Peer-Referreed Articles
* Student advisee; # co-first authors contributed equally to the study
Feng, Z.,* Chen, Q., Griffin, P., & Bao, L. (2026). A Bayesian Multi-State Data Integration Approach for Estimating County-Level Prevalence of Opioid Misuse in the United States. Statistics in medicine, 45(20-22), e70707. https://doi.org/10.1002/sim.70707
Fan, Y.,* Chen, Q., Sun, H., Bärnighausen, T., Wang, C., Yang, T., & Chen, S. (2026). Economic evaluations of screening and case-finding for Chronic Obstructive Pulmonary Disease (COPD): a systematic review. NPJ primary care respiratory medicine, 36(1), 7. https://doi.org/10.1038/s41533-025-00467-1
Barbosa, C., Chen, Q., Sahinkoc, M., Zarkin, G. A., Dowd, W., Villani, J., Barocas, J. A., Cerdá, M., Chatterjee, A., Fareed, N., Hyder, A., Keyes, K. M., Larochelle, M. R., Linas, B. P., Roberts, S. M., Schackman, B. R., Seiber, E., Wakeman, S. E., Knudsen, A. B., & Chhatwal, J. (2026). Impact of enhanced practices on opioid overdose deaths: A community-based modeling approach. Addiction (Abingdon, England), 121(7), 1747–1760. https://doi.org/10.1111/add.70367
Chhatwal, J., Sahinkoc, M., Chen, Q., Dowd, W., Xiao, J., Zarkin, G. A., Aldridge, A., Barocas, J. A., Cerdá, M., Fareed, N., Frazier, L. A., Hyder, A., Keyes, K. M., Knott, C. E., LaRochelle, M., Linas, B. P., Oga, E., Roberts, S. M., Samet, J. H., Schackman, B. R., … Barbosa, C. (2026). Cost-effectiveness of community-based interventions for reducing opioid overdose and non-overdose deaths: simulation modeling of HEALing Communities Study. Lancet regional health. Americas, 59, 101480. https://doi.org/10.1016/j.lana.2026.101480
Chen, S.,# Min, K.,# Chen, Q.,# Jiao, L., Geldsetzer, P., Yang, T., Huang, K., Niu, H., Wang, W., Moshabela, M., Atun, R., Liu, D. P., Yang, J., Wang, C., & Bärnighausen, T. (2026). Health insurance coverage and health-related Sustainable Development Goal indicators in 62 low- and middle-income countries: a household fixed-effects analysis. Science bulletin, 71(16), 4128–4132. https://doi.org/10.1016/j.scib.2026.07.001
Chen, Q.,# Newton, R.# & Griffin, P. (2025). Fair allocation strategies for opioid settlements. Health care management science, 28(3), 335–356. https://doi.org/10.1007/s10729-025-09716-8
Tuan, W.-J., Yan, Y.,* Adat, B., Felix, T., and Chen, Q. (2025) Predicting missed appointment in primary care setting: A personalized machine learning approach. The Annals of Family Medicine, 23(4), 294-301.
Huang, S.,* Chen, Q., Griffin, P., and Azagba, S. (2025) Effect of state e-cigarette tax policies on the transitions of youth tobacco/nicotine use patterns: Evidence from national longitudinal data. Accepted in Tobacco Control.
Yan, Y.,* Chen, Q., Nasir, R., Griffin, P., Bone, C., & Tuan, W. J. (2025). Characterizing patients at higher cardiovascular risk for prescribed stimulants: Learning from health records data with predictive analytics and data mining techniques. Computers in Biology and Medicine, 188, 109870.
Feng, Z.,* Ye, Q., Xie, W., and Chen, Q. (2025) A Spatio-temporal Cluster-aware Supervised Learning Framework for Predicting County-level Drug Overdose Deaths. Accepted in AAAI 2025 Artificial Intelligence for Social Impact Track (acceptance rate 23.3%, 89/382).
Chen, Q.,# Fan, Y.,* # Huang, K.,# Li, W., Geldsetzer, P., Barnighausen, T., Yang, T., Wang, C., & Chen, S. (2024) Cost-effectiveness Analysis of Population-based Screening for Chronic Obstructive Pulmonary Disease in China. The Lancet Regional Health – Western Pacific, 46, 101065.
Featured article on the cover of the journal's Issue of May 2024
Chen, Q.,# Sterner, G.,# Rhubart, D., Newton, R., Shaw, B., & Scanlon, D. (2024). Creating a robust coordinated data and policy framework for addressing substance use issues in the United States. International Journal of Drug Policy, 134, 104629. https://doi.org/10.1016/j.drugpo.2024.104629
Feng, Z.,* Chen, Q., Griffin, P., Li, J., Abedi, V., & Zand, R. (2024) Care settings of transient ischemic attack in the United States: A cohort study from the TriNetX health research network. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 33(9), 107888.
Feng, Z.,* # Chen, Q.,# Jiao, L.,# Ma, X., Geldsetzer, P., Barnighausen, & Chen, S. (2024) The impact of health insurance on hypertension care: a household fixed effects study in India. BMC Public Health, 24:2287.
Li, M., Ka, D.-H.,* and Chen, Q. (2024) Disparities in availability of new cancer drug worldwide: 1990-2022. BMJ Global Health, 9:e015700.
Zafarnejad, R.*, Chen, Q., & Griffin, P. (2024) Cost-effectiveness of screening for chronic kidney disease using a cumulative eGFR-based statistic. PloS one, 19(3), e0299401.
Chung, A.,* Chen, Q., Curry, W., Felix, T., Tuan, W. (2024) Breast cancer screening during the COVID-19 pandemic in the United States: Results from real-world data. Annals of Family Medicine, 22(3), 208–214.
Bai, A., Chen, Q., Geldsetzer, P., Gray, M., Xie, Z., Zhang, D., Baernighausen, T., Hu, Y., Jiang, Y., & Chen, S. (2024). Functional dependency and cardiometabolic multimorbidity in older people: pooled analysis of individual-level data from 20 countries. Age and ageing, 53(12), afae269. https://doi.org/10.1093/ageing/afae269
Yu, F.,# Jiao, L.,# Chen, Q.,# Wang, Q., De Allegri, M., Cao, Z., Chen, W., Ma, X., Wang, C., Wachinger, J., Jin, Z., Bunker, A., Geldsetzer, P., Yang, J., Xue, L., Bärnighausen, T., & Chen, S. (2024). Preferences regarding COVID-19 vaccination among 12,000 adults in China: A cross-sectional discrete choice experiment. PLOS Global Public Health, 4(7), e0003387.
Wu, Z., Yu, Y., Xie, F., Chen, Q., Cao, Z., Chen, S., & Liu, G. G. (2024). Economic burden of patients with leading cancers in China: a cost-of-illness study. BMC Health Services Research, 24(1), 1-13.
Zhang, Q., Jiao, L., Chen, Q., Bulstra, C.A., Geldsetzer, P., de Oliveira, T., Yang, J., Wang, C., Bärnighausen, T. & Chen, S. (2024). COVID-19 antibody responses in individuals with natural immunity and with vaccination-induced immunity: a systematic review and meta-analysis. Systematic Reviews, 13(1), 189.
Chen, Y-H.,* # Drye, M.#, Chen, Q., Fecher, M., Liu, G. & Guthrie, W. (2023). Delay from Screening to Diagnosis in Autism Spectrum Disorder: Results from a Large National Health Research Network. The Journal of pediatrics, 113514. Advance online publication. https://doi.org/10.1016/j.jpeds.2023.113514
Huang, S.*, Chen, Q., Griffin, P., Liu, G., & Azagba, S. (2023). Longitudinal transitions in tobacco use in youth and young adults: A latent transition analysis of the population assessment of tobacco and health study from Wave 1 to 5. Addictive behaviors, 138, 107548. https://doi.org/10.1016/j.addbeh.2022.107548
Weng, X.*, Chen, Q., Sathapathi, T.*, Yin, X., Wang, L. (2023) Impact of school operating scenarios on COVID-19 transmission under vaccination in the US: an agent-based simulation model. Scientific reports, 13(1), 12836.
Chhatwal, J., Mueller, P. P., Chen, Q., Kulkarni, N., Adee, M., Zarkin, G., LaRochelle, M. R., Knudsen, A. B., & Barbosa, C. (2023). Estimated Reductions in Opioid Overdose Deaths With Sustainment of Public Health Interventions in 4 US States. JAMA network open, 6(6), e2314925.
Chen, Q., Griffin, P., Kawasaki, S. (2023). Disability-Adjusted Life-Years for Drug Overdose Crisis and COVID-19 Are Comparable During the Two Years of Pandemic in the United States. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 26(6), 796–801.
Rhubart, D., Chen, Q., Sterner, G., Newton, R., Shaw, B., and Scanlon, D. (2022), Conceptualizing and Measuring Abatement from the Opioid Epidemic: A Case Study from Pennsylvania. Milbank Quarterly. In Press
Chen, Y. H.*, Chen, Q., Kong, L. & Liu, G. (2022) Predicting Diagnosis of Autism Spectrum Disorder Using Health Claims Data in Young Children. BMJ Health & Care Informatics. 29:e100544.
Chen, Q., Sterner, G., Segel, J., & Feng, Z.* (2022) Trends in opioid-related crime incidents and comparison with opioid overdose outcomes in the United States. International Journal of Drug Policy, 101, 103555.
Chen, S., Geldsetzer, P., Chen, Q., Jiao, L., Moshabela, M., Oguoji, O., Sie, A., Atun, R., Bärnighausen, T. (2022) Health Insurance Coverage In Low-And Middle-Income Countries Remains Far From The Goal Of Universal Coverage. Health Affairs, 41(8), 1142-1152.
Mueller, P. P. #, Chen, Q. #, Ayer, T., Nemutlu, G. S., Hajjar, A., Bethea, E. D., Peters, M., Lee, B. P., Janjua, N. Z., Kanwal, F., & Chhatwal, J. (2022). Duration and cost-effectiveness of hepatocellular carcinoma surveillance in hepatitis C patients after viral eradication. Journal of hepatology, 77(1), 55–62.
Shahjouei, S., Li, J., Koza, E., Abedi, V., Sadr, A. V., Chen, Q., Mowla, A., Griffin, P., Ranta, A., & Zand, R. (2022). Risk of Subsequent Stroke Among Patients Receiving Outpatient vs Inpatient Care for Transient Ischemic Attack: A Systematic Review and Meta-analysis. JAMA network open, 5(1), e2136644.
Chen, S. #, Chen, Q. #, Yang, J., Lin, L., Li, L., Jiao, L., Geldsetzer, P., Wang, C., Wilder-Smith, A., & Bärnighausen, T. (2021). Curbing the COVID-19 pandemic with facility-based isolation of mild cases: a mathematical modeling study. Journal of travel medicine, 28(2), taaa226.
Adee, M., Zhuo, Y., Zhan, T., Chen, Q., Toumi, A., Ayer, T., Nwankwo, C., Zhong, H., Puenpatom, A., & Chhatwal, J. (2021). A Tool to Inform Hepatitis C Elimination: A Case for Hepatitis C Elimination in China. Clinical liver disease, 17(3), 99–106.
Chen, Q., Ayer, T., Adee, M. G., Wang, X., Kanwal, F., & Chhatwal, J. (2020). Assessment of Incidence of and Surveillance Burden for Hepatocellular Carcinoma Among Patients With Hepatitis C in the Era of Direct-Acting Antiviral Agents. JAMA network open, 3(11), e2021173-e2021173.
Chen, S.#, Chen, Q. #, Yang, W., Xue, L., Liu, Y., Yang, J., Wang, C., & Bärnighausen, T. (2020). Buying Time for an Effective Epidemic Response: The Impact of a Public Holiday for Outbreak Control on COVID-19 Epidemic Spread. Engineering (Beijing, China), 6(10), 1108–1114.
Zhuo, Y., Hayashi, T., Chen, Q., Aggarwa, R., Hutin, Y., Chhatwal, J. (2020) Estimating the price at which hepatitis C treatment with direct-acting antivirals would be cost-saving in Japan. Sci Rep 10, 4089.
Chen, Q., Ayer, T., Bethea, E., Kanwal, F., Wang, X., Roberts, M., Zhuo, Y., Fagiuoli, S., Petersen, J., Chhatwal, J. (2019) Changes in Hepatitis C Burden and Treatment Trends in Europe During the Era of Direct-Acting Antivirals: A Modeling Study. BMJ Open. 9(6), e026726
Chhatwal J, Chen Q, Bethea E, Hur C, Spaulding AC, Kanwal F. (2019) The Impact of Direct-Acting Antivirals on the Hepatitis C Care Cascade: Identifying Progress and Gaps towards Hepatitis C Elimination in the United States. Aliment Pharmacol Ther. 50(1):66-74
Chhatwal, J., Chen, Q., Wang, X., Ayer, T., Zhuo, Y., Janjua, N. Z., & Kanwal, F. (2019). Assessment of the Feasibility and Cost of Hepatitis C Elimination in Pakistan. JAMA network open, 2(5), e193613-e193613
Chen, Q., LaRochelle, M., Weaver, D., Lietz, A., Mueller, P., Mercaldo, S., Wakeman, S., Freedberg, K., Raphel, T., Knudsen, A., Pandharipande, P., Chhatwal, J. Prevention of prescription opioid misuse and projected overdose deaths in the United States. JAMA Network Open. 2019;2(2):e187621.
Çağlayan, Ç., Terawaki, H., Ayer, T., Goldstein, J. S., Rai, A., Chen, Q., & Flowers, C. (2019). Assessing the Effectiveness of Treatment Sequences for Older Patients With High-risk Follicular Lymphoma With a Multistate Model. Clinical lymphoma, myeloma & leukemia, 19(5), 300–309.e5.
Chen, Q., Ayer, T., Chhatwal, J. (2018), Optimal M-Switch Surveillance Policies for Liver Cancer in a Hepatitis C–Infected Population. Operations Research, 66(3), 673-696.
First prize winner, 2016 INFORMS Decision Analysis Society Student Paper Competition.
Honorable mention, 2016 Public Sector Operations Research (PSOR) Best Paper Competition
Goel, A., Chen, Q., Chhatwal, J., & Aggarwal, R. (2018). Cost‐effectiveness of generic pan‐genotypic sofosbuvir/velpatasvir versus genotype‐dependent direct‐acting antivirals for hepatitis C treatment. Journal of gastroenterology and hepatology, 33(12), 2029-2036.
Chhatwal, J., Chen, Q., Bethea, E. D., Ladd, M. A., Mueller, P. P., Hutin, Y., & Aggarwal, R. (2018). Hep C Calculator: an online tool for cost-effectiveness analysis of DAAs. The Lancet Gastroenterology & Hepatology, 3(12), 819.
Chhatwal, J., Chen, Q., Aggarwal. R. (2018) Estimation of hepatitis C disease burden and budget impact of treatment using health economic modeling. Infectious Disease Clinics of North America, 32(2): 461-480.
Chhatwal, J., Chen, Q., Ayer, T., Bethea, E., Kanwal, F., Kowdley, K., Wang, X., Roberts, M., Gordon, S. (2018) Hepatitis C Virus Re‐treatment in the Era of Direct‐acting Antivirals: Projections in the USA. Alimentary pharmacology & therapeutics, 47(7), 1023-1031.
Chen, Q., Ayer, T., Chhatwal, J. (2017) Sensitivity Analysis in Sequential Decision Models: A Probabilistic Approach. Medical Decision Making, 37(2), 243-252.
Chhatwal, J., Chen, Q., Ayer, T., Bethea, E., Kanwal, F., Kowdley, K., Wang, X., Roberts, M., Gordon, S. (2017) Hepatitis C Retreatment in the Era of Direct-Acting Antivirals: Projections in the United States. In press, Alimentary Pharmacology & Therapeutics
Bethea, E.#, Chen, Q.#, Hur, C., Chung, R., & Chhatwal, J. (2017) Should We Treat Acute Hepatitis C? A Decision and Cost-effectiveness Analysis. In press Hepatology.
Bethea, E., Chen, Q., & Chhatwal, J. (2018) Reply to Treatment of Acute HCV Cost-Effective but at What Price. In press Hepatology.
Chen, Q., Staton A.D., Ayer, T., Goldstein, D.A., Koff, J.L, & Flowers, C.R. (2017) Exploring the Potential Cost-Effectiveness of Precision Medicine Treatment Strategies for Diffuse Large B-cell Lymphoma. Leukemia & lymphoma (2017): 1-10.
Aggarwal, R., Chen, Q., Goel A., Seguy, N., Pense, R., Ayer T., & Chhatwal, J. Cost-Effectiveness of Hepatitis C Treatment using Generic Direct-Acting Antivirals Available in India. Plos One 12(5): e0176503.
Goldstein, D.A., Chen, Q., Ayer, T., Chan, K., Virik, K., Hammerman, A., Brenner, B., Flowers, C.R., & Hall, P.S. (2017) Bevacizumab for Metastatic Colorectal Cancer: A Global cost-effectiveness Analysis. Oncologist 22(6): 694-699
Kohn, C. G., Zeichner, S. B., Chen, Q., Montero, A. J., Goldstein, D. A., & Flowers, C. R. (2017). Cost-effectiveness of immune checkpoint inhibition in BRAF wild-type advanced melanoma. Journal of Clinical Oncology, 35(11), 1194-1202.
Kohn, C. G., Zeichner, S. B., & Chen, Q. (2017). Reply to Á. Benedict et al. Journal of Clinical Oncology 35(26): 3086-3087.
Chen, Q., Jain, N., Ayer, T., Flowers, C. R., O'Brien, S., Keating, M., Wierda, W., Kantarjian, H. M., & Chhatwal, J. (2016) Economic Burden of Chronic Lymphocytic Leukemia in the Era of Oral Targeted Therapies in the United States. Journal of Clinical Oncology1, 35(2), 66-174
Mass General News: Targeted therapy drugs could radically increase the costs of leukemia treatment
Chen, Q., Jain, N., Flowers, C. R. & Chhatwal, J. (2017). Reply to C. Nabhan et al.. Journal of Clinical Oncology, 35, 1864-1865.
Chen, Q., Ayer, T., Nastoupil, L. J., Rose, A. C., & Flowers, C. R. (2015). Comparing the Cost-Effectiveness of Rituximab Maintenance and Radioimmunotherapy Consolidation versus Observation Following First-line Therapy in Patients with Follicular Lymphoma. Value in Health, 18(2), 189-197.
Goldstein, D. A., Chen, Q., Ayer, T., Howard, D. H., Lipscomb, J., Ramalingam, S. S. & Flowers, C. R. (2015). Necitumumab in Metastatic Squamous Cell Lung Cancer: Establishing a Value-Based Cost. JAMA oncology, 1(9), 1293-1300.
Chen, Q., Ayer, T., Nastoupil, L. J., Koff, J. L., Staton, A. D., Chhatwal, J., & Flowers, C. R. (2015). Population-Specific Prognostic Models are Needed to Stratify Outcomes for African-Americans with Diffuse Large B-cell Lymphoma. Leukemia & Lymphoma, 1-10.
Chhatwal, J., Chen, Q. & Kanwal, F. (2015). Why We Should Be Willing to Pay for Hepatitis C Treatment. Clinical Gastroenterology and Hepatology, 13, 1711-1713.
Goldstein, D. A., Chen, Q., Ayer, T., Howard, D. H., Lipscomb, J., El-Rayes, B. F., & Flowers, C. R. (2015). First-and Second-Line Bevacizumab in Addition to Chemotherapy for Metastatic Colorectal Cancer: A United States–based Cost-effectiveness Analysis. Journal of Clinical Oncology, 33(10), 1112-1118.
Goldstein, D. A., Ahmad, B. B., Chen, Q., Ayer, T., Howard, D. H., Lipscomb, J. & Flowers, C. R. (2015). Cost-Effectiveness Analysis of Regorafenib for Metastatic Colorectal Cancer. Journal of Clinical Oncology1, 33(32), 3727-3732.
Staton, A. D., Koff, J. L., Chen, Q., Ayer, T., & Flowers, C. R. (2015). Next-Generation Prognostic Assessment for Diffuse Large B-Cell Lymphoma. Future Oncology, 11(17), 2443-2457.
Goldstein, D. A., Chen, Q., Ayer, T., Howard, D. H., Lipscomb, J., Harvey, R. D., & Flowers, C. R. (2014). Cost Effectiveness Analysis of Pharmacokinetically-Guided 5-Fluorouracil in FOLFOX Chemotherapy for Metastatic Colorectal Cancer. Clinical colorectal cancer, 13(4), 219-225.
Ayer, T., Chen, Q., & Burnside, E. S. (2013). Artificial Neural Networks in Mammography Interpretation and Diagnostic Decision Making. Computational and mathematical methods in medicine, 2013. doi:10.1155/2013/832509.
Chen, Q., Ayer, T., Nastoupil, L. J., Seward, M., Zhang, H., Sinha, R., & Flowers, C. R. (2012). Initial Management Strategies for Follicular Lymphoma. International journal of hematologic oncology, 1(1), 35-45.