發表文獻 (Publications)

論文連結 (Publications) 

過去研究

• 1. 首位發現水溶性調節鐵調素可作為早期預測術後急性腎損傷的生物指標，調節鐵調素在急性腎損傷期間扮演的角色為減緩腎臟內鐵沉積。Guang-Huar Young, Tao-Min Huang, Che-Hsiung Wu ,Chun-Fu Lai, Chun-Cheng Hou, Kang-Yung Peng, Chan-Jung Liang, Shuei-Liong Lin, Shih-Chung Chang, Pi-Ru Tsai, Kwan-Dun Wu, Vin-Cent Wu*, Wen-Je Ko*, the NSARF group (2014, Mar). Hemojuvelin modulates iron stress during acute kidney injury: improved by furin inhibitor. Antioxid Redox Signal. 2014 Mar 10;20(8):1181-94. 

  2. 首先發表在急性腎損傷中硫酸吲哚酚在急性腎損傷影響內皮前驅幹細胞管狀形成能力和促 進細胞老化。Vin-Cent Wu, Guang-Huar Young, Po-Hsun Huang, Shyh-Chyi Lo, Kuo-Chuan Wang, Chiao-Yin Sun, Chan-Jung Liang, Tao-Ming Huang, Jou-Han Chen, Fan-Chi Chang, Yuh-Lien Chen, Yih-Shing Kuo, Jin-Bor Chen, Jaw-Wen Chen, Yung-Ming Chen, Wen-Jo Ko, Kwan-Dun Wu (2013, Feb). In acute kidney injury, indoxyl sulfate impairs human endothelial progenitor cells: modulation by statin. Angiogenesis, 2013 Jul;16(3):609-24. doi: 10.1007/s10456-013-9339-8. Epub 2013 Feb 14.

  3. 首位提出蛋白質親和性尿毒素誘導腎臟表皮生長因子接受器重組理論。Chiao-Yin Sun, Guang-Huar Young, Yu-Ting Hsieh, Yau-Hung Chen, Mai-Szu Wu, Vin-Cent Wu, Jia-Hung Lee and Chin-Chan Lee. Protein-Bound Uremic Toxins Induce Tissue Remodeling by Targeting the EGF Receptor. JASN ASN.2014010021; published ahead of print July 10, 2014,

  4. 提出慢性腎病對急性腎損傷預後不利的影響理論，可能因尿毒累積導致基因受到甲基化修飾而靜默。Guang-Huar Young and Vin-Cent Wu (2012, Apr). KLOTHO methylation is linked to uremic toxins and chronic kidney disease. Kidney International, 81:611-612. (SCI). NSC 98-2314-B-002-155-MY4.

  5. 發現蛋白尿對於預測急性腎損傷扮演的角色。Tao-Min Huang, Vin-Cent Wu, Guang-Huar Young, Yu-Feng Lin, Chih-Chung Shiao, Pei-Chen Wu, Wen-Yi Li, Hsi-Yu Yu, Fu-Chang Hu, Jou-Wei Lin, Yih-Sharng Chen, Yen-Hung Lin, Shoei-Shen Wang, Ron-Bin Hsu, Fan-Chi Chang, Nai-Kuan Chou, Tzong-Shinn Chu, Yu-Chang Yeh, Pi-Ru Tsai, Jenq-Wen Huang, Shuei-Liong Lin, Yung-Ming Chen, Wen-Je Ko and Kwan-Dun Wu (2010, Nov). Preoperative Proteinuria Predicts Adverse Renal Outcomes after Coronary Artery Bypass Grafting. Journal of the American Society of Nephrology, 22(1):156-63; Vin-Cent Wu, Tao-Min Huang, Pei-Chen Wu, Wei-Jie Wang, Chia-Ter Chao, Shao-Yu Yang, Chih- Chung Shiao, Fu-Chang Hu, Chun-Fu Lai, Yu-Feng Lin, Yin-Yi Han, Yih-Sharng Chen, Ron-Bin Hsu, Guang-Huar Young, Shoei-Shen Wang, Pi-Ru Tsai, Yung-Ming Chen, Ting-Ting Chao, Wen-Je Ko, Kwan-Dun Wu, the NSARF Group (2012, Jan). Preoperative Proteinuria Is Associated with Long-Term Progression to Chronic Dialysis and Mortality after Coronary Artery Bypass Grafting Surgery. PLoS One, 7:e27687. (IF=3.73) 

  6. 對於術後群組早期腎臟支持療法所作的貢獻 (RIFLE 和 BUN, 住院早晚分期）。Chih-Chung Shiao, Wen-Je Ko, Vin-Cent Wu, Tao-Min Huang, Chun-Fu Lai, Yu-Feng Lin, Chia-Ter Chao, Tzong-Shinn Chu, Hung-Bin Tsai, Pei-Chen Wu, Guang-Huar Young, Tze-Wah Kao, Jenq-Wen Huang, Yung-Ming Chen, Shuei-Liong Lin, Ming-Shou Wu, Pi-Ru Tsai, Kwan-Dun Wu, Ming-Jiuh Wang (2012, Aug). U-Curve Association between Timing of Renal Replacement Therapy Initiation and In-Hospital Mortality in Postoperative Acute Kidney Injury. PLoS One, doi:10.1371/journal.pone.0042952.

  7. 對停止透析預測所作的分析。Vin-Cent Wu, Chun-Fu Lai, Chih-Chung Shiao, Yu-Feng Lin, Pei-Chen Wu, Chia-Ter Chao, Fu- Chang Hu, Tao-Min Huang, Yu-Chang Yeh, I-Jung Tsai, Tze-Wah Kao, Yin-Yi Han, Wen-Chung Wu,Chun-Cheng Hou, Guang-Huar Young, Wen-Je Ko, Tun-Jun Tsai, Kwan-Dun Wu (2012, Mar). Effect of Diuretic Use on 30-Day Postdialysis Mortality in Critically Ill Patients Receiving Acute Dialysis. PLoS One, 7:e30836; Chih-Chung Shiao, Vin-Cent Wu, Wen-Yi Li, Yu-Feng Lin, Fu-Chang Hu, Guang-Huar Young (2009, Oct). Late initiation of renal replacement therapy is associated with worse outcomes in acute kidney injury after major abdominal surgery. Critical Care, 13:R171. NSC 98-2314-B-002-108-MY2.

  8. 認定急性腎損傷是心血管疾病的相當危險因子。Vin-Cent Wu, Tao-Min Huang, Chun-Fu Lai, Chih-Chung Shiao, Yu-Feng Lin, Tzong-Shinn Chu,Pei-Chen Wu, Chia-Ter Chao, Jann-Yuan Wang, Tze-Wah Kao, Guang-Huar Young, Pi-Ru Tsai,Hung-Bin Tsai, Chieh-Li Wang, Ming-Shou Wu, Wen-Chih Chiang, I-Jung Tsai, Fu-Chang Hu, Shuei-Liong Lin, Yung-Ming Chen, Tun-Jun Tsai, Wen-Je Ko and Kwan-Dun Wu, on behalf of the NSARF Group (2011, Aug). Acute-on-chronic kidney injury at hospital discharge is associated with long-term dialysis and mortality. Kidney International, 7:e27687. NSC 98-2314-B-002-155-MY4. 

  9. 國內最先推廣低效能延長式每日腎臟替代療法(Slow Low-Efficiency Daily Dialysis, SLEDD)。Yu-Hsiang Chou, Tao-Min Huang, Vin-Cent Wu, Cheng-Yi Wang, Chih-Chung Shiao, Chun-Fu Lai, Hung-Bin Tsai, Chia-Ter Chao, Guang-Huar Young, Wei-Jei Wang, Tze-Wah Kao, Shuei-Liong Lin, Yin-Yi Han, Anne Chou, Tzu-Hsin Lin, Ya-Wen Yang, Yung-Ming Chen, Pi-Ru Tsai, Yu-Feng Lin, Jenq-Wen Huang, Wen-Chih Chiang, Nai-Kuan Chou, Wen-Je Ko6, Kwan-Dun Wu, Tun-Jun Tsai1 and the NSARF Study Group (2011, Jun). Impact of timing of renal replacement therapy initiation on outcome of septic acute kidney injury. Critical Care, 15:R134.

  10. 提出急性腎損傷長期預後的綜合論述，並獲美國腎臟醫學會專文介紹。 Vin-Cent Wu, Che-Hsiung Wu,  Tao-Min Huang, Cheng-Yi Wang, Chun-Fu Lai, Chih-Chung Shiao, Chia-Hsui Chang, Shuei-Liong Lin, Yen-Yuan Chen, Yung-Ming Chen, Tzong-Shinn Chu, Wen-Chih Chiang, Kwan-Dun Wu, Pi-Ru Tsai, Li-Kwang Chen and Wen-Je Ko for the NSARF Group (March 2014). Long-Term Risk of Coronary Events after AKI. JASN  25: 595-605.