Spiegel Lab

Our research group is interested in using structural and biochemical approaches to better understand three specific areas in biology: (1) structural and functional characterization of blood coagulation factor VIII circulatory complexes; (2) the activation and inhibition of ribosomal GTPases in prokaryotic translation; (3) structural investigations of computationally-engineered enzymes and protein complexes.

To accomplish our goals, we employ a variety of molecular biology techniques, biochemical and immunological assays for measurement of enzyme activity and protein-ligand binding, and various structural biology techniques, such as x-ray crystallography and small angle x-ray scattering. We are also actively interested in harnessing structure-based inhibitor screening as well as the evolutionary capabilities of RNA to develop new biotechnologies that address clinical needs in blood coagulation.

If you have an interest in our research, or would like to inquire about joining our efforts, please contact Prof. Spiegel via email.