Publications

1.            Seo R, de Guzman ACV, Park S, Lee J, Kang SJ. (2025) Cancer-intrinsic Cxcl5 orchestrates a global metabolic reprogramming for resistance to oxidative cell death in 3D. Cell Death and Differentiation, Accepted.

2.            Chun D,¶ Park J,¶ Lee S, Kim HJ, Park JE, Kang SJ. (2024) Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells. Cell Reports 43:115023 (doi: 10.1016/j.celrep.2024.115023).

3.            Hong S, Kim K, Shim YR, Park J, Choi SE, Min H, Lee S, Song JJ, Kang SJ, Jeong WI, Seong RH, Kim S. A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex. Cell Commun Signal. 2024 Oct 30;22(1):526. (doi: 10.1186/s12964-024-01907-0).

4.            Park J, Kang SJ. (2024) The ontogenesis and heterogeneity of basophils. Discov Immunol. 3:kyae003. (doi: 10.1093/discim/kyae003).

5.            Park J,¶ Cho Y¶, Yang D, Yang H, Lee D, Kubo M, Kang SJ. (2024) The transcription factor NFIL3/E4BP4 regulates the developmental stage-specific acquisition of basophil function. J Allergy Clin Immunol 153:132. (doi: 10.1016/j.jaci.2023.09.029).

6.            Son K¶, Jeong S¶, Eom E¶, Kwon D, Kang SJ. (2023) MARCH5 promotes STING pathway activation by suppressing polymer formation of oxidized STING. EMBO Rep 24:e57496. (doi: 10.15252/embr.202357496).

7.            Choi B¶, Kang CK¶, Park S¶, Lee D, Lee AJ, Ko Y, Kang SJ, Kang K, Kim S, Koh Y, Jung I. (2022) Single-cell transcriptome analyses reveal distinct gene expression signatures of severe COVID-19 in the presence of clonal hematopoiesis. Exp Mol Med 54:1756-65 (doi: 10.1038/s12276-022-00866-1).

8.            Lee M¶, Chun D¶, Park S, Choi G, Kim Y, Kang SJ, Im SG. (2022) Engineering of Surface Energy of Cell-Culture Platform to Enhance the Growth and Differentiation of Dendritic Cells via Vapor-Phase Synthesized Functional Polymer Films. Small 17:e2106648. (doi: 10.1002/smll.202106648).

9.            Park J¶, Choi SW¶, Cha BG, Kim J, Kang SJ. (2021) Alternative Activation of Macrophages through Interleukin-13-Loaded Extra-Large-Pore Mesoporous Silica Nanoparticles Suppresses Experimental Autoimmune Encephalomyelitis. ACS Biomater Sci Eng 7:4446-53. (doi: 10.1021/acsbiomaterials.1c00946).

10.          Kim BS, Kuen DS, Koh CH, Kim HD, Chang SH, Kim S, Jeon YK, Park YJ, Choi G, Kim J, Kang KW, Kim HY, Kang SJ, Hwang S, Shin EC, Kang CY, Dong C, Chung Y. (2021) Type 17 immunity promotes the exhaustion of CD8+ T cells in cancer. J Immunother Cancer 9: e002603. (doi: 10.1136/jitc-2021-002603).

11.          Basit A, Cho MG, Kim EY, Kwon D, Kang SJ, Lee JH. (2020) The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels. Exp Mol Med 52:643-57. (doi: 10.1038/s12276-020-0416-y).

12.          Kim KH, Hwang J, Kim JH, Son KP, Jang Y, Kim M, Kang SJ, Lee JO, Kang JY, Choi BS. (2020) Structural and biophysical properties of RIG-I bound to dsRNA with G-U wobble base pairs. RNA Biol 17:325-34. (doi:10.1080/15476286.2019.1700034).

13.          Lim GJ, Kang SJ, Lee JY. (2020) Novel invasion indices quantify the feed-forward facilitation of tumor invasion by macrophages. Sci Rep 10:718 (doi: 10.1038/s41598-020-57517-6).

14.          Chung WC, Hwang KY, Kang SJ, Kim JO, Song MJ. (2020) Development of a neutralization assay based on the pseudotyped chikungunya virus of a Korean isolate. J Microbiol 58:46-53 (doi: 10.1007/s12275-020-9384-0).

15.          Yoon BH, Kim M, Kim MH, Kim HJ, Kim JH, Kim JH, Kim J, Kim YS, Lee D, Kang SJ, Kim SY. (2018) Dynamic Transcriptome, DNA Methylome, and DNA Hydroxymethylome Networks During T-Cell Lineage Commitment. Mol Cells 41:953-63 (doi: 10.14348/molcells.2018.0213).

16.          Ng YC, Chung WC, Kang HR, Cho HJ, Park EB, Kang SJ, Song MJ. (2018) A DNA-sensing-independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-κB-mediated innate immunity against DNA virus infection. Nucleic Acids Res 46:9011-26 (doi: 10.1093/nar/gky742).

17.          Lee Y, Lim B, Lee SW, Lee WR, Kim YI, Kim M, Ju H, Kim MY, Kang SJ, Song JJ, Lee JE, Kang C. (2018) ANKRD9 is associated with tumor suppression as a substrate receptor subunit of ubiquitin ligase. Biochim Biophys Acta Mol Basis Dis 1864:3145-53 (doi: 10.1016/j.bbadis.2018.07.001).

18.          Kwon D, Sesaki H, Kang SJ. (2018) Intracellular calcium is a rheostat for the STING signaling pathway. Biochem Biophys Res Commun 500:497-503 (doi: 10.1016/j.bbrc.2018.04.117).

19.          Min J¶, Yang D¶, Kim M, Haam K, Yoo A, Choi JH, Schraml B, Kim YS, Kim D, Kang SJ. (2018) Inflammation induces two types of inflammatory dendritic cells in inflamed lymph nodes. Exp Mol Med 50:33 (doi: 10.1038/s12276-018-0086-1).

20.          Kim SY, Jeong JM, Kim SJ, Seo W, Kim MH, Choi WM, Yoo W, Lee JH, Shim YR, Yi HS, Lee YS, Eun HS, Lee BS, Chun K, Kang SJ, Kim SC, Gao B, Kunos G, Kim HM, Jeong WI. (2017) Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex. Nat Commun 8:2247 (doi: 10.1038/s41467-017-02325-2).

21.          Bok S, Kim YE, Woo Y, Kim S, Kang SJ, Lee Y, Park SK, Weissman IL, Ahn GO. (2017) Hypoxia-inducible factor-1α regulates microglial functions affecting neuronal survival in the acute phase of ischemic stroke in mice. Oncotarget 8:111508-21 (doi: 10.18632/oncotarget.22851).

22.          Cho Y, Kwon D, Kang SJ. (2017) The cooperative role of CD326+ and CD11b+ dendritic cell subsets for a hapten-induced Th2 differentiation. J Immunol 199:3137-46 (doi: 10.4049/jimmunol.1601262).

23.          Kwon D, Park EB, Sesaki H, Kang SJ. (2017) Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondria fission. Biochem Biophys Res Commun 493:737-43 (doi: 10.1016/j.bbrc.2017.08.121).

24.          Jo Y¶, Park S¶, Jung J, Yoon J, Joo H, Kim MH, Kang SJ, Choi MC, Lee SY, Park Y. (2017) Holographic deep learning for rapid optical screening of anthrax spores. Sci Adv 3: e1700606 (doi: 10.1126/sciadv.1700606).

25.          Kwon D, Park EB, Kang SJ. (2017) STING-mediated DNA sensing pathway is suppressed by NLRP3 agonists and regulated by MFN1 and TBC1D15, mitochondria dynamics mediators. FASEB J 31:4866 -78 (doi: 10.1096/fj.201700328R).

26.          Yoon J¶, Jo Y¶, Kim MH, Kim K, Lee SY, Kang SJ, Park Y. (2017) Identification of non-activated lymphocytes using three-dimensional refractive index tomography and machine learning. Sci Rep 7:6654 (doi: 10.1038/s41598-017-06311-y).

27.          Seo H, Jeon I, Kim BS, Park M, Bae EA, Song B, Koh CH, Shin KS, Kim IK, Choi K, Oh T, Min J, Min BS, Han YD, Kang SJ, Shin SJ, Chung Y, Kang CY. (2017) IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours. Nat Commun 8:15776 (doi: 10.1038/ncomms15776).

28.          Kwon D¶, Cha BG¶, Cho Y¶, Min J, Park EB, Kang SJ, Kim J. (2017) Extra-Large Pore Mesoporous Silica Nanoparticles for Directing in Vivo M2 Macrophage Polarization by Delivering IL-4. Nano Lett 17: 2747-56 (doi: 10.1021/acs.nanolett.6b04130).

29.          Kim E, Beon J, Lee S, Park SJ, Ahn H, Kim MG, Park JE, Kim W, Yuk JM., Kang SJ, Lee SH, Jo EK, Seong RH, Kim S. (2017) Inositol polyphosphate multikinase promotes Toll-like receptor–induced inflammation by stabilizing TRAF6. Sci Adv 3: e1602296 (doi: 10.1126/sciadv.1602296).

30.          Seo J¶, Kang JA¶, Suh DI¶, Park EB, Lee CR, Choi SA, Kim SY, Kim Y, Park SH, Ye M, Kwon SH, Park JD, Lim BC, Lee DH, Kang SJ, Choi M, Park SG, Chae JH. (2017) Tofacitinib relieves symptoms of stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy caused by 2 de novo variants in TMEM173. J Allergy Clin Immunol 139: 1396-9 (doi: 10.1016/j.jaci.2016.10.030).

31.          Lee A¶, Park EB¶, Lee J, Choi BS, Kang SJ. (2017) The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity. FEBS Lett 591, 954-61 (doi: 10.1002/1873-3468.12598).

32.          Kim MH, Yang D, Kim M, Kim SY, Kim D, Kang SJ. (2017) A late-lineage murine neutrophil precursor population exhibits dynamic changes during demand-adapted granulopoiesis. Sci Rep 7, 39804 (doi: 10.1038/srep39804).

33.          Lee MK, Kim HE, Park EB, Lee J, Kim KH, Lim K, Yum S, Lee YH, Kang SJ, Lee JH, Choi BS. (2016) Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate. Nucleic Acids Res 44:8407-16 (doi: 10.1093/nar/gkw525).

34.          Kim J, Yum S, Kang C, Kang SJ. (2016) Gene-gene interactions in gastrointestinal cancer susceptibility. Oncotarget 7, 67612-25 (doi: 10.18632/oncotarget.11701).

35.          Kim HS, Kim DC, Kim HM, Kwon HJ, Kwon SJ, Kang SJ, Kim SC, Choi GE. (2015) STAT1 deficiency redirects IFN signaling toward suppression of TLR response through a feedback activation of STAT3. Sci Rep 5:13414 (doi: 10.1038/srep13414).

36.          Jo Y, Jung J, Kim MH, Park H, Kang SJ, Park Y. (2015) Label-free identification of individual bacteria using Fourier transform light scattering. Optics Express 23: 15792-15805 (doi: 10.1364/OE.23.015792).

37.          Cheong WC, Kang HR, Yoon H, Kang SJ, Ting JPY, Song MJ. (2015) Influenza A virus NS1 protein inhibits the NLRP3 inflammasome. PLoS One 10: e0126456 (doi: 10.1371/journal.pone.012645).

38.          Kim K¶, Cho SK¶, Han TU, Kim JH, Kang SJ, Kang C, Bae SC. (2013) A redundant epistatic interaction between IRF5 and STAT4 of the type I interferon pathway in susceptibility to lupus and rheumatoid arthritis. Lupus 22: 1336-1340 (doi: 10.1177/0961203313504479).

39.          Kang SJ. (2012) The bloodline of CD8a+ dendritic cells. Mol Cells 34: 219-29 (doi: 10.1007/s10059-012-0058-6).

40.          Yuan W, Kang SJ, Evans JE, Cresswell P. (2009) Natural lipid ligands associated with human CD1d targeted to different subcellular compartments. J Immunol 182: 4784-91 (doi: 10.4049/jimmunol.0803981).

41.          Kang SJ, Locksley RM. (2009) The inflammasome and alum-mediated adjuvanticity. F1000 Biology Reports 2009 1:15 (doi: 10.3410/B1-15).

42.          Kang SJ, Liang HE, Reizis B, Locksley RM. (2008) Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29: 819-33. (doi: 10.1016/j.immuni.2008.09.017) (Selected for ‘Previews’, Immunity 29, 672-4; as ‘Must-read’, Faculty of 1000 Biology).

43.          Yuan W, Qi X, Tsang P, Kang SJ, Illarionov PA, Besra GS, Gumperz J, Cresswell P. (2007) Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules. Proc Natl Acad Sci U S A. 104: 5551-6 (doi: 10.1073/pnas.0700617104).

44.          Reinhardt RL¶, Hong S¶, Kang SJ, Wang ZE, Locksley RM. (2006) Visualization of IL-12/23p40 In Vivo Reveals Immunostimulatory Dendritic Cell Migrants that Promote Th1 Differentiation. J Immunol 177: 1618-27 (doi: 10.4049/jimmunol.177.3.1618).

45.          Reinhardt RL, Kang SJ, Liang HL, Locksley RM. (2006) T helper cell effector fates – who, how, and where?. Curr Opin Immunol 18: 271-7 (doi:10.1016/j.coi.2006.03.003).

46.          Kang SJ, Cresswell P. (2004) Saposins Facilitate CD1d-Restricted Presentation of an Exogenous Lipid Antigen to T Cells. Nat Immunol 5: 175-81. (doi: 10.1038/ni1034)(Selected for ‘News and Views’, Nat Immunol 5, 126-7).

47.          Park JJ¶, Kang SJ¶, De Silva AD, Stanic AK, Casorati G, Hachey DL, Cresswell P, Joyce S. (2004) Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved. Proc Natl Acad Sci U S A 101: 1022-6 (doi: 10.1073/pnas.0307847100).

48.          Kang SJ, Cresswell P. (2002) Calnexin, calreticulin and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain. J Biol Chem 277: 44838-44 (doi: 10.1074/jbc.M207831200).

49.          Kang SJ, Cresswell P. (2002) Regulation of intracellular trafficking of human CD1d by association with MHC class II molecules. EMBO J 21: 1650-60 (doi: 10.1093/emboj/21.7.1650).

50.          Carrithers MD, Visintin I, Kang SJ, Janeway CA. (2000) Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment. Brain 123: 1092-101.

NOTE: Underlined, correspondence; ¶, equal contribution