Recent Publications

Kawasaki, Y., C. Nischwitz, M. M. Grilley, J. Jones., J. D. Brown, and J. Y. Takemoto. 2016. Production and application of syringomycin E as an organic fungicide seed protectant against pythium damping-off. J Phytopathol 164, 801-810. DOI10.1111/jph.12500T

Takemoto J., D. Chen, C-W. T. Chang. 2016. Meso-biliverdin compositions and methodsPatent Issued, US 9,242,932 B2, Jan 26, 2016, U.S. Patent and Trademark Office

Takemoto, J. Y., D. Chen, C-W. T. Chang and *J. Wood, 2015. Therapeutic meso-biliverdin IXα compositions and associated methods, Patent assigned, US 14/028,313, Sept 1, 2015, U.S. Patent and Trademark Office

Shrestha, S.K., Grilley, M., Anderson, T., Dhiman, C., Oblad, J., Chang, C.-W.T., Sorensen, K.N., and Takemoto, J.Y. (2015). In vitro antifungal synergy between amphiphilic aminoglycoside K20 and azoles against Candida species and Cryptococcus neoformans. Medical Mycology. doi: 10.1093/mmy/myv063.

Wood, J.L., C. D. Miller, R. C. Sims, R. C., and J. Y.Takemoto. 2015. Biomass and phycocyanin production from cyanobacteria dominated biofilm reactors cultured using oilfield and natural gas extractionproduced water. Algal Research 11:165-168. DOI:10.1016/j.algal.2015.06.015

Fosso, M., AlFindee, M. N., Zhang, Q., Nziko,, P, Kawasaki, Y., Shrestha, S.K., Bearss, J., Gregory, R., Takemoto, J. Y., and Chang, C. W. 2015. Structure-activity relationships for antibacterial to antifungal conversion of kanamycin to amphiphilic analogues. J Org Chem 80:4398-4411. DOI:10.1021/acs.joc.5b00248

Zhang, Q., Peng, X., Grilley, M., Takemoto, J.Y., and Chang, C.W.T. 2015. Using fluorogenic probes for the investigation of selective biomass degradation by fungi. Green Chem. 17, 1918-1925. doi: DOI: 10.1039/c4gc01659a.

Napan, K.L., S. Zhang, T. Anderson, J.Y. Takemoto and J. Zhan. 2015. Three enzymes involved in the N-methylation and incorporation of the pradimicin sugar moieties. Bioorg. Med. Chem. Lett. DOI:

Shrestha, S.K., C.-W. T. Chang, N. Meissner, J. Oblad, J.P. Shrestha, K.N. Sorensen, M.M. Grilley, and J.Y. Takemoto. 2014. Antifungal amphiphilic aminoglycoside K20: bioactivities and mechanism of action.  Front Microbiol.  DOI: 10.3389/fmicb.2014.00671

Chang, C.-W. T. and  J.Y. Takemoto. 2014. Antifungal amphiphilic aminoglycosides (review article).  Med. Chem. Commun. DOI:10.1039/C4MD00078A

Napan, K., S. Zhang, W. Morgan, T. Anderson, J.Y. Takemoto, and J. Zhan. 2014. Synergistic actions of tailoring enzymes in pradimicin biosynthesis. ChemBioChem 15: 2289-2296. DOI: 10.1002/cbic.201402306

Golo, P. S., D. R. Gardner, M. M. Grilley, J. Y. Takemoto, S. B. Krasnoff, M. S. Pires, E. K. Fernandes, V. R. Bittencourt, D. W. Roberts. 2014. Production of destruxins from Metarhizium spp. fungi in artificial medium and in endophytically colonized cowpea plants. PLoS One 9:e104946.

Takemoto, J., C.-W. Chang, S. Shrestha and M. Grilley. 2014. Aminoglycoside and azole compositions and methods. Nov. 20, 2014. Non-provisional Patent Application, PCT/US2014/038649, WIPO/PCT, filed 19/05/2014,

Shrestha, S., M. Grilley, M. Y. Fosso, C.-W. T. Chang, and J. Y. Takemoto. 2013. Membrane lipid-modulated mechanism of action and non-cytotoxicity of novel fungicide aminoglycoside FG08. PLoS One 8:e73843.

Ito, T., D. Chen, C.W.T. Chang, T. Kenmochi, T. Saito, S. Suzuki, and J.Y.Takemoto. 2013. Mesobiliverdin-IXα enhances rat pancreatic islet yield and function. Front. Pharmacol. 4:50 DOI:10.3389/fphar.2013.00050

Takemoto, J.Y. and D. Chen. 2013. Biliverdin from a Non-Animal Source, Patent No. US 8,455,222 B2, issued June 4, 2013, U.S. Patent and Trademark Office
Chen, D., J. D. Brown, Y. Kawasaki, J. Bommer, and J. Y. Takemoto. 2012. Scalable production of biliverdin IXalpha by Eschericha coli. BMC Biotechnol.12:89. DOI:10.1186/1472-6750 12-89

Bessonov, A., J. Y. Takemoto, and F. C. Simmel. 2012. Probing DNA-lipid membrane interactions with a lipopeptide nanopore. ACS Nano 6:3356-3363 doi:10.1021/nn3003696

Napan, K.L., J. Zeng, J.Y. Takemoto, and J. Zhan. 2012. A key cytochrome P450 hydroxylase in pradimicin biosynthesis. Bioorg. Med. Chem. Lett. 22:606-609, doi:10.1016/j.bmcl.2011.10.075

Takemoto, J. Y.,  D. Chen and C-W. T. Chang. 2012. Meso-Biliverdin, Compositions, Methods and Applications, Non-Provisional Patent Application, US13/650,842 and PCT/US12/60086, U.S. Patent and Trademark Office, filed October 12, 2012

Takemoto, J. Y., D. Chen, C.-W. T. Chang, J. Wood. 2012. Therapeutic compositions and associated methods. Provisional Patent Application, P12034_01, filed September 14, 2012.

Takemoto, J. Y., M. Grilley, C. Nischwitz, Y. Kawasaki. 2012. Organic syringomycin methods and compositions. Non-Provisional Patent Application, PCT/US12/41960, U.S. Patent and Trademark Office, filed June 11, 2012

Chang, C-W. T., J. Takemoto. 2012. Aminoglycosides: synthesis and use as antifungals, Appl. No. 13/316,720, US 2012/0316125 A1, U.S. Patent and Trademark Office