Research Interests
Preclinical targeted therapy of esophageal squamous cell carcinoma (ESCC):
Preclinical targeted therapy of esophageal squamous cell carcinoma (ESCC):
We are particularly interested in developing targeted therapy of ESCC in vitro and in vivo with specific molecular alterations. These studies can be potentially translated into clinical studies.
We are particularly interested in developing targeted therapy of ESCC in vitro and in vivo with specific molecular alterations. These studies can be potentially translated into clinical studies.
Current target: Nrf2 signaling pathway
Current target: Nrf2 signaling pathway
Molecular mechanism and prevention of alcohol and tobacco-associated oro-esophageal cancer:
Molecular mechanism and prevention of alcohol and tobacco-associated oro-esophageal cancer:
The goal of this research direction is to understand how alcohol and tobacco carcinogens may cause oro-esophageal cancer, and how to prevent this type of cancer. Both pharmacological (pharmaceutical and dietary agents) and genetic approaches are employed to elucidate the mechanism of oro-esophageal carcinogenesis and design preventive strategies for clinical studies.
The goal of this research direction is to understand how alcohol and tobacco carcinogens may cause oro-esophageal cancer, and how to prevent this type of cancer. Both pharmacological (pharmaceutical and dietary agents) and genetic approaches are employed to elucidate the mechanism of oro-esophageal carcinogenesis and design preventive strategies for clinical studies.
Molecular mechanism, prevention and treatment of gastroesophageal reflux disease (GERD), Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC):
Molecular mechanism, prevention and treatment of gastroesophageal reflux disease (GERD), Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC):
The goal of this research direction is to study the roles of gastroesophageal reflux, genetic and epigenetic pathways in the development of GERD, BE and EAC, in cell culture, animal models, and humans. In addition, we are also interested in the molecular aspect of esophageal development.
The goal of this research direction is to study the roles of gastroesophageal reflux, genetic and epigenetic pathways in the development of GERD, BE and EAC, in cell culture, animal models, and humans. In addition, we are also interested in the molecular aspect of esophageal development.