Org. Lett.. 2013, 15, 3774–3777. Link
102. Yin, W. B., Chooi, Y., Cacho, R. A., Smith, A. R., White, T. C., Tang, Y.* “Discovery of Cryptic Polyketide Metabolites from Dermatophytes using Heterologous Expression in Aspergillus nidulans.” ACS Syn. Biol. 2013, 2, 629–634. Link.
101. Xu, W., Chooi, Y., Choi, J. W., Li, S., Vederas, J. C., Da Silva, N. A., Tang, Y.* “Finding the Missing Link in Lovastatin Biosynthesis: LovG is the Thioesterase Required for Dihydromonacolin L Release and Lovastatin Nonaketide Synthase Turnover.” Angew. Chem. Intl. Ed. 2013, 52, 6472-6475. Link Highlighted by Nature Chem. Biol.
100. Wang, P., Bashiri, G., Gao, X., Sawaya, M. R. Tang, Y. * “Uncovering the Enzymes that Catalyze the Final Steps in Oxytetracycline Biosynthesis.” J. Am. Chem. Soc. 2013, 135, 7138-7141. Link
99. Walsh, C. T.*, Haynes, S. W., Ames, B. D., Gao, X., Tang, Y. “Short Pathways to Complexity Generation: Fungal Peptidyl Alkaloid Multicyclic Scaffolds from Anthranilate Building Blocks.” ACS Chem. Biol. 2013, 8, 1366–1382. Link
98. Wei, W., Du, J., Li, J., Yan, M., Zhu, Q., Jin, X., Zhu, X., Hu, Z., Tang, Y.*, Lu, Y.* “Construction of Robust Enzyme Nanocapsules for Effective Organophosphate Decontamination, Detoxification, and Protection.” Adv. Mater. 2013, 25, 2212-2218. Link
97. Lin, H-S., Chooi, Y., Dhingra, S., Xu, W., Calvo, A. M., Tang, Y.* “The Fumagillin Biosynthetic Gene Cluster in Aspergillus fumigatus Encodes a Cryptic Terpene Cyclase Involved in the Formation of b-trans-Bergamotene.” J. Am. Chem. Soc. 2013, 135, 4616-4619. Link
96. Jiang, W., Cacho, R. A., Chiou, G. Garg. N. K., Tang, Y.*, Walsh, C. T.*, “EcdGHK Are Three Tailoring Iron Oxygenases for Amino Acid Building Blocks of the Echinocandin Scaffold.” J. Am. Chem. Soc. 2013, 135, 4457-4466. Link
95. Chooi, Y., Fang, J., Liu, H., Filler, S., Wang, P., Tang, Y.* “Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi.” Org. Lett. 2013, 15, 780-783. Link
94. Gao, Z.+, Wang, J.+, Norwqay, A. K., Qiao, K., Tang, Y.*, Vederas, J. C.* “Investigation of Fungal Iterative Polyketide Synthase Functions Using Partially Assembled Intermediates.” J. Am. Chem. Soc. 2013, 135, 1735-1738. Link
93. Cacho, R. A., Tang, Y.* “Bringing Protein Engineering and Natural Product Biosynthesis Together.” Chem, Biol. 2013, 20, 3-5. (Commentary) Link
92. Haynes, S. W., Gao, X., Tang, Y.*, Walsh, C. T.*, “Complexity Generation in Fungal Peptidyl Alkaloid Biosynthesis: a Two Enzyme Pathway to the Hexacyclic MDR Export Pump Inhibitor Ardeemin.” ACS Chem. Biol. 2013, 8, 741-748. Link
91. Zhao, M., Hu, B., Gu, Z., Joo, K., Wang, P.*, Tang, Y.* “Degradable Polymeric Nanocapsule for Efficient Intracellular Delivery of a High Molecular Weight Tumor-Selective Protein Complex.” Nano Today. 2013, 8, 11-20. Link
90. Xu, W., Qiao, K., Tang, Y.* “Structural Analysis of Protein-Protein Interactions in Polyketide Biosynthesis.” Crit. Rev. Biochem. Mol. Biol. 2012, 48, 98-122. Link
89. Winter, J. M. Sato, M., Sugimoto, S., Chiou, G., Garg, N. K., Tang, Y.*, Watanabe, K.*, “Identification and Characterization of the Chaetoviridin and Chaetomugilin Gene Cluster in Chaetomium globosum Reveal Dual Functions of an Iterative Highly-Reducing Polyketide Synthase.” J. Am. Chem. Soc. 2012, 134, 17900–17903. Link
88. Haynes, S. W., Gao, X., Tang, Y.*, Walsh, C. T.*, “Assembly of Asperlicin Peptidyl Alkaloids from Anthranilate and Tryptophan: A Two-Enzyme Pathway Generates Hepta-cyclic Scaffold Complexity in Asperlicin E.” J. Am. Chem. Soc., 2012, 134, 17444–17447. Link
87. Cacho, R. A., Jiang, W., Chooi, Y., Walsh, C. T.*, Tang, Y.* “Identification and Characterization of the Echinocandin B Biosynthetic Gene Cluster from Emericella rugulosa NRRL 11440.” J. Am. Chem. Soc. 2012, 134, 16781–16790. Link
86. Chooi, Y.*, Tang, Y.* “Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules.” J. Org. Chem. 2012, 77, 9933–9953. (invited perspective) Link
85. Wang, P., Kim. W., Pickens, L. B., Gao, X., Tang, Y.* “Heterologous Expression and Manipulation of Three Tetracycline Biosynthetic Pathways.” Angew. Intl. Chem. Ed. 2012, 51, 11136–11140. (selected as Very Important Paper). Link
84. Gao, X., Haynes, S. W., Ames, B. D., Wang, P., Vien, L. P., Walsh, C. T.*, Tang, Y.* “Cyclization of Fungal Nonribosomal Peptides Catalyzed by a Terminal Condensation-Like Domain.” Nat. Chem. Biol. 2012, 8, 823-830. Link
83. Zabala, A. O., Xu, W., Chooi, Y.*, Tang, Y.* “Discovery and Characterization of a Silent Gene Cluster that Produces Azaphilones from Aspergillus niger ATCC 1015 Reveal a Hydroxylation-Mediated Pyran-Ring Formation.” Chem. Biol. 2012, 19, 1049–1059. Link
82. Ames, B. D., N., Chi, Smith, P., Ma, S. M., Wong, E., Wong, S., Xie, X., Li, J. W., Vederas, J. C., Tang, Y.*, Tsai, S. C.* “Biosynthesis of Lovastatin: Crystal Structure and Biochemical Studies of LovC, a Trans-acting Polyketide Enoyl Reductase.” Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 11144-11149.Link
81. Chooi, Y.*, Wang, P., Fan, J., Li, Y., Wu, K., Wang, P., Tang, Y.* “Characterization of a Group of Fungal Aromatic Polyketide Prenyl-transferases.” J. Am. Chem. Soc. 2012, 134, 9428–9437. Link
80. Biswas, A., Liu, Y., Fan, G.*, Tang, Y.* “Polyethylene Glycol-based Protein Nanocapsules for Functional Delivery of a Differentiation Transcription Factor” Biomaterials. 2012, 33, 5459–5467. Link
79. Wang, P., Gao, X., Tang, Y.* “Complexity Generation during Natural Product Biosynthesis using Redox Enzymes.” Curr. Opin. Chem. Biol. 2012, 16, 362-369. Link
78. Zhou, H., Gao, Z., Qiao, K., Wang, J., Vederas, J. C.*, Tang, Y.* “A fungal ketoreductase domain that displays substrate-dependent stereospecificity.” Nat. Chem. Biol. 2012, 9, 331-333. (Cover Story) Link
77. Liu, Q., Yao, F., Chooi, Y., Kang, Q., Xu, W., Li, Y., Shao, Y., Shi, Y., Deng, Z., Tang, Y.*., You, D.* “Elucidation of Piericidin A1 Biosynthetic Locus Revealed an Thioesterase-dependent Mechanism of α-Pyridone Ring Formation.” Chem. Biol. 2012, 19, 243-253. Link
76. Winter, J. M., Tang, Y.* “Synthetic Biological Approaches to Natural Product Biosynthesis.” Curr. Opin. Biotech. 2012, 5, 736-743. Link
75. Zabala, A. O., Cacho, R., Tang, Y.* “Protein Engineering Towards Natural Product Synthesis and Diversification.” J. Ind. Microb. Biotechnol. 2012, 39, 227-241. (Invited Review) Link
74. Pickens, L. B., Sawaya, M. R., Pashkov, I., Rasool, H., Yeates, T. O., Tang, Y.* “Structural and Biochemical Characterizations of the GDSL Salicylyl-Acyltranferase SsfX3 from a Tetracycline Biosynthetic Pathway.” J. Biol. Chem. 2011, 286, 41539-41553 (selected as Paper of the Week). Link
73. Qiao, K. Chooi, Y., Tang, Y.* “Identification and Engineering of the Cytochalasin E Gene Cluster from Aspergillus clavatus.” Metab. Eng. 2011, 13, 723-732. Link
72. Li, Y., Chooi, Y., Sheng, Y., Valentine, J. S., Tang, Y.* “Comparative Characterization of Fungal Anthracenone and Naphthacenedione Biosynthetic Pathways Reveals an alpha-Hydroxylation-Dependent Claisen-Like Cyclization Catalyzed by a Dimanganese Thioesterase.” J. Am. Chem. Soc. 2011, 133, 15773-15785. Link
71. Ames, B. D., Haynes, S. W., Gao, X., Evans, B. S., Kelleher, N. L., Tang, Y., Walsh, C. T.*, “Complexity Generation in Fungal Peptidyl Alkaloid Biosynthesis: Oxidation of Fumiquinazoline A to the Heptacyclic Hemiaminal Fumiquinazoline C by the Flavoenzyme Af12070 from Aspergillus fumigatus.” Biochemistry 2011, 50, 8756-8769.Link
70. Ames, B. D., Lee, M., Moody, C., Zhang, W., Tang, Y., Tsai, S. C.* “Structural and Biochemical Characterization of ZhuI Aromatase/Cyclase from the R1128 Polyketide Pathway.” Biochemistry 2011, 50, 8392–8406. Link
69. Wang, P., Gao., X., Deng, Z., Tang, Y.* “Genetic Characterization of Enzymes Involved in the Priming Steps of Oxytetracycline Biosynthesis in Streptomyces rimosus.” Microbiology, 2011, 157, 2401-2409. Link
68. Haynes, S. W., Ames, B. D., Gao, X., Tang, Y., Walsh, C. T.* “Unraveling Terminal C-Domain-Mediated Condensation in Fungal Biosynthesis of Imidazoindolone Metabolites.” Biochemistry 2011, 50, 5668-5679. Link
67. Gu, Z., Biswas, A., Zhao, M., Tang, Y.* “Nanocarriers for Protein Intracellular Delivery.” Chem. Soc. Rev. 2011, 40, 3638-3655. Link
66. Zhao, M., Biswas, A., Hu, B., Joo, K., Wang, P., Gu, Z., Tang, Y.* “Redox-Responsive Nanocapsules for Intracellular Protein Delivery.” Biomaterials 2011, 32, 5223-5230. Link
65. Joo, K., Fang, Y., Liu, Y., Xiao, L., Gu, Z., Tai, A., Lee, C., Tang, Y., Wang, P.* “Enhanced Real-Time Monitoring of Adeno-Associated Virus Trafficking by Virus-Quantum Dot Conjugates.” ACS Nano 2011, 5, 3523-3535. Link
64. Gu, Z., Zhao, M., Sheng, Y., Bentolila, L. A. Tang, Y.* “Detection of Mercury Ion by Infrared-Fluorescent Protein and Its Hydrogel-Based Paper Assay.” Anal. Chem. 2011, 83, 2324-2329. Link
63. Qiao, K., Zhou, H., Xu, W., Zhang, W., Garg, N., Tang, Y.* “A Fungal Nonribosomal Peptide Synthetase Module that can Synthesize Thiopyrazines.” Org. Lett. 2011, 13, 1758-1761. Link
62. Gao, X., Chooi, Y., Ames, B. D., Wang, P., Walsh, C. T., Tang, Y.* “Fungal Quinazoline Alkaloid Biosynthesis: Genetic and Biochemical Investigation of the Tryptoquialanine Pathway in Penicillium aethiopicum.” J. Am. Chem. Soc. 2011, 133, 2729-2741. Link Highlighted by Nature Chem Biol.
61. Biswas, A., Joo, K., Zhao, M., Fan, G., Wang, P., Zhen, G., Tang, Y.* “Endoprotease-Mediated Intracellular Protein Delivery using Nanocapsules.”ACS Nano 2011, 5, 1385-1394. Link
60. Pickens, L., Tang, Y.*, Chooi, Y. H. “Metabolic Engineering for the Production of Natural Products” Annu. Rev. Chem. Bio. Eng. 2011, 2, 211-236. (Invited Review) Link
59. Meehan, M. J.; Xie, X.; Zhao, X.; Xu, W.; Tang, Y.*; Dorrestein, P. C.* “FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF.” Biochemistry 2011, 50, 287–299. Link
58. Zhou, H., Qiao, K., Gao, Z., Vederas, J. C.*, Tang, Y.* “Insights into Radicicol Biosynthesis via Heterologous Synthesis of Advanced Intermediates and Analogs.” J. Biol. Chem. 2010, 285, 41412-4121. Link
57. Xu, W., Cai, X., Jung, M. E., Tang, Y.* “Analysis of Intact and Dissected Fungal Polyketide Synthase-Nonribosomal Peptide Synthetase in vitro and in Saccharomyces cerevisiae” J. Am. Chem. Soc. 2010, 132, 13604-13607. Link
56. Gao, X., Wang, P., Tang, Y.*, “Engineered polyketides biosynthesis and biocatalysis in Escherichia coli.” Appl. Microbiol. Biotechnol. 2010, 88, 1233-1242. (Invited Minireview) Link
55. Chooi, Y. H., Tang, Y.*, “Adding the Lipo to Lipopeptides: Do More with Less.” Chem. Biol. 2010, 17, 791-793. Link
54. Gu, Z., Biswas, A., Joo, K., Hu, B., Wang, P. and Tang, Y.*, “Probing Protease Activity with a Single Fluorescent Protein Nanobeacon.” Chem. Commun. 2010, 46, 6467-6469. Link
53. Pickens, L., Tang, Y.*, “Oxytetracycline Biosynthesis.” J. Biol. Chem. 2010, 285, 27509-27515 (Invited minireview). Link
52. Chooi, Y. H., Cacho, R., Tang, Y.*, “Identification of the Viridicatumtoxin and Griseofulvin Gene Clusters from Penicillium aethiopicum.” Chem. Biol. 2010, 17, 483-494. Link
51. Li, Y., Xu, W., Tang, Y.*, “Classification, Prediction and Verification of the Regioselectivity of Fungal Polyketide Synthase Product Template Domains.” J. Biol. Chem. 2010, 285, 22762-22771. Link Highlighted by Nature Chem Biol.
50. Gu, Z., Tang, Y.*, “Enzyme-Assisted Photolithography for Spatial Functionalization of Hydrogels.” Lab on Chip 2010, 10, 1946-1951. (FRONT COVER) Link
49. Zhou, H., Li, Y., Tang, Y.*, “Cyclization of Aromatic Polyketides from Bacteria and Fungi.” Nat. Prod. Rep. 2010, 27, 839-868. Link
48. Zhou, H., Qiao, K., Gao, Z.; Meehan, M. J., Li, J., Dorrestein, P. C., Vederas, J. C.*, Tang, Y.*, “Enzymatic Synthesis of Resorcylic Acid Lactones by Cooperation of Fungal Iterative Polyketide Synthases Involved in Hypothemycin Biosynthesis.” J. Am. Chem. Soc. 2010, 132, 4530–4531. Link
47. Yan, M, Du, J. J. Gu, Z., Liang, M., Hu, Y., Zhang, W., Segura, T., Liu, Z., Tang, Y. Lu, Y*. “A Novel Intracellular Protein Delivery Platform Based on Single-Protein Nanocapsules” Nat. Nano., 2010, 5.
2006-2009
46. Gu, Z., Yan, M., Hu, B., Joo, K., Biswas, A., Lu, Y.*, Wang, P.*, Tang, Y.* “Protein Nanocapsules Weaved by an Enzymatically Degradable Polymer Network.” Nano. Lett. 2009, 9, 4533-4538. Link
45. Gao, X., Xie, X., Pashkov, I., Sawaya, R. M., Laidmen, J., Zhang, W., Cacho, R., Yeates, T. O.*, Tang, Y.* “Directed Evolution and Structural Characterization of a Simvastatin Synthase.” Chem. Biol. 2009, 16, 1064-1074. Link
44. Pickens, L. B., Kim, W., Wang, P., Zhou, H., Watanabe, K., Gomi, S., Tang, Y.* “Biochemical Analysis of the Biosynthetic Pathway of an Anticancer Tetracycline SF2575.” J. Am. Chem. Soc. 2009, 131, 17677–17689. Link
43. Ma, S. A., Li, J., Choi, J. W., Zhou, H., Lee, M., Moorthie, V., Xie, X., Kealey, J. T., Da Silva, N. A., Vederas, J. C.*, Tang, Y.* “Complete Reconstitution of a Highly-Reducing Iterative Polyketide Synthase.” Science 2009, 326, 589-592. Link
42. Wang, M., Zhou, H., Wirz, M., Tang, Y., Boddy, C. N.* “A Versatile Thioesterase from an Iterative Fungal Polyketide Synthase.” Biochemistry 2009, 48, 6288-6290. Link
41. Xie, X., Meehan, M. J. Xu, W., Dorrestein, P. C., Tang, Y.* “Acyltransferase Mediated Polyketide Release From Fungal Megasynthase.” J. Am. Chem. Soc. 2009, 131, 8388-8389. Link
40. Wang, P., Zhang, W., Zhan, J., Tang, Y.* “Identification of OxyE as an Ancillary Oxygenase During Tetracycline Biosynthesis.” ChemBioChem, 2009, 10, 1554-1550. Link
39. Zhan, J., Qiao, K., Tang, Y.* “Investigation of Post-PKS Tailoring Modifications in Pradimicin Biosynthesis.” ChemBioChem, 2009, 10, 1447-1452. Link
38. Ma, S. M., Pickens, L. B., Tang, Y.* “Antibiotics, Polyketides.” Encyclopedia of Industrial Biotechnology, 2009, DOI: 10.1002/9780470054581.eib041.
37. Zhang, W., Tang, Y.* “In vitro Analysis of Type II Polyketides.” Methods in Enzymology Volume: Complex Enzymes in Microbial Natural Product Biosynthesis. 2009, 459, 367-393. Link
36. Pickens, L. B., Tang, Y. * “Decoding and Engineering Tetracycline Biosynthesis.” Metab. Eng. 2009, 11, 69-75. (Cover article). Link
35. Xie, X., Pashkov, I., Xue, G., Guerrero, J., Yeates, T., Tang, Y.* “Rational Improvement of Simvastatin Synthase Solubility in Escherichia coli Leads to Higher Whole-cell Biocatalytic Activity.” Biotechnol. Bioeng. 2009, 102, 20-28. Link
34. Zhang, W., Li, Y., Tang, Y. “Engineered Biosynthesis of Bacterial Aromatic Polyketides in Escherichia coli.” Proc. Natl. Acad. Sci. USA., 2008, 105, 20683-20685. Link
33. Zhou, H., Xie, X., Tang, Y.* “Engineering Natural Products Using Combinatorial Biosynthesis and Biocatalysis.” Curr. Opin. Biotechnol., 2008, 19, 590-596. Link
32. Zhan, J., Watanabe, K., Tang, Y.* “Synergistic Actions of Monooxygenase and Cyclases in Aromatic Polyketide Biosynthesis.” ChembioChem 2008, 9, 1710 – 1715. Link
31. Zhang, W., Watanabe, K., Cai, X., Jung, M. E., Tang, Y.*, Zhan, J.* “Identifying the Minimal Enzymes Required for Anhydrotetracycline Biosynthesis.” J. Am. Chem. Soc. 2008, 130, 6068-6069. Link
30. Zhou, H., Zhan, J., Watanabe, K., Xie, X., Tang, Y.* “A Polyketide Macrolactone Synthase from the Filamentous Fungus Gibberella zeae.” Proc. Natl. Acad. Sci. USA, 2008, 105, 6249-6254. Link
29. Ames, B., Korman, T., Zhang, W., Smith, P., Vi, T., Tang, Y., Tsai, S-C. “Crystal Structure and Functional Analysis of Tetracenomycin ARO/CYC: Implications for Cyclization Specificity of Aromatic Polyketides.” Proc. Natl. Acad. Sci. USA, 2008, 105, 5349-5354. Link
28. Ma, S. M., Zhan, J., Xie, X., Watanabe, K., Tang, Y.*, Zhang, W. “Redirecting the Cyclization Steps of Fungal Polyketide Synthase.” J. Am. Chem. Soc. 2008, 130, 38-39.Link
27. Zhang, W., Tang, Y.* “Combinatorial Biosynthesis of Natural Products” J. Med Chem. 2008, 51, 2629-2633. Link
26. Ma, S. M., Zhan, J., Watanabe, K., Xie, X., Zhang, W., Wang, C. C., Tang, Y.* “Enzymatic Synthesis of Aromatic Polyketides using PKS4 from Gibberella fujikuroi.” J. Am. Chem. Soc. 2007, 129, 10642-10643. Link
25. Zhang, W.; Wilke, B. I.; Zhan, J.; Watanabe, K.; Boddy, C. N.*; Tang, Y.* “A New Mechanism for Benzopyrone Formation in Aromatic Polyketide Biosynthesis.” J. Am. Chem. Soc. 2007, 129, 9304-9305. Link.
24. Zhang, W., Watanabe. K., Wang, C. C. C., Tang, Y.* “Investigation of Early Tailoring Reactions in the Oxytetracycline Biosynthetic Pathway.” J. Biol. Chem. 2007, 282, 25717-25725. Link.
23. Xie, X., Wong, W. W., Tang, Y.* “Improving Simvastatin Bioconversion in Escherichia coli by Deletion of bioH.” Metab. Eng. 2007, 9, 379-386. Link
22. Ma, S. M., Tang, Y.* “Biochemical Characterization of the Minimal Polyketide Synthase Domains in the Lovastatin Nonaketide Synthase LovB.” FEBS J. 2007, 274, 2854–2864. Link
21. Xie, X., Tang, Y.* “Efficient Synthesis of Simvastatin Using Whole-Cell Biocatalysis.” Appl. Environ. Microb. 2007, 73, 2054-2060. Link
20. Zhang, W., Watanabe, K., Wang, C. C. C., Tang, Y.* “Heterologous Biosynthesis of Amidated Polyketides with Novel Cyclization Regioselectivity from Oxytetracycline Polyketide Synthase” J. Nat. Prod. 2006, 69, 1633-1636. Link
19. Xie, X., Watanabe, K., Wojcicki, W. A., Wang, C. C. C., Tang, Y.* “Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.” Chem. Biol. 2006, 13, 1161-1169. Link
18. Zhang, W., Ames, B., Tsai, S-C., Tang, Y.*, "Tetracycline Biosynthesis: Sequencing of the Oxytetracycline Gene Cluster and Reconstitution of the Malonamyl-Specific Initiation module." Appl. Environ. Microb. 2006, 72, 2573-2580. link
Publication from Postdoctoral Work
17. Tang, Y. Lee, H.Y., Tang, Y., Kim, C-Y., Mathews, I. and Khosla, C. “Structural and Functional Studies on SCO1815: A -Ketoacyl-Acyl Carrier Protein Reductase from Streptomyces coelicolor A3(2).” Biochemistry, 2006, 45, 14085-14093.
16. Lee. T. S.*, Khosla, C., Tang, Y.* "Orthogonal Protein Interactions in Spore Pigment Producing and Antibiotic Producing Type II Polyketide Synthases." J. Antibiotics, 2005, 58, 664-667.
15. Lee. T. S.*, Khosla, C., Tang, Y.* "Engineered Biosynthesis of Aklanonic Acid Analogs." J. Am. Chem. Soc., 2005, 127, 12254-12262.
14. Khosla, C., Tang, Y., "Chemistry. A new route to designer antibiotics." Science 2005, 308, 367-368.
13. Tang, Y., Koppisch, A., Khosla, C. "The Acyltransferase Homolog Found in Initiation Modules of Type II PKS is an Acetyl-ACP Thiolase that Suppresses Acetate-Priming of the KS-CLF." Biochemistry 2004, 43, 9546-9555.
12. Tang, Y., Lee, T. S., Lee, H. Y., Khosla, C. "Exploring the Biosynthetic Potential of Bimodular Aromatic Polyketide Synthases." Tetrahedron, 2004, 7659-7671.
11. Kumar, P.*, Khosla, C., Tang, Y.* "Manipulation and Analysis of Polyketide Synthases." Methods in Enzymology Volume 388: Protein Engineering 2004, 269-293.
10. Tang, Y., Lee, T. S., Khosla, C. "Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases." PLoS Biol. 2004, 2, 227-237.
9. Tang, Y., Tsai, S. C., Khosla, C. "Polyketide Chain Length Control by Chain Length Factor." J. Am. Chem. Soc. 2003, 125, 12708-12709.
8. Tang, Y., Lee, T. S., Kobayashi, S., Khosla, C. "Ketosynthases in the Initiation and Elongation Modules of Aromatic Polyketide Synthases Have Orthogonal Acyl-Carrier Protein Specificity." Biochemistry 2003, 42, 6588-6595.
Publication from Graduate Work
7. Tang, Y., Wang, P., Van Deventer, J. A., Link, A. J., Tirrell, D. A. “Introduction of an Aliphatic Ketone into Recombinant Proteins in a Bacterial Strain that Overexpresses an Editing-Impaired Leucyl-tRNA Synthetase.” ChembioChem 2009, 10, 2188-2190.
6. Cirino, P.C , Tang, Y., Takahashi, K., Tirrell, D. A., Arnold, F. H. "Global Incorporation of Norleucine in Place of Methionine in Cytochrome P450 BM-3 Heme Domain Increases Peroxygenase Activity." Biotechnol Bioeng. 2003, 20, 729-734.
5. Wang, P., Tang, Y., Tirrell, D. A., "Incorporation of Trifluoroisoleucine into Proteins In Vivo." J. Am. Chem. Soc. 2003, 125, 6900-6906.
4. Tang, Y., Tirrell, D. A. "Attenuation of Leucyl-tRNA Synthetase Proofreading Activity in Escherichia coli Allows Introduction of An Array of Unnatural Amino Acids in vivo." Biochemistry 2002, 41, 10635-10645.
3. Tang, Y., Tirrell, D. A. "Biosynthesis of Highly Stable Coiled-coils Containing Hexafluoroleucine Using an Engineered Bacterial Host." J. Am. Chem. Soc. 2001, 123, 11089-11090.
2. Tang, Y., Ghirlanda, G., Petka, W. A., Nakajima, T., W. A., DeGrado, W. F., Tirrell, D. A. "Fluorinated Coiled-coils Prepared in vivo Display Enhanced Thermal and Chemical Stability." Angew. Chem. Int. Ed. 2001, 40, 1494-1497.
1. Tang, Y., Ghirlanda, G., Vaidehi, N., Kua, J., Mainz, D. T., Goddard, W. A., DeGrado, W. F., Tirrell, D. A. "Stabilization of Leucine Zipper Coiled-coils using Trifluoroleucine." Biochemistry 2001, 40, 2790-2796.
Previous Book Chapters
6. Gu, Z.*, Tang, Y., Chen, Y., “Fabrication of Biomolecular Nanopatterns.” In Advances in Nanotechnology Volume III. eds Bartul, Z. and Jérôme Trenor, J.; NOVA scientific publisher, 2010.
5. Xie, X., Qiao, K. J., Tang, Y.* “Metabolic Engineering of Natural Product Biosynthesis.” In Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery. ed Tringlai, C., Taylor and Francis Group, 2010.
4. Zhang, W., Ferreira, J. P., Tang, Y. "Regulation of Secondary Metabolism Biosynthesis." In: Smolke, C.D., ed. Handbook for Metabolic Pathway Engineering. CRC Press. 2009 in press.
3. Tang, Y.; Ma, S.M; Wojcicki, W. A. "Applications of Metabolic Engineering for Natural Drug Discovery." In: Smolke, C.D., ed. Handbook for Metabolic Pathway Engineering. CRC Press. 2009 in press.
2. Zhang, W., Tang, Y., "Engineering Starter Units in Aromatic Polyketides." In ACS Volume Based on Polyketides: Biosynthesis, Biological Activity and Genetic Engineering. eds S. R. Baerson; American Chemical Society, 2006.
1. Tang, Y., Khosla, C., "Diversity from Mother Nature: natural and unnatural products." In Exploiting Chemical Diversity for Drug Discovery, eds P. Bartlett and M. Entzeroth; Royal Society of Chemistry, 2006. Link