Publications

2024

1. Raghunath, B.V., Asthana, S., Vyopkamma, D., Saini, D.K. and Alladi, A. Understanding the endocrine and molecular signaling cascade regulation pathways in children with Hypospadias. (2024) J. Ped. Genet. (Accepted). 

2. Jain, N., Bhushan, B.L.S., M. Natrajan, M., Mehta, R., Saini, D.K. and Chatterjee, K. Advanced 3D In Vitro Lung Fibrosis Models: Contemporary Status, Clinical Uptake, and Prospective Outlooks. ACS Biomat. Sci. Engg. 2024, (Accepted)

3. Thapa, B.V., Banerjee, M., Glimm, T., Saini, D.K. and Bhat, R. The senescent mesothelial matrix accentuates colonization by ovarian cancer cells. (2023) Cell Mol. Life Sci. 81(1):2. Link  

2023

1. Sawase, L.R., Kumar, T.A., Mathew, A.B., Khodade, V., Toscano, J., Saini, D.K. and Chakrapani, H. β-galactosidase-activated Nitroxyl (HNO) Donors Provide Insights into Redox Cross-Talk in Senescent Cells. (2023) Chem. Comm. 59(85):12751-12754. Link DOI

2. https://doi.org/10.1039/D3CC03094F

3. Yadav, P., Shah, R., Roy, A., Jani, S., Chatterjee, K.* and Saini, D.K.* Cellular Senescence Program is Sensitive to Physical Differences in Polymeric Tissue Scaffolds. (2023) ACS Material Au. 4(1); 35-44. eCollection 2024 Jan 10. Link 10.1021/acsmaterialsau.3c00057 

4. Upadhyay, A., Nepalia, A., Bera, A., Saini, D.K.* and Chakravarty, A*. Platinum(II) boron-dipyrromethene complex for cellular imaging and mitochondria-targeted photodynamic therapy in red light. (2023) Chem. Asian J. 18(21):e202300667. Epub 2023 Sep 27.. *, corresponding authors. Link 

5. Bera, A., Nepalia, A., Upadhyay, A. and Saini, D.K.* and Chakravarty, A*. Biotin and boron-dipyrromethene tagged platinum(IV) prodrug for cellular imaging and mito-targeted photocytotoxicity in red ligh. (2023) Dalton Trans., Link 

6. Sankhe, G.D., Raja, R., Singh, D.P., Bheemireddy, S., Rana, S., Athira, P., Dixit, N.M.* and Saini, D.K*. Sequestration of histidine kinases by non-cognate response regulators establishes a threshold level of stimulation for bacterial two-component signaling. (2023) Nature Communications. 14(1):4483. Link 

7. Nepalia, A., Fernandes, S.E., Singh, H., Rana, S. and Saini, D.K. Anti-microbial resistance and Aging – A design for evolution. (2023) WIREs Mech. Dis. e1626. Link  

8. Chattopadhyay, A., Joseph, J.P., Jagdish, S., Chaudhuri, S., Ramteke, N.S., Karhale, A.K., Waturuocha, U., Saini, D.K. and Nandi, D. High throughput screening identifies auranofin and pentamidine as potent compounds that lower IFN-γ-induced Nitric Oxide and inflammatory responses in mice: DSS-induced colitis and Salmonella Typhimurium induced sepsis. (2023) Int. Immunopharmacol. 122:110569. Link  

9. Aceves-Sánchez, M.L., Barrios-Payán, J.A., Segura-Cerda, C.A., Flores-Valdez, M.A. Mata-Espinosa, D., Pedroza-Roldán, C., Yadav, R., Saini, D.K. de la Cruz, M.A., Ares, M.A. Bielefeldt-Ohmann, H., Baay-Guzmán, G., Vergne, I., Velázquez-Fernández, J.B., Barba León, J. and Hernández-Pando, R. BCG∆BCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice. (2023) Vaccine, 41(26), 3824–3835. Link 

10. Sidhu, J.S., Rajendran, K., Mathew, A.B., Iqbal, T., Saini, D.K., Das, D. Acetylcholine structure-based small activatable fluorogenic probe for specific detection of acetylcholinesterase. (2023) Analytical Chemistry  95 (19), 7594-7602. Link 

2022

1. Tiwari, P., Gosain, T.P., Chugh, S., Singh, M., Sankhe, G.D., Arora, G., Kidwai, S., Agarwal, S., Saini, D.K. and Singh, R. Exopolyphosphatases PPX1 and PPX2 from Mycobacterium tuberculosis regulate dormancy response and pathogenesis. (2022) Microbial Pathogenesis, 173, 105885. Link 

2. Singh, S., Kumbhar, D., Reghu, D., Venugopal, S.J., Rekha, P.T., Mohandas, S., Rao, S., Rangaiah, A., Chunchanur, S.K.*, Saini, D.K.* and, Umapathy, S*.  Culture-Independent Raman Spectroscopic Identification of Bacterial Pathogens from Clinical Samples Using Deep Transfer Learning. (2022) Analytical Chem. 94(42): 14745-14754. Link  * Corresponding authors

3. Verma, A., Ayappa, G. and Saini, D.K. Understanding the loss of CXCR4-mediated signalling in the presence of oxysterols. (2022) Biophy J. 121 (3), 194. Link 

4. Vemparala, B., Parambathu, A.V., Saini, D.K. and Dixit, N. An evolutionary paradigm favoring crosstalk between bacterial two-component signaling systems. mSystems. e0029822. doi: 10.1128/msystems.00298-22. Link 

5. Gupta, K., Mathew, A. B., Chakrapani, H., and Saini, D. K. H2S contributed from CSE during cellular senescence suppresses inflammation and nitrosative stress (2022). Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 119388. Link 

6. Ramachandran, R.V., Barman, A., Modak, P., Bhat, R., Ghosh, A.* and Saini, D.K.* How safe are magnetic nanomotors: From cells to animals. (2022) Biomaterials Advances. 140, 213048. doi: 10.1016/j.bioadv.2022.213048. Link  *Corresponding authors

7. Behera, P., Singh, K.K., Saini, D.K. and De, M. Rapid discrimination of bacterial drug resistivity by array based cross-validation using 2D-MoS2. Chemistry. doi: 10.1002/chem.202201386. Link 

8. Paddillaya N, Ingale K, Gaikwad C, Saini DK, Pullarkat P, Kondaiah P, Menon GI, Gundiah N. Cell adhesion strength and tractions are mechano-diagnostic features of cellular invasiveness. Soft Matter. (2022) 18(23):4378-4388. doi: 10.1039/d2sm00015f.  Link.

9. Dasgupta, D., Peddi, S.D., Saini, D.K. and Ghosh, A. Mobile nanobots for prevention of root canal treatment failure. (2022) Adv. Healthcare Mat. doi: 10.1002/adhm.202200232. Link 

10. Malhotra, V., Okon, B., Satsangi, A., Das, S., Waturuocha, U., Vashist, A., Clark-Curtiss, J.  and Saini, D.K. Mycobacterium tuberculosis PknK substrate profiling reveals essential transcription terminator protein Rho, and Two-component response regulators PrrA and MtrA as novel targets for phosphorylation. (2022) Microbiol. Spectrum. 10(2):e0135421. doi: 10.1128/spectrum.01354-21. Link 

11. Usha, T., Middha, S.M., Babu, D., Goyal, A.K., Das, A.J. Saini, D., Rohith, B.S., Krishnamurthy, V., Kumar, M.KP., Saini, D.K. and Sidhalinghamurthy, K.R. Hybrid assembly and annotation of the genome of the Indian Punica granatum, a superfood. (2022) Front. Genet. Link 

2021

1. Fernandes, S.E. and Saini, D.K. The ERK-p38MAPK-STAT3 Signalling Axis Regulates iNOS Expression and Salmonella Infection in Senescent Cells. (2021) Front. Cell. Infect. Microbiol. 11:744013. doi: 10.3389/fcimb.2021.744013. Link 

2. Bora, P., Manna, S., Nair, M., Sathe, R.R., Singh, S., Adury, V.S.S., Gupta, K., Mukherjee, A., Saini, D.K., Kamat, S.S., Hazra, A.B. and Chakrapani, H. Leveraging an Enzyme/ Artificial Substrate System to Enhance Cellular Persulfides and Mitigate Neuroinflammation. (2021) Chem. Sci.  12(39):12939-12949. doi: 10.1039/d1sc03828a. Link 

3. Waturuocha, U.W., Athira, P.J., Singh, K.K., Krishna, M.S., Malhotra, V. and Saini, D.K. A high-frequency Single Nucleotide Polymorphism in the MtrB Sensor Kinase in clinical strains of Mycobacterium tuberculosis alters its biochemical and physiological properties (2021). PLoS One. 16(9):e0256664. doi: 10.1371/journal.pone.0256664. Link 

4. Waturuocha, U.W., Krishna, M.S., Malhotra, V., Dixit, N., and Saini, D.K. (2021) A low prevalence SNP in the sensor kinase PhoR in Mycobacterium tuberculosis suppresses its autophosphatase activity and reduces pathogenic fitness: Implications in evolutionary selection. (2021) Front. Microbiol. 12:724482. doi: 10.3389/fmicb.2021.724482.  Link 

5. Biji, A. Khatun, O., Swaraj, S., Narayan, R., Rajmani, R.S., Sardar, R., Satish, D., Mehta, S., Bindhu, H., Jeevan, M., Saini, D.K., Singh, A., Gupta, D., and Tripathi, S.. Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples. (2021) EBioMed, 70. 70:103525. doi: 10.1016/j.ebiom.2021.103525.  Link 

6. Yadav, P., Chatterjee, K. and Saini, D.K. Senescent Cells in 3D Culture Show Suppressed Senescence Signatures (2021)  Biomat. Sci. 9(19):6461-6473. doi: 10.1039/d1bm00536g.  Link  

7. Theragnostic nanomotors: successes and upcoming challenges, Reshma, V.R. Bhat, R., Saini, D.K. and Ghosh, A. WIREs Nanomed. Nanobiotech. Link 

8. Jagtap, S., Ratnasri, K., Valloly, P., Sharma, R., Maurya, S., Gaigore, A., Ardhya, C., Biligi, D.S., Desiraju, B.K., Natchu, U.C.M., Saini, D.K., and Roy, R. Evaluation of spike protein antigens for SARS-CoV-2 serology. (2021) J. Virol. Meth. ;296:114222. doi: 10.1016/j.jviromet.2021.114222. Link 

9. Fernandes, S.E., Singh, A., Rajmani, R.S., Jhunjhunwala, S. and Saini, D.K. Aging associated altered response to intracellular bacterial infections and its implication on the host. (2021) BBA Mol Cell Res. 1868(9):119063. doi: 10.1016/j.bbamcr.2021.119063.  Link  

10. Behera, P., Singh, K.K., Pandit, S., Saha, D., Saini, D.K., and De, M. Machine Learning Assisted Array-Based Detection of Proteins in Serum Using Functionalized MoS2 Nanosheets and Green Fluorescent Protein Conjugates. (2021) ACS Appl. Nano Mater. 4, 3843-3851. Link 

11. Hariharan, V.N., Yadav, R.,Thakur, C., Singh, A., Gopinathan, R.,Singh, D.P., Sankhe, G., Malhotra, V., Chandra, N., Bhatt, A., Saini, D.K. (2021) Cyclic di‐GMP sensing histidine kinase PdtaS controls mycobacterial adaptation to carbon sources. The FASEB Journal. 35(4):e21475. doi: 10.1096/fj.202002537RR.  Link 

12. Ramesh, M., Raajasekhar, Gupta, K., Babagond, V., Saini, D.K. and Govindraju, T. (2021) Matrix Targeted Strategy to Track Mitophagy and Amyloid-mediated Mitochondrial Dynamics. Org. Biol. Chem. 19(4):801-808. doi: 10.1039/d0ob02128h.  Link 

13. Singh, K.K., Athira, P.J., Bhardwaj, N., Singh, D.P., Watson, U. and Saini, D.K. (2021) Acetylation of Response Regulator Protein MtrA in M. tuberculosis regulates its repressor activity. Front. Micro. 11:516315. doi: 10.3389/fmicb.2020.516315.  Link 

2020

1. Dasgupta, D., Pally, D., Saini, D.K., Bhat, R. and Ghosh, A. Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments. (2020) Angewandte Chemie. ;59(52):23690-23696. doi: 10.1002/anie.202008681.  Link 

2. Vega-Dominguez, P., Peterson. E., Pan, M., Di Maio, A., Singh, S., Umapathy, S., Saini, D.K., Baliga, N. and Bhatt, A.  Biofilms of the non-tuberculous Mycobacterium chelonae form an extracellular matrix and display distinct expression patterns. (2020) Cell Surface. 6:100043. doi: 10.1016/j.tcsw.2020.100043.  Link 

3. Kumar, S., Gopinathan, R., Chandra, G.K., Umapathy, S., Saini, D.K. Rapid detection of bacterial infection and viability assessment with high specificity and sensitivity using Raman microspectroscopy. (2020) Anal Bioanal Chem. 412(11):2505-2516. doi: 10.1007/s00216-020-02474-2. Link 

4. Pal, M., Dasgupta, D., Somalwar, N., Reshma, V.R., Tiwari, M., Pally, D., Narayana, S., Katke, A., Jayashree, R.S., Bhat, R., Saini, D.K. and Ghosh, A. Helical Nanobots as Mechanical Probes of Intra- and Extracellular Environments. (2020) J. Phy: Condens. Matter.  2(22):224001. Link 

5. Samanta, S., Biswas, P., Banerjee, A., Bose, A., Siddiqui, N., Nambi, S., Saini, D.K. and Visweswariah, S. A universal stress protein in M. smegmatis acts to sequester the cAMP regulated lysine acetyltransferase and modulate biofilm formation (2020). J. Biol. Chem.  295(6):1500-1516. doi: 10.1074/jbc.RA119.011373. Link 

2019

1. Chauhan, P., Gupta ,K., Ravikumar, G., Saini, D.K., Chakrapani, H. Carbonyl Sulfide (COS) Donor Induced Protein Persulfidation Protects against Oxidative Stress. (2019) Chem Asian J. 14(24):4717-4724. doi: 10.1002/asia.201901148. Link 

2. Vasudevan, L., Borroto-Escuela, D.O., Huysentruyt, J., , Fuxe, K., Saini, D.K.* and Stove, C*. Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor. (2019) Biomolecules 9(8), 368. *, corresponding authors.Link

3. Kidwai, S., Bouzeyne, R., Chakraborti, S., Khare, N., Das, S. Gosain, T., Behura, A.,  Meena, C., Dhiman, R. Essafi, M., Bajaj, A., Saini, D.K., Srinivasan, N., Mahajan, D. and Singh, R. NU-6027 inhibits growth of Mycobacterium tuberculosis by targeting Protein Kinase D and Protein Kinase G. (2019) Anti. Agents. Chemo. AAC.00996-19.Link

4. Wouters, E., Vasudevan, L., Crans, R., Saini, D.K. and Stove, C. Luminescence- and fluorescence-based complementation assays to screen for GPCR oligomerization: current state of the art. (2019) Int. J. Mol. Sci. Link

5. Singh, K.K., Singh, D.P., Singh, R. and Saini, D.K. In Vitro and In Vivo Assessment of Protein Acetylation Status in Mycobacteria. Bioprotocols (2019) Link

6. Vasudevan, L., Wouters, E., Cannaert, A., Meyrath, M., Szpakowska, M., Chevigné, A., Saini, D.K. and Stove, C. Bioassays to study biased signalling of novel synthetic opioids. Toxicol Anal Clin (2019). 31(2), S66.

7. Kaur, P., Rausch, M., Malakar, B., Watson, U., Damle, N.P., Chawla, Y., Srinivasan, S., Sharma, K., Schneider, T., Jhingan, G.D., Saini, D.K., Mohanty, D., Grein, F. and Nandicoori, V.K. LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation. (2019) Nat Commun. 15;10(1):1231 Link

8. Singh,K.K., Bhardwaj, N., Sankhe,G.D.,Uday K.N., Singh,R., Malhotra,V., and  Saini,D.K., Acetylation of Response Regulator Proteins, TcrX and MtrA in M. tuberculosis Tunes their Phosphotransfer Ability and Modulates Two-Component Signaling Crosstalk. (2019) Journal of Molecular Biology doi:10.1016/j.jmb.2019.01.004. Link

2018

1. Nair, R.R., Madiwale, S. and Saini, D.K. Clampdown of inflammation in aging and anti-cancer therapies by limiting upregulation and activation of GPCR, CXCR4. (2018) NPJ Aging Mech. Dis. 4:9 ; doi:10.1038/s41514-018-0028-0. Link

2. Wouters, E., Vasudevan, L., Ciruela, F., Saini, D.K., Stove, C. and Craenenbroeck, K. Assessing GPCR Dimerization in Living Cells: Comparison of the NanoBiT Assay with Related Bioluminescence- and Fluorescence-Based Approaches. (2018) Neuromethods 140: 239-250. Link

3. Sankhe, G.D., Dixit, N.M.* and Saini, D.K.* Activation of Bacterial Histidine Kinases: Insights into kinetics of cis-autophosphorylation mechanism. (2018) mSphere. doi: 10.1128/mSphere.00111-1. Link

4. Pal., M., Somalavar, N., Singh, A., Bhat, R., Eswarappa, S.E., Saini, D.K and Ghosh, A. Manoeuvrability of Magnetic Nanomotors Inside Living Cells. (2018) Advanced Materials. e1800429. Link

5. Jain, R.#, Watson, U.#, Vasudevan, L. and Saini, D.K. ERK Activation Pathways Downstream of GPCRs. (2018) Int. Rev. Cell Mol. Biol. 338:79-109. (#, Equal contribution)Link

6. Watson, U.#, Jain, R.#, Asthana, S. and Saini, D.K. Spatiotemporal Modulation of ERK Activation by GPCRs. (2018) Int. Rev. Cell Mol. Biol. 338:111-140. (#, Equal contribution)Link

2017

1. Ravikumar, G., Bagheri, M., Saini, D.K.# and Chakrapani, H.# A small molecule for TheraNOstic targeting of cancer cells (2017) Chem Commun (Camb). 53(100):13352-13355. (#, Corresponding Authors)Link

2. Sharma, A.K., Nair, M., Chauhan, P., Gupta, K., Saini, D.K. and Chakrapani, H. Visible-Light-Triggered Uncaging of Carbonyl Sulfide for Hydrogen Sulfide (H2S) Release. (2017) Organic Lett. 19(18):4822-4825.Link

3. Ravikumar, G., Bagheri, M., Saini, D.K. and Chakrapani, H. FLUORO/NO, a Nitric Oxide Donor with a Fluorescence Reporter. (2017) Chembiochem. 18(15):1529-1534.Link

4. Bhat, I.A., Jain, R., Siddiqui, M.M., Saini, D.K.# and Mukherjee, P.S.# Water-Soluble Pd8L4 Self-Assembled Molecular Barrel as an Aqueous Carrier for Hydrophobic Curcumin. (2017) Inorg. Chem. 56(9):5352-5360.  (#, Corresponding authors)Link

5. Nair, R.R., Kiran, A. and Saini, D.K. G protein Signaling, Journeys Beyond the Plasma Membrane. (2017) J. Indian Inst. Sci. 97, 1195-108.Link

6. Singh, K.K., Jain, R., Ramanan, H. and Saini, D.K. Expression and purification of matrix metalloproteases in Escherichia coli. (2017) Meth. Mol. Biol. 1579, 3-16.Link

7. Bagheri M., Nair, R.R., Singh, K.K. and Saini, D.K. ATM-ROS-iNOS axis regulates nitric oxide mediated cellular senescence. (2017) Biochim Biophys Acta. (Mol Cell Res) 1864(10), 177-190.Link

2016

1. Jain, R., Watson, U. and Saini, D.K. ERK activated by Histamine H1 receptor is anti-proliferative through spatial restriction in the cytosol. (2016) Eur J.Cell Biol. 95(12):623-634.Link

2. Narayanaswamy, N., Nair, R.R., Suseela, Y.V., Saini, D.K. and Govindaraju, T. Molecular beacon-based DNA switch for reversible pH sensing in vesicles and live cells. (2016) Chem. Commun. 52(56), 8741-8744.Link

3. Agrawal, R., Kumar, P., Ramanan, H. and Saini, D.K.  FRET reveals multiple interaction states between Two Component Signalling System Proteins of M. tuberculosis. (2016) BBA Gen Sub. 1860(7), 1498- 1507.Link

4. Agrawal, R., Sahoo, B.K. and Saini, D.K. Cross-Talk and Specificity in Two Component Signal Transduction Pathways. (2016) Future Microbiol. 11, 685-697.Link

5. Narayanaswamy, N., Narra, N., Nair, R.R., Saini, D.K., Kondaiah, P. and Govindaraju, T. Stimuli-Responsive Colorimetric and NIR Fluorescence Combination Probe for Selective Reporting of Cellular Hydrogen Peroxide. (2016) Chem. Sci. 7, 2832-2841.Link

2015

1. Sunilkumar, B., Ravikumar, K., Saini, D.K. and Basu, B. Differential viability response of prokaryotes and eukaryotes to high strength pulsed magnetic stimuli. (2015) Bioelectrochem. 106(Pt B), 276 – 289.Link

2. Agrawal, R., Pandey, A., Rajankar, M.P., Dixit, N.M. and Saini, D.K.  The Two Component Signaling Networks of Mycobacterium tuberculosis Displays Extensive Crosstalk In Vitro. (2015) Biochem. J. 469 (1), 121 – 134.Link

3. Malhotra, V.§,†, Agrawal, R.†, Duncan, T.R., Saini, D.K.§ and Clark-Curtiss, J.E. M. tuberculosis Response Regulators, DevR and NarL Interact In Vivo and Co-Regulate Gene Expression during Aerobic Nitrate Metabolism. (2015) J. Biol. Chem. 290, 8294 – 8309. †, Equal contribution; §, Corresponding authors.Link

4. Nair, R.R., Bagheri, M. and Saini, D.K. Temporally Distinct Roles of ATM and ROS in Genotoxic Stress Dependent Induction and Maintenance of Cellular Senescence. (2015) J. Cell Sci. 128, 342 – 353.Link

2014

1. Singh, K.K., Jain, R., Ramanan, H. and Saini, D.K. Matrix-Assisted Refolding, Purification and Activity Assessment Using a 'Form Invariant' Assay for Matrix Metalloproteinase 2 (MMP2) (2014). Mol Biotechnol. 56(12), 1121-1132.Link

2. Agrawal, R. and Saini, D.K. Rv1027c-Rv1028c encode functional KdpDE two - Component system in Mycobacterium tuberculosis. (2014)Biochem Biophys Res Commun. 2014 Apr 18;446(4):1172-8. Link

2013

1. Jain, R. and Saini, D.K. Imaging cellular signaling: Many 'moving tales' in MAP kinase odyssey. (2013) Current Science. 105(11), 1512-1523. Link

2. Agrawal, R., Hariharan, V.N. and Saini, D.K. Two - Component Signaling Systems of M. tuberculosis: Regulators of Pathogenicity and More. (2013). "Dynamic Models of Infectious Diseases - Vol.2" Editor, Rao, V.S.H. & Durvasula, R. Publisher, Springer, USA. Chapter 4, pages 79-110.

3. Hariharan, V.N., Nair, R.R. and Saini, D.K. A Serpentine Way to Signalling - The Nobel Prize in Chemistry. (2013) Resonance Vol. 18(6), 397 - 409.Link

Before 2011

1. Cho, J.H.*, Saini, D.K.*, Karunarathne, W.K.A., Kalyanaraman, V. and Gautam, N.  Alteration of Golgi structure in senescent cells and its regulation by a G protein gamma subunit. (2011) Cellular Signaling. 23(5):785-93. (*Equal contribution). Link

2. Saini, D.K., Karunarathne, W.K.A, Angaswamy, N., Saini, D., Cho, J-H., Kalyanaraman, V. and Gautam, N. Regulation of Golgi Structure and Secretion by Receptor induced G protein betagamma Complex Translocation. (2010) Proc. Natl. Acad. Sci. USA.107(25):11417-22. Link

3. Saini, D.K. and Gautam, N. Live cell imaging for studying GPCRs activation in single cells. (2010) Methods Mol. Biol. 617: 191-207. Link

4. Chisari, M., Saini, D.K., Kalyanaraman, V. and Gautam, N. G protein subunit dissociation and translocation regulate cellular response to receptor stimulation. (2009) PLoS One. 4(11): e7797. Link

5. Saini, D.K., Chisari, M. and Gautam, N. Shuttling and Translocation of Heterotrimeric G Proteins and Ras. (2009) Trends Pharmacol. Sci.  30(6): 278-86.  Link

6. Saini, D.K., Kalyanaraman, V., Chisari, M. and Gautam, N. A family of G protein betagamma subunits translocate reversibly from the plasma membrane to endomembranes on receptor activation. (2007) J Biol Chem. 282: 24099-108. [Comment - A Moving Story. Sci. STKE 2007, tw301 (2007)] Link

7. Chisari, M., Saini, D.K., Kalyanaraman, V. and Gautam, N. Shuttling of G protein subunits between the plasma membrane and intracellular membranes. (2007) J Biol Chem. 282: 24092-8. [Comment - A Moving Story. Sci. STKE 2007, tw301 (2007)] Link

8. Saini, D.K. and Tyagi, J.S. High throughput microplate phosphorylation assays based on DevR-DevS /Rv2027c two-component signal transduction pathway to screen for novel anti-tubercular compounds.  (2005) J. Biomol. Screen. 10: 215-224. Link

9. Saini, D.K., Malhotra, V. and Tyagi, J.S. Cross talk between DevS sensor kinase homologue, Rv2027c, and DevR response regulator of Mycobacterium tuberculosis. (2004) FEBS Lett. 565, 75. Link

10. Saini, D.K., Malhotra, V., Dey, D., Pant, N., Das, T.K. and Tyagi, J.S.  DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.  (2004) Microbiology 150, 865-875. Link

11. Malhotra, V., Sharma, D., Ramanathan, V., Shakila, H.S., Saini, D.K., Chakravorty, S., Das, T.K., Li, Q., Silver, R.F., Narayanan, P.R. and Tyagi, J.S.  Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis. (2004) FEMS Microbiol. Lett. 231, 237. Link

12. Tyagi, J.S. and Saini, D.K.  Did the loss of two component systems initiate pseudogene accumulation in M. leprae?  (2004) Microbiology 150, 4-7.  Link

13. Saini, D.K., Pant, N., Das, T.K. and Tyagi, J.S.  Cloning, overexpression, purification and matrix assisted refolding of DevS (Rv3132c) Histidine Protein Kinase of Mycobacterium  tuberculosis.  (2002) Protein Express Purif. 25, 203-208. Link

    PATENTS

1. Tyagi, J.S. and Saini, D.K. (2003) Patent No. WO/2004/036224. International Application No. PCT/IB03/04555. Publication Date. 29.04.2004. A screening method for developing drugs against pathogenic microbes having two-component system.

2. Tyagi, J.S. and Saini, D.K. (2009) A screening method for developing drugs against pathogenic microbes having two-component system. US patent No. 7,566,550.

3. Tyagi, J.S., Bagchi, G., Mayuri, Kumra, N., Kaur, K., Saini, D.K. and Tyagi, A.K. (2004). A simple and fast process for evaluating Mycobacterium tuberculosis promoters under hypoxic and aerobic