Mizuki Takenaka lab
- We are interested in the RNA editing mechanism in plant mitochondria
RNA editing in plant mitochondria
- RNA editing events are found in all flowering and almost all non-flowering land plants in the two organelles mitochondria and plastids. This posttranscriptional process alters specific C nucleotides to U, in plastids about 35, in mitochondria more than 400. Most of these nucleotide alterations in mRNAs change the encoded amino acid to one better conserved in evolution, suggesting that these editing events are important for the function of the protein. How a C nucleotide is selected to be edited to a U remained an enigma for more than a decade, since no common nucleotide motifs distinguish these sites.
- In our recent research work, we have identified and characterized two types of factors involved in RNA editing in plant mitochondria, MEF (Mitochondrial RNA editing factor) and MORF (Multiple organellar RNA editing factor) proteins.