Curriculum Vitae
Paul Clinton Spiegel, Jr., Ph.D.
Paul Clinton Spiegel, Jr., Ph.D.
Western Washington University
Department of Chemistry
516 High Street, Bellingham, WA 98225-9150
(360) 650-3137 office, (360) 650-4969 lab
Email: Paul.Spiegel@wwu.edu
Homepage: https://sites.google.com/site/spiegelresearch/home
EDUCATION:
Doctor of Philosophy, Biochemistry
Program in Biomolecular Structure and Design
University of Washington Department of Biochemistry and the Fred Hutchinson Cancer Research Center, Seattle, WA (2004)
Honors Bachelor of Science, Biochemistry and Biophysics
University Honors College, Oregon State University, Corvallis, OR (1999)
EXPERIENCE:
06/20 – present Department Chair, Dept. of Chemistry, Western Washington University
09/16 – present Professor, Department of Chemistry, Western Washington University
04/18 – 06/20 Healthcare Professions Faculty Advisor, Western Washington University
09/12 – 09/16 Associate Professor, Dept. of Chemistry, Western Washington University
09/13 – 06/14 Visiting Professor, Dept. of Mol. Biol. and Biochem, Simon Fraser University
09/07 – 09/12 Assistant Professor, Department of Chemistry, AMSEC, Western Washington University. Research Focus: Ribosome structure and function, Antibody Structure, Blood Coagulation, X-ray Crystallography.
09/04 – 09/07 Jane Coffin Childs Postdoctoral Fellow, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz, in the lab of Dr. Harry F. Noller. Research Focus: Structural and functional studies of ribosome translocation.
06/99 – 08/04 Graduate Student in the Division of Basic Sciences (Fred Hutchinson Cancer Research Center) and the Department of Biochemistry (University of Washington) in the lab of Dr. Barry L. Stoddard. Research Focus: Structural and mechanistic studies of blood coagulation factor VIII.
HONORS/AWARDS:
JTH Editors Award 2021
ISTH “State of the Art” Honored Speaker 2021
Arlan Norman Award for Excellence in Student Mentoring 2017
Henry Dreyfus Teacher-Scholar Award 2015
Visiting Professor, Aflac Visiting Professor Series 2013
Summer Research Grant, WWU Research and Sponsored Projects 2009
Project Development Award, WWU Research and Sponsored Projects 2008-2010
Jane Coffin Childs Fund for Medical Research Postdoctoral Fellow 2005-2008
NIH Ruth Kirschstein Predoctoral Molecular Biophysics Training Grant 2001-2004
Summer Undergraduate Research Fellowship, Univ. of Texas, Southwestern 1998
Oregon Space Grant Scholar 1998-1999
Graduated from OSU Magna Cum Laude, member of the OSU Honors College 1999
TEACHING EXPERIENCE:
Course Number: Title: Terms Taught:
CHEM 122 General Chemistry II S18
CHEM 122 (Lab) General Chemistry II Lab 3 since F11, most recent S18
CHEM 123 (Lab) General Chemistry III Lab 6 since F08, most recent S11
CHEM 375 Elements of Biochemistry S16
CHEM 467 Biophysical Chemistry I 7 since W08, most recent W17
CHEM 468 Biophysical Chemistry II 3 since S08, most recent S13
CHEM 471 Biochemistry I 10 since F07, most recent F21
CHEM 472 Biochemistry II 8 since S11, most recent W20
CHEM 473 Biochemistry III F22
CHEM 474 Biochemistry Lab 13 since W08, most recent F19
CHEM 425h/573 Enzyme Chemistry 5 since S10, most recent S20
HNRS 355 History and Future of Genetics S19
INDEPENDENT PUBLICATIONS († - WWU undergraduate, * - WWU MS graduate student):
22. Belofski G, Ahn H, Zapata M, Wilcox D, Salomon CE, Spiegel PC Jr. (2023) Antimicrobial Isoflavans and Other Metabolites of Dalea jamesii (Fabaceae). Planta Medica Online ahead of print.
- collected CD data for confirmation of natural products identification.
21. *Peters SC, Childers KC, *Mitchell CE, †Avery NG, †Reese SS Jr, †Mitchell C, *Wo SW, *Swanson CD, †Brison CM, Spiegel PC Jr. (2022). Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII. Frontiers in Molecular Biosciences 9:1040106.
20. McPherson V, Wolhart H, Engels L, Sullivan K, Coria A, Bicchieri T, Torrey B, Spiegel PC Jr, Danforth S, Belofsky G, Dondji B. (2022). Assessment of the anthelmintic activity and toxicity of metabolites of Dalea pogonathera (Fabaceae). Phytochem Letters 51(2022): 75-81. – collected CD data for confirmation of natural products identification.
19. Childers KC, *Peters SC, Spiegel PC Jr. (2022). Structural insights into blood coagulation factor VIII: Procoagulant complexes, membrane binding, and antibody inhibition. J Thromb Haemostasis 20(9): 1957-1970. Cover Article, Review
18. Spiegel PC Jr. (2022). Shining a Light on Thrombin Generation. Blood 139(24): 3451-3453.
17. Childers KC, *Peters SC, Lollar P, Spencer HT, Doering CB, Spiegel Jr PC. (2022). SAXS Analysis of Intrinsic Tenase Complex Bound to Lipid Nanodisc Highlights Intermolecular contacts between factors VIIIa/IXa. Blood Advances 6(11): 3240-3254.
16. Spiegel PC Jr. (2021). VWF Self-Association Requires Tensile Force. Blood 138(23): 2309-2310.
15. Krishnaswamy S, Ageno W, Arabi Y, Barbui T, Cannegieter S, Carrier M, Cleuren AC, Collins P, Panicot-Dubois L, Freedman JE, Freson K, Hogg P, James AH, Kretz CA, Lavin M, Leebeek FWG, Li W, Maas C, Machlus K, Makris M, Martinelli I, Medved L, Neerman-Arbez M, O'Donnell JS, O'Sullivan J, Rajpurkar M, Schroeder V, Spiegel PC Jr, Stanworth SJ, Green L, Undas A. (2021). Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress. Res Pract Thromb Haemost 5(5): e12532.
14. †Ronayne EK, *Peters SC, *Gish JS, †Wilson C, Spencer HT, Doering CB, Lollar P, Spiegel Jr PC, Childers KC. (2021). Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor. Frontiers in Immunology 12: 2260.
13. *Gish JS, †Jarvis L, Childers KC, †Peters SC, †Garrels CS, *Smith IW, Spencer HT, Doering CB, Lollar P, Spiegel PC Jr. (2021). Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor. Blood 137(21): 2981-2986. Cover Article
12. *Smith IW, †d'Aquino AE, Coyle CW, Fedanov A, Parker ET, Denning G, Spencer HT, Lollar P, Doering CB, Spiegel PC Jr. (2020). The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain. J Thromb Haemostasis 18(1): 57-69.
11. *Vincent CT, †Long ET, †Jones HC, Young JC, Spiegel PC, O'Neil GW. (2019) Suzuki Coupling-based Synthesis of VATPase Inhibitor Archazolid Natural Product Derived Fragments. RSC Advances 9(55): 32210-32218.- performed COX enzyme inhibition assays for compounds in this manuscript.
10. *Carlson MA, †Haddad BG, *Weis AJ, †Blackwood CS, †Shelton CD, †Wuerth ME, *Walter JD, Spiegel PC. (2017). Ribosomal Protein L7/L12 is Required for GTPase Translation Factors EF-G, RF3 and IF2 to Bind in their GTP State to 70S Ribosomes. FEBS J 284(11):1631-1643.
9. O’Neil GW, †Craig AM, *Williams JR, Young JC, Spiegel PC. (2017) Synthesis of the C1-C23 Fragment of the Archazolids and Evidence for V-ATPase but not COX Inhibitory Activity. Synlett 28(09): 1101-1105.- performed COX enzyme inhibition assays for synthesized compounds in this manuscript.
8. *Wuerth ME, †Cragerud, RK, Spiegel PC. (2015). X-ray Crystal Structure of the Human Factor VIII C2 Domain in Complex with the Classical 3E6 Inhibitory Antibody. Scientific Reports 5:17216.
7. †Brison CM, †Mullen SM, *Wuerth ME, †Podolsky K, †Cook M, †Herman JA, *Walter JD, Meeks SL, Spiegel PC. (2015). The 1.7 Å X-ray Crystal Structure of the Porcine Factor VIII C2 Domain and Binding Analysis to Anti-Human C2 Domain Antibodies and Phospholipid Surfaces. PLoS One 10(3): e0122447.
6. Sevy AM, Healey JF, Deng W, Spiegel PC, Meeks SL, Li R. (2013). Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry. J Thromb Haemost 11(12): 2128-36. Cover Article
5. *Walter JD, *Werther RA, †Brison CM, †Cragerud RK, Healey JF, Meeks SL, Lollar P, Spiegel PC Jr. (2013). Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes. Blood 122(26): 4270-8. Cover Article
4. *Walter JD, *Werther RA, †Polozova MS, Healey JF, Meeks SL, Lollar P, Spiegel PC. (2013). Characterization and Solution Structure of the Factor VIII C2 Domain in a Ternary Complex with Classical and Non-Classical Antibody Inhibitors. Journal of Biological Chemistry 288(14): 9905-14.
3. *Walter JD, †Hunter M, †Cobb M, †Traeger G, Spiegel PC. (2012). Thiostrepton Inhibits Stable 70S Ribosome Binding and Ribosome-Dependent GTPase Activation of Elongation Factor G and Elongation Factor 4. Nucleic Acids Research 40(1): 360-70.
2. Karanicolas J, Corn JE, Chen I, Joachimiak LA, Dym O, Chung S, Albeck S, Unger T, Hu W, Liu G, †Delbecq S, Montelione G, Spiegel C, Liu DR, Baker D. (2011). A De Novo Protein Binding Pair by Computational Design and Directed Evolution. Molecular Cell. 42(2): 250-60.
1. *Walter JD, †Littlefield P, †Delbecq S, Prody G, Spiegel PC. (2010). Expression, Purification, and Analysis of Unknown Translation Factors from Escherichia coli: A Synthesis Approach. Biochemistry and Molecular Biology Education. 38(1): 17-22.
PREVIOUS PUBLICATIONS
10. Shen BW*, Spiegel PC*, et. al., Stoddard, BL. (2008). Tertiary Structure and Domain Organization of Coagulation Factor VIII. Blood. 111(3): 1240-7. * Co-first author.
9. Spiegel PC, Ermolenko DN, Noller HF. (2007). Elongation Factor G Stabilizes the Hybrid-State Conformation of the 70S Ribosome. RNA. 13(9): 1473-82.
8. Ermolenko DN, Majumdar ZK, Hickerson RP, Spiegel PC, Clegg RM, Noller HF. (2007). Observation of Intersubunit Movement of the Ribosome in Solution Using FRET. Journal of Molecular Biology. 370(3): 530-40.
7. Ermolenko DN*, Spiegel PC*, Majumdar ZK, Hickerson RP, Clegg RM, Noller HF. (2007). The Antibiotic Viomycin Traps the Ribosome in an Intermediate State of Translocation. Nature Structural and Molecular Biology. 14(6): 493-7. *Co-first author.
6. Spiegel PC, Chevalier B, Sussman D, Turmel M, Lemieux C, Stoddard BL. (2006). The Structure of I-CeuI Homing Endonuclease: Evolving Asymmetric DNA Recognition from a Symmetric Protein Scaffold. Structure. 14(5): 869-880.
5. Spiegel PC, Murphy P, Stoddard BL. (2004). Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities. Journal of Biological Chemistry. 279(51): 53691-8. Cover Article
4. Spiegel PC, Kaiser SM, Simon JA, Stoddard BL. (2004). Disruption of protein-membrane binding and identification of small molecule inhibitors of coagulation factor VIII. Chemistry and Biology. 11(10): 1413-22.
3. Bolduc JM, Spiegel PC, Chatterjee P, Caprara MG, Waring RB Stoddard BL. (2003). The structure and DNA recognition of a bifunctional homing endonuclease and group I intron splicing factor. Genes and Development. 17(23): 2875-88. Cover Article
2. Spiegel PC and Stoddard BL. (2002). Optimization of factor VIII replacement therapy: can structural studies help in evading antibody inhibitors? British Journal of Haematology. 119(2): 310-22.
1. Spiegel PC, Jacquemin M, Saint-Remy JM, Stoddard BL, Pratt KP. (2001). Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII. Blood. 98(1): 13-9. Plenary Cover Article.
BOOK CHAPTERS
1. Noller HF, Ermolenko DN, Korostelev A, Laurberg M, Zhu J, Asahara H, Lancaster L, Horan L, Hirschi A, Donohue JP, Trakhanov S, Spiegel C, Hickerson R, Cornish P, Ha T. (2011). Studies on the Mechanisms of Translocation and Termination. Ribosomes. Ch 28. ISBN 978-3-7091-0214-5
ORAL PRESENTATIONS:
“Structural and Dynamic Studies of Factor VIII Inhibitor Complexes”, NIH Factor VIII U54 Steering Committee Meeting, Virtual Presentation, August 2022
“Structural Studies of Factor VIII Inhibitor Complexes”, NIH Factor VIII U54 Steering Committee Meeting, Virtual Presentation, March 2022
“Factor VIII Structure: Determinants of Inhibitor Development” State-of-the-Art Lecture, The International Society of Thrombosis and Hemostasis Conference, Philadelphia, PA, July 2021
“Structural Characterization of Anti-C Domain Antibody Inhibitors in Complex with Bioengineered Factor VIII”, NIH Factor VIII U54 Steering Committee Meeting, Virtual Presentation, February 2021
“Crystal Structure of an Anti-C1 Domain Antibody Inhibitor Bound to B Domain-Deleted Factor VIII”, NIH Factor VIII U54 Steering Committee Meeting, Virtual Presentation, February 2020
“Structural Evidence of an Anti-C1 Domain Antibody Bound to B Domain-Deleted Factor VIII”, BIC Meeting on Factor VIII Inhibitors, Genoa, Italy, September 2019
“The 3.2 Å Crystal Structure of a Bioengineered Variant of Blood Coagulation Factor VIII Indicates Two Distinct Conformations of the C2 Domain”, NIH Factor VIII U54 Steering Committee Meeting, Bethesda, Maryland, March 2019
“The 3.2 Angstrom Crystal Structure of a Bioengineered Factor VIII Construct Illustrates Two Conformations of the C2 Domain”, Annual Meeting of the American Society of Hematology, San Diego, California, December 2018
“Structural and Bioengineering Studies of Blood Coagulation Factor VIII to Overcome the Immune Response to Hemophilia A Treatment”, Chemistry Lecture Series, Portland State University, Portland, Oregon, September 2018
“Structurally Deciphering the Antibody Response to Hemophilia A Treatment”, University of Puget Sound Science Seminar Series, Tacoma, WA, March 2018
“Structurally Deciphering the Antibody Response to Hemophilia A Treatment”, AEES Seminar Course, Instructor: Emily Borda, January 2018
“X-ray Crystallographic Studies of the Factor VIII C2 Domain in Complex with O-phospho-L-serine Indicate that Arginine 2320 Contributes to the Phospholipid Membrane Binding Site”, The International Society of Thrombosis and Hemostasis Conference, Berlin, Germany, July 2017
“Should Human Genetic Data be Public or Private?” WWU Ethics in Research Seminar Series, May 2017
“Structurally Deciphering the Antibody Response to Hemophilia A Treatment” WWU Biology Department Seminar Series, February 2016
“Structurally Deciphering the Immune Response to Blood Coagulation Factor VIII: Hemophilia A and Antibody Inhibitors” WWU Chemistry Promotion Talk, October 2015.
“Inhibitors: What Can We Learn From Crystal Structure Modeling” Symposium on Inhibitors of FVIII: Translating the Bench to Bedside. Nationwide Children’s Hospital, Columbus, Ohio, May 18, 2015.
“Structural Studies of Blood Coagulation Factor VIII to Overcome the Immune Response” The Centre for Blood Research Seminar Series, University of British Columbia, December 2013
“Structural Studies of Blood Coagulation Factor VIII to Overcome the Immune Response” Department of Molecular Biology and Biochemistry, Simon Fraser University, October 2013
“Structurally Deciphering the Immune Response to Blood Coagulation Factor VIII” Seattle Pacific University, May 2013
“Structurally Deciphering the Immune Response to Blood Coagulation Factor VIII” Aflac Cancer and Blood Disorders Center, Aflac Visiting Lecture Series, Emory University, April 2013
“Activation, Function and Inhibition of Ribosome-Dependent GTPases” Department of Biochemistry and Biophysics, Oregon State University, January 2013
“Where did all these structures come from? A survey of current structural biology methods” WWU Chemistry REU Lunch Seminar Series, July 2012
“Blood Coagulation: Hemophilia Treatments and Complications” Bellingham Rotary Club, February 2012
“Better Living Through Biochemistry: Structural and Mechanistic Studies of Hemophilia Treatment, Antibiotic Function, and Protein Design” WWU Chemistry Tenure and Promotion Talk, October 2011
“Ribosomes: Inhibition and Activation of GTPases Associated with Ribosomal Translocation” WWU Chemistry REU Symposium, August 2011
“Ancient Molecules, Antibiotic Targets, and the Connection between Genotype and Phenotype”, Western Washington University Faculty Lectures, February 2011
“Structural Movements of the 70S Ribosome: The Elongation Phase of Translation and the Mechanism of Inhibition by Viomycin”, Simon Fraser University, Burnaby, BC, 2009
“Structural Movements of the 70S Ribosome: The Elongation Phase of Translation and the Mechanism of Inhibition by Viomycin”, Volcano Conference, Pack Forest, WA, 2009
“Structural Dynamics of the Ribosome”, Pacific University, Forest Grove, OR, 2008
“The Structure and Function of the Ribosome”, Fred Hutchinson Cancer Research Center, Graduate Course Lecture, Seattle, WA, 2008
“Movements of Ribosome-bound tRNA During the Elongation Phase of Translation”, Western Washington University, October, 2007.
“Movements of tRNA during ribosomal translocation”, UC Santa Cruz RNA Club, January 2007.
“Ribosome Function in an RNA World”, Western Washington University, December 2006.
“Structural investigations into tRNA movements during ribosomal translocation”, The Scripps Research Institute, August 2006.
“Crystal Structure of the LAGLIDADG Homing Endonuclease, I-CeuI”, UC Santa Cruz Structure Club, January 2005.
“Factor VIII, Hemophilia A, and Antibody Inhibitors”, Dissertation Defense, FHCRC, July 2004.
“Identification and characterization of small molecule inhibitors of Factor VIII and coagulation”, Friday Evening Seminar, FHCRC, November 2003.
“Identification and characterization of small molecule inhibitors of Factor VIII and coagulation”, Molecular Biophysics Seminar, UW, December 2003.
“Crystallographic studies of a group I intron-encoded homing endonuclease and putative maturase from Chlamydomonas eugametos (I-CeuI)”, Molecular Biophysics Seminar, UW, March 2003.
“Coagulation factor VIII, hemophilia A, and antibody inhibitors”, 2002 Volcano Conference in Bioorganic Chemistry, Feb. 23, 2002.
“Structural and Mechanistic Studies of Blood Coagulation Factor VIII”, Molecular Biophysics Seminar, UW, December 2001.
“Crystal structure of the factor VIII C2 domain complexed with the Fab fragment of a factor VIII inhibitor antibody”, Friday Evening Seminar, FHCRC, December 2000.
“Crystal structure of the factor VIII C2 domain complexed with the Fab fragment of a factor VIII inhibitor antibody”, 42nd Annual Meeting of the American Society of Hematology, Dec 2000.
GRANTS AND GRANT PROPOSAL ACTIVITY:
“Structural and Biochemical Studies of Blood Coagulation Factor VIII to Overcome the Immune Response” Academic Research Enhancement Award (AREA), National Institutes of Health (NIH), 2021-2024, $389,770 (Principal Investigator).
“Unraveling the Immune Response to Factor VIII” National Institutes of Health (NIH/NHLBI), U54, 2018-2023, $620,000 to WWU (Senior Personnel, sub-contracted project).
- An NIH U54 grant is what is known as a ‘program grant’ that funds a large, coordinated project as a ‘program center’ site (Emory University). This grant is basically three separate R01 grants that are inter-related. I was responsible for drafting one-third of one of the grants, which has funded my lab through a sub-contract for ~15% of the total budget (>$5M for five years).
“’CURE’ing the Biochemistry Laboratory Curriculum” Summer Teaching Grant, Western Washington University, $6,000. (Principal Investigator, split with Prof. Jeanine Amacher)
“REU Site: Research Experience for Undergraduates at Western Washington University” National Science Foundation (NSF), 2018-2021, $270,000 (Co-Principal Investigator).
- Prof. Amanda Murphy wrote/updated most of this proposal. My role was to draft minor portions of the proposal and to serve as an editor and advisor through the application process.
“Structure and Biochemical Studies of Factor VIII to Overcome the Immune Response” Academic Research Enhancement Award (AREA), National Institutes of Health (NIH), 2017-2020, $388,491 (Principal Investigator).
“Plasmon Resonance Biosensors Based on Guided-Wave Plasmon Polariton Modes” AMSEC Seed Grant, 2016 (Co-Principal Investigator).
- This grant was to fund Prof. Janelle Leger’s research program. I served as a collaborator and consultant for the biological component of the project.
2015 Henry Dreyfus Teacher-Scholar Award, Dreyfus Foundation, 2015-2020, $60,000
“MRI: Acquisition of a Single Crystal X-Ray Diffractometer for Molecular Structure Analysis at Western Washington University” National Science Foundation (NSF), 2014-2016, $300,000 (Principal Investigator).
- Prof. John Gilbertson and I co-wrote this proposal.
“REU Site: Research Experience for Undergraduates at Western Washington University” National Science Foundation (NSF), 2014-2018, $280,000 (Principal Investigator).
- Prof. Greg O’Neil and I co-wrote this proposal.
“Structural Requirements for Ribosome-Dependent GTPase Activation and Hybrid State Formation” Academic Research Enhancement Award (AREA), National Institutes of Health (NIH), 2014-2017. $284,083 (Principal Investigator).
“Molecular Recognition in Biochemistry with Optical Biosensors” WWU Student Technology Fee Grant, 2013-2015, $44,000 (Principal Investigator).
“REU Site: Research Experience for Undergraduates at Western Washington University” National Science Foundation (NSF), 2011-2013, $330,000 (Co-Principal Investigator).
“Structure and Stability Studies of Factor VIII to Overcome the Immune Response” Academic Research Enhancement Award (AREA), National Institutes of Health (NIH), 2010-2013, $389,288 (Principal Investigator).
“Homing Endonuclease Genes (HEGs) as a New Platform for Malaria Control” Grand Challenges in Global Health, Foundation for the National Institutes of Health, 2010 – 2012, $25,000 (sub-contract).
“Biochemical Studies of Bacterial Ribosomes: From Genotype to Phenotype” Summer Research Grant, Western Washington University, $5,000.
“Crossing the Biology/Chemistry Bridge: An Integrated Undergraduate Research Project that Harnesses Genetics, Cell Biology, and Biochemistry to Dissect mRNA Processing in Neurodevelopment” Conservation, Research and Education Opportunities (“CREO”), 2009-2010, $9,700.
“Deciphering the Roles of Ribosomal Translocases in the Regulation of Translation” Cottrell College Science Award, Research Corporation, 2010-2012, $44,661 (Principal Investigator).
“Biochemical Engineering of Molecules that Regulate Blood Coagulation” Partners in Science Program, M.J. Murdock Charitable Trust, 2009-2010, $15,000 (Principal Investigator).
“Biochemical Engineering of Molecules that Regulate Blood Coagulation” Project Development Award, Western Washington University, 2009-2010, $40,691.
SERVICE:
Academic Community:
Reviewer, eLife, since 2022
Reviewer, Blood, since 2021
Reviewer, Nucleic Acids Research, since 2008
Reviewer, Journal of Chemical Education, since 2010
Reviewer, Enzyme Purification and Characterization: An Introduction, Wiley (2012)
Reviewer, PLoS One, since 2014
Reviewer, Journal of the American Chemical Society, since 2015
Reviewer, Journal of Thrombosis and Haemostasis, since 2016
Reviewer, Journal of Biological Chemistry, since 2018
Review Panelist, NSF Chemistry REU proposal review, December 2014
Grant Proposal Reviewer, French National Research Agency, May 2017
Reviewer, Purification and Characterization of Secondary Metabolites, Elsevier (2017)
External Consultant, Biochemistry Hiring Committee, University of Puget Sound (2017, 2018)
Western Washington University:
Beckman Scholars Program Proposal Committee, Chair (Summer 2009)
NSF REU Program at WWU, Co-Director (2011-2013)
CSE Personnel Committee (2014-2015)
WWU Faculty Senator (2012-2017)
STS Task Force/Council (2015-2020)
Radiation Safety Committee (2014-present)
University Biosafety Committee (2014-2020)
Presenter, NIH Grant Proposal Workshop, WWU RSP (solo presenter 2016, lead panelist 2019)
Molecular Genetics Faculty Search Committee, Biology Department (2016-2017)
Arlan Norman Mentorship Award Selection Committee (2017)
Western Reads Book Selection Committee (2017)
Faculty Advisor, Pre-healthcare Advising (2018-2020)
Faculty Reviewer, WWU RSP Research Compliance Investigation (2018-2019)
Faculty Advisor, WWU Fall Advising and Orientation for Incoming Freshmen (2018-2019)
Inter-Departmental Faculty Mentor (2019-2020)
Panelist, Faculty Research Panel, WWU Pre-Med Club (2020, 2021)
Panelist, WWU Faculty Q and A, “Human Nature” documentary, Pickford Theater (2020)
Participant, Leader as Coach Workshop, WWU (2020)
Marine and Coastal Sciences Program Policy Committee (2020-present)
CSE Dean’s Advisory Council (2020-present)
WWU Radiation Safety Officer (2021-present)
Western Washington University Department of Chemistry:
Department Graduate Committee (2007-2013, 2015-2020), Chair (Fall 2009-2013)
Department Newsletter Committee, Chair (2008-2011)
Lowell Eddy Memorial Fund for Summer Undergraduate Research Committee (2008-2012)
Department Library Committee (2007-2008)
“What, When, Where, and How of Graduate School in the Sciences”
Panelist (Fall 2007)
Lead Panel Moderator and Organizer (Fall 2008-2010)
Biochemistry Faculty Search Committee (2007-2008)
Result: hiring of Dr. Serge Smirnov
Analytical Chemistry Faculty Search Committee (2008-2009)
Result: hiring of Dr. Amanda Murphy
Organic Chemistry Faculty Search Committee (2011-2012)
Result: hiring of Dr. John Antos, served as his faculty mentor
Department Chair Search Committee (Summer 2012)
Result: selection of Prof. James Vyvyan as chair of Chemistry
Department Space Committee (2012-2015)
Department Chair’s Executive Committee (2014-2015)
Department Budget Committee (2014-2016)
Department Fundraising Committee (2014-2015)
Department Curriculum Committee (2017-present)
Department Mission Statement Focus Group (2019)
Temporary Instrument Specialist Search Committee Chair (March-April 2015)
Result: Hiring of Cyrus Schaaf
NSF REU Program at WWU, PI/Director (2014-2018), Co-PI (2018-2021)
Biochemistry Faculty Search Committee, Chair (Fall 2016)
Result: hiring of Dr. Jeanine Amacher, serve as faculty mentor
Co-organizer of “Survey of Molecular, Cell, Chemical and Structural Biology”, Sehome High School AP Biology Class (annual event from 2016-2019)
Department Safety Officer and Stockroom Manager Search Committee (2020)
Result: hiring of Amanda Weis
Session Organizer, ACS NORM meeting (2020, 2021)
Department Chair (2020-present) Committees: Safety, Curriculum, Budget (chair), Assessment
COPEP Working Group, lead (2020-2021)
Faculty Mentor, Karin Lemkau
Morse Hall Reopening Taskforce (2020)
Search Committees: Instrumentation Specialist, Fiscal Technician, General Chemistry Lab Coordinator
Diversity, Equity and Inclusion Activities
Director, WWU Chemistry REU Program, (2014-2018)
Presenter, WWU Ethics in Research Seminar Series (2017)
Completion of the CSE ISMs four-part workshop (2018)
Faculty Presenter, AEES Seminar Course (2018-2019)
Instructor, “The Natural History and Supernatural Future of Human Genetics” WWU Honors
Faculty Mentor, AEES Program (2019-2020)
HHMI AEES Teacher Training Program, Cohort 2, (2018-2020)
Participant, SACNAS REU Application Workshop (2019, 2020)
Participant, Courageous Conversations, Beyond Diversity, Brownsville, Texas (2020)
Steering Committee Member, ACS Bridge Site Pre-proposal (2020)
Participant, Seeing White podcast discussion group (2020)
U-RISE NIH training grant proposal group, PI (2021-2)
Participant, Courageous Conversations, Beyond Diversity, WWU (2022)
Leadership Training Activities
“Leader as Coach” Professional Leadership Course, WWU (2020)
PKAL STEM Leadership Institute, AAC&U (2021)
M.S. Thesis Committees:
Laura Dettinger (2008) Justin Walter (2010) Halena Van Deusen (2008)
Jim Hall (2010) Toby Ligon (2010) Rachel Werther (2012)
Danielle Pfaff (2011) Jacob Brockerman (2012) Michael Murphy (2012)
Zach Tommavongsy (2013) Jamie Apperson (2013) Stanislav Fedechkine (2013)
Michelle Wuerth (2015) Markus Carlson (2015) R. Corey Henderson (2016)
Rachel Hubbard (2016) Joanna Hoppins (2016) David Gruber (2017)
Heather Miers (2017) Orion Banks (2017) Amanda Weis (2017)
Serena Wo (2017) Ian Smith (2018) Sierra Reed (2018)
Johann Sigurjonsson (2018) Sarah Clark (2018) Nick Horvath (2019)
Joseph Gish (2019) Chris Swanson (2019) Sarah Struyvenberg (2020)
Shaun Peters (2019-2021) Micah Nakao (2019-22) AP Wang (2019-2021)
Haley Bamonte (2019-2021) Corbin Mitchell (2020-22) Ashlee Hoffmann (2021-present)
Jordan Vaughn (2021-present) Nathan Avery (2022-pres) Jess Blair (2022-present)
UNDERGRADUATE RESEARCH STUDENTS:
Total number of undergraduate students mentored to date: 75
Current undergraduate research students: 7
Rishav Chopra Juliet McGill Justin McGlone
Shelby Robinson Terry Brown Patrick Korus
Mady Jacobs
Student Research Awards:
Melanie Cobb, Kelsey Roe – Honorable Mention, Scholars Week Poster Presentation, (2008)
Scott Delbecq – Lowell Eddy Memorial Fellowship for Summer Research (2008)
Peter Littlefield – WWU Washington Space Grate Research Award (2009)
Geoff Traeger – WWU Washington Space Grant Research Award (2009)
Peter Littlefield – WWU Washington Space Grant Summer Research Award (2009)
Scott Delbecq – Department of Chemistry Outstanding Graduate (2009)
Justin Walter – Best Graduate Poster, Scholars Week Poster Presentation, WWU (2009)
Justin Walter – Best Graduate Poster, Scholars Week Poster Presentation, WWU (2010)
Ben Allen – Lowell Eddy Memorial Fellowship for Summer Research (2010)
Bryan Ager – Sea Bong Chang Memorial Award for Outstanding Biochemistry Student (2010)
Ben Allen – Sea Bong Chang Memorial Award for Outstanding Biochemistry Student (2011)
Levi Vincent – Sea Bong Chang Memorial Award for Outstanding Biochemistry Student (2012)
Ayana Robinson – Olson Foundation Scholarship (2012-2013)
Caileen Brison – Best Undergraduate Presentation, Protein Society Symposium (2012)
Michelle Wuerth – Sea Bong Chang Memorial Award for Outstanding Biochem Student (2013)
Anne d’Aquino, Amanda Weis – Best Undergraduate Poster, Scholars Week, WWU (2014)
Anne d’Aquino – NSF Predoctoral Fellowship (2014 – 2018)
Mikko Sayre – Karen and Joe Morse Summer Undergraduate Fellowship (2016)
Rachel Blazevic – Best Undergraduate Poster, Scholars Week Presentation, WWU (2017)
Ian Smith – Arlan Norman Honorable Graduate Scholar, WWU (2018)
Micah Nakao – RSP Graduate Student Mini-Grant, WWU (2019)
Chris Swanson – WWU Chemistry Outstanding Graduate Student (2020)
Estelle Ronayne – Best Undergraduate Poster, Murdock Charitable Trust Annual Mtg (2020)
Ian Smith – Journal of Thrombosis and Haemostasis Editors Award (2021)
WWU Chemistry Honors Thesis Advisor
Jake Herman (2010) Alexis Neuman (2016)
Ben Allen (2011) Lucy Innes (2021)
Michelle Wuerth (2013) Estelle Ronayne (2021)
Catherine Shelton (2016) Sarah Haines (2021)
Nathan Avery (2022) Jess Blair (2022)
GRADUATE STUDENTS:
Justin Walter Fall 2008 – Fall 2010
Rachel Werther Winter 2010 – Winter 2012
Michelle Wuerth Fall 2013 – Summer 2015
Markus Carlson Fall 2013 – Spring 2015
Amanda Weis Fall 2015 – Summer 2017
Serena Wo Fall 2015 – Summer 2017
Ian Smith Fall 2016 – Spring 2018
Joseph Gish Fall 2017 – Summer 2019
Christopher Swanson Fall 2017 – Fall 2019
Shaun Peters Fall 2019 – Fall 2021
AP Wang Fall 2019 – Summer 2021
Micah Nakao Fall 2019 – present
Corbin Mitchell Fall 2020 – Summer 2022
Jordan Vaughn Fall 2021 – present
Ashlee Hoffman Fall 2021 – present
Nathan Avery Fall 2022 – present
Jess Blair Fall 2022 – present