Introduction

   KAIST

Laboratory of Metabolism Signaling Network  (대사 신호전달 네트워크 연구실)  

The main goal of our research is to better understand the biological functions and their molecular mechanisms of metabolism-based signaling regulations. Currently, we employ all levels of biochemical, cell biological, and mouse models of metabolism signaling research to identify the ways in which nutrients or hormones regulates the physiological functions of metabolic tissues and organs. Our major interests include inositol polyphosphate biosynthetic pathway and its signaling roles in the control of major physiologic processes in mammals. We strongly believe obtained molecular and biological information can guide us to the development of improved treatments of medical conditions such as diabetes, inflammation as well as cancer. 

                                     

                Inositol Polyphosphate (IP) Biosynthesis


    Versatile Roles of IP Metabolism in Signaling Networks 

1. 호르몬과 영양물질에 의한 생리학적 활성들을 정교하게 조절하는 이노시톨 다인산 대사체 및 각종 세포내 저분자물질등에 기반한 신호전달계를 체계적으로 규명하고,            

2. 대사장애 관련질병(예. 암, 신경계 질환, 당뇨 및 염증)들을 조절하는 신약 및 질병 치료표적등을 발굴, 개발하는 것이 궁극적인 목표입니다.   


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