Mandip Singh Sachdeva

OUR RESEARCH

Our team works in a multidisciplinary approach using Nanotechnology to combat devastating diseases like Breast and lung cancer. One of the emphases here is to overcome lung cancer mutations which are induced after using various Tyrosine kinase inhibitors. Our laboratory is using various novel compounds which are acting as chemosensitizers and help in overcoming resistance in lung and breast cancers.  We are also using extracellular vesicles as markers of tumor progression which can enable in diagnosis and tumor progression as a liquid biopsy. Exosomes, specifically are being used to deliver anticancer drugs and now our focus is on using them in immunotherapy to aid chemotherapy. Another emphasis is to use 3D printing approaches to develop tumor scaffolds and also to conduct cytotoxicity assays using 3D printed co-cultures of tumor cells and fibroblasts. Apart from this our team is also printing Cornea using various bioinks. Transdermal drug delivery using 3D printing is also something we are focusing on apart from developing scaffolds. We are also looking into various synthetic and natural cannabinoids like CBD, THCV and CBG and terpenes for their anticancer potential in both lung and breast cancer.