• Microbial signature for Crohn's Disease:

https://www.youtube.com/watch?v=Y21reEQ90g4&list=PL80fezoRY4BDr-oZjQVFikD4M2dtRDS6b

• Definition of a "healthy" Human microbiota

• Human gut microbiota associated with IBD (Inflammatory Bowel DIsease)

Manichanh et al., Gut 2006

• Human gut microbiota associated with Functional Bowel Disorders such as IBS (Irritable Bowel Syndrome)

• Translocation of bacteria in human organs associated with severity of diseases

• Human Microbiome Manipulation

Manichanh et al., Gen. Res. 2010

• Molecular and Bioinformatics tools:

Development of molecular tools for DNA and RNA extraction from human samples

Development of qPCR systems for bacterial quantification

Developement of Bioinformatics tools for diversity and function analysis of the human Microbiome: MetaTrans

• Partner of the METAHIT Consortium:

MetaHIT stands for Metagenomics of the Human Intestinal Tract. The consortium is composed of 7 different European countries and a Chinese partner. Its seeks to uncover the diversity and function of the human gut microbiota, which is the aggregate of microorganisms that reside inside our body, using metagenomics approaches. Metagenomics is described as the study of genetic material recovered directly from environmental samples bypassing the need to isolate and culture individual bacterial community members. MetaHIT has first contributed to comprehensively characterize the diversity and gene content of the vast intestinal microbial ecosystem of 124 european individuals through a publication in Nature in 2010. Its second contribution allowed to classify the human microbiome in different types called enterotypes based on the microbial composition and abundance of each individual in a second publication in Nature in 2011. The consortium is now working on a association between the microbiota and metabolic disorders such as obesity and chronic intestinal disease such as inflammatory bowel disease (IBD).

• Partner of the International Human Microbiome Standards (IHMS):