Articles in Peer-Reviewed Journals – Lab members underlined
Longobardi C., Helderman RFCPA., Choudhury A., Paulson J., Gaggioli V., Cameron K., Zamora Valdivieso B., Chanchabi C., Xavier G., Remblière E., Cleef Y., Persiani F., Garnier E., Lemmers B., Helmlinger D., Lorenzo-Martin LF., Lutolf MP., Hahne M., Taneja N., Pradet-Balade B., Medema JP. Intrinsic replication stress underlies selective sensitivity of mesenchymal colorectal cancer to attenuated RUVBL1/2 activity. Submitted
Pussacq—Caillet MA.#, Noly A.#, Fisogni A., Zanutto J., Helmlinger D.#,*, Vanderplanck M.#,* (2026) Evidence for fission yeast survival and dispersal through social and solitary bees. bioRxiv 2026.08.14.744814; DOI: 10.64898/2026.08.14.744814. https://doi.org/10.64898/2026.08.14.744814. #These authors contributed equally; *Corresponding authors
Noly A., Faux C., Shaldaeva M., Bois-Naegelin L., Fort P., Helmlinger D. (2026) Evolutionary diversification of invertase paralogs couples carbon metabolism and sexual reproduction in fission yeasts. Molecular Biology & Evolution. In press. Preprint available at bioRxiv: https://doi.org/10.64898/2026.04.13.718246
Jia GS., Suo F., Noly A., Fort P., Liang Y., Li W., Zhang WC., Li HL., Du XM., Zhang FY., Du TY., Hua Y., Bai FY., Wang QM., Brysch-Herzberg M., Helmlinger D., Du LL. (2026) Schizosaccharomyces orthogroup (SOG) resource: a web platform for exploring gene conservation in fission yeasts. Yeast 43:101-111. DOI: 10.1002/yea.70019.
Bois Naegelin L., Courgnaud V., Helmlinger D.*, Majzoub K.* (2025) No evidence for human or rodent deltavirus replication in yeast. microPublication Biology DOI: 10.17912/micropub.biology.001743. *Corresponding authors
Protacio RU., Davidson MK., Malone EG., Helmlinger D., Smith JR., Gibney PA., Wahls WP. (2024) Agar lot-specific inhibition in the plating efficiency of yeast spores and cells. G3 Genes|Genomes|Genetics Sep 23;14(12):jkae22. DOI: 10.1093/g3journal/jkae229. News report in Science: https://www.science.org/content/blog-post/agar-and-yeast-and-mystery
Fréchard A., Faux C., Hexnerova R., Crucifix C., Papai G., Smirnova E., McKeon C., Ping FLY., Helmlinger D.*, Schultz P.*, Ben-Shem A.* (2023) Nature Structural & Molecular Biology Sep;30(9):1337-1345. DOI: 10.1038/s41594-023-01056-x. *Corresponding authors. News & Views highlight: https://doi.org/10.1038/s41594-023-01057-w
Mahrik L., Stefanovie B., Maresova A., Princova J., Kolesar P., Lelkes E., Faux C., Helmlinger D., Prevorovsky M., Palecek JJ. (2023) The SAGA histone acetyltransferase module targets SMC5/6 to specific genes. Epigenetics & Chromatin 16(6). DOI: 10.1186/s13072-023-00480-z.
Fischer V., Hisler V., Scheer E., Lata E., Morlet B., Plassard D., Helmlinger D., Devys D., Tora L., Vincent SD. (2022) SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells. Nucleic Acids Research Aug 12;50(14):7972-7990. DOI: 10.1093/nar/gkac637.
Elías-Villalobos A., Duncan C., Mata J., Helmlinger D. (2022) Quantitative analysis of protein-RNA interactions in fission yeast. STAR Protocols May 9;3(2):101373. DOI: 10.1016/j.xpro.2022.101373.
Detilleux D., Raynaud P., Pradet-Balade B., Helmlinger D. (2022) The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells. ELife 11:e69705. DOI: 10.7554/eLife.69705.
Toullec D.#, Elías-Villalobos A.#, Faux C., Noly A., Lledo G., Séveno M., Helmlinger D. (2021) The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKK kinases prior to assembly. Cell Reports 37(3):109867. DOI: 10.1016/j.celrep.2021.1098
#These authors contributed equally
Maurizy C., Abeza C., Pinet V., Ferrand M., Paul C., Bremond J., Langa F., Gerbe F., Jay P., Verheggen C., Tinari N., Helmlinger D., Lattanzio R., Bertrand E., Hahne M., Pradet-Balade B. (2021) The R2TP chaperone assembles cellular machineries in intestinal CBC stem cells and progenitors. Nature Communications 12(1):4810. DOI: 10.1038/s41467-021-24792-4.
Helmlinger D., Papai G., Devys D., Torá L. (2020) What do the structures of GCN5-containing complexes teach us about their function? Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms Jul 31:194614. DOI: 10.1016/j.bbagrm.2020.194614.
Elías-Villalobos A., Toullec D., Faux C., Séveno M., Helmlinger D. (2019) Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast. Nature Communications 10(1):5237. DOI: 10.1038/s41467-019-13243-w. Featured in Editors’ Highlights webpage.
Elías-Villalobos A., Fort P., and Helmlinger D. (2019) New insights into the evolutionary conservation of Tra1, the only pseudoPIKK. Biochemical Society Symposia Dec 20;47(6):1597-1608. DOI: 10.1042/BST20180496.
Laboucarié T., Detilleux D., Rodriguez-Mias RA., Faux C., Romeo Y., Franz-Wachtel M., Krug K., Maček B., Villén J., Petersen J., Helmlinger D. (2017) TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability. EMBO Reports (12):2197-2218. DOI: 10.15252/embr.201744942.
Helmlinger D.* and Tora L.* (2017) Sharing the SAGA. Trends in Biochemical Sciences 42(11):850-861. Opinion Article. *Co-corresponding authors. DOI: 10.1016/j.tibs.2017.09.001.
Elías-Villalobos A., Helmlinger D., Ibeas JI. (2015) Histone deacetylases: revealing the molecular base of dimorphism in pathogenic fungi. Microbial Cell 4;2(12):491-493. Review.
Elías-Villalobos A., Fernández-Álvarez A., Moreno-Sánchez I., Helmlinger D.*, Ibeas JI.* (2015) The Hos2 histone deacetylase controls Ustilago maydis virulence through direct regulation of mating-type genes. PLOS Pathogens 11(8): e1005134. *Joint senior authors.
Helmlinger D. (2012) New insights into the SAGA complex from studies of the Tra1 subunit in budding and fission yeast. Transcription. 3(1):13-18. Review.