Natural Killer cell receptors

We started the work in 2006 within SPINE2Complexes project. We participate in structural studies of various receptors of NK cells.

The first protein of our interest was extracellular domain of human CD69. We solved several structures from crystals soaked with different potential physiological ligands. Unfortunately, functional aspects of this protein were not clearly identified yet. We also work on structure-functional studies of C-type lectin-like proteins expressed on NK-cell surface to identify their function and physiological ligand binding for further application in therapies.