The names of the members/ex-members of the group (in IOP-AS and MBI) are bolded and underlined. * means contact authors. # means equal contribution.
Preprints (in English)
K. W. Leong, Y. Lou*, A. Biswas, J. Y. K. Tan, B. H. Ng, X. Lu, X. P. J. Teo, T. B. Lu, C. Bevilacqua, I. Bonne, R. Prevedel, T. Hiraiwa, C. J. Chan*: Critical phenomenon underlies de novo luminogenesis during mammalian follicle development. bioRxiv https://doi.org/10.1101/2025.09.09.674793
Y. Lou*, S. Theis*, J.-F. Rupprecht*, T. Saunders*, T. Hiraiwa*: Stress anisotropy in 3D active curved structures. bioRxiv https://www.biorxiv.org/content/10.1101/2025.04.13.648577v1
T. Guyomar, L. Lu, T. Hiraiwa*, D. Riveline*: Asymmetry of acto-myosin cortices as active fluids shape cells in organoids. bioRxiv https://www.biorxiv.org/content/10.1101/2024.08.22.609097v1
B. H. Lee*, K. Fuji, H. Petzold, P. A. Seymour, S. Yennek, C. Schewin, A. Lewis, D. Riveline, T. Hiraiwa, M. Sano, A. Grapin-Botton*: Control of lumen geormetry and topology by cell proliferation rate and pressure. bioRxiv https://www.biorxiv.org/content/10.1101/2024.05.29.596462v1
S. Wu*#, C. Z. Ho#, F. Sun#, Y. Lou#, B.-X. Huang, J. Xiao, M. Shagirov, I. Yow, J. F. L. Chin, S. Verma, A. S. Yap, Y. Lin*, T. Hiraiwa, B. C. Low*: Co-evolution of spheroid fluidization and mechanical fracture in a morphogenic cascade. bioRxiv https://www.biorxiv.org/content/10.1101/2023.09.25.559247v1
R. Suzuki, T. Hiraiwa, A. Tursch, S. Höger, K. Hayashi, S. Özbek, T. W. Holstein*, M. Tanaka*: Tight junctions regulate lumen morphology via hydrostatic pressure and junctional tension. bioRxiv https://www.biorxiv.org/content/10.1101/2023.09.18.558226v1
Publications (Published, In press or Accepted) (in English)
S. Tanida, K. Fuji, L. Lu, T. Guyomar, B. H. Lee, A. Honigmann, A. Grapin-Botton, D. Riveline, T. Hiraiwa*, M. Nonomura*, M. Sano* (2025): Predicting organoid morphology through a phase field model: Insights into cell division and lumenal pressure. PLoS Computational Biology 21, e1012090 [Journal]
L. Lu#, K. Fuji#, T. Guyomar, M. Lieb, S. Tanida, M. Nonomura, T. Hiraiwa, Y. Alcheikh, S. Yennek, H. Petzold, C. Martin-Lemaitre, A. Grapin-Botton, A. Honigmann, M. Sano, D. Riveline* (2025): Generic comparison of lumen nucleation and fusion in epithelial organoids with and without hydrostatic pressure. Nature Communications. 16, 6307 [Journal]
K. Tsubota*, S. Horikoshi, T. Hiraiwa, S. Okuda* (2025): Strain softening and hysteresis arising from 3D multicellular dynamics during long-term large deformation. Journal of the Mechanical Behavior of Biomedical Materials 168, 107001 [Journal]
M. Mukenhirn, C.-H. Wang, T. Guyomar, M. J. Bovyn, M. F. Staddon, R. Maraspini, L. Lu, C. Martin-Lemaitre, M. Sano, T. Hiraiwa, D. Riveline*, A. Honigmann* (2024): Tight junctions regulate lumen morphology via hydrostatic pressure and junctional tension. Developmental Cell. 59, 2866–2881. [Journal]
R. Das*, T. Sakaue, G. V. Shivashankar, J. Prost*, T. Hiraiwa* (2024): Transient-linking activity enhances subnuclear dynamics by affecting chromatin remodeling. Physical Review Letters. 132, 058401. [Journal]
<Review article> #H. Delanoë-Ayari*, #T. Hiraiwa*, #P. Marcq*, #J.-P. Rieu*, #T. B. Saw* (2023): 2.5D Traction Force Microscopy: Imaging three-dimensional cell forces at interfaces and biological applications. The International Journal of Biochemistry & Cell Biology. 161, 106432. [Journal] [official shared version by the beginning of Aug 2023]
S. Okuda*, T. Hiraiwa (2023): Modelling contractile ring formation and division to daughter cells for simulating proliferative multicellular dynamics. The European Physical Journal E. 46, 56 [Journal]
S. Okuda*, T. Hiraiwa (2023): Long-term adherent cell dynamics emerging from energetic and frictional interactions at the interface. Physical Review E. 107, 034406 [Journal]
Y. Lou*, J.-F. Rupprecht*, S. Theis, T. Hiraiwa*, T. Saunders* (2023): Curvature-induced cell rearrangements in biological tissues. Physical Review Letters. 130, 108401. [Journal]
T. Kawaue, I. Yow, A. P. Le, Y. Lou, M. Loberas, M. Shagirov, J. Prost, T. Hiraiwa, B. Ladoux, Y. Toyama* (2023): Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation. Developmental Cell. 45, 267 [Journal]
R.Das*, T. Sakaue, G. V. Shivashankar, J. Prost, T. Hiraiwa* (2022): How enzymatic activity is involved in chromatin organization. eLife. 11:e79901. [Journal]
#T. Hiraiwa*, #R. Akiyama, D. Inoue, A. Md. R. Kabir, A. Kakugo (2022): Collision-induced torque mediates transition of chiral dynamic patterns formed by active particles. Physical Chemistry Chemical Physics. 24, 28782. (#: These authors equally contributed to this work) [Journal]
- Research image was selected for the journal's back cover (the artwork was created by Dr. Daisuke Inoue (Kyushu Univ), one of the authors)
S. Okuda*, K. Sato, T. Hiraiwa (2022): Continuum modeling of non-conservative fluid membrane for simulating long-term cell dynamics. The European Physical Journal E. 45, 69 [Journal]
Y. Lou*, T. Kawaue, I. Yow, Y. Toyama, J. Prost, T. Hiraiwa* (2022): Interfacial friction and substrate deformation mediate long-range signal propagation in tissues. Biomechanics and Modeling in Mechanobiology, 21, 1511. [Journal] [official shared version ("As part of the Springer Nature Content Sharing Initiative")]
<Review article> #K. Fuji, #S. Tanida, M. Sano, M. Nonomura, D. Riveline, H. Honda, #T. Hiraiwa* (2022): Computational approaches for simulating luminogenesis. Seminars in Cell and Developmental Biology, 131, 173-185. (#: These authors equally contributed to this work.) [Journal]
T. Hiraiwa* (2022): Dynamic self-organization of migrating cells under constraints by spatial confinement and epithelial integrity. The European Physical Journal E (Topical Collection “Tissue Mechanics”), 45, 16. (Invited) [Journal]
F. Afroze, D. Inoue, T. Farhana, T. Hiraiwa, R. Akiyama, A. Kabir, K. Sada, A. Kakugo* (2021): Monopolar flocking of microtubules in collective motion. Biochemical and Biophysical Research Communications. 563, 73-78 [Journal].
T. Hiraiwa* (2020): Dynamic self-organization of idealized migrating cells by contact communication: Physical Review Letters 125, 268104. [Journal]
T. Yamamoto*, T. Hiraiwa, T. Shibata* (2020): Collective cell migration of epithelial cells driven by chiral torque generation. Physical Review Research 2, 043326 [Journal]
R. Sakamoto, M. Tanabe, T. Hiraiwa, K. Suzuki, S. Ishiwata, Y. T. Maeda, M. Miyazaki* (2020): Tug-of-war between actomyosin-driven antagonistic forces determines the positioning symmetry in cell-sized confinement. Nature Communications. 11, 3063 [Journal].
- I was in charge of mathematical modeling and analytical calculations.
M. Hayakawa, T. Hiraiwa, Y. Wada, H. Kuwayama, T. Shibata* (2020): Polar pattern formation induced by contact following locomotion in a multicellular system. eLife. 9: e53609. [Journal] [eLife digest]
- I was in charge of theoretical modeling and performed all numerical simulations.
S. Tanida*, K. Furuta, K. Nishikawa, T. Hiraiwa*, H. Kojima, K. Oiwa, M. Sano* (2020): Gliding filament system giving both global orientational order and clusters in collective motion. Physical Review E, 101, 032607. [Journal]
- I performed all numerical simulations and proposed equations for quantitative analysis.
<Review article> T. Hiraiwa*, F.-L. Wen, T. Shibata* and E. Kuranaga* (2019): Mathematical Modeling of Tissue Folding and Asymmetric Tissue Flow during Epithelial Morphogenesis. Symmetry 11, 113. (Invited) [Journal]
T. Hiraiwa* (2019): Two types of exclusion interactions for self-propelled objects and collective motion induced by their combination. Physical Review E 99, 012614. [Journal]
T. Hiraiwa, and R. R. Netz (2018): Systematic bottom-up theory for the viscoelastic response of worm-like-chain networks. Europhysics Letters 123, 58002. [Journal] [SI]
T. Hiraiwa, E. Kuranaga, and T. Shibata* (2017): Wave propagation of junctional remodeling in collective cell movement of epithelial tissue: Numerical simulation study. Frontiers in Cell and Developmental Biology, 5, 66. (Invited) [Journal]
T. Hiraiwa and G. Salbreux (2016): Role of turnover in active stress generation in a filament network. Phys. Rev. Lett. 116, 188101. [Journal]
K. Sato, T. Hiraiwa, and T. Shibata* (2015) Cell chirality induces collective cell migration in epithelial sheets. Phys. Rev. Lett. 115: 118102. [Journal]
#K. Sato, #T. Hiraiwa, #E. Maekawa, A. Isomura, T. Shibata, and #E. Kuranaga* (2015) Left-right asymmetric cell intercalation drives directional collective cell movement in epithelial morphogenesis: Nature Communications 6: 10074. (#: These authors equally contributed to this work.) [Journal].
T. Hiraiwa, A. Nagamatsu, N. Akuzawa, M. Nishikawa, and T. Shibata* (2014) Relevance of intracellular polarity to accuracy of eukaryotic chemotaxis. Physical Biology 11: 056002. [Journal].
T. Hiraiwa, A. Baba and T. Shibata* (2013) Theoretical model for cell migration with gradient sensing and shape deformation. Euro. phys. J. E 36: 32. [Journal].
A. Baba, T. Hiraiwa, and T. Shibata* (2012): Directional sensing of deformed cells under faint gradients. Phys. Rev. E 86, 060901(R). [Journal].
K. Shitara, T. Hiraiwa, and T. Ohta* (2011): Deformable self-propelled domain in an excitable reaction-diffusion system in three dimensions. Phys. Rev. E 83, 066208. [Journal]
T. Hiraiwa, K. Shitara and T. Ohta* (2011): Dynamics of a Deformable Self-Propelled Particle in Three Dimensions. Soft Matter 7, 3083-3086. [Journal]
T. Hiraiwa, M. Matsuo, T. Ohkuma, T. Ohta* and M. Sano (2010): Dynamics of a deformable self-propelled domain: Europhys. Lett. 91, 20001(p1-p6). [Journal]
T. Hiraiwa, and T. Ohta* (2010): Linear viscoelasticity of a single semiflexible polymer with internal friction. J. Chem. Phys. 133, 044907(1-7). [Journal]
T. Hiraiwa, and T. Ohta* (2009): Viscoelasticity of a Single Semiflexible Polymer Chain. Macromolecules 42, 7553-7562. [Journal]
T. Hiraiwa, and T. Ohta* (2008): Viscoelastic Behavior of a Single Semiflexible Polymer Chain. J. Phys. Soc. Jpn. 77, 023001(1-4). [Journal]
Publications in Japanese (Published or In press)
<和文総説・解説 > 平岩徹也 (2023) :「遊走細胞集団の動的自己組織化についての数理モデルと数値シミュレーション」: 「生物物理」誌 63, (通巻368号) 207-211. (Invited)
<和文総説・解説 > 永井健、平岩徹也、太田隆夫 (2018) :「アクティブソフトマターの動的秩序」: 固体物理 53, (8月号 通巻630号) 423-434. (Invited)
<和文総説・解説 > 平岩徹也 (2018) :「アクトミオシン細胞骨格のダイナミクスと力学の数値シミュレーション」: 分子シミュレーション研究会会誌「アンサンブル」20, (No. 3, 7月号 通巻83号) 167-172. (Invited) [Journal]