Liao T.-S. Chen C.-Y. Lin C.-S. Chang C.-W. T. Takemoto J. Y. and Lin Y.-Y. (2023). Mesobiliverdin IXα-enriched microalgae feed additive eliminates reliance on antibiotic tylosin to promote intestinal health of weaning piglets.  Journal of Animal Physiology and Animal Nutrition (online 04 August 2023 https://doi.org/10.1111/jpn.13867

Lin, Y.-Y.;  Takemoto, J. Y.;  Chang, C.-W. T.; Peng, C.-A., (2022) Mesobiliverdin IXα ameliorates osteoporosis via promoting osteogenic differentiation of mesenchymal stem cells. Biochem Biophys Res Commun,  619, 56-61.  

Takemoto J. Y. Altenberg G. A. Poudyal N. Subedi Y. P. and Chang C.-W. T. (2022). Amphiphilic aminoglycosides: Modifications that revive old natural product antibiotics. Frontiers in Microbiology 13:1000199  https://www.frontiersin.org/articles/10.3389/fmicb.2022.1000199

Wood, J., Takemoto, J.Y, Sims, R.C, (2022). Rotating algae biofilm reactor for management and valorization of produced wastewater. Frontiers in Energy Research, 10, 774760. doi: doi: 10.3389/fenrg.2022.774760

Chang, C.T, Takemoto, J.Y, Chang, P., Alfindee, M.N, Lin, Y., (2021). Effects of mesobiliverdin IX alpha-enriched microalgae feed on gut health and microbiota of broilers. Front Vet Sci, 7, doi: 10.3389/fvets.2020.586813

Hamill, P.G, Stevenson, A., McMullan, P.E, Williams, J.P, Lewis, A.D, S, S., Stevenson, K.E, Farnsworth, K.D, Khroustalyova, G., Takemoto, J.Y, Quinn, J.P, Rapoport, A., Hallsworth, J.E, (2020). Microbial lag phase can be indicative of, or independent from, cellular stress. Sci Rep, 10:1, 5948.

Zhang, W., Rhodes, J., Garg, A., Takemoto, J.Y, Qi, X., Harihar, S., Chang, C.T, Moon, K., Zhou, A., (2020). Label-free discrimination and quantitative analysis of oxidative stress induced cytotoxicity and potential protection of antioxidants using Raman spectroscopy and machine learning algorithms . Anal Chem Acta, 1128, 221-230. doi: https://doi.org/10.1016/j.aca.2020.06.074

Subedi, Y.P, Pandey, U., Alfindee, M.N, Montgomery, H., Roberts, P., Wight, J., Nichols, G., Grilley, M.M, Takemoto, J.Y, Chang, C.T, (2019). Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6''-modified amphiphilic kanamycins. Eur J Med Chem, 182, 111639.

Alfindee, M.N, Subedi, Y.P, Grilley, M.M, Takemoto, J.Y, Chang, C.T, (2019). Antifungal activities of 4″,6″-disubstituted amphiphilic kanamycins. Molecules, 24:10, e1882. doi: 10.3390/molecules24101882

Subedi, Y.P, Paul, R., Grilley, M.M, Takemoto, J.Y, Chang, C.T.  (2019). Development of fungal selective amphiphilic kanamycin: cost effective synthesis and use of fluorescent analogs for mode of action investigation. ACS Infect Diseases, 5, 473-483.

Chang, C.T, Takemoto, J.Y, Zhan, J.  (2019). Natural bioactive compounds. Isr J Chem, 59, 325-326.

Takemoto, J.Y, Chang, C.T, Chen, D., Hinton, G.  (2019). Heme-derived bilins. Isr J Chem 59, 378-386. 

Takemoto, J.Y, Wegulo, S., Yuen, G.Y, Stevens, J.A, Jochum, C.C, Chang, C.T, Kawasaki, Y., Miller, G.A. 2018. Suppression of wheat fusarium head blight by novel amphiphilic aminoglycoside fungicide K20 . Fungal Biol 122:465-470.

AlFindee, M.N, Zhang, Q., Subedi, Y.P, Shrestha, J.P, Kawasaki, Y., Grilley, M.M, Takemoto, J.Y, Chang, C.T. 2018.  One-step synthesis of carbohydrate esters as antibacterial and antifungal agents. Bioorg Med Chem 26:765-774.

Subedi, Y. P., AlFindee, M. N., Takemoto, J. Y., Chang, C.-W. T. 2018. Antifungal amphiphilic kanamycins: new life for an old drug. Med Chem Comm 9:909-919.

Alder-Rangel, A., Bailao, A.M, da Cunha, A.F, Soares, C.M, Wang, C., Bonatto, D., Dadachova, E., Hakalehto, E., Eleutherio, E.C, Fernandes, E.K, Gadd, G.M, Braus, G.H, Braga, G.U, Goldman, G.H, Malavazi, I., Hallsworth, J.E, Takemoto, J.Y, Fuller, K.K, Selbmann, L., Corrochano, L.M, von Zeska Kress, Marcia R., , Bertolini, M.C, Schmoll, M., Pedrini, N., Loera, O., Finlay, R.D, Peralta, R.M, Rangel, D.E. 2018. The second international symposium on fungal stress: ISFUS. Fungal Biol, 122:386-399 doi.org/10.1016/j.funbio.2017.10.011

Takemoto, J.Y., C.W.T. Chang, S.K. Shrestha and M.M. Grilley. 2017.  Aminoglycoside and azole compositions and methods. 

Patent Issued, US US 9,669,044 , June 6, 2017, U.S. Patent and Trademark Office.

Xu, F., Napan, K., Zhang, S., Gladwin, T., Takemoto, J.Y, Zhan, J., 2017. New insights into pradimicin biosynthesis revealed by two O-methyltransferases. Bioorg Med Chem Lett, 27:15, 3499-3502.

Shrestha, J.P., C. Baker, Y. Kawasaki, Y. P. Subedi, N.N. Vincent de Paul, J.Y. Takemoto, C-W.T. Chang. 2017. Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens. Eur Med Chem 126:696-704.

Zhang, Q., M. N. Alfindee, J. P. Shrestha, V. d. P. Nziko, Y. Kawasaki, X. Peng, J. Y. Takemoto, C-W. T. Chang. 2016. Divergent synthesis of three classes of antifungal amphiphilic kanamycin derivatives. J Org Chem 81:10651-10663.

Kawasaki, Y., C. Nischwitz, M. M. Grilley, J. Jones., J. D. Brown, and J. Y. Takemoto. 2016. Production and application of syringomycin E as an organic fungicide seed protectant against pythium damping-off. J Phytopathol 164, 801-810. DOI10.1111/jph.12500T

Takemoto J., D. Chen, C-W. T. Chang. 2016. Meso-biliverdin compositions and methods. Patent Issued, US 9,242,932 B2, Jan 26, 2016, U.S. Patent and Trademark Office

Takemoto, J. Y., D. Chen, C-W. T. Chang and *J. Wood, 2015. Therapeutic meso-biliverdin IXα compositions and associated methods, Patent assigned, US 14/028,313, Sept 1, 2015, U.S. Patent and Trademark Office

Shrestha, S.K., Grilley, M., Anderson, T., Dhiman, C., Oblad, J., Chang, C.-W.T., Sorensen, K.N., and Takemoto, J.Y. (2015). In vitro antifungal synergy between amphiphilic aminoglycoside K20 and azoles against Candida species and Cryptococcus neoformans. Medical Mycology. doi: 10.1093/mmy/myv063.

Wood, J.L., C. D. Miller, R. C. Sims, R. C., and J. Y.Takemoto. 2015. Biomass and phycocyanin production from cyanobacteria dominated biofilm reactors cultured using oilfield and natural gas extractionproduced water. Algal Research 11:165-168. DOI:10.1016/j.algal.2015.06.015

Fosso, M., AlFindee, M. N., Zhang, Q., Nziko, V.de., P, Kawasaki, Y., Shrestha, S.K., Bearss, J., Gregory, R., Takemoto, J. Y., and Chang, C. W. 2015. Structure-activity relationships for antibacterial to antifungal conversion of kanamycin to amphiphilic analogues. J Org Chem 80:4398-4411.DOI:10.1021/acs.joc.5b00248

Zhang, Q., Peng, X., Grilley, M., Takemoto, J.Y., and Chang, C.W.T. 2015. Using fluorogenic probes for the investigation of selective biomass degradation by fungi. Green Chem. 17, 1918-1925. doi: DOI: 10.1039/c4gc01659a.

Napan, K.L., S. Zhang, T. Anderson, J.Y. Takemoto and J. Zhan. 2015. Three enzymes involved in the N-methylation and incorporation of the pradimicin sugar moieties. Bioorg. Med. Chem. Lett. DOI: http://dx.doi.org/10.1016/j.bmcl.2015.01.043

Shrestha, S.K., C.-W. T. Chang, N. Meissner, J. Oblad, J.P. Shrestha, K.N. Sorensen, M.M. Grilley, and J.Y. Takemoto. 2014. Antifungal amphiphilic aminoglycoside K20: bioactivities and mechanism of action.  Front Microbiol.  DOI: 10.3389/fmicb.2014.00671

Chang, C.-W. T. and  J.Y. Takemoto. 2014. Antifungal amphiphilic aminoglycosides (review article).  Med. Chem. Commun. DOI:10.1039/C4MD00078A

Napan, K., S. Zhang, W. Morgan, T. Anderson, J.Y. Takemoto, and J. Zhan. 2014. Synergistic actions of tailoring enzymes in pradimicin biosynthesis. ChemBioChem 15: 2289-2296. DOI: 10.1002/cbic.201402306

Golo, P. S., D. R. Gardner, M. M. Grilley, J. Y. Takemoto, S. B. Krasnoff, M. S. Pires, E. K. Fernandes, V. R. Bittencourt, D. W. Roberts. 2014. Production of destruxins from Metarhizium spp. fungi in artificial medium and in endophytically colonized cowpea plants. PLoS One 9:e104946.

Takemoto, J., C.-W. Chang, S. Shrestha and M. Grilley. 2014. Aminoglycoside and azole compositions and methods. Nov. 20, 2014. Non-provisional Patent Application, PCT/US2014/038649, WIPO/PCT, filed 19/05/2014,

Shrestha, S., M. Grilley, M. Y. Fosso, C.-W. T. Chang, and J. Y. Takemoto. 2013. Membrane lipid-modulated mechanism of action and non-cytotoxicity of novel fungicide aminoglycoside FG08. PLoS One 8:e73843.

Ito, T., D. Chen, C.W.T. Chang, T. Kenmochi, T. Saito, S. Suzuki, and J.Y.Takemoto. 2013. Mesobiliverdin-IXα enhances rat pancreatic islet yield and function. Front. Pharmacol. 4:50 DOI:10.3389/fphar.2013.00050

Takemoto, J.Y. and D. Chen. 2013. Biliverdin from a Non-Animal Source, Patent No. US 8,455,222 B2, issued June 4, 2013, U.S. Patent and Trademark Office  

Chen, D., J. D. Brown, Y. Kawasaki, J. Bommer, and J. Y. Takemoto. 2012. Scalable production of biliverdin IXalpha by Eschericha coli. BMC Biotechnol.12:89. DOI:10.1186/1472-6750 12-89

Bessonov, A., J. Y. Takemoto, and F. C. Simmel. 2012. Probing DNA-lipid membrane interactions with a lipopeptide nanopore. ACS Nano 6:3356-3363 doi:10.1021/nn3003696

Napan, K.L., J. Zeng, J.Y. Takemoto, and J. Zhan. 2012. A key cytochrome P450 hydroxylase in pradimicin biosynthesis. Bioorg. Med. Chem. Lett. 22:606-609, doi:10.1016/j.bmcl.2011.10.075

Takemoto, J. Y.,  D. Chen and C-W. T. Chang. 2012. Meso-Biliverdin, Compositions, Methods and Applications, Non-Provisional Patent Application, US13/650,842 and PCT/US12/60086, U.S. Patent and Trademark Office, filed October 12, 2012

Takemoto, J. Y., D. Chen, C.-W. T. Chang, J. Wood. 2012. Therapeutic compositions and associated methods. Provisional Patent Application, P12034_01, filed September 14, 2012.

Takemoto, J. Y., M. Grilley, C. Nischwitz, Y. Kawasaki. 2012. Organic syringomycin methods and compositions. Non-Provisional Patent Application, PCT/US12/41960, U.S. Patent and Trademark Office, filed June 11, 2012

Chang, C-W. T., J. Takemoto. 2012. Aminoglycosides: synthesis and use as antifungals, Appl. No. 13/316,720, US 2012/0316125 A1, U.S. Patent and Trademark Office