Publications
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* Corresponding author, # Co-first author.
70. LTP. Le, AHQ. Nguyen, HTT. Ngo, X. Wang, B. Cunningham, E. Valera, R. Bashir, AW. Taylor-Robinson and CD. Do, Current smartphone-assisted point-of-care cancer detection: Towards supporting personalized cancer monitoring, TrAC Trends in Analytical Chemistry, 174, 117681 (2024). Link
69. T. Song, L. Cooper, J. Galvan Achi, X. Wang, A. Dwivedy, L. Rong and X. Wang*, Polyvalent nanobody structure designed for boosting SARS-CoV-2 inhibition, Journal of the American Chemical Society, 146, 5894-5900 (2024). Link
68. S. Umrao, M. Zheng, Xiaojin Lin, Sherwood Yao and X. Wang*, Net-shaped DNA nanostructure-based lateral flow assays for rapid and sensitive SARS-CoV-2 detection, Analytical Chemistry, 96, 3291-3299 (2024). Link
67. Z. Fang, Z. Wu, X. Wu, S. Chen, X. Wang*, S. Umrao* and A. Dwivedy*, APIPred: An XGBoost-based method for predicting aptamer-protein interactions, Journal of Chemical Information and Modeling, 64, 2290-2301 (2024). Link
This article is part of the Machine Learning in Bio-cheminformatics special issue.
66. H. Zhu, J. Wu, J. Zhao, L. Yu, B.R. Liyarita, X. Xu, Y. Xiao, X. Hu, S. Shao, J. Liu, X. Wang and F. Shao, Dual-function DNA nanogels for anticancer drug delivery, Acta Biomaterialia, 175, 240-249 (2024). Link
64. A. Rodriguez#, D. Gandavadi#, J. Mathivanan, T. Song, B.R. Madhanagopal, H. Talbot, J. Sheng, X. Wang* and A.R. Chandrasekaran*, Self-assembly of DNA nanostructures in different cations, BioRxiv, DOI: 10.1101/2023.05.04.539416 (2023). Link
63. L. Zhou#, Y. Xiong#, L. Cooper, S. Shepherd, T. Song, A. Dwivedy, L. Rong, T. Wang, B.T. Cunningham and X. Wang*, Designer DNA NanoGripper, BioRxiv, DOI: 10.1101/2023.04.26.538490 (2023). Link
62. H. Lee, W. Wang, N. Chauhan, Y. Xiong, N. Magazine, O. Valdescruz, D-Y. Kim, T. Qiu, W. Huang, X. Wang and B.T. Cunningham, Rapid, sensitive detection of intact SARS-CoV-2 using DNA nets and a smartphone-linked fluorimeter, Proc. SPIE 12387, Optical Diagnostics and Sensing XXIII: Toward Point-of-Care Diagnostics, 123870B (2023). Link
61. H. Lee#, W. Wang#, N. Chauhan, Y. Xiong, N. Magazine, O. Valdescruz, D-Y. Kim, T. Qiu, W. Huang, X. Wang and B.T. Cunningham, Rapid detection of intact SARS-CoV-2 using designer DNA nets and a pocket-size smartphone linked fluorimeter, Biosensors and Bioelectronics, 228, 115228 (2023). Link
60. A. Bacon, W. Wang, H. Lee, S. Umrao, P. D. Sinawang, D. Akin, K. Khemtonglang, A. Tian, S. Hirshfield, U. Demirci, X. Wang and B.T. Cunningham, Review of HIV self testing technologies and promising approaches for the next generation, Biosensors, 13, 298 (2023). Link
59. L. Liu, J. Tibbs, N. Li, A. Bacon, S. Shepherd, H. Lee, N. Chauhan, U. Demirci, X. Wang and B.T. Cunningham, A photonic resonator interferometric microscope for label-free detection of nanometer-scale objects with digitial precision in point-of-use environments, Biosensors and Bioelectronics, 228, 115197 (2023). Link
58. H. Lee, W. Wang, N. Chauhan, Y. Xiong, N. Magazine, O. Valdescruz, D-Y. Kim, T. Qiu, W. Huang, X. Wang and B.T. Cunningham, Rapid detection of intact SARS-CoV-2 using designer DNA nets and a pocket-size smartphone linked fluorimeter, SSRN, DOI: 10.2139/ssrn.4290284 (2022). Link
57. N. Chauhan, A. Karanastasis, C.K. Ullal and X. Wang*, Homologous pairing in short double-stranded DNA-grafated colloidal microspheres, Biophysical Journal, 121, 4819-4829 (2022). Link
56. Y. Xiong, Q. Huang, T.D. Canady, P. Barya, S. Liu, O.H. Arogundade, C.M. Race, C. Che, X. Wang, L. Zhou, A. Igarashi, X. Wang, M. Kohli, A.M. Smith and B.T. Cunningham, Photonic crystal enhanced quantum dot biosensor for cancer-associated miRNA detection, 2022 IEEE Sensors, 1-4 (2022). Link
55. Y. Xiong, Q. Huang, T.D. Canady, P. Barya, S. Liu, O.H. Arogundade, C.M. Race, C. Che, X. Wang, L. Zhou, X. Wang, M. Kohli, A.M. Smith and B.T. Cunningham, Photonic crystal enhanced fluorescence emission and blinking suppression for single quantum dot digital resolution biosensing, Nature Communications, 13, 4647 (2022). Link
54. Y. Xiong, Q. Huang, T.D. Canady, P. Barya, S. Liu, O.H. Arogundade, C.M. Race, C. Che, X. Wang, L. Zhou, X. Wang, M. Kohli, A.M. Smith and B.T. Cunningham, Photonic crystal enhanced fluorescence emission and blinking suppression for single quantum dot digital resolution biosensing of cancer-associated miRNA biomarkers, CLEO: QELS Fundamental Science, JTh6A.2 (2022). Link
53. N. Chauhan, Y. Xiong, S. Ren, A. Dwivedy, N. Magazine, L. Zhou, X. Jin, T. Zhang, B.T. Cunningham, S. Yao, W. Huang and X. Wang*, Net-shaped DNA nanostructures designed for rapid/sensitive detection and potential inhibition of SARS-CoV-2 virus, Journal of the American Chemical Society, 145, 20214-20228 (2023). Link
52. N. Chauhan, W. Wang, H-K. Lee, Y. Xiong, T. Zhang, N. Magazine, L. Peng, L. Zhou, W. Huang, X. Wang and B.T. Cunningham, V-Pods: rapid, sensitive detection of intact SARS-CoV-2 in saliva using DNA nets and a smartphone-linked fluorimeter, SPIE: Smart Biomedical and Physiological Sensor Technology XIV, 1212306 (2022). Link
51. N. Chauhan, Y. Xiong, S. Ren, A. Dwivedy, N. Magazine, L. Zhou, X. Jin, T. Zhang, B.T. Cunningham, S. Yao, W. Huang and X. Wang*, Net-shaped DNA nanostructures designed for rapid/sensitive detection and potential inhibition of SARS-CoV-2 virus, BioRxiv, DOI: 10.1101/2022.05.04.490692 (2022). Link
50. N. Li, X. Wang, J. Tibbs, T.D. Canady, Q. Huang, G.A. Fried, X. Wang, L. Cooper, L. Rong, Y. Lu and B.T. Cunningham, Photonic resonator interferometric scattering microscopy, SPIE: Integrated Optics: Devices, Materials, and Technologies XXVI, 12004, 136-140 (2022). Link
49. J. Hu, H. Zhe, A. Sokolov, X. Wang and M. Scully, Resolving the sequence of DNA and RNA strands by tip-enhanced Raman spectroscopy, SPIE: Smart Photonic and Optoelectronic Integrated Circuits, PC1200503 (2022). Link
48. B. Chakraborty*, S. Das, A. Gupta, Y. Xiong, V. T V, M. E. Kizer, J. Duan, A.R. Chandrasekaran* and X. Wang*, Aptamers for viral detection and inhibition, ACS Infectious Diseases, 8, 667-692 (2022). Link
47. S. Ren#, K. Fraser#, L. Kuo#, N. Chauhan, A.T. Adrian, F. Zhang, R.J. Linhardt, P.S. Kwon and X. Wang*, Designer DNA nanostructures for viral inhibition, Nature Protocols, 17, 282-326 (2022). Regular link and Open access link
46. N. Li#, X. Wang#, J. Tibbs#, C. Che, A.S. Peinetti, B. Zhao, L. Liu, P. Barya, L. Cooper, L. Rong, X. Wang, Y. Lu and B.T. Cunningham, Label-free digital detection of intact virions by enhanced scattering microscopy, Journal of the American Chemical Society, 144, 1498-1502 (2022). Link
45. N. Li, B. Zhao, R. Stavins, A.S. Peinetti, N. Chauhan, R. Bashir, B.T. Cunningham, W.P. King, Y. Lu, X. Wang and E. Valera, Overcoming the limitations of COVID-19 diagnostics with nanostructures, nucleic acid engineering, and additive manufacturing, Current Opinion in Solid State and Materials Science, 26, 100966 (2022). Link
44. N. Chauhan and X. Wang*, Nanocages for virus inhibition, Nature Materials, 20, 1176-1177 (2021). Regular link and Open access link
An intriguing editorial in the same issue: A molecular jack-of-all-trades. Link
43. Z. He, W. Qiu, Q. M.E. Kizer, J. Wang, A.V. Sokolov, X. Wang*, J. Hu* and M.O. Scully*, Gap mode tip-enhanced and AFM imaging of RNA strands, Conference on Lasers and Electro-Optics, AM1R.3 (2021). Link
41. B.T. Cunningham, T.D. Canady, B. Zhao, S. Ghosh, N. Li, Q. Huang, Y. Xiong, G. Fried, M. Kohli, U. Demirci and X. Wang, Photonic metamaterial surfaces for digital resolution biosensor microscopies using enhanced absorption, scattering, and emission, Proceedings- Integrated Sensors for Biological and Neural Sensing, 11663, 116630K (2021). Link
40. Z. He#, W. Qiu#, M.E. Kizer, J. Wang, W. Chen, A.V. Sokolov, X. Wang*, J. Hu* and M.O. Scully*, Resolving the sequence of RNA strands by tip-enhanced Raman spectroscopy, ACS Photonics, 8, 424-430 (2021). Link
39. X. Wang*, S-J. Kwon, J.S. Dordick, R.J. Linhardt, P.S. Kwon, DNA nanoarchitectures for pattern-recognized targeting of diseases, US Patent, Application number: PCT/US20/33398 (2020). Link
38. J. Duan*, X. Wang* and M.E. Kizer*, Biotechnological and therapeutic applications of natural nucleic acid structural motifs, Topics in Current Chemistry, 378, Article number: 26 (2020). Link
37. P.S. Kwon#, S. Ren#, S-J. Kwon#, M.E. Kizer#, L. Kuo# [...] X. Wang*, Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition, Nature Chemistry, 12, 26-35, DOI: 10.1038/s41557-019-0369-8 (2020). Regular Link and Open access Link
Selected as a journal cover story. Link
The Times-London report. Link
The Scientific American report. Link
Nature Biotechnology report. Link
Nature Materials report. Link
360DX report. Link
FNANO 2020 talk. Link
See PR and news reports from RPI, HMNTL-UIUC, Illinois News Bureau, IGB-UIUC, AIChE, Science & Vie in France, linkresearcher, MDPI Journal-Molecules-Medicinal Chemistry, Clinical OMICs, Cosmos Magazine, Phys.org, Clinical Lab Products, News Wise, Med Gadget, Nano Werk, The Science Advisory Board, AAAS-EurekAlert, Spektrumde, Nanotechnology World Association, News Medical, Precision Vaccinations, Innovations Report, Biotecnika, BioNews Central, Nano.gov, Labroots, Science Buddies, NRC Science, 7thSpace, Long Room, Spektrum, MDLinx, Mirage News, Molecular Laboratory Observer, Asian Campus Tribune, Biotecnika, Nanoer
Harvard Business Review. Link
"Nano comes to life" with Professor Sonia Contera @ Oxford Martin School. YouTube Link.
See the DNA Star Technology. Link
36. N.T. Anderson, S. Ren, J. Chao, P.H. Dinolfo* and X. Wang*, Exploiting plasmon-mediated energy transfer to enhance end-to-end efficiency in a DNA origami energy transfer array, ACS Applied Nano Materials, 2, 5563-5572 (2019). Link
35. V.A. Valsangkar, A.R. Chandrasekaran, L. Zhuo, S. Mao, G.W. Lee, M.E. Kizer, X. Wang, K. Halvorsen and J. Sheng, Click and photo-release dual-functional nucleic acid nanostructures, Chemical Communications, 55, 9709-9712 (2019). Link
34. X. Wang* and J.R. Bracht*, DNA origami nanoparticle delivery of programmed chromosome breakage machinery, US Patent, Patent number: WO/2019/126627, Application number: PCT/US2018/067058 (2019). Link
33. X. Wang#*, A.R. Chandrasekaran#*, et al., Paranemic crossover DNA: there and back again, Chemical Reviews, 119, 6273-6289 (2019). Link
Included in Nucleic Acid Nanotechnology special issue.
32. M.E. Kizer, Nucleic acid nanostructures and biosensors in biotechnological applications, Wang Group PhD Thesis, Rensselaer Polytechnic Institute, ProQuest Dissertations Publishing, 2019. 13811011. Link
31. P.S. Kwon#, S. Ren#, S-J. Kwon#, M.E. Kizer#, L. Kuo#, F. Zhou, F. Zhang, D. Kim, K. Fraser, L.D. Kramer, N.C. Seeman, J.S. Dordick, R.J. Linhardt, J. Chao and X. Wang*, Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition, BioRxiv, DOI: 10.1101/608380 (2019). Link
29. M.E. Kizer#, Y. Deng#, G-Y. Kang, M. Paiyz, X. Wang* and A.J. Chung*, Hydroporator: A hydrodynamic cell membrane perforator for high-throughput vector-free nanomaterial intracellular delivery and DNA origami biostability evaluation, Lab on a Chip, 19, 1747-1754 (2019). Link
First work to truly test the biostability of vanilla DNA nanostructures in live cells.
The work has been selected as a journal cover. Link
28. M. Kizer, I.D. Huntress, B.D. Walcott, K. Fraser, C. Bystroff and X. Wang*, Complex between a multi-crossover DNA nanostructure, PX-DNA, and T7 endonuclease I, Biochemistry, 58, 1332-1342 (2019). Link
27. S. Cheng, P.I. Wantuch, M. Kizer, D.R. Middleton, R. Wang, M. DiBello, M. Li, X. Wang, X. Li, V. Ramachandiran, F.Y. Avci, F. Zhang, X. Zhang and R.J. Linhardt, Glycoconjugate synthesis using chemoselective ligation, Organic & Biomolecular Chemistry, 17, 2646-2650 (2019). Link
26. Z. He, Z. Han, M. Kizer, R.J. Linhardt, X. Wang*, A.M. Sinyukov, J. Wang, V. Deckert, A.V. Sokolov*, J. Hu* and M.O. Scully*, Tip-enhanced Raman imaging of single-stranded DNA with single base resolution, Journal of the American Chemical Society, 141, 753-757 (2019). Link
See the report by Laser Focus World: TERS images single-stranded DNA without amplification. Link
25. M. Kizer, P. Li*, B.F. Cress, L. Lin, T.T. Jing, X. Zhang, K. Xia, R.J. Linhardt* and X. Wang*, RNA aptamers with specificity for heparosan and chondroitin glycosaminoglycans, ACS Omega, 3, 13667-13675 (2018). Link
24. W.F. Hooper, B.D. Walcott, X. Wang and C. Bystroff, Fast design of arbitrary length loops in protein using interactiveRosetta, BMC Bioinformatics, 19, 337-345 (2018). Link
23. N.T. Anderson, DNA-nanostructured modular energy transfer arrays and their enhancement with gold nanoparticles, Wang Group PhD Thesis, Rensselaer Polytechnic Institute, ProQuest Dissertations Publishing, 2018. 10981100. Link
22. Y. Deng, M. Kizer, M. Rada, J. Sage, X. Wang, D-J. Cheon and A.J. Chung, Intracellular delivery of nano materials via an inertial microfluidic cell hydroporator, Nano Letters, 18, 2705-2710 (2018). Link
First work that demonstrates the intracellular delivery of DNA nanostructures. If interested, see the recent Chemical Reviews article by Drs. Stewart, Langer, and Jensen.
21. N. Anderson, P. Dinolfo* and X. Wang*, Synthesis and characterization of porphyrin-DNA constructs for the self-assembly of modular energy transfer arrays, Journal of Materials Chemistry C, 6, 2452-2459 (2018). Link
Selected as a back-cover story.
20. J.S. Khurana, D.M. Clay, S. Moreira, X. Wang and L.F. Landweber, Small RNA-mediated regulation of DNA dosage in the ciliate Oxytricha, RNA, 24, 18-29 (2018). Link
19. K. Halvorsen, M. Kizer, X. Wang, A.R. Chandrasekaran and M. Basanta-Sanchez, Shear dependent LC purification of an engineered DNA nano switch and implications for DNA origami, Analytical Chemistry, 89, 5673-5677 (2017). Link
17. B. Walcott, T. Jing, I. Huntress, M. Kizer, J. Bromley, K. Fraser, C. Bystroff*, X. Wang*, Computational Modeling of the Interface between a Multi-junction DNA Motif and T7 Endonuclease I, Protein Science, 26, 53-54 (2017). Link
16. P. Li, Z. Cao, Z. Wu, X. Wang and X. Li, The effect and action mechanisms of oligochitosan on control of stem dry rot of Zanthoxylum bungeanum, Int. J. Mol. Sci., 17, 1044 (2016). Link
15. A.R. Chandrasekaran*, N. Anderson, M. Kizer, K. Halvorsen and X. Wang*, Beyond the fold, emerging biological applications of DNA origami, ChemBioChem, 17, 1081-1089 (2016). Link
14. Y.P. Ohayon, R. Sha, O. Flint, A.R. Chandrasekaran, H.O. Abdallah, T. Wang, X. Wang, X. Zhang and N.C. Seeman, Topological linkage of DNA tiles bonded by paranemic cohesion, ACS Nano, 9, 10296-10303 (2015). Link
13. Y.P. Ohayon, R. Sha, O. Flint, W. Liu, B. Chakraborty, H.K.K. Subramanian, J. Zheng, A.R. Chandrasekaran, H.O. Abdallah, X. Wang, X. Zhang and N.C. Seeman, Covalent linkage of one-dimensional DNA arrays bonded by paranemic cohesion, ACS Nano, 9, 10304-10312 (2015). Link
12. J.R. Bracht#*, X. Wang#*, K. Shetty, X. Chen, M. Nowacki and L.F. Landweber*, Chromosome fusions triggered by noncoding RNA, Cancer Research, 2015;75(22 Suppl 1):Abstract nr A1-28 (2015). Link
11. J.S. Khurana, X. Wang, X. Chen, D. Perlman and L.F. Landweber, Transcription-independent functions of an RNA Polymerase II subunit, Rpb2, during genome rearrangement in the ciliate, Oxytricha trifallax, Genetics, 197, 839-849 (2014). Link
Before 2014 (10-selected):
10. Fang, Wang, Bracht, Nowacki and Landweber, Piwi-interacting RNAs protect DNA against loss during Oxytricha genome rearrangement, Cell, 151, 1243-1255 (2012). Link
Cell "Small RNAs of opposite sign...but same absolute value" (E. J. Sontheimer).
Princeton Research "Pond-dweller uses tiny tags to mark DNA as non-junk" (C. Zandonella)
08. Lin#, Rinker#, Wang#, Liu, Seeman and Yan, In vivo cloning of artificial DNA nanostructures, Proceedings of the National Academy of Sciences of the United States of America, 105, 17626-17632 (2008). Link
Nature News “Nanotech comes alive” (Philip Ball)
Nature Nanotechnology “DNA nanostructures: Replication with viruses” (Ai Lin Chun)
Nature Methods: “DNA nanostructures go ‘live’” (Research Highlight)
Nature Nanotechnology “Bacteria as factories” (C. Zhang, and C. Mao)
PNAS “Rolling out DNA nanostructuresin vivo” (P. J. Paukstelis, and A. D. Ellington)
Faculty of 1000 Biology (J. Reif)
07. Liu, Wang, Wang, Sha and Seeman, PX DNA triangle oligomerized using a novel three-domain motif, Nano Letters, 8, 317-322 (2008). Link
06. Lin, Wang, Liu, Seeman and Yan, Rolling circle enzymatic replication of a complex multi-crossover DNA nanostructure, Journal of the American Chemical Society, 129,14475-14481 (2007). Link
Faculty of 1000 Biology (J. Zubieta)
05. Wang and Seeman, Assembly and characterization of 8-Arm and 12-Arm DNA branched junctions, Journal of the American Chemical Society, 129, 8169-8176 (2007). Link
04. Constantinous, Wang, Kopatsch, Israel, Zhang, Ding, Sherman, Wang, Zheng, Sha and Seeman, Double cohesion in structural DNA nanotechnology, Organic & Biomolecular Chemistry, 4, 3414-3419 (2006). Link
03. Sha, Zhang, Liao, Constantinou, Ding, Wang, Garibotti, Zhong, Israel, Wang, Wu, Chakraborty, Chen, Zhang, Mao, Yan, Kopatsch, Zheng, Lukeman, Sherman and Seeman, Motifs and methods in structural DNA nanotechnology, Proc. Intl. Conf. Nanomaterials, NANO 2005, July 13-15, 2005, Mepco Schlenk Engineering College, Srivakasi, India, V. Rajendran, ed., 3-10 (2005).
02. Sha, Zhang, Liao, Constantinou, Ding, Wang, Garibotti, Zhong, Israel, Wang, Wu, Chakraborty, Chen, Zhang, Yan, Shen, Shen, Sa-Ardyen, Kopatsch, Zheng, Lukeman, Sherman, Mao, Jonoska and Seeman, Structural DNA Nanotechnology: Molecular construction and composition, Unconventional Computation 2005, LNCS 3699, C. S. Calude et al. Ed., Springer-Verlag Berlin Heidelberg, 20-31 (2005). Link
01. Liu, Wang and Li, Deoligomerization: A New Route to Lactams from Unsaturated Amides via Radical Oligomerization, Organic Letters, 5, 361-363 (2003). Link