Our topic is mainly structure-function relation of proteins, protein-ligand complexes and protein-protein complexes. We are also interested in structure and function of other macromolecules. Proteins studied are usually prepared in cooperating laboratories.

• • Protein-polymer interaction (partner: SPINE2 laboratories)

  • Extracellular domains of receptors of killer cells of immune system (partners: Institute of Microbiology of the Czech Academy of Sciences and Faculty of Science, Charles University)

• Industrially interesting oxidoreductases (partner: Novozymes)

• Two domain laccase - a link between laccases and nitrite reductases (partner: Novozymes)

• Proteins operating on DNA/RNA

• Systematic structure studies of Fc fragments of immunoglobulines

• Chitinolytic complex of enzymes from bacteria of intestinal microflora (partner: Institute of Animal Physiology and Genetics of the Czech Academy of Sciences)

• Cold-active beta-galactosidase (partner: University of Chemistry and Technology, Prague)

  • HIV-1 protease and its interaction with inhibitors. Structural effects of protease mutations and inhibitor modifications (partner: IOCB Czech Academy of Sciences)