Publications

Tønnesen J, Inavalli VVGK, Nägerl UV. Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue. Cell. 2018 (Highlighted in Nat Methods)

Tønnesen J, Katona G, Rózsa B, Nägerl UV. Spine neck plasticity regulates compartmentalization of synapses. Nat Neurosci. 2014

Tønnesen J, Nadrigny F, Willig KI, Wedlich-Söldner R, Nägerl UV. Two-color STED microscopy of living synapses using a single laser-beam pair. Biophys J. 2011 (F1000 recommended; Highlighted in Nat Methods)

Tønnesen J, Parish CL, Sørensen AT, Andersson A, Lundberg C, Deisseroth K, Arenas E, Lindvall O, Kokaia M. Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model. PLoS One. 2011 (Top 10% cited on Plos One)

Tønnesen J, Sørensen AT, Deisseroth K, Lundberg C, Kokaia M. Optogenetic control of epileptiform activity. Proc Natl Acad Sci U S A. 2009

Krishna Inavalli VVG, Puente Muñoz V, Draffin J, Tønnesen J. Fluorescence Microscopy Shadow Imaging for Neuroscience. Frontiers in Cellular Neuroscience. 2024 Link

Tønnesen J, Hrabĕtová S, Soria FN. Local diffusion in the extracellular space of the brain. Neurobiology of Disease. 2023 Link

Mora-Jimenez L, Valencia M, Sanchez-Carpintero R, Tønnesen J, Fadila S, Rubinstein M, Gonzalez-Aparicio M, Bunuales M, Fernandez-Pierola E, Jesus Nicolas M, Puerta E, Miguelez C, Gimenez P, Lumbreras S, Gonzalez-Aseguinolaza G, Ricobaraza A, Hernandez-Alcoceba R. Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations. Molecular Therapy - Nucleic Acids. 2021 Link

Calovi S, Soria FN, Tønnesen J. Super-resolution STED microscopy in live brain tissue. Neurobiology of Disease. 2021  Link

Calovi S, Mut-Arbona P, Tod P, Iring A, Nicke A, Mato S, Vizi ES, Tønnesen J, Sperlagh B. P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia. Frontiers in Molecular Neuroscience. 2020

Soria FN, Miguelez C, Peñagarikano O, Tønnesen J. Current Techniques for Investigating the Brain Extracellular Space. Frontiers in Neuroscience. 2020

Sierra-Arregui T, Llorente J, Giménez Minguez P, Tønnesen J, Peñagarikano O. Neurobiological Mechanisms of Autism Spectrum Disorder and Epilepsy, Insights from Animal Models. Neuroscience. 2020 

Levet F, Tønnesen J, Nägerl UV, Sibarita JB. SpineJ: A software tool for quantitative analysis of nanoscale spine morphology. Methods. 2020

Inavalli VVGK, Lenz MO, Butler C, Angibaud J, Compans B, Levet F, Tønnesen J, Rossier O, Giannone G, Thoumine O, Hosy E, Choquet D, Sibarita JB, Nägerl UV. A super-resolution platform for correlative live single-molecule imaging and STED microscopy. Nat Methods. 2019

Tønnesen J, Inavalli VVGK, Nägerl UV. Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue. Cell. 2018

Tønnesen J, Kokaia M. Epilepsy and optogenetics: can seizures be controlled by light? Clin Sci (Lond). 2017

Tønnesen J, Nägerl UV. Dendritic Spines as Tunable Regulators of Synaptic Signals. Front Psychiatry. 2016

Mohapatra N, Tønnesen J, Vlachos A, Kuner T, Deller T, Nägerl UV, Santamaria F, Jedlicka P. Spines slow down dendritic chloride diffusion and affect short-term ionic plasticity of GABAergic inhibition. Sci Rep. 2016

Chéreau R, Tønnesen J, Nägerl UV. STED microscopy for nanoscale imaging in living brain slices. Methods. 2015

Tønnesen J, Katona G, Rózsa B, Nägerl UV. Spine neck plasticity regulates compartmentalization of synapses. Nat Neurosci. 2014

Tønnesen J. Optogenetic cell control in experimental models of neurological disorders. Behav Brain Res. 2013

Tønnesen J, Nägerl UV. Superresolution imaging for neuroscience. Exp Neurol. 2013

Seiz EG, Ramos-Gómez M, Courtois ET, Tønnesen J, Kokaia M, Liste Noya I, Martínez-Serrano A. Human midbrain precursors activate the expected developmental genetic program and differentiate long-term to functional A9 dopamine neurons in vitro. Enhancement by Bcl-X(L). Exp Cell Res. 2012

Tønnesen J, Nadrigny F, Willig KI, Wedlich-Söldner R, Nägerl UV. Two-color STED microscopy of living synapses using a single laser-beam pair. Biophys J. 2011

Tønnesen J, Parish CL, Sørensen AT, Andersson A, Lundberg C, Deisseroth K, Arenas E, Lindvall O, Kokaia M. Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model. PLoS One. 2011 

Tønnesen J, Seiz EG, Ramos M, Lindvall O, Martinez-Serrano A, Kokaia M. Functional properties of the human ventral mesencephalic neural stem cell line hVM1. Exp Neurol. 2010

Tønnesen J, Sørensen AT, Deisseroth K, Lundberg C, Kokaia M. Optogenetic control of epileptiform activity. Proc Natl Acad Sci U S A. 2009

Parish CL, Castelo-Branco G, Rawal N, Tonnesen J, Sorensen AT, Salto C, Kokaia M, Lindvall O, Arenas E. Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. J Clin Invest. 2008

Tonnesen J, Pryds A, Larsen EH, Paulson OB, Hauerberg J, Knudsen GM. Laser Doppler flowmetry is valid for measurement of cerebral blood flow autoregulation lower limit in rats. Exp Physiol. 2005 

Pryds A, Tønnesen J, Pryds O, Knudsen GM, Greisen G. Cerebral pressure autoregulation and vasoreactivity in the newborn rat. Pediatr Res. 2005

Rasmussen M, Zhu W, Tønnesen J, Cadet P, Tønnesen E, Stefano GB. Effects of morphine on tumour growth. Neuro Endocrinol Lett. 2002

Mantione K, Zhu W, Rialas C, Casares F, Cadet P, Franklin AL, Tonnesen J, Stefano GB. Morphine 6 glucuronide stimulates nitric oxide release in mussel neural tissues: evidence for a morphine 6 glucuronide opiate receptor subtype. Cell Mol Life Sci. 2002

Lenz MO & Tønnesen J. Considerations for Imaging and Analyzing Neural Structures by STED Microscopy (2019). In Glutamate Receptors. Methods in Molecular Biology. Humana Press.

Tønnesen J, Ledri M & Kokaia M. Toward an Optogenetic Therapy for Epilepsy (2017). In Optogenetics: From Neuronal Function to Mapping and Disease Biology. Cambridge University Press. 

Tønnesen J & Nägerl U V. Two-color STED imaging of synapses in living brain slices (2013). In Methods in Molecular Biology. Humana Press.

Tønnesen J & Kokaia M. Stem-Cell-Based Cell-Replacement Therapy in Parkinson’s Disease (2013). In RSC Drug Discovery: Emerging Drugs and Targets for Parkinson’s Disease. 

Tønnesen J & Kokaia M. Electrophysiological investigations of synaptic connectivity between host and graft neurons (2012). In Prog Brain Res.

Arizono M, Bancelin S, Bethge P, Chéreau R, Idziak A, Inavalli K.V.V.G. , Pfeiffer T, Tønnesen J and Nägerl UV. Nanoscale imaging of the functional anatomy of the brain. Neuroforum. 2021.

Tønnesen J. Methods - Progress in super-resolution fluorescence microscopy (Editorial). Methods. 2020

Lissek T, Adams M, Adelman J, ... , Stuart G, Südhof TC, Tønnesen J, ... , Hasan MT. Building Bridges through Science. Neuron. 2017 

I Vedarethinam, N Avaliani, J Tønnesen, J Hansen, D Sabourin, M Dimaki, M Kokaia, M Dufva, WE Svendsen, J Emnéus, A Heiskanen. Long-term brain slice culturing in a microfluidic platform (2011). Proc. 37th International Conference on Micro and Nano Engineering

A Heiskanen, C Spegel, J Tønnesen, Z Fohlerova, L FS Goulart, JS Hansen, M Kokaia, T Ruzgas, H M Dufva, J Emnéus. Development of a Microfluidic On-Line Culture System for Combined Electrochemical and Optical Real-Time Detection of Cellular Processes (2008). Proc. 12th International Conference of Miniaturized Systems for Chemistry and Life Sciences (µTAS)