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I am a Theoretical Physicist trained in Computer Science. I develop computational methods for inference, modelling, simulation and analysis of complex systems representable as dynamical networks.

I am focused on the mathematical formalization and the algorithmic procedures implementing efficient solutions for the identiafiability, the controllability, and the dynamics simulation of such systems.

The main goals of my research are

  • to understand the functional organization governing time and space evolution of such systems and predict their response to stimuli and perturbations

  • to unravel the mechanisms responsible for their emergent properties.

The main applicative domains of my studies are network biology, biochemistry, biological physics, microbiology, and synthetic biology.

As Senior Member of the Association for Computing Machinery (ACM), New York, USA, I am contributing to the organization and promotion of the scientific events of ACM in the fields of computational biology, artificial intelligence and applied computing.


CALL FOR PAPERS/ABSTRACTS

I cordially invite you to attend and submit your abstract for the session “Multiphysics modelling at the 17th International Symposium on Computer Methods on Biomechanics and Biomedical Engineering & 5th Conference on Imaging and Visualization (CMBBE Symposium 2021). More details are available and will be added to the conference website.


NEWS

Press release

Cystic Fibrosis project (April 2021)

Cystic Fibrosis project (February 2021)

New books

P. Lecca, Identifiability and Regression Analysis of Biological Systems Models, Statistical and Mathematical Foundations and R Scripts, Springer 2020.

P. Lecca, A. Re, Theoretical Physics for Biological Systems, CRC Press Taylor & Francis Group, 2019

Recent publications

  • Marco Pedrazzi, Silvia Vercellone , Elettra Barberis, Michela Capraro, Roberta De Tullio, Federico Cresta, Rosaria Casciaro, Carlo Castellani, Mauro Patrone, Emilio Marengo, Paola Lecca, Paola Melotti, Claudio Sorio, Marcello Manfredi and Monica Averna, Identification of Potential Leukocyte Biomarkers Related to Drug Recovery of CFTR: Clinical Applications in Cystic Fibrosis, Int. J. Mol. Sci. 22, no. 8: 3928. https://www.mdpi.com/1422-0067/22/8/3928.

  • P. Lecca, Control Theory and Cancer Chemotherapy: How They Interact. Front. Bioeng. Biotechnol. 8:621269, 2021, doi: 10.3389/fbioe.2020.621269 (here).

  • P. Lecca, A. Re, Stiffness estimate of information propagation in biological systems modelled as spring networks, Proceedings of International Workshop on Biological Network Analysis and Integrative Graph-Based Approaches, Mingon Kang, Ananda - 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2020 (here).

  • P. Lecca, A. Re, Observability of Bacterial Growth Models in Bubble Column Bioreactors, Computational Intelligence Methods for Bioinformatics and Biostatistics, Springer International Publishing pp. 309-322, Springer International Publishing, 2020 (here),

  • P. Lecca, M. Lecca, P. Melotti, V. Lotti, S. Preato, K. Kleinfelder, A. Farinazzo, C. Sorio, Computing organoids’ volume in medical images: the case study of cystic fibrosis, 2020 IEEE International Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB 2020), pp. 1-8, Viña del Mar, October 27-29, 2020 (here)

  • Cecilia Ada Maestri , Antonella Motta, Lorenzo Moschini, Andreas Bernkop‐Schnürch, Randi Angela Baus, Paola Lecca, Marina Scarpa, Composite nanocellulose‐based hydrogels with spatially oriented degradation and retarded release of macromolecules, Journal of Bioemdical Research Part A, Volume 108, Number 7}, pp. 1509--1519. https://doi.org/10.1002/jbm.a.36922.

  • P. Lecca, A. Re, A reaction-based model of the state space of chemical reaction systems enables efficient simulations, IEEE/ACM Transactions on Computational Biology and Bioinformatics, Volume: 17 , Issue: 2 , March-April 1 2020 .

  • A. Re, P. Lecca, On TD-WGcluster: Theoretical Foundations and Guidelines for the User. In: Canzar S., Ringeling F. (eds) Protein-Protein Interaction Networks. Methods in Molecular Biology, pp 233-262, vol. 2074. Humana, New York, NY, 2020 (here).

Recent and upcoming talks

P. Lecca (speaker), A. Re, Stiffness estimate of information propagation in biological systems modelled as spring networks, International Workshop on Biological Network Analysis and Integrative Graph-Based Approaches, Mingon Kang, Ananda - 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM).

P. Lecca, A network analysis computational pipeline to detect altered gene pathways in chronic myeloid leukemia, Free Software Conference, Bozen-Bolzano, Italy, November 13-14, 2020.

P. Lecca (speaker), M. Lecca, P. Melotti, V. Lotti, S. Preato, K. Kleinfelder, A. Farinazzo, C. Sorio, Computing organoids’ volume in medical images: the case study of cystic fibrosis, 2020 IEEE International Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB 2020, October 27-29, 2020)

P. Lecca, A Computational Control Theory Approach to the Analysis of Virus-Host Interactome in Covid-19, ACM - WonEncourage 2020, September 24-25, 2020.

P. Lecca (speaker), A. Re, A. Mosca, M. Moraschini, B. Carpentieri, E. Moratti, M. Vezzalini, C. Sorio, P. S. Labini, F. Vella, Comparative dynamic network analysis to detect altered pathways in chronic myeloid leukemia human cell model, 24th International Conference On Research in Computational Molecular Biology, 22-25 June 2020.

Recent publications included in eBooks

Article published in the eBook edited by Spyros Petrakis, Miguel A. Andrade-Navarro: "Protein interaction networks in health and disease".

Article published in the eBook edited by Imrich Barak, Neil Fairweather, Simon Michael Cutting, Ezio Ricca, Ivan Mijakovic: "Spores and spore formers".

Organization of recent and forthcoming events


THESIS

Thesis available (click here for more information).