Publications

2024

• Roberto Bello-Madruga, Marc Torrent Burgas: The limits of prediction: Why intrinsically disordered regions challenge our understanding of antimicrobial peptides (2024) Computational and Structural Biotechnology Journal, 23:972-981. PDF 

• Jordi Gómez Borrego, Marc Torrent Burgas: Structural assembly of the bacterial essential interactome (2022) eLife 13:e94919. PDF 

2023

• Daniel Sandín García, Javier Valle, Jordi Gómez, Laura Comas, Maria Nieves Larrosa, Juan José González, María Angeles Jiménez, David Andreu, Marc Torrent: Mining the heparinome for cryptic antimicrobial peptides that selectively kill gram-negative bacteria (2023) bioRxiv, 2023.10.19.563059.

• Roberto Bello-Madruga, Javier Valle, M. Ángeles Jiménez, Marc Torrent, Vivian Montero-Alejo, David Andreu. The C-Terminus of Panusin, a Lobster β-Defensin, Is Crucial for Optimal Antimicrobial Activity and Serum Stability (2023) Pharmaceutics, 15(6), 1777. PDF 

• Andrea Vandelli, Magdalena Arnal Segura, Michele Monti, Jonathan Fiorentino, Laura Broglia, Alessio Colantoni, Natalia Sanchez de Groot, Marc Torrent Burgas, Alexandros Armaos, Gian Gaetano Tartaglia: The PRALINE database: Protein and Rna humAn singLe nucleotIde variaNts in condEnsates (2023) Bioinformatics, Accepted. PDF

2022

• Javier Macho Rendón, Rocío Rebollido Ríos, Marc Torrent: HPIPred: Host-Pathogen Interactome Prediction with phenotypic scring (2022) Computational and Structural Biotechnology Journal, 20:6534-6542. PDF

• Daniel Sandin, Javier Valle, Jordi Morata, David Andreu, Marc Torrent: Antimicrobial Peptides can Generate Tolerance by Lag and Interfere with Antimicrobial Therapy (2022) Pharmaceutics, 14:2169. PDF 

• Jordi Gómez Borrego, Marc Torrent Burgas: Analysis of Host–Bacteria Protein Interactions Reveals Conserved Domains and Motifs That Mediate Fundamental Infection Pathways (2022) International Journal of Molecular Sciences, 23:11489. PDF 

• Riccardo Delli Ponti, Laura Broglia, Andrea Vandelli, Alexandros Armaos, Marc Torrent Burgas, Natalia Sanchez de Groot, Gian Gaetano Tartaglia: A high-throughput approach to predict A-to-I effects on RNA structure indicates a change of double-stranded content in non-coding RNAs (2022) IUBMB Life, In Press. PDF 

• Adam Carrera-Aubesart, Sira Defaus, Clara Pérez-Peinado, Daniel Sandín, Marc Torrent, Maria Ángeles Jiménez, David Andreu: Examining Topoisomers of a Snake-Venom-Derived Peptide for Improved Antimicrobial and Antitumoral Properties (2022) Biomedicines, 10:2110. PDF 

• María Ángeles Abengózar, María Fernández-Reyes, Vivian A. Salazar, Marc Torrent, Beatriz G. de la Torre, David Andreu, Ester Boix, Luis Rivas: Essential Role of Enzymatic Activity in the Leishmanicidal Mechanism of the Eosinophil Cationic Protein (RNase 3) (2022) ACS Infect. Dis., 8:1207-1217. PDF 

• Jiarui Li, Guillem Prats-Ejarque, Marc Torrent, David Andreu, Klaus Brandenburg, Pablo Fernández-Millán, Ester Boix: In Vivo Evaluation of ECP Peptide Analogues for the Treatment of Acinetobacter baumannii Infection (2022) Biomedicines, 10:386. PDF 

• Andrea Vandelli, Fernando Cid Samper, Marc Torrent Burgas, Natalia Sanchez de Groot, Gian Gaetano Tartaglia: The interplay between disordered regions in RNAs and proteins modulates interactions within stress granules and processing bodies (2022) J. Mol. Biol, 434:167159. PDF

2021

• Daniel Sandin, Javier Valle, Belén Chaves-Arquero, Guillem Prats-Ejarque, María Nieves Larrosa, Juan José González-López, María Ángeles Jiménez, Ester Boix, David Andreu, Marc Torrent: Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability (2021) J. Med. Chem, 64:11472-11482. PDF 

• Andrea Vandelli, Fernando Cid Samper, Marc Torrent Burgas, Natalia Sanchez de Groot, Gian Gaetano Tartaglia: The Interplay Between Disordered Regions in RNAs and Proteins Modulates Interactions Within Stress Granules and Processing Bodies (2021) J. Mol. Biol. 434:167159. PDF 

• Núria Crua Asensio, Javier Macho Rendón, Marc Torrent Burgas: Time-Resolved Transcriptional Profiling of Epithelial Cells Infected by Intracellular Acinetobacter baumannii (2021) Microorganisms, 9:354. PDF 

• Javier Macho Rendón, Benjamin Lang, Marc Ramos Llorens, Gian Gaetano Tartaglia, Marc Torrent Burgas: DualSeqDB: the host–pathogen dual RNA sequencing database for infection processes (2021) Nucleic Acids Res, 49:D687–D693. PDF 

2020

• Lu Lu, RanLei Wei, Guillem Prats-Ejarque, Maria Goetz, Gang Wang, Marc Torrent, Ester Boix: Human RNase3 immune modulation by catalytic-dependent and independent modes in a macrophage-cell line infection model (2020) Cell. Mol. Life Sci, In Press. PDF 

• Nieves Lorenzo Gotor, Alexandros Armaos, Giulia Calloni, Marc Torrent Burgas, R Martin Vabulas, Natalia Sanchez De Groot, Gian Gaetano Tartaglia: RNA-binding and prion domains: the Yin and Yang of phase separation (2020) Nucleic Acids Research, 48:9491–9504. PDF 

• Natalia S. de Groot, Marc Torrent Burgas: Bacteria use structural imperfect mimicry to hijack the host interactome (2020) PLoS Comput Biol 16(12): e1008395. PDF 

• Javier Macho Rendón, Benjamin Lang, Gian Gaetano Tartaglia, Marc Torrent: BacFITBase: a database to assess the relevance of bacterial genes during host infection (2020) Nucleic Acids Research, 48:D511-D516. PDF 

2019

• Natalia S. de Groot, Marc Torrent: A coordinated response at the transcriptome and interactome level is required to ensure uropathogenic Escherichia coli survival during bacteremia (2019) Microorganisms, 7:292. PDF 

• Vivian Salazar, Javier Arranz-Trullén, Guillem Prats-Ejarque, Marc Torrent, David Andreu, David Pulido, and Ester Boix: Insight into the antifungal mechanism of action of human RNase N-terminus derived peptides. (2019) International journal of molecular sciences, 20:4558. PDF 

• Natalia S. de Groot, Marc Torrent, Charles NJ Ravarani, Ala Trusina, Salvador Ventura, Madan Babu: The fitness cost and benefit of phase separated protein deposits (2019) Molecular Systems Biology, 15:e8075. PDF 

2018

• David Pulido, Guillem Prats-Ejarque, Clara Villalba, Marcel Albacar, Mohammed Moussaoui, David Andreu, Rudolf Volkmer, Marc Torrent, Ester Boix: Positional Scanning Library applied to the human eosinophil cationic protein/RNase3 N-terminus reveals novel and potent anti-biofilm peptides (2018) European Journal of Medicinal Chemistry, 152:590-599. PDF 

• Marc Torrent, Guilhem Chalancon, Natalia S. de Groot, Madan Babu: Cells alter their tRNA abundance to selectively regulate protein expression during stress conditions (2018) Science Signalling, 11: eaat6409. PDF 

2017

• David Pulido, Rocío Rebollido-Ríos, Javier Valle, David Andreu, Ester Boix, Marc Torrent: Structural similarities in the CPC clip motif explain peptide-binding promiscuity between glycosaminoglycans and lipopolysaccharides (2017) Journal of The Royal Society Interface, 14:20170423. PDF 

• Núria Crua, Natalia S. de Groot, Marc Torrent: Centrality in the host-pathogen interactome is associated with pathogen fitness during infection (2017) Nature Communications, 8: 14092. PDF 

2016

• David Pulido, M. Flor García-Mayoral, Mohammed Moussaoui, Diego Velázquez, Marc Torrent, Marta Bruix, Ester Boix: Structural basis for endotoxin neutralization by the Eosinophil Cationic Protein (2016) FEBS Journal, 283 (22), 4176-4191. PDF 

• David Pulido, Guillem Prats-Ejarque, Clara Villalba, Marcel Albacar, Juanjo González-López, Marc Torrent, Mohammed Moussaoui, Ester Boix: A novel RNase 3/ECP peptide for Pseudomonas aeruginosa biofilm eradication. Combining antimicrobial, lipopolysaccharide binding and cell agglutinating activities. (2016) Antimicrobial agents and Chemotherapy, 60(10):6313-6325. PDF 

• David Pulido, Javier Arranz, Guillem Prats, Diego Velazquez, Marc Torrent, Mohammed Moussaoui, Ester Boix: Insights into the antimicrobial mechanism of action of human RNase 6: structural determinants for bacterial cell agglutination and membrane permeation (2016) International Journal of Molecular Sciences, 17(4):552. PDF 

2015

• Natalia S. de Groot, Marc Torrent: Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases? (2015) Cellular and Molecular Life Sciences 72(24):4795-4805. PDF 

• David Andreu, Marc Torrent: Prediction of bioactive peptides using artificial neural networks. Methods in molecular biology: Artificial Neural Networks, edited by Hugh Cartwright (2015) pages 101-118; Springer, ISBN: 978-1-4939-2239-0. PDF 

2013

• David Pulido, Mohammed Moussaoui, M. Victòria Nogués, Marc Torrent, Ester Boix: Towards the rational design of antimicrobial proteins: single point mutations can switch on bactericidal and agglutinating activities on the RNase A superfamily lineage (2013) FEBS Journal 280(22):5841-5852. PDF 

• Marc Torrent*, David Pulido, Javier Valle, M Victoria Nogués, David Andreu, Ester Boix: Ribonucleases as a host-defense family: Evidence of evolutionary conserved antimicrobial activity at the N-terminus. (2013) Biochemical Journal 456(1):99-108. PDF 

• David Pulido, Marc Torrent, David Andreu, M Victoria Nogués, Ester Boix: Two human host defense ribonucleases against mycobacteria: the eosinophil cationic protein (ECP/RNase 3) and RNase 7. (2013) Antimicrobial Agents and Chemotherapy 57(8):3797-3805. PDF 

2012

• Marc Torrent, David Pulido, M Victòria Nogués, Ester Boix: Exploring new biological functions of amyloids: bacteria cell agglutination mediated by host protein aggregation (2012) PLoS Pathogens 8(11):e1003005. PDF 

• Natalia S. de Groot, Marc Torrent, Anna Villar-Piqué, Benjamin Lang, Salvador Ventura, Jörg Gsponer, M Madan Babu: Evolutionary selection for protein aggregation (2012) Biochemical Society Transactions 40(5):1032-1037. PDF 

• Marc Torrent, M. Victòria Nogués, David Andreu, Ester Boix: The "CPC clip motif": a conserved structural signature for heparin-binding proteins (2012) PLoS ONE 7(8):e42692. PDF 

• Ester Boix, Vivian A. Salazar, Marc Torrent, David Pulido, M. Victòria Nogués, Mohammed Moussaoui: Structural determinants of the eosinophil cationic protein antimicrobial activity (2012) Biological Chemistry 393(8):801-815. PDF 

• Marc Torrent, M. Victòria Nogués, Ester Boix: Discovering new in silico tools for antimicrobial peptide prediction (2012) Current drug targets 13(9):1148-1157. PDF 

• Marc Torrent, David Pulido, Luis Rivas, David Andreu: Antimicrobial peptide action on parasites (2012) Current drug targets 13(9):1138-1147. PDF 

• David Pulido, M. Victòria Nogués, Ester Boix, Marc Torrent: Lipopolysaccharide neutralization by antimicrobial peptides: a gambit in the innate host defense strategy (2012) Journal of Innate Immunity 4(4):327-336. PDF 

• David Pulido, Mohammed Moussaoui, David Andreu, M. Victòria Nogués, Marc Torrent, Ester Boix: Antimicrobial action and cell agglutination by the eosinophil cationic protein are modulated by the cell wall lipopolysaccharide structure (2012) Antimicrobial Agents and Chemotherapy 56(5):2378-85. PDF 

2011

• Marc Torrent, Paolo Di Tommaso, David Pulido, M. Victòria Nogués, Cedric Notredame, Ester Boix, David Andreu: AMPA: an automated web server for prediction of protein antimicrobial regions (2011) Bioinformatics 28(1):130-131. PDF 

• Marc Torrent, Javier Valle, M. Victòria Nogués, Ester Boix, David Andreu: The generation of antimicrobial peptide activity: a trade-off between charge and aggregation? (2011) Angewandte Chemie International Edition 50(45):10686-91068. PDF 

• Marc Torrent, David Pulido, Beatriz G. de la Torre, M. Flor García-Mayoral, M. Victòria Nogués, Marta Bruix, David Andreu, Ester Boix: Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization (2011) Journal of Medicinal Chemistry 54(14):5237-5244. PDF 

• Marc Torrent, David Andreu, M. Victòria Nogués, Ester Boix: Connecting peptide physicochemical and antimicrobial properties by a rational prediction model (2011) PLoS ONE 6(2):e16968. PDF 

2010

• Daniel Sánchez, Mohammed Moussaoui, Esther Carreras, Marc Torrent, M. Victòria Nogués, Ester Boix: Mapping the eosinophil cationic protein antimicrobial activity by chemical and enzymatic cleavage (2010) Biochimie 93(2):331-338. PDF 

• Marc Torrent, Francesco Odorizzi, M. Victòria Nogués, Ester Boix: Eosinophil cationic protein aggregation: identification of an N-terminus amyloid prone region (2010) Biomacromolecules 11(8):1983-1990. PDF 

• Marc Torrent, M. Victòria Nogués, Ester Boix: Eosinophil cationic protein (ECP) can bind heparin and other glycosaminoglycans through its RNase active site (2010) Journal of Molecular Recognition 24(1):90-100. PDF 

• Marc Torrent, Marina Badia, Mohammed Moussaoui, Daniel Sanchez, M. Victòria Nogués, Ester Boix: Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall (2010) FEBS Journal 277(7):1713-1725. PDF 

2009

• Marc Torrent, M. Victòria Nogués, Ester Boix: A theoretical approach to spot active regions in antimicrobial proteins (2009) BMC Bioinformatics 10:373. PDF 

• Marc Torrent, Beatriz G. de la Torre, M. Victòria Nogués, David Andreu, Ester Boix: Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment (2009) Biochemical Journal 421(3):425-434. PDF 

• Marc Torrent, Daniel Sánchez, Víctor Buzón, M. Victòria Nogués, Josep Cladera, Ester Boix: Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7 (2009) BBA-Biomembranes 1788(5):1116-1125. PDF 

2008

• Ester Boix, Marc Torrent, Daniel Sánchez, M. Victòria Nogués: The antipathogen activities of eosinophil cationic protein (2008) Current pharmaceutical biotechnology 9(3):141-152. PDF 

• Marc Torrent, Susanna Navarro, Mohammed Moussaoui, M. Victòria Nogués, Ester Boix: Eosinophil cationic protein high-affinity binding to bacteria-wall lipopolysaccharides and peptidoglycans (2008) Biochemistry 47(11):3544-3555. PDF 

2007

• Marc Torrent, Elisabet Cuyás, Esther Carreras, Susanna Navarro, Olga López, Alfons de la Maza, M. Victòria Nogués, Yana K Reshetnyak, Ester Boix: Topography studies on the membrane interaction mechanism of the eosinophil cationic protein (2007) Biochemistry 46(3):720-733. PDF