Publications
Journal Covers
Publications (*Wooster undergraduate, †authors contributed equally)
20. West, J.D. (2022) Experimental Approaches for Investigating Disulfide-Based Redox Relays in Cells. Chem. Res. Toxicol., in press (invited review manuscript)
19. Freije, B.J.,* Freije, W.M.,* Do, T.U.,* Adkins, G.E.,* Bruch, A., Hurtig, J.E.,* Morano, K.A., Schaffrath, R. and West, J.D. (2022) Identifying Interaction Partners of Yeast Protein Disulfide Isomerases Using a Small Thiol-Reactive Cross-Linker: Implications for Secretory Pathway Proteostasis. Chem. Res. Toxicol., 35, 326-336.
18. Vicker, S.L.,*,† Maina, E.N.,*,† Showalter, A.K.,*,† Bailey, M.R.,* McGarry, S.W.,* Tran, N.,* Davidson, E.E.,* Freije, W.M.,* and West, J.D. (2022) Broader than Expected Tolerance for Substitutions in the WCGPCK Catalytic Motif of Yeast Thioredoxin 2. Free Radic. Biol. Med., 178, 308-313.
17. Kaduhr, L., Brachmann, C., Ravichandran, K.E., West, J.D., Glatt, S., and Schaffrath, R. (2021) Urm1, not quite a ubiquitin-like modifier? Microb. Cell, 8, 256-261.
16. Brachmann, C., Kaduhr, L., Judes, A., Ravichandran, K.E., West, J.D., Glatt, S., and Schaffrath, R. (2020) Redox requirements for ubiquitin-like urmylation of Ahp1, a 2-Cys peroxiredoxin from yeast. Redox Biol. 30, 101438.
15. Loberg, M.A.,* Hurtig, J.E.,* Graff, A.H., Allan, K.M.,* Buchan, J.A.,* Spencer, M.K.,* Kelly, J.E.,* Clodfelter, J.E., Morano, K.A., Lowther, W.T., and West, J.D. (2019) Aromatic Residues at the Dimer-Dimer Interface in the Peroxiredoxin Tsa1 Facilitate Decamer Formation and Biological Function. Chem. Res. Toxicol. 32, 474-483.
14. West, J.D., Roston, T.J.,* David, J.B.,* Allan, K.M.,* and Loberg, M.A.* (2018) Piecing Together How Peroxiredoxins Maintain Genomic Stability. Antioxidants 7, 177. (review)
13. Allan, K.M.,* Loberg, M.A.,* Chepngeno, J.,* Hurtig, J.E.,* Tripathi, S.,* Kang, M.G.,* Allotey, J.K.,* Widdershins, A.H.,* Pilat, J.M.,* Sizek, H.J.,* Murphy, W.J.,* Naticchia, M.R.,* David, J.B.,* Morano, K.A., and West, J.D. (2016) Trapping Redox Partnerships in Oxidant-Sensitive Proteins with a Small, Thiol-Reactive Cross-Linker. Free Radic. Biol. Med. 101, 356-366.
12. Spencer, M.K.,* Radzinski, N.P.,* Tripathi, S., Chowdhury, S., Herrin, R.P., Chandran, N.N., Daniel, A.K., and West, J.D. (2013) Pronounced Toxicity Differences between Homobifunctional Protein Cross-Linkers and Analogous Monofunctional Electrophiles. Chem. Res. Toxicol. 26, 1720-1729.
11. Naticchia, M.R.,* Brown, H.A.,* Garcia, F.J.,* Lamade, A.M.,* Justice, S.L.,* Herrin, R.P.,* Morano, K.A., and West, J.D. (2013) Bifunctional Electrophiles Cross-Link Thioredoxins with Redox Relay Partners in Cells. Chem. Res. Toxicol. 26, 490-497.
10. West, J.D., Wang, Y., and Morano, K.A. (2012) Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise. Chem. Res. Toxicol. 25, 2036-2053. (featured review)
9. Wang, Y., Gibney, P.A., West, J.D., and Morano, K.A. (2012) The yeast Hsp70 Ssa1 is a sensor for heat shock response activation by thiol-reactive compounds. Mol. Biol. Cell 23, 3290-3298. (highlighted article)
8. West, J.D., Stamm, C.E.,* Brown, H.A.,* Justice, S.L.,* and Morano, K.A. (2011) Enhanced Toxicity of the Protein Cross-Linkers Divinyl Sulfone and Diethyl Acetylenedicarboxylate in Comparison to Related Monofunctional Electrophiles. Chem. Res. Toxicol. 24, 1457-1459.
7. West, J.D. , Stamm, C.E.,* and Kingsley, P.J.* (2011) Structure-Activity Comparison of the Cytotoxic Properties of Diethylmaleate and Related Molecules: Identification of Diethyl Acetylenedicarboxylate as a Thiol Cross-Linking Agent. Chem. Res. Toxicol. 24, 81-88.
6. Trott, A.†, West, J.D.†, Klaić, L., Westerheide, S.D., Silverman, R.B., Morimoto, R.I., and Morano, K.A. (2008) Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-Targeted Molecule. Mol. Biol. Cell, 19, 1104-1112.
5. West, J.D. and Marnett, L.J. (2006) Reactive Intermediates as Modulators of Cell Signaling and Cell Death. Chem. Res. Toxicol. 19, 173-194. (featured review)
4. West, J.D. and Marnett, L.J. (2005) Alterations in Global Gene Expression Induced by the Lipid Peroxidation Product, 4-Hydroxy-2-nonenal. Chem. Res. Toxicol. 18, 1642-1653.
3. West, J.D., Ji, C., and Marnett, L.J. (2005) Modulation of DNA Fragmentation Factor 40 Nuclease Activity by Poly(ADP-Ribose) Polymerase-1. J. Biol. Chem. 280, 15141-15147.
2. West, J.D., Ji, C., Amarnath, V., Schneider, C., Duncan, S., Rizzo, C.J., Brash, A.R., and Marnett, L.J. (2004) Induction of Apoptosis in Colorectal Carcinoma Cells Treated with 4-Hydroxy-2-nonenal and Related Compounds. Chem. Res. Toxicol. 17, 453-462.
1. Marnett, L.J., Riggins, J.N., and West, J.D. (2003) Endogenous Generation of Reactive Oxidants and Electrophiles and Their Reactions with DNA and Protein. J. Clin. Invest. 111, 583-593. (invited review)