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Bringing Discovery into Clinics -
Actionable Molecular Test for Risk Assessment of Oral Precancers Recent findings showed that there is a specific set of molecular signatures, called loss of heterzygosity, that is characteristics of abnormal tissues with high risk of progression to cancer, superseding clinical and pathological features. Working with clinical diagnostic genetics lab at the BC Cancer Agency and Genome BC, we are transforming this set of markers into clinically acceptable application (both effective and time / economically friendly). The success of this development will impact on national and global scale helping to triage patients into different follow-up schedule and justify high-risk patients for more systematic treatment.
Changing Standard Practice -
The Canadian Optically Guided Approach for Oral Lesions Surgical Trial, The COOLS Trial
University of British Columbia, Vancouver; University of Calgary, University of Alberta, Alberta; London Health Sciences Centre, London; Health Sciences Centre, Winnipeg; Sunnybrook Hospital, Toronto; Capital Health, Nova Scotia
Local-regional recurrence is one of the reason for the death rate of oral cancer patients. In a surgical or clinical setting, the naked eyes of clinicians often miss the clinically not apparent lesions, leaving diseased tissue behind from a surgical treatment. Changing this, a Phase III pan-Canadian surgical trial assess the method of using fluorescent visualization to guide the surgical margin and control the outcome in local recurrence and improve overall survival. The effectiveness of the method of will evaluated on levels of clinical, molecular, economical, quality of life, and acceptance to the community.
Targeting Risks of Cancer Development -
iTOP (Combined Otolaryngology Head & Neck Surgery Oral Medicine) Clinic
Catherine Poh, Scott Durham, Donald Anderson, Samson Ng, Kenneth Berean, Lewei Zhang, Calum MacAulay
About 18% of commonly seen oral diseases, such as leukoplakia or , progress to cancer. Symptomatically, these lesions are similar to one another and management strategy. On the biological and molecular level, some of these lesions are aggressive and dangerous by nature and that they are in the high-risk group of cancer development; thus, require close follow-up and surveillance. Aside from experiences of the clinicians themselves, there is no strategies that can be incorporated into the routine of standard management to identify high-risk from low-risk groups. The iTOP clinic at the Vancouver General Hospital joins the two most prestigious oral pathologists and specialists for patients with oral reactive lesions. Click for referral form for iTOP clinic.
Targeting Disparities in Oral Health Care -
Community Oral Health and Oral Health Needs of Low Incomes in Vancouver's Downtown Eastside
Catherine Poh, Charles Frankish, Doreen Littlejohn, Samson Ng, Bertrand Chan
Vancouver's Downtown Eastside is one of the poorest yet versatile community in BC. The residents in the community engage in activities and lifestyle that may put them in the high-risk group for oral diseases and dysplastic lesions. Under the leadership of Dr. Catherine Poh, the group outreach to the community to provide oral assessments and refer those who need follow-up or treatment. While doing so, we are also collecting evidence on the characteristics of oral health in this community, weighing the need and accessibility to oral health care, and raising awareness on the importance of a healthy mouth.
Outreaching to Global Oral Health Care Community -
Strategic planning for oral cancer control in Mexico
Oral health and oral cancer impact people on a global scale, especially in developing Asian countries where there is a higher consumption in tobacco products and alcohol and other risk factors that predispose the population develop oral dysplastic or cancerous lesions. Oral health and oral cancer continue to be a critical aspect of the general health in Mexico which over 112 million people reside. A good portion of this population, with estimated of 39% who are under the age of 19, faces inequalities in oral health care. The lack of awareness is not only among the public community, but also clinicians in the dental communities. This raises concern because great possibility of mis- or late of high risk oral lesions. There are a number of oral diseases which could have different predisposing factors according to the geographical region in Mexico and even, the same intervention may not have the same benefit to patients with similar conditions or lesions. Thus, in collaborating with researchers from Portal de la Universidad Nacional Autonoma de Mexico, we are building a partnership and bringing the Canadian experience in the field of oral diseases / cancer research across countries that could expand familiarity with various oral diseases and promote oral health, reduce oral heath inequality in Mexico through research, education, and training.
Building a Risk Model on Oral Cancer Development
Catherine Poh, Jack J. Lee
The development of oral cancer is a multifaceted disease. On top of the genetic nature of the human genome, there is also epigenetic factors or immunological balances that may sets off a person to develop oral cancer. The objective of this study is to identify a single independent or a combination of risk factors that will distinguish high-risk from low-risk oral lesions using retrospective cohorts. The outcome is a tool that can potentially encompassing all aspects of patients' care, from screening, early detection to more targeted prevention plans.
Ye A, Ho C, Liu YK, Poh CF, Wu J. Is radiation with cetuximab an effective treatment in HPV positive head and neck squamous cell carcinoma? Radiotherapy & Oncology. February 2013, Volume 106, Suppliment 1, S52.
Hallani SE, Poh CF, MacAulay C, Follen M, Guillaud M, Lane P. Ex Vivo Confocal Imaging with Contrast Agents for the Detection of Oral Potentially Malignant Lesions. Oral Oncology, OO-D-12-809R1. (Article in press, e-pub date: Febrary 12, 2013)
Macdonald D, Gu Y, Zhang L, Poh CF. Canc Clinical and Radiological Features Predict Recurrence in Solitary Keratocystoic Odontogenic Tumors? Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endotology, 2013, 115 (2): 63-271.
Zhang L, Poh CF, Williams M, Laronde DM, Berean K, Gardner PJ, Jiang H, Lang W, Lee JJ, Rosin MP. Loss of Heterozygosity (LOH) Profile - Validated Risk Predictors for Progression to Oral Cancer. Cancer Prevention Research 2012, 5(9):1081-9 [IF=4.908]
MacAulay C, Poh CF, Guillaud M, Williams PM, Laronde DM., Zhang L, Rosin, MP. High Throughput Image Cytometry Platform for Detection of Suspicious Lesions in the Oral Cavity. Journal of Biomedical Optics 2012;17(8), 086004. [IF=3.480]
Lin Jun R., Lubpairee T., Liu KY, Anderson DW, Durham S, Poh CF. Cyclin D1 Overexpression is Associated with Poor Prognosis in Oropharyngeal Cancer. (Manuscript in preparation to submit to Canadian Otolaryngology Surgery Journal).
Saini R., Poh CF. Topical photodynamic therapy: A review and its prospective role in the management of oral potentially malignant disorders. Oral Diseases, 2012, doi: 10.1111/odi.12003
MacLellan S, Lawson J, Baik J, Guillaud M, Poh CF, Garnis C. Differential Expression of miRNAs in the Serum of Patients with High-risk Oral Lesions. Cancer Medicine (Accepted, June 13, 2012)
Poh CF, Zhu Y, Chen E, Berean KW, Wu L, Zhang L, Rosin MP. Unique FISH Patterns Associated with Cancer Progression of Oral Dysplasia. J Dent Res 2012, 91 (1):52-57.[IF=3.773]
Poh CF, Durham JS, Brasher PM, Anderson DW, Berean KW, MacAulay CE, Lee JJ, Rosin MP. Canadian Optically-guided approach for Oral Lesions Surgical (COOLS) trial: Study protocol for a randomized controlled trial. BMC Cancer 2011, 11:462. [IF=3.15]
Gorenchtein M, Poh CF, Saini R, Garnis C. MicroRNAs in an Oral Cancer Context – from Basic Biology to Clinical Utility. J Dent Res 2011; 91(5):440-6). [IF=3.773]
Poh CF, MacAulay CE, Laronde DM, Williams PM, Zhang L, Rosin MP. Squamous cell carcinoma and precursor lesions: Diagnosis and screening in a technical era.Periodontology 2000, 2011; 57:1- 16. [IF=2.082]
Auluck A, Hislop G, Bajdik C, Zhang L, Poh C, Rosin M. Trends in oral cancer incidence in a multicultural region: the BC experience. Cancer, 2010;116 (11):2635-44.[IF=5.131]
Zhang LL, Yang R, Zhang L, Li W, MacDonald-Jankowski D, Poh CF. Dentigerous cyst: a retrospective clinicopathological analysis of 2,082 dentigerous cysts in British Columbia, Canada. International Journal of Oral and Maxillofacial Surgery 2010;39: 878–882. [IF=1.302]
Gu Y, Williams P.M, Poh CF. How do I evaluate a patient with a swollen lip? J Can Dent Assoc 2010:76:a92. [IF=1.320]
Tsui IL, Garnis C, Poh CF. A Dynamic Oral Cancer Field: Unraveling the Underlying Biology and Its Clinical Implication. American Journal of Surgical Pathology, 2009; 33 (11): 1732-1738. [IF=4.106]
Auluck A, Hislop G, Poh C, Zhang L, Rosin MP. Areca nut and betel quid chewing among South Asian immigrants to Western countries and its implications for oral cancer screening. Rural Remote Health, 2009; 9(2):1118-21. [IF=0.931]
Poh CF, MacAulay CE, Zhang L, Rosin MP. Tracing the “At-Risk” Oral Mucosa Field with Autofluorescence: Steps Toward Clinical Impact. Cancer Prevention Research, 2009; 2(5):401-404. [IF=4.978]
Tsui IL, Poh CF, Garnis C, Rosin MP, Zhang L, Lam WL. Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias.International Journal Cancer, 2009; 125(9): 2219-2228. *Cited 11 times by February 01, 2012.[IF=4.926]
Poh CF, Ng S, Berean KW, Williams PM, Rosin MP, Zhang L. Biopsy and Histopathological Diagnosis of Oral Premalignant and Malignant Lesions. J Can Dent Assoc, 2008; 74(3): 283-288. [IF=1.320]
Guillard M, Zhang L, Poh CF, Rosin MP, MacAulay C. Potential Use of Quantitative Tissue Phenotype to Predict Malignant Risk for Oral Premalignant Lesions. Cancer Res, 2008; 68(9): 1-9. [IF=8.234]
Rosin MP, Poh CF, Elwood M, Williams PM, Gallagher R, MacAulay C, Lam WL, Auluck A, Zhang L, Hislop TG. New Hope for Oral Cancer Solutions: Together We Can Make a Difference. J Can Dent Assoc, 2008; 74(3): 261-266. [IF=1.320]
Williams PM, Poh CF, Hovan A, Ng PS, Rosin MP. Evaluation of a suspicious oral mucosal lesion. J Can Dent Assoc, 2008; 74(3): 275-280. [IF=1.320]
Currie LB, Williams PM, Poh CF. Is the message clear? Talking with your patient about oral cancer screening. J Can Dent Assoc, 2008; 74(3): 255-256. [IF=1.320]
Poh CF, Ng S, Berean KW, Williams PM, Rosin MP, Zhang L. Biopsy and Histopathological Diagnosis of Oral Premalignant and Malignant Lesions. J Can Dent Assoc, 2008; 74(3): 283-288.
Biggar H, Poh CF, Rosin MP, Williams PM. The Voice of An Oral Cancer Patient. J Can Dent Assoc, 2008; 74(3): 237-238. [IF=1.320]
Laronde DM, Bottorff J, Hislop TG, Poh CF, Currie LB, Williams PM, Rosin MP. Experiences from the Dental Office: Initiating Oral Cancer Screening. J Can Dent Assoc, 2008; 74(3): 239-241. [IF=1.320]
British Columbia Oral Cancer Prevention Program - The early detection of oral cancer working group, BC Oral Cancer Prevention Program. Guideline for the Early Detection of Oral Cancer in British Columbia 2008. J Can Dent Assoc, 2008; 74(3): 245-52 (Invited publication by the College of Dental Surgeons of British Columbia). [IF=1.320]
Poh CF, Ng SP, Williams PM, Zhang L, Laronde DM, Lane P, Macaulay C, Rosin MP. Direct fluorescence visualization of clinically occult high-risk oral premalignant disease using a simple hand-held device. Head Neck, 2007; 29(1): 71-6. [IF=2.182]
Poh CF, Hislop TG, Currie B, Lee R, Sikorski S, Zed C, Zhang L, MacAulay C, Rosin MP. Oral Cancer Screening in the Vancouver Downtown Eastside -- a High-Risk Underserved Population. J Health Care for the Poor and Underserved, 2007; 18: 767-778. [IF=0.964]
Gratzinger D, Salama ME, Poh CF, Rouse RV. Ameloblastoma, calcifying epithelial odontogenic tumor, and glandular odontogenic cyst show a distinctive immunophenotype with some myoepithelial antigen expression. J Oral Pathol Med, 2007; 37(3): 177-84. [IF=2.075]
Biggar H, Forrest A, Poh CF. Global Oral Cancer Screening Programs- Review and Recommendations. Can J Dent Hyg, 2007; 41(3): 138-146.
Laronde DM, Poh CF, William M, Hislop TG, Zhang L, MacAulay C, Rosin MP. A Magic Wand for the Community Dental Office? Observations from the British Columbia Oral Cancer Prevention Program. J Can Dent Assoc, 2007; 73(7): 607-610. [IF=1.320]
Poh CF, Ng SP, Williams PM, Zhang L, Laronde DM, Lane P, MacAulay C, Rosin MP. Detection of clinically occult high-risk oral premalignant disease using direct autofluorescent visualization. Head Neck, 2007; 29(1): 71-6. [IF=2.182]
Rosin MP, Poh CF, Guillard M, Williams M, Zhang L, MacAulay C. Visualization and other emerging technologies as changes-makers for oral cancer prevention. J New York Acad Sci, 2007; 1098: 167-183. [IF=2.847]
Ng SP, Poh CF, Williams PM, Zhang L, Macaulay C, Rosin MP. Use of Direct Fluorescence Visualization to Identify High-Risk Oral Pre-malignant Lesions in British Columbia: Update. Inside Dentistry, 2007; 3(4, Supplement), 199: 19-20.
Click for complete publication list
Page last modified Dec 17, 2012
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