論文 / Journal

Journal Papers

1. *渡部 媛珠, 下条 裕, 新宮 麻子, 伊東 秀典, 福原 秀雄, 三宅 牧人, 井上 啓史, 藤本 清秀, *西村 隆宏: 上部尿路上皮癌の光線力学治療に向けた組織内光伝搬のin silico評価, 日本レーザー医学会誌 46, 108 (2025).

2. *Yu Shimojo, Takahiro Nishimura, Daisuke Tsuruta, Toshiyuki Ozawa, Taro Kono: Association between irradiation parameters and outcomes for picosecond laser treatment of nevus of Ota: An in-silico-supported meta-analysis. JAAD Reviews, 5, 82-90 (2025). 

3. *Takahiro Nishimura, Yusuke Watanabe, Yu Shimojo, Toshiyuki Ozawa, Daisuke Tsuruta: In silico design of blue laser soft tissue vaporization with optimized optical power efficiency and mitigated thermal side effects. Lasers in Medical Science 40, 273 (2025).

4. *Gakuto Takeda, *Yu Shimojo, Toshiyuki Ozawa, Takahiro Nishimura: Spatial distribution of light-melanosome interaction dependent on irradiation fluence and spot size for short-pulsed laser skin treatment: A phantom study, Lasers in Medical Science  40, 251 (2025).

5. *Tomohiro Osaki, Hikaru Shiomi, Takahiro Nishimura, Kei Sakanoue, Kazuhiro Eguchi, Yutaka Miyazono, Ryoichi Yamaguchi, Katsuhiko Fujita, Kenji Kuwata Naoki Kobayashi, Tsuyoshi Goya, Katsuyuki Morii, Urara Ota, Hideo Imazato, Kiwamu Takahashi, Masahiro Ishizuka: 5-Aminolevulinic Acid-Mediated Metronomic Photodynamic Therapy for Mouse Mammary Tumors, Yonago Acta Medic, 68(2), 114-122 (2025).

6. *Y. Shimojo, Y. Morizane, T. Sonokawa, J. Usuda, *T. Nishimura: Optical characteristics of human lung cancer for photodynamic therapy with measured absorption and reduced scattering coefficients. Journal of Biomedical Optics, 30, 048001 (2025).

7. *J. Jiracheewee, Y. Shimojo, *T. Nishimura: Persistent homology-based optical properties of microscopic turbid media for realistic light propagation analysis. Biomedical Optics Express, 16, 1651-1665 (2025).

8. *Yu Shimojo, Takahiro Nishimura, Daisuke Tsuruta, Toshiyuki Ozawa, Taro Kono: "In silico evaluation of nanosecond laser treatment of pigmented lesions based on skin optical properties using a model of melanosome disruption threshold fluence.", Lasers in Surgery and Medicine, 57, 130-140 (2025). 

9. *H. Fukuhara, T. Nishimura, Y. Shimojo, K. Inoue: "Comparison of fluorescence intensity of protoporphyrin IX as observed on the screen of different cystoscopic systems.", Photodiagnosis and Photodynamic Therapy, 51, 104425 (2025). 

10. H. Watabe, *Y. Shimojo, A. Shingu, H. Ito, H. Fukuhara, M. Miyake, K. Inoue, K. Fujimoto, *T. Nishimura: "Measurement of tissue optical properties in the 400–700 nm range to assess light penetration depths for laser treatment of upper tract urothelial carcinomas.", Journal of Biomedical Optics, 29, 125001(2024). 

11. *Y. Shimojo, *T. Nishimura, D. Tsuruta, T. Ozawa: "Ultralow radiant exposure of a short-pulsed laser to disrupt melanosomes with localized thermal damage through a turbid medium.", Scientific Reports, 14, 20112 (2024). 

12. *Naoya Tate, Seiya Yamaguchi, Shunichi Sakai, Suguru Shimomura, Takahiro Nishimura, Jun Kozuka, Yusuke Ogura, and Jun Tanida, ''Demonstration of quantum dot reservoir computing based on spatio-temporal optical processing,'' Applied Optics 63 (28): G30-G36 (2024).

13. *Y. Shimojo, T. Nishimura, D. Tsuruta, T. Ozawa, H. H. L. Chan, T. Kono, ''Wavelength‐dependent threshold fluences for melanosome disruption to evaluate the treatment of pigmented lesions with 532‐, 730‐, 755‐, 785‐, and 1064‐nm picosecond lasers,'' Lasers in Surgery and Medicine 56(4): 404--418 (2024) [プレスリリース、EurekAlert!他掲載].

14. *Yusaku Takai, *Takahiro Nishimura, Yu Shimojo, Kunio Awazu: "Artificial neural network-based determination of denoised optical properties in double integrating spheres measurement," Journal of Innovative Optical Health Sciences 16(6):2350012 (2023). 

15. *Sochi Ogbonna, William Y. York, *Takahiro Nishimura, Hisanao Hazama, Hideo Fukuhara, Keiji Inoue, and Kunio Awazu: "Increased fluorescence observation intensity during the photodynamic diagnosis of deeply located tumors by fluorescence photoswitching of protoporphyrin IX," Journal of Biomedical Optics 28(5):055001 (2023). 

16. Hinano Imanishi, *Takahiro Nishimura, Yu Shimojo, and Kunio Awazu: "Deep learning based depth map estimation of protoporphyrin IX in turbid media using dual wavelength excitation fluorescence, "Biomed. Opt. Express 14:5254-5266 (2023). 

17. *Yu Shimojo, Kazuma Sudo, *Takahiro Nishimura, Toshiyuki Ozawa, Daisuke Tsuruta, Kunio Awazu: "Transient simulation of laser ablation based on Monte Carlo light transport with dynamic optical properties model, "Scientific Reports 13(1):11898 (2023). 

18. *Yuto Miyoshi, *Takahiro Nishimura, Yu Shimojo, Keita Okayama, Kunio Awazu: "Endoscopic image-guided laser treatment system based on fiber bundle laser steering," Scientific Reports 13(1):2921 (2023). 

19. *Yu Shimojo, *Takahiro Nishimura, Toshiyuki Ozawa, Daisuke Tsuruta, Kunio Awazu: "Nonlinear absorption-based analysis of energy deposition in melanosomes for 532-nm short-pulsed laser skin treatment," Lasers in Surgery and Medicine 55(3):305-315 (2023). 

20. *Naoya Tate, Yuki Miyata, Shun-ichi Sakai, Akihiro Nakamura, Suguru Shimomura, Takahiro Nishimura, Jun Kozuka, Yusuke Ogura, Jun Tanida: “Quantitative analysis of nonlinear optical input/output of a quantum-dot network based on the echo state property,” Optics Express 30: 14669-14676 (2022)

21. *Takahiro Nishimura, Takuro Suzuki, Yu Shimojo, Rie Teranishi, Toshiyuki Ozawa, Daisuke Tsuruta, Kunio Awazu: "Mathematical modelling for antimicrobial photodynamic therapy mediated by 5-aminolaevulinic acid: an in vitro study," Photodiagnosis and Photodynamic Therapy 40:103116 (2022). 

22. *Hinano Imanishi, *Takahiro Nishimura, Kunio Awazu: "Depth estimation of protoporphyrin IX objects in turbid media considering the fluorescence intensity ratio between two wavelengths of light for applicationin invasive diagnosis of gastric cancer," Optical Review 29:310-319 (2022).  

23. *Kazuma Sudo, Yu Shimojo, *Takahiro Nishimura, Kunio Awazu: "Three-dimensional transient simulation of CO2 laser tissue vaporization and experimental evaluation with a hydrogel phantom," Journal of Innovative Optical Health Sciences (2022).

24. *下条裕, *西村隆宏, 粟津邦男, “XCAVATOR ファイバーによる接触式レーザー蒸散術のブタ前立腺組織を用いた熱影響解析,” 日本レーザー医学会誌42(4):219-227 (2022)．

25. *Yu Shimojo, *Takahiro Nishimura, Hisanao Hazama, Nobuhisa Ito, Kunio Awazu: "Incident Fluence Analysis for 755-nm Picosecond Laser Treatment of Pigmented Skin Lesions Based on Threshold Fluences for Melanosome Disruption," Lasers in Surgery and Medicine 53(8):1096-1104 (2021).

26. *冨岡穣, 守顕大, *西村隆宏, 臼田実男, 粟津邦男, “光伝搬シミュレーションに基づく末梢型肺癌に対する光線力学治療用プローブの比較評価,” 日本レーザー医学会誌42(2):37-43 (2021). [selected as ”令和4年度日本レーザー医学会奨励賞”].

27. *Takahiro Nishimura, Yusaku Takai, Yu Shimojo, Hisanao Hazama, Kunio Awazu: "Determination of optical properties in double integrated sphere measurement by artificial neural network based method," Optical Review 28(1):42-47 (2021).

28. *滝島 裕貴, 井原 大祐, *西村 隆宏, 間 久直, 粟津 邦男: "膀胱癌に対するアミノレブリン酸光線力学診断における診断深度拡張に向けた励起光波長の検討" 日本レーザー医学会誌 41(4), 297-306 (2021) [令和3年度日本レーザー医学会論文賞].

29. *Masaki Nakagawa, Yuki Miyata, Naoya Tate, Takahiro Nishimura, Suguru Shimomura, Sho Shirasaka, *Jun Tanida, *Hideyuki Suzuki: "Spatiotemporal model for FRET networks with multiple donors and acceptors: multicomponent exponential decay derived from the master equation," Journal of the Optical Society of America B 38(2): 294-299 (2021).

30. *Yu Shimojo, *Takahiro Nishimura, Hisanao Hazama, Nobuhisa Ito, Kunio Awazu, "Picosecond Laser-Induced Photothermal Skin Damage Evaluation by Computational Clinical Trial," Laser Therapy 29(1):61-72 (2020).

31. *Takahiro Nishimura, Keisuke Hara, Norihiro Honda, Shigetoshi Okazaki, Hisanao Hazama, Kunio Awazu: "Determination and analysis of singlet oxygen quantum yields of talaporfin sodium, protoporphyrin IX, and lipidated protoporphyrin IX using near-infrared luminescence spectroscopy," Lasers in Medical Science 35(6):1289–1297 (2020).

32. *西村 隆宏, 下条 裕, 粟津 邦男, レーザー治療における計算機援用レギュラトリーサイエンス, 日本レーザー医学会誌 41(1): 37-43 (2020).

33. *Suguru Shimomura, Takahiro Nishimura, Yuki Miyata, Naoya Tate, Yusuke Ogura, Jun Tanida: "Spectral and temporal optical signal generation using randomly distributed quantum dots," Optical Review 27: 264-269 (2020).

34. *Jinya Inoue, Takahiro Nishimura, *Yusuke Ogura, Jun Tanida: "Nanoscale Optical Logic Circuits by Single-Step FRET," IEEE Photonics Journal 12(2): 1-12 (2020).

35. *Y. Shimojo, *T. Nishimura, H. Hazama, T. Ozawa, K. Awazu, "Measurement of absorption and reduced scattering coefficients in Asian human epidermis, dermis, and subcutaneous fat tissues in the 400- to 1100-nm wavelength range for optical penetration depth and energy deposition analysis," Journal of Biomedical Optics 25 (4), 045002 (2020).

36. *D. Ihara, H. Hazama, *T. Nishimura, Y. Morita, K. Awazu, "Fluorescence detection of deep intramucosal cancer excited by green light for photodynamic diagnosis using protoporphyrin IX induced by 5-aminolevulinic acid: an ex vivo study," Journal of Biomedical Optics 25(6), 063809 (2020).

37. *T. Nishimura, Y. Shimojo, H. Hazama, K. Awazu, "A Method of Computational Clinical Trial of a Nanosecond Pulsed Laser Skin Treatment Device by Numerical Simulation of Photothermal Damage," Journal of Japan Society for Laser Surgery and Medicine 40(4):301-308 (2020). [in Japanese]

38. *M. Yamashita, T. Osaki, Y. Sunden, S. Saito, M. Inai, N. Honda, T. Nishimura, H. Hazama, K. Awazu, Y. Kaneda, Y. Okamoto, "Histological Changes of Feline Mammary Carcinoma Treated by NPe6 HVJ-E PDT," Journal of Japan Society for Laser Surgery and Medicine 40(4):403-407 (2020). [in Japanese] 

39. *T. Noguchi, H. Hazama, T. Nishimura, Y. Morita, K. Awazu, " Enhancement of the safety and efficacy of colorectal endoscopic submucosal dissection using a CO2 laser," Lasers in Medical Science 35, 421-427 (2020).

40. *S. Shimomura, T. Nishimura, Y. Ogura, J. Tanida: "Optical decomposition of DNA gel and modification of object mobility on micrometre scale," Scientific Reports 9(1), 19858 (2019).

41. *A. Izumoto, *T. Nishimura, H. Hazama, N. Ikeda, Y. Kajimoto, K. Awazu, "Singlet oxygen model evaluation of interstitial photodynamic therapy with 5-aminolevulinic acid for malignant brain tumor," Journal of Biomedical Optics 25(6):063803 (2019).

42. *T. Nishimura, H. Kimura, Y. Ogura, and J. Tanida, “Experimental assessment and analysis of super resolution in fluorescence microscopy based on multiple-point spread function fitting of spectrally demultiplexed images ," Optical Review 25, pp. 384–390 (2018).

43. *S. Shimomura, T. Nishimura, H. Kimura, Y. Ogura, and J. Tanida, “Photothermal Fabrication of Microscale Patterned DNA Hydrogels,” Royal Society Open Science 5, pp.171779 (2018).

44. *T. Nishimura, H. Kimura, Y. Ogura, and J. Tanida, “Fluorescence encoded super resolution imaging based on a location estimation algorithm for high-density fluorescence probes," Optical Review 24, pp. 212–218 (2017).

45. *T. Nishimura, Y. Ogura, and J. Tanida, “Multiplexed fluorescence readout using time responses of color coded signals for biomolecular detection," Biomedical Optics Express 7, pp. 5284-5293 (2016).

46. *Y. Ogura, A. Onishi, T. Nishimura, and Jun Tanida, “Optically controlled release of DNA based on nonradiative relaxation process of quenchers," Biomedical Optics Express 7, pp. 2142-2153 (2016).

47. *T. Nishimura, R. Fujii, Y. Ogura, and Jun Tanida, “Optically controllable molecular logic circuits," Applied Physics Letters 107, 013701 (2015) [Editor's picks].

48. R. Fujii, T. Nishimura, *Y. Ogura, and Jun Tanida, “Nanoscale energy-route selector consisting of multiple photo-switchable fluorescence-resonance-energy-transfer structures on DNA," Optical Review 22, 316-321 (2015).

49. *横山萌恵, 西村隆宏, 山田憲嗣, 丁憙勇, 木戸倫子, 櫻井芳昭, 大野ゆう子, ”ポイントオブケア治療薬物モニタリングに向けた紙製基板を用いた涙液ラマン分光法の可能性,” 看護理工学会誌2, 25-31 (2015)

50. *T. Nishimura, Y. Ogura, K. Yamada, Y. Ohno, and Jun Tanida, “Biomolecule-to-fluorescent-color encoder: modulation of fluorescence emission via DNA structural changes," Biomedical Optics Express 5, 2082-2090 (2014).

51. *K. Yoshimoto, K. Yamada, K. Watabe, M. Takeda, T. Nishimura, M. Kido, T. Nagakura, H. Takahashi, T. Nishida, H. Iijima, M. Tsujii, T. Takehara, Y. Ohno, "Gastric Contraction Imaging System Using a 3-D Endoscope," IEEE Journal of Translational Engineering in Health and Medicine 2, 1, 1-8 (2014).

52. *T. Nishimura, Y. Ogura, and J. Tanida, “A nanoscale set-reset flip-flop in fluorescence resonance energy transfer-based circuits," Applied Physics Express 6, 015201 (2013) [Editor’s choice, Top 20 Most Downloaded Articles-Feb 2013].

53. *T. Nishimura, Y. Ogura, and J. Tanida, “Fluorescence resonance energy transfer-based molecular logic circuit using a DNA scaffold," Applied Physics Letters 101, 233703 (2012).

54. *T. Nishimura, Y. Ogura, and J. Tanida, “Optofluidic DNA computation based on optically manipulated microdroplets," Microfluidics and Nanofluidics 13, 1–7 (2012).

55. *T. Nishimura, Y. Ogura, and J. Tanida, “Reusable molecular sensor based on photonic activation control of DNA probes," Biomedical Optics Express 3, 920–926 (2012).

56. *Y. Ogura, Y. Kazayama, T. Nishimura, and J. Tanida, “Large-area manipulation of microdroplets by holographic optical tweezers based on a hybrid diffractive system," Applied Optics 50, H36- H41(2011).

57. *Y. Ogura, T. Nishimura, and J. Tanida, “Spatially parallel control of DNA reactions in optically manipulated micro-droplets," Journal of Nanophotonics 5, 05107 (2011) [Selected for Virtual Journal of Biological Physics Research, Vol. 21, Issue 10.]

58. *Y. Ogura, T. Nishimura, and J. Tanida, “Self-contained photonically-controlled DNA tweezers," Applied Physics Express 2, 025004 (2009).

Books, Chapters in Book, Review Articles, etc.

1. *西村隆宏: "「生体組織光学を基盤とした光医療技術・評価の展望」 の特集によせて," 日本レーザー医学会誌 46 p.76 (2025).[in Japanese]

2. *下条裕, 寺西梨絵, 西村隆宏, 桑田健二, 呉屋剛, 森井克行, 鶴田大輔, 小澤俊幸： ''有機発光ダイオードを用いた細菌に対する光線力学治療,'' 日本レーザー医学会誌 45(2), 153-160 (2024).

3. *西村隆宏, 下条裕: ''皮膚レーザー治療に対するin silico評価,'' 光学　53(4), 148−153（2024）.

4. Takahiro Nishimura: "Fluorescence Energy Transfer Computing," Photonic Neural Networks with Spatiotemporal Dynamics: Paradigms of Computing and Implementation, Springer Nature (2023)

5. 西村隆宏: "蛍光イメージングによる内視鏡下腫瘍観察における診断深度・診断時間の拡張," 光技術コンタクト2023年11月号 p.4-11 (2023).[in Japanese]

6. 西村隆宏, 守顕太, 須藤圭麻, 粟津邦男: "末梢型肺癌に対する光線力学治療のための in silico 光照射評価," 日本レーザー医学会誌, 43(1)•13-21•2022

7. 西村隆宏, 守顕太, 粟津邦男: "一重項酸素ドーズに基づいた光線力学治療効果シミュレーション," レーザー研究  49(11): 616-620 (2021) [in Japanese].

8. 西村隆宏, 守顕太, 粟津邦男: "計算機シミュレーションによるPDT光照射プローブの比較評価," JPA日本光線力学学会 NEWS LETTER NO.25 AUG (2021).

9. 西村隆宏, “大学の国際化," 生産と技術 68, No. 2, pp. 58–59 (2016).

10. Y. Ogura, T. Nishimura, H. Yamamoto, K. Yamada, and J. Tanida, "Photonic DNA nano-processor: a photonics-based approach to molecular processing mediated by DNA," Nanophotonic Information Physics, M. Naruse Ed., Chapter 4, 91- 113 (2014).

11. 小倉裕介, 西村隆宏, 谷田 純, “フォトニックDNAナノマシン,” 光学 41, No. 2, pp. 90–92 (2012).

12. Y. Ogura, T. Nishimura, H. Sakai, and J. Tanida, “Photonic DNA computing: concept and implementation methods,” iConcept Press, In Zhongming Zhao, editor, Sequence and Genome Analysis: Methods and Applications, Chapter 7 (2011).

13. Y. Ogura, T. Nishimura, and J. Tanida, “Photonically controlled DNA nanomachines,” SPIE Newsroom. DOI: 10.1117/2.1200908.1780 (2009).