56. Morales M, Xue X#. Targeting Iron Metabolism in Cancer Therapy. Theranostics 2021; Jul 25;11(17):8412-8429. PMID: 34373750 PMCID: PMC8344014 DOI: 10.7150/thno.59092 (# Corresponding author)

55. Schwartz AJ, Goyert JW, Solanki S, Kerk S, Chen B, Castillo C, Hsu P, Do B, Singhal R, Dame M, Lee H, Spence J, Lakhal-Littleton S, Vander Heiden MG, Lyssiotis C, Xue X#, Shah Y#. Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells. Nat Metab. 2021Jul;3(7):969-982. PMID: 34155415. PMCID: PMC8316354 (available on 2021-12-21). DOI: 10.1038/s42255-021-00406-7 (# Corresponding author, highlighted by Cancer Discovery with a research watch article “Colorectal Cancer Cells Ectopically Express Hepcidin to Sequester Iron. 2021 Jul 2. PMID: 34215630 DOI: 10.1158/2159-8290.CD-RW2021-092”)

54. Yin K, Lee J, Liu Z, Kim H, Martin DR, Wu D, Liu M, Xue X#. Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production. Cell Death Differ (2021). Aug;28(8):2421-2435. Epub 2021 Mar 15. PMID: 33723373 PMCID: PMC8329176 (available on 2022-08-01) DOI: 10.1038/s41418-021-00760-9 (# Corresponding author, Highlighted by NIEHS Superfund Research Program)

53. Pang R, Zhao J, Gan Z, Hu Z, Xue X, Wu Y, Qiao Q, Zhong A, Xia X, Liao H, Wang Z, Zhang L. Evolution of COVID-19 in patients with autoimmune rheumatic diseases. Aging (Albany NY) 2020 Dec 3;12(23):23427-23435. PMID: 33289698

52. Zheng W, Ma Z, Sun X, Huang Y, Lu B, Chen X, Xue X#, Yang X#, Wu X#. Exposure time determines the protective effect of Trichinella spiralis on experimental colitis. Microb Pathog. 2020;May 20;147:104263. PMID: 32442663 (# Co-corresponding author)

51. Zhang L, Pang R, Xue X, Bao J, Ye S, Dai Y, Zheng Y, Fu Q, Hu Z, Yi Y. Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19. Aging (Albany NY). 2020 Apr 22;12(8):6536-6542. PMID: 32320384 (As of March/April 2021, this Highly cited received enough citations to place it in the top 1% of the academic field of Molecular Biology & Genetics based on a highly cited threshold for the field and publication year.)

50. Zhan M, Qin Y, Xue X, Zhu S.Death from Covid-19 of 23 Health Care Workers in China. N Engl J Med. 2020 Jun 4;382(23):2267-2268. PMID: 32294342. (All four authors contributed equally)

49. Kim H, Xue X#. Detection of Total Reactive Oxygen Species in Adherent Cells by 2',7'-Dichlorodihydrofluorescein Diacetate Staining. J Vis. Exp. 2020 Jun 23;(160). PMID: 32658187 (# Corresponding author)

48. Xue X#, Falcon DM. The role of immune cells and cytokines in intestinal wound healing. Int. J. Mol. Sci. 2019, 20(23), 6097. (# Corresponding author)

47. Kim H, Yin KL, Falcon D, Xue X#. The interaction of Hemin and Sestrin2 Modulates Oxidative Stress and Colon Tumor Growth. Toxicol Appl Pharmacol. 2019 July 1; 374: 77–85. PMID: 31054940 PMCID: PMC6613364 DOI: 10.1016/j.taap.2019.04.025 (# Corresponding author)

46. Ramakrishnan SK, Zhang H, Ma X, Jung I, Schwartz AJ, Triner D, Devenport SN, Das NK, Xue X, Zeng MY, Hu Y, Mortensen RM, Greenson JK, Cascalho M, Wobus CE, Colacino JA, Nunez G, Rui L, Shah YM. Intestinal non-canonical NFκB signaling shapes the local and systemic immune response. Nat Commun. 2019 Feb 8;10(1):660. PMID: 30737385

45. Triner D, Castillo C, Hakim JB, Xue X, Greenson JK, Nuñez G, Chen GY, Colacino JA, Shah YM. Myc-Associated Zinc Finger Protein Regulates the Pro-Inflammatory Response in Colitis and Colon Cancer via STAT3 Signaling. Mol Cell Biol. 2018 Sep 4. pii: MCB.00386-18. PMID: 30181395

44. Dame MK, Attili D, McClintock SD, Dedhia PH, Ouillette P, Hardt O, Chin AM, Xue X, Laliberte J, Katz EL, Newsome GM, Hill DR, Miller AJ, Tsai YH, Agorku D, Altheim CH, Bosio A, Simon B, Samuelson LC, Stoerker JA, Appelman HD, Varani J, Wicha MS, Brenner DE, Shah YM, Spence JR, Colacino JA. Identification, isolation and characterization of human LGR5-positive colon adenoma cells. Development. 2018 Mar 14;145(6). pii: dev153049. PMID: 29467240

43. Park MJ, Iyer S, Xue X, Cunha JB, Gu S, Moons D, Pipe SW, Williams JA, Simeone DM, Shah YM, Omary MB. HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas. Gastroenterology. 2018 May;154(6):1630-1634. PMID: 29409830; PMCID: PMC5927829

42. Sherman M, Madathilparambil S, Dolgachev V, Xue X, Li Z, Machado-Aranda D, Shah Y, Raghavendran K. Molecular Characterization of Hypoxic Alveolar Epithelial Cells Following Lung Contusion Indicates an Important Role for HIF-1α. Ann Surg. 2018 Feb;267(2):382-391. PMID: 27811509

41. Xue X #, Bredell BX, Anderson ER, Martin A, Mays C, Nagao-Kitamoto H, Huang S, Győrffy B, Greenson JK, Hardiman K, Spence JR, Kamada N, Shah YM#. Quantitative Proteomics Identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9608-E9617. PMID: 29078383 PMCID: PMC5692584 DOI: 10.1073/pnas.1712946114 (# Corresponding author)

40. Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med. 2017 Nov;23(11):1298-1308. PMID: 29035368

39. Ma X, Zhang H, Xue X, Shah YM. Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. J Biol Chem. 2017 Oct 13;292(41):17046-17056. PMID: 28848049

38. Huang L, Gong L, Xue X^#, Zhang Y^#. Marine Neurotoxins: a Double-edged Sword in Food Industry and Brain Research. Med One. 2017 Jun 25; 2:e170012. (^#Co-corresponding author) Review.

37. Triner D*, Xue X*, Schwartz AJ, Jung I, Colacino JA, Shah YM. Epithelial hypoxia-inducible factor-2α facilitates the progression of colon tumors through recruiting neutrophils. Mol Cell Biol. 2017 Feb 15;37(5). pii: e00481-16. PMID: 27956697 (*Co-first author, selected as a Spotlight article by the editors)

36. Ji T, Takabayashi H, Mao M, Han X, Xue X, Brazil JC, Eaton KA, Shah YM, Todisco A. Regulation and function of Bone Morphogenetic Protein signaling in colonic injury and inflammation. Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1): G24-G33. PMID: 27856416

35. Xue X, Shah YM. Iron, Cancer and HIF Signaling. Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Chapter 17. 2016 Sep 29; 203-213. Academic Press.

34. Xue X, Ramakrishnan S, Weisz K, Triner D, Xie L, Győrffy B, Zhan M, Carter-Su C, Hardiman KM, Dame M, Varani J, Brenner D, Fearon ER, Shah YM. Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis. Cell Metab. 2016. Sep 13;24(3)447-461. PMID: 27546461. PMCID: PMC5023486 DOI: 10.1016/j.cmet.2016.07.015 (Selected as a Cover Article and highlighted by the journal with a commentary article “The Irony of Tumor-Induced Inflammation. Cell Metab. 2016. Sep 13;24(3)368-369. PMID: 27626194 DOI: 10.1016/j.cmet.2016.08.025”)

33. Bakirtzi K, Law IK, Xue X, Iliopoulos D, Shah YM, and Pothoulakis C. Neurotensin promotes the development of colitis and intestinal angiogenesis via HIF-1α-miR-210 signaling. J Immunol. 2016 May 15;196(10):4311-21.

32. Xue X^#, Jungles K, Onder G, Samhoun J, Győrffy B, Hardiman KM. HIF-3α1 promotes colorectal tumor cell growth by activation of JAK-STAT3 signaling. Oncotarget. 2016 Mar 8;7(10):11567-79. (# Corresponding author)

31. Ro SH*, Xue X*, Ramakrishnan SK, Jang I, Semple IA, Ho A, Park HW, Shah YM and Lee JH. Tumor suppressive role of Sestrin2 during colitis and colon carcinogenesis. Elife. 2016 Feb 25;5:e12204. (*Co-first author) 285.

30. Mori H, Yao Y, Learman SB, Kurozumi K, Ishida J, Ramakrishnan S, Overmyer K, Xue X, Cawthorn W, Reid M, Taylor M, Ning X, Shah Y, MacDougald O. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Sci Rep. 2016 Feb 10; 6:21520.

29. Fu Y, Zheng X, Bao L, Xu K, Cheng X, Sun M, Xue X, Chen H, Yang T, Zhang M. Assessment of physiological factors for the establishment of serum insulin reference intervals in healthy Chinese Han adults: a community-based large cross-sectional study. Scand J Clin Lab Invest. 2015 Mar 5:1-8.

28. Xie L*, Xue X*, Taylor M, Ramakrishnan SK, Nagaoka K, Hao C, Gonzalez FJ, Shah YM. HIF/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin leading to hypoxia-induced inflammation. Mol Cell Biol. 2014 Aug;34(16):3013-23. (*Co-first author)

27. Xue X, Ramakrishnan SK, Shah YM. Activation of HIF-1α does not increase intestinal tumorigenesis. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G187-95.

26. Manna SK, Tanaka N, Krausz KW, Haznadar M, Xue X, Matsubara T, Bowman ED, Fearon ER, Harris CC, Shah YM, Gonzalez FJ. Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans. Gastroenterology. 2014 May;146(5):1313-24. PMID: 24440673 PMCID: PMC3992178

25. Anderson ER, Taylor M, Xue X, Ramakrishnan SK, Martin A, Xie L, Bredell BX, Gardenghi S, Rivella S, Shah YM. Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4922-30.

24. Xue X, Ramakrishnan S, Anderson E, Taylor M, Zimmermann EM, Spence JR, Huang S, Greenson JK, Shah YM. Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice. Gastroenterology. 2013 Oct;145(4):831-41.

23. Xue X, Shah YM. Intestinal iron homeostasis and colon tumorigenesis. Nutrients. 2013 Jun 28;5(7):2333-51. PMID: 23812305 PMCID: PMC3738976 DOI: 10.3390/nu5072333

22. Xue X^#, Shah YM. In vitro organoid culture of primary mouse colon tumors. J Vis Exp. 2013 May 17;(75):e50210. PMID: 23711911 PMCID: PMC3684363 DOI: 10.3791/50210 (# Corresponding author)

21. Xue X, Shah YM. Hypoxia-inducible factor-2α is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer. Carcinogenesis. 2013 Jan;34(1):163-9.

20. Wu XX, Xue X, Tang J, Cheng X, Tian WJ, Jiang R, Zang RY. Evaluation of risk factors for venous thromboembolism in Chinese women with epithelial ovarian cancer. Int J Gynecol Cancer 2013 Jan;23(1):65-72.

19. Anderson E, Taylor M, Xue X, Martin A, Moons D, Omary BM, Shah Y. The HIF-C/EBPα Axis Controls Ethanol-Mediated Hepcidin Repression. Mol Cell Biol. 2012 Oct;32(19):4068-77.

18. Liu X*, Xue X*, Gong L, Qi X, Wu Y, Xing G, Luan Y, Xiao Y, Wu X, Li Y, Chen M, Miao LL, Yao J, Gu J, Lin DH, Ren J. ¹H NMR-Based Metabolomic Analysis of Triptolide-Induced Toxicity in Liver-Specific Cytochrome P450 Reductase Knockout Mice. Metabolomics. 2012 Oct 1; 8(5): 907-918. (*Co-first author)

17. Xue X, Taylor M, Anderson E, Hao C, Qu A, Greenson JK, Zimmermann EM, Gonzalez FJ, Shah YM. Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res. 2012 May 1;72(9):2285-93. PMID: 22419665. PMCID: PMC3342485 DOI: 10.1158/0008-5472.CAN-11-3836

16. Xue X, Gong LK, Maeda K, Qi XM, Luan Y, Sugiyama Y, Ren J. Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid I. Mol Pharm. 2011 Dec 5;8(6):2183-92.

15. Qu A, Taylor M, Xue X, Matsubara T, Metzger D, Chambon P, Gonzalez FJ and Shah YM. Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation and fibrosis. Hepatology. 2011 Aug;54(2):472-83.

14. Xue X, Gong L, Qi X, Wu Y, Xing G, Yao J, Luan Y, Xiao Y, Li Y, Wu X, Chen M, Gu J, Ren J. Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity. Toxicol Lett. 2011 Aug 10;205(1):47-54.

13. Chen M, Gong L, Qi X, Xing G, Luan Y, Wu Y, Xiao Y, Yao J, Li Y, Xue X, Pan G, Ren J. Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity. Toxicol Sci. 2011 Aug;122(2):288-96.

12. Anderson ER, Xue X, and Shah YM. Intestinal Hypoxia-Inducible Factor (Hif)-2α Is Critical For Efficient Erythropoiesis. J Biol Chem. 2011 Jun 3;286(22):19533-40.

11. Li Y, Luan Y, Qi X, Li M, Gong L, Xue X, Wu X, Wu Y, Chen M, Xing G, Yao J, Ren J. Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II. Toxicol Sci. 2010 Dec;118(2):435-43.

10. Xue X, Gong LK, Ren J. [Progress of the study of mechanism on drug induced kidney injury]. Yao Xue Xue Bao. 2010 Oct;45(10):1199-204. Review. PubMed PMID: 21348296.

9. Xiao Y*, Xue X*, Wu YF, Xing GZ, Qian Y, Xie TP, Gong LK, Ren J. β-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism. Acta Pharmacol Sin. 2009 Nov; 30(11):1559-65. (*Co-first author)

8. Li Y, Qi XM, Xue X, Wu XF, Wu YF, Chen M, Xing GZ, Luan Y, Ren J. The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury. Toxicol Lett. 2009 Apr 25; 186(2):111-4.

7. Xue X, Xiao Y, Zhu H, Wang H, Liu Y, Xie T, Ren J. Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury. Nephrol Dial Transplant. 2008 Oct; 23(10):3074-81.

6. Xue X, Xiao Y, Gong L, Guan S, Liu Y, Lu H, Qi X, Zhang Y, Li Y, Wu X, Ren J. Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice. J Ethnopharmacol. 2008 Sep 2; 119(1):87-93.

5. Zhang Y, Qi X, Gong L, Li Y, Liu L, Xue X, Xiao Y, Wu X, Ren J. Roles of reactive oxygen species and MAP kinases in the primary rat hepatocytes death induced by toosendanin. Toxicology. 2008 Jul 10; 249(1):62-8.

4. Xiao Y, Ge M, Xue X, Wang C, Wang H, Wu X, Li L, Liu L, Qi X, Zhang Y, Li Y, Luo H, Xie T, Gu J, Ren J. Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity. Kidney Int. 2008 Jun; 73(11):1231-9.

3. Liu LL, Gong LK, Wang H, Xiao Y, Wu XF, Zhang YH, Xue X, Qi XM, Ren J. Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock. Biochem Pharmacol. 2008 Feb 15;75(4):914-22.

2. Qi X, Cai Y, Gong L, Liu L, Chen F, Xiao Y, Wu X, Li Y, Xue X, Ren J. Role of mitochondrial permeability transition in human renal tubular epithelial cell death induced by aristolochic acid. Toxicol Appl Pharmacol. 2007 Jul 1; 222(1):105-10.

1. Liu LL, Gong LK, Wang H, Xiao Y, Wu XF, Zhang YH, Xue X, Qi XM, Ren J. Baicalin protects mouse from Concanavalin A-induced liver injury through inhibition of cytokine production and hepatocyte apoptosis. Liver Int. 2007 May; 27(4):582-91.