Publications

Oh, Y., Yoo, E.S., Ju, S.H., Kim, E., Lee, S., Kim, S., Wickman, K., Sohn, J.W. (2023) GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice. PLoS Biology. 21(8): e3002252.

Lee, H.*, Park, J.*, Kim, S. (2023) Metabolic and transcriptomic signatures of the acute psychological stress response in the mouse brain. Metabolites. 13(3):453. (*equally contributed to this work) 

Ahn, M.*, Park, S.E.*, Choi, J.*, Choi, J., Choi, D., An, D., Jeon, H., Oh, S., Lee, K., Kim, J., Jang, J.+, Kim, S.+, Byun, Y.+ (2023) Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors. J. Enzyme Inhib. Med. Chem. 38(1): 2193866 (*equally contributed to this work, +co-corresponding authors) 

Kim, J.*, Hong, S.*, Park, J., Kim, S. (2023) Metabolic and transcriptomic changes in the mouse brain in response to short-term high-fat metabolic stress. Metabolites. 13(3):407. (*equally contributed to this work)

Lee, H., Kim, E., Kim, S. (2023) miRNA-induced downregulation of IPMK in macrophages mediates lipopolysaccharide-triggered TLR4 signaling. Biomolecules. 13(2): 332.

Kim, S., Lim, S., Choi, J. (2022) Drug discovery inspired by bioactive small molecules from nature. Anim. Cells Syst. 26(6): 254–265. (invited review article)

Park, S.E.*, Lee, D.*, Jeong, J.W., Lee, S., Park, S.J., Ryu, J., Oh, S.K., Yang, H.+, Fang, S.+, Kim, S.+ (2022) Gut epithelial inositol polyphosphate multikinase alleviates experimental colitis via governing tuft cell homeostasis. Cellular and Molecular Gastroenterology and Hepatology. 14(6):1235. (*equally contributed to this work, +co-corresponding authors)

Lee, B.*, Park, S.J.*, Lee, S., Lee, J., Lee, E.B., Yoo, E., Chung, W., Sohn, J., Oh, B., Kim, S. (2022) Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR. Cell Death & Disease. 13:603. (*equally contributed to this work)

Min, H., Kim, W., Hong, S., Lee, S., Jeong, J., Kim, S.+, Seong, R.H.+ (2022) Differentiation and homeostasis of effector Treg cells are regulated by inositol polyphosphates modulating Ca2+influx. Proc. Natl. Acad. Sci. USA. 119(27):e2121520119.  (+co-corresponding authors)

Beon, J.*, Han, S.*, Park, S.E., Hyun, K., Lee, S., Rhee, H., Seo, J.K., Kim, J., Kim, S.+, Lee, D.+ (2022) IPMK physically binds to the SWI/SNF complex and modulates BRG1 occupancy. eLife 11:e73523. (*equally contributed to this work, +co-corresponding authors)

Lee, H.*,  Park, S.J.*,  Hong, S.,  Lim, S., Kim S. (2022) Deletion of IP6K1 in mice accelerates tumor growth by dysregulating the tumor-immune microenvironment Anim. Cells Syst. 26(1):19-27.  (*equally contributed to this work) 

Lee, S.*, Park, B.B.*, Kwon, H., Kim, V., Jeon, J.S., Lee, R., Subedi, M., Lim, T., Ha, H., An, D., Kim, J., Kim, D., Kim, S.K.+, Kim, S.+, Byun Y.+ (2022) TNP and its analogs: Modulation of IP6K and CYP3A4 inhibition. J. Enzyme Inhib. Med. Chem. 37(1):269-279. (*equally contributed to this work, +co-corresponding authors)

Ahn, H*., Roh, J.S.*, Lee, S., Beon, J., Lee, B., Sohn, D.H.+, Kim, S.+ (2021) Myeloid IPMK promotes the resolution of serum transfer-induced arthritis in mice. Anim. Cells Syst. 25(4):219-226. (*equally contributed to this work, +co-corresponding authors)

Lee, B., Park, S.J., Hong, S., Kim, K., Kim, S. (2021) Inositol polyphosphate multikinase signaling: multifaceted functions in health and disease. Mol. Cells 44(4): 187-194. (invited review article)

Lee, S., Beon, J., Kim, M.G., Kim, S. (2020) Inositol polyphosphate multikinase in adipocytes is dispensable for regulating energy metabolism and whole-body metabolic homeostasis. Am J Physiol Endocrinol Metab. 319(2):E401-E409. 

Son, M.J., Oh, K.J., Park, A., Kwon, M.G., Suh, J.M., Kim, I.C., Kim, S., Lee, S.C., Kim, W.K., Bae, K.H. (2020) GATA3 induces the upregulation of UCP-1 by directly binding to PGC-1α during adipose tissue browning. Metabolism. 27:154280.

Lee, S., Kim, M.G., Ahn, H., Kim, S. (2020) Inositol pyrophosphates: Signaling molecules with pleiotropic actions in mammals. Molecules. 25: 2208. (invited review article)

Kim, M.G.*, Zhang, S.*, Park, H., Park, S.J., Kim, S.+, Chung, C.+ (2020) Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory. Molecular Brain. 13:72. (*equally contributed to this work, +co-corresponding authors)

Park, S.J.*, Park, H.*, Kim, M.G.*, Zhang, S., Park, S.E., Kim, S.+, Chung, C.+ (2020) Inositol pyrophosphate metabolism regulates presynaptic vesicle cycling at central synapses. iScience. 23(4):101000. (*equally contributed to this work, +co-corresponding authors)

Lee, B., Park, S.J., Lee, S., Park, S.E., Lee, E., Song, J.J., Byun, Y.+, Kim, S.+ (2020) Identification of the antidepressant vilazodone as an inhibitor of inositol polyphosphate multikinase by structure-based drug repositioning. Mol. Cells 43(3): 222-227. (+co-corresponding authors)

Kim, H., Yoon, Β.H., Oh, C.M., Lee, J., Lee, K., Song, H., Kim, E., Yi, K., Kim, M.Y., Kim, H., Kim, Y.K., Seo, E.H., Heo, H., Kim, H.J., Lee, J., Suh, J.M., Koo, S.H., Seong, J.K., Kim, S., Ju, Y.S., Shong, M., Kim, M., Kim, H. (2020) PRMT1 is required for the maintenance of mature β cell identity. Diabetes. 69(3):355-368. 

Park, J., Park, S.J., Kim, S. (2019) Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain. Molecular Brain 12(1):58. 

Kim, W., Kim, E., Min, H., Kim, M.G., Eisenbeis, V.B., Dutta, A.K., Pavlovic, I., Jessen, H.J., Kim, S.+, Seong, R.H.+ (2019) Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase. Proc. Natl. Acad. Sci. USA. 116(26):12952-12957. (+co-corresponding authors) 

Park, J., Longo, F., Park, S.J., Lee, S., Bae, M., Tyagi, R., Han, JH., Kim, S.+, Santini, E.+, Klann, E.+, Snyder, S.H.+ (2019) Inositol polyphosphate multikinase mediates extinction of fear memory. Proc. Natl. Acad. Sci. USA. 116(7):2707-2712. (+co-corresponding authors)

Lee, C.H., Kim, H.J., Lee, Y-S., Kang, G.M., Lim, H.S., Lee, S-h., Song, D.K., Kwon, O., Hwang, I., Son, M., Byun, K., Sung, Y.H., Kim, S., Kim, J.B., Choi, E.Y., Kim, Y-B., Kim, K., Kweon, M-N., Sohn, J.W., Kim M.S. (2018) Hypothalamic macrophage inducible nitric oxide synthase mediates obesity-associated hypothalamic inflammation. Cell Reports 25:934–946.

Park, S.J., Lee, S., Park, S.E., Kim, S. (2018) Inositol pyrophosphates as multifaceted metabolites in the regulation of mammalian signaling networks. Animal Cells and Systems 22(1)1-6. (invited review article) 

Kim, E., Beon, J., Lee, S., Park, S.J., Ahn, H, Kim, M.G., Park, J.E., Kim, W., Yuk, J.M., Kang, S.J., Lee, S.H., Jo, E.K., Seong, R.H.+, Kim, S.+ (2017) Inositol polyphosphate multikinase promotes Toll-like receptor–induced inflammation by stabilizing TRAF6. Science Advances 3(4):e1602296. (+co-corresponding authors)

Kim, E., Ahn, H., Kim, M.G., Lee, H., Kim, S. (2017) The expanding significance of inositol polyphosphate multikinase as a signaling hub. Molecules and Cells 40(5):315-321. (invited review article)

Kim, D.E*., Jang, M.J.*, Kim, Y.R.*, Lee, J.Y., Cho, E.B., Kim, E., Kim, Y., Kim, M.Y., Jeong, W.I., Kim, S.+, Han, Y.M.+ , Lee, S.H.+ (2017) Prediction of drug-induced immune-mediated hepatotoxicity using hepatocyte-like cells derived from human embryonic stem cells. Toxicology 387:1-9. (*equally contributed to this work, +co-corresponding authors)

Ramazzotti, G., Billi, A.M., Manzoli, L., Mazzetti, C., Ruggeri, A., Erneux, C., Kim, S., Suh, P.G., Cocco, L., Faenza, I. (2016) IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation. Oncotarget 7(51):84118-84127. 

Lee, T.*, Lee, J.*, Kyung, J.W., Yang, Y., Park, S.J., Lee, S., Pavlovic, I., Kong, B., Jho, Y.S., Jessen, H.J., Kweon, D., Shin, Y., Kim, S.H.+, Yoon, T.+, Kim. S.+ (2016) Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis. Proc. Natl. Acad. Sci. USA. 113(29):8314-8319. (*equally contributed to this work, +co-corresponding authors)

Kim, E., Beon, J., Lee, S., Park, J., Kim, S. (2016) IPMK: A versatile regulator of nuclear signaling events. Advances in Biological Regulation 61:25-32. (invited review article)

Kwak, S.S., Kang, K.H., Kim, S., Lee, S., Lee, J.H., Kim, J.W., Byun, B., Meadows, G.G., Joe, C.O. (2016) Amino acid-dependent NPRL2 interaction with raptor determines mTOR complex 1 activation. Cellular Signalling 28(2):32-41. 

Kim, T., Yang, S.J., Hwang, D., Song, J., Kim, M., Kim S.K., Kang, K., Ahn, J., Lee, D., Kim, M.Y., Kim, S., Koo, S.J., Koh, S.S., Kim, S.Y., Lim, D.S. (2015) A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness. Nature Communications 6:10186. 

Im, I., Jang, M.J., Park, S.J., Lee, S.H., Choi, J.H., Yoo, H.W., Kim, S., Han, Y.M. (2015) Mitochondrial respiratory defect causes dysfunctional lactate turnover via AMP-activated protein kinase activation in human-induced pluripotent stem cell-derived hepatocytes. Journal of Biological Chemistry 290(49):29493-29505. 

Ahmed, I., Sbodio, J.I., Harraz, M.M., Tyagi, R., Grima, J.C., Albacarys, L.K., Hubbi, M.E., Xu, R., Kim, S., Paul, B.D., Snyder, S.H. (2015) Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase. Proc. Natl. Acad. Sci. USA. 112(31):9751-9756.

Cha, J.Y., Kim, H.J, Yub, J.H., Xu, J., Kim, D., Paul, B.D., Choi, H., Kim, S., Lee, Y.J., Ho, G.P., Rao, F., Snyder, S.H., Kim, J.W. (2013) Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity. Proc. Natl. Acad. Sci. USA. 110(51):20575-20580. 

Kim, E.*, Tyagi, R.*, Lee, J.Y., Park, J., Kim, Y.R., Beon, J., Chen, P.Y., Cha, J.Y., Snyder, S.H.+, Kim, S.+ (2013) Inositol polyphosphate multikinase is a co-activator for serum response factor-dependent induction of immediate early genes. Proc. Natl. Acad. Sci. USA. 110(49):19938-19943. (*equally contributed to this work, +co-corresponding authors)

Lee, J.Y., Kim, Y.R., Park, J.A., Kim, S. (2012) Inositol polyphosphate multikinase signaling in the regulation of metabolism. Annals of the New York Academy of Sciences 1271:68-74. (invited review article)

Dailey, M.J., Kim, S. (2012) Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase. Biochemical and Biophysical Research Communications 421(1):1-3. (review article)

Bang, S.*, Kim, S.*, Dailey, M.J., Chen, Y., Moran, T.H., Snyder, S.H., Kim, S.F. (2012) AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase. Proc. Natl. Acad. Sci. USA. 109(2):616-620. (*equally contributed to this work)

Sen, N., Paul, B.D., Gadalla, M.M., Mustafa, A.K., Sen, T., Xu, R., Kim, S., Snyder, S.H. (2012) Hydrogen sulfide-linked sulfhydration of NF-kB mediates its antiapoptotic actions. Molecular Cell 45(1):13-24.

Subramaniam, S., Napolitano, F., Mealer, R.G., Kim, S., Errico, F., Barrow, R., Shahani, N., Tyagi, R., Snyder, S.H., Usiello, A. (2011) Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia. Nature Neuroscience 15(2):191-193.

Mazei-Robison, M., Koo, J., Friedman, A., Lansink, C., Robison, A.J., Vinish, M., Krishnan, V., Kim, S., Siuta, M., Galli, A., Niswender, K., Appasani, R., Horvath, M., Neve, R., Worley, P., Snyder, S.H., Hurd, Y., Cheer, J., Han, M., Russo, S., Nestler, E. (2011) Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. Neuron 72(6):977-990.

Chakraborty, C., Kim, S., Snyder, S.H. (2011) Inositol pyrophosphates as mammalian cellular signals. Science Signaling 4(188):re1. (invited review article)

Kim, S., Snyder, S.H. (2011) Nutrient amino acids signal to mTOR via inositol polyphosphate multikinase. Cell Cycle 10(11):1708-1710. (invited review article)

Kim, S.*, Kim, S.F.*, Maag, D., Maxwell, M.J. Resnick, A.C., Juluri, K.R., Cha, S.H., Chakraborty, A., Koldobskiy, M.A., Barrow, R., Snowman, A.M., Snyder, S.H. (2011) Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metabolism 13(2):215-221. (*equally contributed to this work)

Chakraborty, C., Koldobskiy, M.A., Bello, N.T., Maxwell, M., Potter, J.P., Juluri, K.R., Maag, D., Kim, S., Huang, A.S., Dailey, M.J., Saleh, M., Snowman, A.M., Moran, T.H., Mezey, E., Snyder, S.H. (2010) Inositol pyrophosphates inhibit Akt signaling, regulate insulin sensitivity and weight gain. Cell 143(6):897-910.

Koldobskiy, M.A., Chakraborty, A., Werner, Jr. J.K., Snowman, A.M., Juluri, K.R., Vandiver, M.S., Kim, S., Heletz, S., Snyder, S.H. (2010) p53 mediated apoptosis requires inositol hexakisphosphate kinase-2. Proc. Natl. Acad. Sci. USA. 107(49):20947-20951.

Kim, S., Coulombe, P.A. (2010) Emerging role for the cytoskeleton as an organizer and regulator of translation. Nature Reviews Molecular Cell Biology 11(1):75-81. 

Mustafa, A.K., Gadalla, M.M., Sen, N., Kim, S., Mu, W., Gazi, S.K., Barrow, R.K., Yang, G., Wang, R., Snyder, S.H. (2009) H2S signals through protein S-sulfhydration: a novel post-translational modification. Science Signaling 2(96):ra72.

Kim, S., Kellner, J, Lee, C-H, Coulombe, P.A. (2007) Interaction between the keratin cytoskeleton and eEF1Bgamma affects protein synthesis in epithelial cells. Nature Structural and Molecular Biology 14(10):982-983.

Kim, S., Coulombe, P.A. (2007) Intermediate filament scaffolds fulfill mechanical, organizational, and signaling functions in the cytoplasm. Genes and Development 21(13):581-597. (invited review article)

Kim, S., Wong, P., Coulombe, P.A. (2006) A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature 441(7091):362-365.

Kim, S., Lee, S.H., Park, D. (2001) Leucine zipper-mediated homodimerization of the p21-activated kinase-interacting factor, beta Pix. Journal of Biological Chemistry 276(14):10581-10584.

Lee, S.H., Eom. M., Lee, S.J., Kim, S., Park, H.J., Park, D. (2001) Beta Pix-enhanced p38 activation by Cdc42/Rac/PAK/MKK3/6-mediated pathway. Journal of Biological Chemistry 276(27):25066-25072.

Kim, S., Kim, T., Lee, D., Park, S., Kim, H., Park, D. (2000) Molecular cloning of neuronally expressed mouse beta Pix isoforms. Biochemical and Biophysical Research Communications 272(3):721-725.