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Development of Drug Delivery Systems
Development of Drug Delivery Systems
Spray drying technology-to increase drug stability, solubility and permeability using a dual chanel spray gun- a proprietary technology. Have used this technology for preparing formulations for Geftinib, DIMs, Betulinic acid, cisplatin and other compounds.
Liposome and nanoparticle formulations-for percutaneous and targeted delivery
Lipid based solid dispersion-to increase drug solubility and stability
Passive and active polymeric/lipid based particulate drug delivery systems
Topical drug delivery systems for small molecules and peptides.
Surface modified polymeric/lipid based drug loaded nanoparticles for brain targeting
Drug delivery systems using Hot melt extrusion principle
Peptide based drug delivery systems for targeted drug delivery for cancer.
We are experts in Analytical and Bio-analytical method development and validation using High Performances Liquid Chromatography.
We have Waters HPLC with auto-sampler and PDI detectors (3 systems)
We have experience in analyzing all matrix samples (Bio-matrix and formulation samples)
We have following tumor models: “Triple negative breast cancer, Lung Cancer (orthotopic and metastatic models). We have expertise and facilities to conduct tumor model studies using athymic nude mice. PDX models are being currently developed.
We also have psoriatic plaque like model to conduct psoriasis studies.
We have a UV-B induced chemoprevention model which has been used for a variety of natural products topically.
We are experts in conducting “in-vivo preclinical pharmacokinetics studies’ for different drugs delivery systems/drugs in tumor bearing mice and rats.
We have in-vitro 3D culture models for tumor cells and have used the Algimatrix system.
Routinely conduct efflux and permeability study using Caco-2 cells
We also conduct in-vitro cytotoxicity study using different cell lines using MTT assay
We are experts in bio-conjugation, polymer modification and fabrication with biomolecules, polymeric nanoparticle synthesis. Synthetic strategies involving development of stimuli responsive polymeric biomaterials.
Spray Drying
Spray Drying
(Piltech YC-501)
(Piltech YC-501)
In-Vitro Drug Release Characterization
In-Vitro Drug Release Characterization
(Franz Diffusion Cells)
(Franz Diffusion Cells)
In vitro drug release and skin deposition study of different drug delivery system for cancer.
USP apparatus I and II for determination of drug release from traditional dosage from tablets and capsules
Homogenization
Homogenization
(Silverson L4R)
(Silverson L4R)
Analytical Development
Analytical Development
We are experts in Analytical and Bio-analytical method development and validation using High Performances Liquid Chromatography.
We have Waters HPLC with auto-sampler and PDI detectors (3 systems)
We have experience in analyzing all matrix samples (Bio-matrix and formulation samples)
High-Pressure Homogenization for Particulate Drug Delivery Systems (NanoDeBEE)
High-Pressure Homogenization for Particulate Drug Delivery Systems (NanoDeBEE)
High Performance Liquid Chromatography (HPLC)
High Performance Liquid Chromatography (HPLC)
Liquid Chromatography - Mass Spectrometry (LC-MS)
Waters Alliance e2695 Separation Module
Peak Scientific Nitrogen Generator
In-Vitro Cell Culture
In-Vitro Cell Culture
We have in-vitro 3D culture models for tumor cells and have used the Algimatrix system.
Routinely conduct efflux and permeability study using Caco-2 cells
We also conduct in-vitro cytotoxicity study using different cell lines using MTT assay
Algimatrix 3D culture system
Algimatrix 3D culture system
In-Vivo Preclinical Pharmacokinetics Studies
In-Vivo Preclinical Pharmacokinetics Studies
Pharmacokinetic Profile
Pharmacokinetic Profile
We are experts in conducting “in-vivo preclinical pharmacokinetics studies" for different drugs delivery systems/drugs in tumor bearing mice and rats.
In-Vivo Pharmacodynamic Studies
In-Vivo Pharmacodynamic Studies
We have the following tumor models: “Triple negative breast cancer, Lung Cancer (orthotopic and metastatic models). We have expertise and facilities to conduct tumor model studies using athymic nude mice. PDX models are being currently developed.
We also have psoriatic plaque like model to conduct psoriasis studies.
We have a UV-B induced chemoprevention model developed which has been used for a long time now for a variety of natural products topically.
Lung Cancer Cell Tumor Bearing Mouse
Lung Cancer Cell Tumor Bearing Mouse
IMQ Psoriatic Plaque Model
IMQ Psoriatic Plaque Model
Polymeric Particulate Synthesis
Polymeric Particulate Synthesis
We are experts in bio-conjugation, polymer modification and fabrication with biomolecules, polymeric nanoparticle synthesis. Synthetic strategies involving development of stimuli responsive polymeric biomaterials.
3D Printing
3D Printing
We are experts in the 3D printing space. We have designed, formulated and printed various 3 dimensional structures for multiple applications.
We are currently working ahead of the industry in the fabrication of 3D printed micro-needles for transdermal drug delivery.
We were successful in 3D printing the human cornea with favorable mechanical properties.
MNs are primarily fabricated using multistep polydimtheylsiloxane (PDMS) micromolding method which makes it a batch process and may face reproducibility issues with final product. In our lab we formulated biocompatible resin using LAP as a biocompatible photo initiator to print dissolvable MN patch using 3D printing technology in order to deliver API
Material Properties Analysis
AR 1500Ex Rheometer
Digital programmable rheometer used to measure the rheological (flow and deformation) properties of materials. Provides mathematical interrelation between force, deformation and time.
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