(complete list is in A. Shekhtman_publications)
Yepuri G, Hasan SN, Kumar V, Manigrasso MB, Theophall G, Shekhtman A, Schmidt AM, Ramasamy R. Mechanistic underpinnings of AGEs-RAGE via DIAPH1 in ischemic, diabetic, and failing hearts. Am J Physiol Heart Circ Physiol. 2025 Mar 25. doi: 10.1152/ajpheart.00685.2024.
Menon RG, Yepuri G, Martel D, Quadri N, Hasan SN, Manigrasso MB, Shekhtman A, Schmidt AM, Ramasamy R, Regatte RR. Assessment of cardiac and skeletal muscle metabolites using 1H-MRS and chemical-shift encoded magnetic resonance imaging: Impact of diabetes, RAGE, and DIAPH1. NMR Biomed. 2025 Jan;38(1):e5275. doi: 10.1002/nbm.5275.
Yu J, Ramirez LM, Lin Q, Burz DS, Shekhtman A. Ribosome External Electric Field Regulates Metabolic Enzyme Activity: The RAMBO Effect. J Phys Chem B. 2024 Jul 25;128(29):7002-7021. doi: 10.1021/acs.jpcb.4c00628.
Ramasamy R, Shekhtman A, Schmidt AM. RAGE/DIAPH1 and atherosclerosis through an evolving lens: Viewing the cell from the "Inside – Out." Atherosclerosis. 2024 Jul;394:117304. doi: 10.1016/j.atherosclerosis.2023.117304.
Ramasamy R, Shekhtman A, Schmidt AM. RAGE/DIAPH1 Axis and Cardiometabolic Disease: From Nascent Discoveries to Therapeutic Potential. Arterioscler Thromb Vasc Biol. 2024 Jul;44(7):1497-1501. doi: 10.1161/ATVBAHA.124.320142.
Chen H, Zhang Y, Wen Y, Fan X, Sciolino N, Lin Y, Breindel L, Dai Y, Shekhtman A, Xue XS, Zhang Q. Production of constrained L-cyclo-tetrapeptides by epimerization-resistant direct aminolysis. Nature Communications. 2024 Jun 25;15(1):5372. doi: 10.1038/s41467-024-49329-3.
Lakshmi Arivazhagan, Collin J Popp , Henry H Ruiz , Robin A Wilson, Michaele B Manigrasso, Alexander Shekhtman, Ravichandran Ramasamy, Mary Ann Sevick, Ann Marie Schmidt. The RAGE/DIAPH1 axis: mediator of obesity and proposed biomarker of human cardiometabolic disease. Cardiovasc Res. 2024 Feb 17;119(18):2813-2824. doi: 10.1093/cvr/cvac175.
Almehmadi LM, Reverdatto SV, Ermolenkov VV, Shekhtman A, Lednev IK. In Situ Stability Test for mRNA Vaccines Based on Deep-UV Resonance Raman Spectroscopy. Anal Chem. 2023 Dec 5. doi: 10.1021/acs.analchem.3c01761.
Theophall GG, Ramirez LMS, Premo A, Reverdatto S, Manigrasso MB, Yepuri G, Burz DS, Ramasamy R, Schmidt AM, Shekhtman A. Disruption of the productive encounter complex results in dysregulation of DIAPH1 activity. Journal of Biological Chemistry. 2023 Nov;299(11):105342. doi: 10.1016/j.jbc.2023.105342.
Gautham Yepuri, Lisa M Ramirez , Gregory G Theophall , Sergei V Reverdatto, Nosirudeen Quadri, Syed Nurul Hasan, Lei Bu, Devi Thiagarajan, Robin Wilson, Raquel López Díez, Paul F Gugger, Kaamashri Mangar, Navneet Narula, Stuart D Katz, Boyan Zhou, Huilin Li, Aleksandr B Stotland, Roberta A Gottlieb, Ann Marie Schmidt, Alexander Shekhtman, Ravichandran Ramasamy. DIAPH1-MFN2 interaction regulates mitochondria-SR/ER contact and modulates ischemic/hypoxic stress. Nature Communications. 2023 Oct 30;14(1):6900. doi: 10.1038/s41467-023-42521-x.
Robin A Wilson, Lakshmi Arivazhagan , Henry H Ruiz , Boyan Zhou , Kun Qian , Michaele B Manigrasso , Rollanda Bernadin , Kaamashri Mangar , Alexander Shekhtman , Huilin Li , Ravichandran Ramasamy , Ann Marie Schmidt. 2023. Pharmacological antagonism of receptor for advanced glycation end products signaling promotes thermogenesis, healthful body mass and composition, and metabolism in mice. Obesity. 2023, 31(7):1825-1843. doi: 10.1002/oby.23774
Senatus L, Egaña-Gorroño L, López-Díez R, Bergaya S, Aranda JF, Amengual J, Arivazhagan L, Manigrasso MB, Yepuri G, Nimma R, Mangar KN, Bernadin R, Zhou B, Gugger PF, Li H, Friedman RA, Theise ND, Shekhtman A, Fisher EA, Ramasamy R, Schmidt AM. 2023 DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice. Commun Biol. 2023 Mar 17;6(1):280. doi: 10.1038/s42003-023-04643-2.
Sciolino N, Reverdatto S, Premo A, Breindel L, Yu J, Theophall G, Burz DS, Liu A, Sulchek T, Schmidt AM, Ramasamy R, Shekhtman A. 2023 Messenger RNA in lipid nanoparticles rescues HEK 293 cells from lipid-induced mitochondrial dysfunction as studied by real time pulse chase NMR, RTPC-NMR, spectroscopy. Sci Rep. 2022 Dec 24;12(1):22293. doi: 10.1038/s41598-022-26444-z.
Arivazhagan L, Popp CJ, Ruiz HH, Wilson RA, Manigrasso MB, Shekhtman A, Ramasamy R, Sevick MA, Schmidt AM. 2022. The RAGE/DIAPH1 axis: mediator of obesity and proposed biomarker of human cardiometabolic disease. Cardiovasc Res. 2022 Nov 30:cvac175. doi: 10.1093/cvr/cvac175.
Ramasamy R, Shekhtman A, Schmidt AM. 2022. The RAGE/DIAPH1 Signaling Axis & Implications for the Pathogenesis of Diabetic Complications. Int J Mol Sci. 2022 Apr 21;23(9):4579. doi: 10.3390/ijms23094579.
Sciolino N, Liu A, Breindel L, Burz DS, Sulchek T, Shekhtman A. 2022. Microfluidics delivery of DARPP-32 into HeLa cells maintains viability for in-cell NMR spectroscopy. Commun Biol. 2022 May 12;5(1):451. doi: 10.1038/s42003-022-03412-x.
Manigrasso MB, Rabbani P, Egaña-Gorroño L, Quadri N, Frye L, Zhou B, Reverdatto S, Ramirez LS, Dansereau S, Pan J, Li H, D'Agati VD, Ramasamy R, DeVita RJ, Shekhtman A, Schmidt AM. 2021. Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice. Science Transl Med. 13(621):eabf7084. doi: 10.1126/scitranslmed.abf7084.
Senatus L, MacLean M, Arivazhagan L, Egaña-Gorroño L, López-Díez R, Manigrasso MB, Ruiz HH, Vasquez C, Wilson R, Shekhtman A, Gugger PF, Ramasamy R, Schmidt AM. 2021. Inflammation Meets Metabolism: Roles for the Receptor for Advanced Glycation End Products Axis in Cardiovascular Disease. Immunometabolism. 3(3):e210024. doi: 10.20900/immunometab20210024.
Ganesan R, Dughbaj MA, Ramirez L, Beringer S, Aboye TL, Shekhtman A, Beringer PM, Camarero JA. 2021. Engineered Cyclotides with Potent Broad in Vitro and in Vivo Antimicrobial Activity. Chemistry. 1;27(49):12702-12708. doi: 10.1002/chem.202101438.
Yu J, Ramirez LM, Premo A, Busch DB, Lin Q, Burz DS, Shekhtman A. 2021. Ribosome-Amplified Metabolism, RAMBO, Measured by NMR Spectroscopy. Biochemistry. 22;60(24):1885-1895. doi: 10.1021/acs.biochem.1c00074.
López-Díez R, Egaña-Gorroño L, Senatus L, Shekhtman A, Ramasamy R, Schmidt AM. 2021. Diabetes and Cardiovascular Complications: The Epidemics Continue. Curr Cardiol Rep. 2021 Jun 3;23(7):74. doi: 10.1007/s11886-021-01504-4.
Mao S, Chang Z, Ying Zheng Y, Shekhtman A, Sheng J. 2021.DNA Functionality with Photoswitchable Hydrazone Cytidine*. Chemistry. 4;27(32):8372-8379. doi: 10.1002/chem.202100742
Yepuri G, Shekhtman A, Marie Schmidt A, Ramasamy R. 2020 Heme & RAGE: A new opportunistic relationship? FEBS J. 2021 Jun;288(11):3424-3427. doi: 10.1111/febs.15723.
Breindel L, Burz DS, Shekhtman A. 2020. Active metabolism unmasks functional protein-protein interactions in real time in-cell NMR. Commun Biol. 2020 May 21;3(1):249. doi: 10.1038/s42003-020-0976-3.
Breindel L, Yu J, Burz DS, Shekhtman A. 2020. Intact ribosomes drive the formation of protein quinary structure. PLoS One. 2020 Apr 24;15(4):e0232015. doi: 10.1371/journal.pone.0232015. eCollection 2020.
Breindel L, Burz DS, Shekhtman A. 2018 Interaction proteomics by using in-cell NMR spectroscopy. J Proteomics. S1874-3919(18)30055-1.
DeMott CM, Girardin R, Cobbert J, Reverdatto S, Burz DS, McDonough K, Shekhtman A.. 2018. Potent Inhibitors of Mycobacterium tuberculosis Growth Identified by Using in-Cell NMR-based Screening. ACS Chem Biol; 13(3):733-741.
Breindel L, DeMott C, Burz DS, Shekhtman A. 2018. Real-Time In-Cell Nuclear Magnetic Resonance: Ribosome-Targeted Antibiotics Modulate Quinary Protein Interactions. Biochemistry. 57(5):540-546. This article was highlighted by the Editor.
Burz DS, DeMott CM, Aldousary A, Dansereau S, Shekhtman A. 2018. Quantitative Determination of Interacting Protein Surfaces in Prokaryotes and Eukaryotes by Using In-Cell NMR Spectroscopy. Methods Mol Biol. 1688:423-444.
Bi T, Li Y, Shekhtman A, Camarero JA. 2018. In-cell production of a genetically-encoded library based on the θ-defensin RTD-1 using a bacterial expression system. Bioorg Med Chem. 26(6):1212-1219.
DeMott CM, Majumder S, Burz DS, Reverdatto S, Shekhtman A. 2017. Ribosome Mediated Quinary Interactions Modulate In-Cell Protein Activities. Biochemistry. (32):4117-4126.
Johnson RM, Bai G, DeMott CM, Banavali NK, Montague CR, Moon C, Shekhtman A, VanderVen B, McDonough KA. 2017. Chemical activation of adenylyl cyclase Rv1625c inhibits growth of Mycobacterium tuberculosis on cholesterol and modulates intramacrophage signaling. Mol Microbiol. 105(2):294-308.
Seebald LM, DeMott CM, Ranganathan S, Asare Okai PN, Glazunova A, Chen A, Shekhtman A, Royzen M. 2017. Cu(II)-Based Paramagnetic Probe to Study RNA-Protein Interactions by NMR. Inorg Chem. 56(7):3773-3780. This article was highlighted in Bioscience technology https://www.biosciencetechnology.com/news/2017/06/visualizing-rna-protein-interactions-live-human-cells.
Seebald LM, DeMott CM, Ranganathan S, Asare-Okai PN, Glazunova A, Chen A, Shekhtman A, Royzen M. 2017. Cobalt-based paramagnetic probe to study RNA-protein interactions by NMR. J Inorg Biochem. 170:202-208. This article was highlighted in Bioscience technology https://www.biosciencetechnology.com/news/2017/06/visualizing-rna-protein-interactions-live-human-cells.
Xue J, Manigrasso M, Scalabrin M, Rai V, Reverdatto S, Burz DS, Fabris D, Schmidt AM, Shekhtman A.. 2016. Change in the Molecular Dimension of a RAGE-Ligand Complex Triggers RAGE Signaling. Structure. 2016 Aug 9. pii: S0969-2126(16)30169-1. doi: 10.1016/j.str.2016.06.021.
Majumder S, DeMott CM, Reverdatto S, Burz DS, Shekhtman A.. Total Cellular RNA Modulates Protein Activity. Biochemistry. 2016 Aug 16;55(32):4568-73. doi: 10.1021/acs.biochem.6b00330.
Paul TJ, Hoffmann Z, Wang C, Shanmugasundaram M, DeJoannis J, Shekhtman A, Lednev IK, Yadavalli VK, Prabhakar R. Structural and Mechanical Properties of Amyloid Beta Fibrils: A Combined Experimental and Theoretical Approach. J Phys Chem Lett. 2016 Jul 21;7(14):2758-64. doi: 10.1021/acs.jpclett.6b01066.
Li Y, Aboye T, Breindel L, Shekhtman A, Camarero JA. Efficient recombinant expression of SFTI-1 in bacterial cells using intein-mediated protein trans-splicing. Biopolymers. 2016 May 14. doi: 10.1002/bip.22875.
López-Díez R, Shekhtman A, Ramasamy R, Schmidt AM. Cellular mechanisms and consequences of glycation in atherosclerosis and obesity. Biochim Biophys Acta. 2016 May 8. pii: S0925-4439(16)30113-2. doi: 10.1016/j.bbadis.2016.05.005.
Manigrasso MB, Pan J, Rai V, Zhang J, Reverdatto S, Quadri N, DeVita RJ, Ramasamy R, Shekhtman A, Schmidt AM. Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction. Sci Rep. 2016 Mar 3;6:22450. doi: 10.1038/srep22450.
Aboye T, Meeks CJ, Majumder S, Shekhtman A, Rodgers K, Camarero JA. Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity. Molecules. 2016 Jan 26;21(2):152. doi: 10.3390/molecules21020152.
Ramasamy R., Shekhtman A, Schmidt AM*. 2015 The multiple faces of RAGE – Opportunities for Intervention in Aging and Chronic Disease. Expert Opinion on therapeutic targets. In press.
Jagadish K, Gould A, Borra R, Majumder S, Mushtaq S, Shekhtman A, Camarero JA*. 2015. Recombinant expression and phenotypic screening of a bioactive cyclotide against α-synuclein induced cytotoxicity in baker’s yeast. Angew Chem Int Ed Engl. [Epub ahead of print]. This article was featured on the cover of Angew Chem Int Ed Engl.
Majumder S, Xue J, DeMott CM, Reverdatto S, Burz DS, Shekhtman A*. 2015. Probing Protein Quinary Interactions by in-cell NMR. Biochemistry. [Epub ahead of print]. This article was selected to be highlighted on the Biochemistry home page.
Reverdatto S, Burz DS, Shekhtman A*. 2015. Peptide aptamers: Development and Applications. Curr. Topics in Med Chem., 15, 1082-1101.
Cobbert JD, DeMott C, Majumder S, Smith EA, Reverdatto S, Burz DS, McDonough KA, Shekhtman A*. 2015. Caught in action: selecting Peptide aptamers against intrinsically disordered proteins in live cells. Sci Rep. 5, 9402. This article was selected by Faculty of 1000 with the “exceptional” rating, http://f1000.com/prime/725402381.
Banerjee PR, Pande A, Shekhtman A, Pande J. 2015. Molecular mechanism of the chaperone function of mini-α-crystallin, a 19-residue peptide of human α-crystallin. Biochemistry. 54, 505-15. This article was reviewed in C&E News, http://cen.acs.org/articles/92/web/2014/12/Study-Suggests-Mechanism-Eye-Protein.html.
Pearson CS, Belfort G, Belfort M, Shekhtman A. 2015. Backbone assignments of mini-RecA intein with short native exteins and an active N-terminal catalytic cysteine. Biomol NMR Assign. 9, 235-8.
Xue J, Ray R, Singer D, Böhme D, Burz DS, Rai V, Hoffmann R, Shekhtman A*. 2014. The receptor for advanced glycation end products (RAGE) specifically recognizes methylglyoxal-derived AGEs. Biochemistry. 53, 3327-35.
Majumder S, DeMott CM, Burz DS and Shekhtman A*. 2014. Using Singular Value Decomposition to Characterize Protein–Protein Interactions by In-cell NMR Spectroscopy. ChemBioChem. 15, 929-33.
Somireddy VB, Shekhtman A, Pande J*. 2014. The cataract-associated V41M mutant of human γS-crystallin shows specific structural changes that directly enhance local surface hydrophobicity. Biochemical and Biophysical Research Communications. 443, 110–114.
Karlsson AB, Washington J, Dimitrova V, Hooper C, Shekhtman A, Bakowska JC*. 2014. The role of spartin and its novel ubiquitin binding region in DALIS occurrence. Mol. Biol. Cell. 25, 1355-1365.
Maldonado AY, Burz DS, Reverdatto S, Shekhtman A*. 2013. Fate of Pup inside the Mycobacterium proteasome studied by in-cell NMR. PLoS One. 8, e74576. doi:10.1371/journal.pone.0074576.
Reverdatto S, Rai V, Xue J, Burz DS, Schmidt AM, Shekhtman A*. 2013. Combinatorial library of improved peptide aptamers, CLIPs to inhibit RAGE signal transduction in mammalian cells. PLoS One. 8, e65180. doi: 10.1371/journal.pone.0065180.
Ji Y, Majumder S, Millard M, Borra R, Bi T, Elnagar AY, Neamati N, Shekhtman A, Camarero JA*. 2013. In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide. J. Am. Chem. Soc. 135, 11623-33. This article was selected by Faculty of 1000.
Harris KA, Shekhtman A, Agris PF*. 2013. Specific RNA-protein interactions detected with saturation transfer difference NMR. RNA Biol. 10, 1307-11.
Jagadish K, Borra R, Lacey V, Majumder S, Shekhtman A, Wang L, Camarero JA*. 2013. Expression of fluorescent cyclotides using protein trans-splicing for easy monitoring of cyclotide-protein interactions. Angew Chem Int Ed Engl. 52, 3126-31. This article was featured on the cover of Angew Chem Int Ed Engl..
Sayahi H, Pugliese KM, Zimhony O, Jacobs WR Jr, Shekhtman A, Welch JT*. 2012. Analogs of the antituberculous agent pyrazinamide are competitive inhibitors of NADPH binding to M. tuberculosis fatty acid synthase I. Chem Biodivers. 29, 2582-96.
59. Aboye TL, Ha H, Majumder S, Christ F, Debyser Z, Shekhtman A, Neamati N, Camarero JA*. 2012. Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity. J Med Chem. 55, 10729-34.
Xue J, Burz DS, Shekhtman A*. 2012. Segmental labeling to study multidomain proteins. Adv Exp Med Biol. 992, 17-33.
Bertrand K, Reverdatto S, Burz DS, Zitomer R, Shekhtman A*. 2012. Structure of proteins in eukaryotic compartments. J Am Chem Soc. 134, 12798-806.
Kurouski D, Washington J, Ozbil M, Prabhakar R, Shekhtman A, Lednev IK*. 2012. Disulfide bridges remain intact while native insulin converts into amyloid fibrils. PLoS One. 7, e36989. doi: 10.1371/journal.pone.0036989.
Aboye TL, Li Y, Majumder S, Hao J, Shekhtman A, Camarero JA*. 2012. Efficient one-pot cyclization/folding of Rhesus θ-defensin-1 (RTD-1). Bioorg Med Chem Lett. 22, 2823-6.
Gould A, Li Y, Majumder S, Garcia AE, Carlsson P, Shekhtman A, Camarero JA*. 2012. Recombinant production of rhesus θ-defensin-1 (RTD-1) using a bacterial expression system. Mol Biosyst. 8, 1359-65.
Rai V, Maldonado AY, Burz DS, Reverdatto S, Yan SF, Schmidt AM, Shekhtman A*. 2012. Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of C-terminal rage (ctRAGE) and its binding to mDia1. J Biol Chem. 287, 5133-44.
Garcia AE, Tai KP, Puttamadappa SS, Shekhtman A, Ouellette AJ, Camarero JA*. 2011. Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins. Biochemistry. 50, 10508-19.
Lin X, Paskaleva EE, Chang W, Shekhtman A, Canki M*. 2011. Inhibition of HIV-1 infection in ex vivo cervical tissue model of human vagina by palmitic acid; implications for a microbicide development. PLoS One. 26, e24803. doi: 10.1371/journal.pone.0024803.
Maldonado AY, Burz DS, Shekhtman A*. 2011. In-cell NMR spectroscopy. Prog Nucl Magn Reson Spectrosc. 59, 197-212.
Banerjee PR, Puttamadappa SS, Pande A, Shekhtman A, Pande J*. 2011. Increased hydrophobicity and decreased backbone flexibility explain the lower solubility of a cataract-linked mutant of γD-crystallin. J Mol Biol. 412, 647-59.
Sayahi H, Zimhony O, Jacobs WR Jr, Shekhtman A, Welch JT*. 2011. Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase I. Bioorg Med Chem Lett. 21, 4804-7.
Xue J, Rai V, Singer D, Chabierski S, Xie J, Reverdatto S, Burz DS, Schmidt AM, Hoffmann R, Shekhtman A*. 2011. Advanced glycation end product recognition by the receptor for AGEs. Structure. 19, 722-32.
Burz DS, Shekhtman A*. 2010. The STINT-NMR method for studying in-cell protein-protein interactions. Curr Protoc Protein Sci. Chapter 17:Unit 17.11. doi: 10.1002/0471140864.ps1711s61
Paskaleva EE, Xue J, Lee DY, Shekhtman A, Canki M*. 2010. Palmitic acid analogs exhibit nanomolar binding affinity for the HIV-1 CD4 receptor and nanomolar inhibition of gp120-to-CD4 fusion. PLoS One. 5, e12168. doi: 10.1371/journal.pone.0012168.
Puttamadappa SS, Jagadish K, Shekhtman A, Camarero JA*. 2010. Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin. Angew Chem Int Ed Engl. 49, 7030-4.
Hooper C, Puttamadappa SS, Loring Z, Shekhtman A, Bakowska JC*. 2010. Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets. BMC Biol. 8:72. doi: 10.1186/1741-7007-8-72.
Ferrage F, Dutta K, Shekhtman A, Cowburn D*. 2010. Structural determination of biomolecular interfaces by nuclear magnetic resonance of proteins with reduced proton density. J Biomol NMR. 47, 41-54.
Lee DY, Lin X, Paskaleva EE, Liu Y, Puttamadappa SS, Thornber C, Drake JR, Habulin M, Shekhtman A, Canki M*. 2009. Palmitic Acid Is a Novel CD4 Fusion Inhibitor That Blocks HIV Entry and Infection. AIDS Res Hum Retroviruses. 25, 1231-41.
Austin J, Wang W, Puttamadappa SS, Shekhtman A, Camarero JA*. 2009. Biosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I. Chembiochem. 10, 2663-70.
Xie J, Thapa R, Reverdatto S, Burz DS, Shekhtman A*. 2009. Screening of small molecule interactor library by using in-cell NMR spectroscopy (SMILI-NMR). J Med Chem. 52, 3516-22. This article was selected by Faculty of 1000. This article was reviewed in Nature Chemical Biology.
Huang Z, Pei W, Han Y, Jayaseelan S, Shekhtman A, Shi H, Niu L*. 2009. One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors. Nucleic Acids Res. 37, 4022-32. This article was selected by Faculty of 1000.
Moroz OV, Burkitt W, Wittkowski H, He W, Ianoul A, Novitskaya V, Xie J, Polyakova O, Lednev IK, Shekhtman A, Derrick PJ, Bjoerk P, Foell D, Bronstein IB*. 2009. Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function. BMC Biochem. 10:11. doi: 10.1186/1471-2091-10-11.
Burz DS, Shekhtman A*. 2009. Inside the living cell. Nature 45, 37-38.
Pande A, Zhang J, Banerjee PR, Puttamadappa SS, Shekhtman A, Pande J*. 2009. NMR study of the cataract-linked P23T mutant of human gammaD-crystallin shows minor changes in hydrophobic patches that reflect its retrograde solubility. Biochemical and Biophysical Research Communications 382, 196-9.
Schwartz EC, Shekhtman A, Dutta K, Pratt MR, Cowburn D, Darst S, Muir TW*. 2008. A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding. Chemistry and Biology 15, 1091-103. This article was selected by Faculty of 1000.
Xie J, Reverdatto S, Frolov A, Hoffmann R, Burz DS, Shekhtman A*. 2008. Structural basis for pattern recognition by the receptor for advanced glycation end products (RAGE). J Biol Chem. 283, 27255-69.
Burz DS, Shekhtman A*. 2008. In-cell biochemistry using NMR spectroscopy. PLoS ONE. 3, e2571.
Liu Q, Dansereau JT, Puttamadappa SS, Shekhtman A, Derbyshire V, Belfort M*. 2008. Role of the interdomain linker in distance determination for remote cleavage by homing endonuclease I-TevI. J Mol Biol 379,1094-106.
Camarero JA, Kimura RH, Woo YH, Shekhtman A, Cantor J*. 2007. Biosynthesis of a fully functional cyclotide inside living bacterial cells. Chembiochem. 8, 1363-6.
Xie J, Burz DS, He W, Bronstein IB, Lednev IK, Shekhtman A*. 2007. Hexameric calgranulin C (S100A12) binds to the receptor for advanced glycated end products (RAGE) using symmetric hydrophobic target-binding patches. J Biol Chem. 282, 4218-31.
Ji H, Shekhtman A, Ghose R, McDonnell JM, Cowburn D*. 2006, NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL. Magn Reson Chem, 44, S101-7.
Burz DS, Dutta K, Cowburn D, Shekhtman A*. 2006. In-cell NMR for protein-protein interactions (STINT-NMR). Nature Protocols, 1, 146 – 152
Burz DS, Dutta K, Cowburn D, Shekhtman A*. 2006. Mapping structural interactions using in-cell NMR spectroscopy (STINT-NMR). Nature Methods, 3, 91-93. This article was selected by Faculty of 1000 Biology and reviewed in Selenko P and Wagner G. NMR mapping of protein interactions in living cells. 2006. Nat Methods. 3, 80-1.
Shekhtman A*. 2005. Protein Chemical Ligation as an Invaluable Tool for Structural NMR. Protein and Peptide Letters 12, 765-768.
Cowburn D, Shekhtman A, Xu R, Ottesen JJ, Muir TW*. 2004. Segmental isotopic labeling for structural biological applications of NMR. Methods Mol Biology, 278, 47-58.
Romanelli A, Shekhtman A, Cowburn D, Muir TW*. 2004. Semisynthesis of a segmental isotopically labeled protein splicing precursor: NMR evidence for an unusual peptide bond at the N-extein-intein junction. Proceedings of the Natural Academy of Sciences U S A 101, 6397-402
Schwartz EC, Shekhtman A, Darst SA, Muir T*. 2003. Segmental isotopic labeling of bacterial RNA polymerase for NMR studies. Biopolymers, 71, 315.
Shekhtman A, Cowburn D*. 2002. A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins. Biochemical and Biophysical Research Communications 296, 1222-7.
Shekhtman A, Ghose R, Goger M, Cowburn D *. 2002. NMR structure determination and investigation using a reduced proton (REDPRO) labeling strategy for proteins. FEBS Letters 524, 177-82.
Camarero JA, Shekhtman A, Campbell EA, Chlenov M, Gruber TM, Bryant DA, Darst SA, Cowburn D, Muir TW*. 2002. Autoregulation of a bacterial sigma factor explored by using segmental isotopic labeling and NMR. Proceedings of the Natural Academy of Sciences U S A 99, 8536-41. Selected by Faculty of 1000 Biology.
Shekhtman A, Ghose R, Wang D, Cole PA, Cowburn D*. 2001. Novel mechanism of regulation of the non-receptor protein tyrosine kinase Csk: insights from NMR mapping studies and site-directed mutagenesis. Journal of Molecular Biology 314, 129-38.
Ghose R, Shekhtman A, Goger MJ, Ji H, Cowburn D*. 2001. A novel, specific interaction involving the Csk SH3 domain and its natural ligand. Nature Structural Biology 8, 998-1004.
Shekhtman A, McNaughton L, Cunningham RP, Baxter SM*. 1999. Identification of the Archaeoglobus fulgidus endonuclease III-DNA interaction surface using heteronuclear NMR methods. Structure with Folding and Design, 7, 919-30.
Begley TJ, Haas BJ, Shekhtman A, Williams WA, Cunningham RP*. 1999. A new member of the endonuclease III family of DNA repair enzymes, which removes methylated purines from DNA. Current Biology 9, 653-656.
Kucirka, J and Shekhtman A*. 1996. On the deracemization of a chiral molecular beam by interaction with circularly polarized light. Physics Letters A221, 273-276.
Shekhtman A and Baryshevsky VG*. 1996. Proton (neutron) spin rotation in polarized nuclear target: a new method for investigating nuclear interactions. Physical Review C53, 267-276I.
Shekhtman A, Tikhomirov VV, and Baryshevsky VG*. 1994. A new mechanism of absorption anisotropy of high energy photons in a crystal. Nuclear Physics B424, 418-428.
Baryshevsky VG and Shekhtman A*. 1994. Proton (neutron) spin rotation in polarized nuclear target: a new technique for investigating exotic baryon states. Physics of Atomic Nuclei 57, 1299-1307
Shekhtman A and Baryshevsky VG*. 1993. Spin oscillation and the possibility of quadrupole moment measurement for omega-minus hyperon moving in a crystal. Nuclear Instruments and Methods in Physics Research B83, 1250-1255.
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